Vaccination reduces central nervous system IL-1 and memory deficits after COVID-19 in mice – Nature.com

Zhu, N. et al. A novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med. 382, 727733 (2020).

Article CAS PubMed PubMed Central Google Scholar

Zhou, P. et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 579, 270273 (2020).

Article CAS PubMed PubMed Central Google Scholar

OMahoney, L. L. et al. The prevalence and long-term health effects of long COVID among hospitalised and non-hospitalised populations: a systematic review and meta-analysis. EClinicalMedicine 55, 101762 (2023).

Article PubMed Google Scholar

Han, Q., Zheng, B., Daines, L. & Sheikh, A. Long-term sequelae of COVID-19: a systematic review and meta-analysis of one-year follow-up studies on post-COVID symptoms. Pathogens 11, 269 (2022).

Article CAS PubMed PubMed Central Google Scholar

Centers for Disease Control and Prevention, National Center for Health Statistics. Long COVIDHousehold Pulse Survey. https://www.cdc.gov/nchs/covid19/pulse/long-covid.htm (2023).

Hua, M. J. et al. Prevalence and characteristics of long COVID 712 months after hospitalization among patients from an urban safety-net hospital: a pilot study. AJPM Focus 2, 100091 (2023).

Article PubMed PubMed Central Google Scholar

Perlis, R. H. et al. Prevalence and correlates of long COVID symptoms among US adults. JAMA Netw. Open 5, e2238804 (2022).

Article PubMed PubMed Central Google Scholar

Taquet, M. et al. Incidence, co-occurrence, and evolution of long-COVID features: a 6-month retrospective cohort study of 273,618 survivors of COVID-19. PLoS Med. 18, e1003773 (2021).

Article CAS PubMed PubMed Central Google Scholar

Xu, E., Xie, Y. & Al-Aly, Z. Long-term neurologic outcomes of COVID-19. Nat. Med. 28, 24062415 (2022).

Article CAS PubMed PubMed Central Google Scholar

Mehandru, S. & Merad, M. Pathological sequelae of long-haul COVID. Nat. Immunol. 23, 194202 (2022).

Article CAS PubMed PubMed Central Google Scholar

Mndez, R. et al. Long-term neuropsychiatric outcomes in COVID-19 survivors: a 1-year longitudinal study. J. Intern. Med. 291, 247251 (2022).

Article PubMed Google Scholar

Douaud, G. et al. SARS-CoV-2 is associated with changes in brain structure in UK Biobank. Nature 604, 697707 (2022).

Hampshire, A. et al. Cognitive deficits in people who have recovered from COVID-19. EClinicalMedicine 39, 101044 (2021).

Article PubMed PubMed Central Google Scholar

Guo, P. et al. COVCOG 2: cognitive and memory deficits in long COVID: a second publication from the COVID and cognition study. Front. Aging Neurosci. 14, 804937 (2022).

Article CAS PubMed PubMed Central Google Scholar

Graham, E. L. et al. Persistent neurologic symptoms and cognitive dysfunction in non-hospitalized COVID-19 long haulers. Ann. Clin. Transl. Neurol. 8, 10731085 (2021).

Article CAS PubMed PubMed Central Google Scholar

Monje, M. & Iwasaki, A. The neurobiology of long COVID. Neuron 110, 34843496 (2022).

Article CAS PubMed PubMed Central Google Scholar

Klein, R. S. Mechanisms of coronavirus infectious disease 2019-related neurologic diseases. Curr. Opin. Neurol. 35, 392398 (2022).

Article CAS PubMed PubMed Central Google Scholar

Soung, A. L. et al. COVID-19 induces CNS cytokine expression and loss of hippocampal neurogenesis. Brain 145, 41934201 (2022).

Article PubMed PubMed Central Google Scholar

Grant, R. A. et al. Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia. Nature 590, 635641 (2021).

Article CAS PubMed PubMed Central Google Scholar

Schwabenland, M. et al. Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microgliaT-cell interactions. Immunity 54, 15941610 (2021).

Article CAS PubMed PubMed Central Google Scholar

Jensen, M. P. et al. Neuropathological findings in two patients with fatal COVID-19. Neuropathol. Appl. Neurobiol. 47, 1725 (2021).

Article CAS PubMed Google Scholar

Matschke, J. et al. Neuropathology of patients with COVID-19 in Germany: a post-mortem case series. Lancet Neurol. 19, 919929 (2020).

Article CAS PubMed PubMed Central Google Scholar

Thakur, K. T. et al. COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital. Brain 144, 26962708 (2021).

Bird, C. M. & Burgess, N. The hippocampus and memory: insights from spatial processing. Nat. Rev. Neurosci. 9, 182194 (2008).

Article CAS PubMed Google Scholar

Zemla, R. & Basu, J. Hippocampal function in rodents. Curr. Opin. Neurobiol. 43, 187197 (2017).

Article CAS PubMed PubMed Central Google Scholar

Basu, J. & Siegelbaum, S. A. The corticohippocampal circuit, synaptic plasticity, and memory. Cold Spring Harb. Perspect. Biol. 7, a021733 (2015).

Article PubMed PubMed Central Google Scholar

Toda, T., Parylak, S. L., Linker, S. B. & Gage, F. H. The role of adult hippocampal neurogenesis in brain health and disease. Mol. Psychiatry 24, 6787 (2019).

Article CAS PubMed Google Scholar

Kumar, A., Pareek, V., Faiq, M. A., Ghosh, S. K. & Kumari, C. Adult neurogenesis in humans: a review of basic concepts, history, current research, and clinical implications. Innov. Clin. Neurosci. 16, 3037 (2019).

CAS PubMed PubMed Central Google Scholar

Hein, A. M. et al. Sustained hippocampal IL-1 overexpression impairs contextual and spatial memory in transgenic mice. Brain Behav. Immun. 24, 243253 (2010).

Article CAS PubMed Google Scholar

Wu, M. D. et al. Adult murine hippocampal neurogenesis is inhibited by sustained IL-1 and not rescued by voluntary running. Brain Behav. Immun. 26, 292300 (2012).

Article CAS PubMed Google Scholar

Soung, A. L. et al. IL-1 reprogramming of adult neural stem cells limits neurocognitive recovery after viral encephalitis by maintaining a proinflammatory state. Brain Behav. Immun. 99, 383396 (2022).

Article CAS PubMed Google Scholar

Garber, C. et al. Astrocytes decrease adult neurogenesis during virus-induced memory dysfunction via IL-1. Nat. Immunol. 19, 151161 (2018).

Article CAS PubMed PubMed Central Google Scholar

Schulthei, C. et al. The IL-1, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19. Cell Rep. Med. 3, 100663 (2022).

Article PubMed PubMed Central Google Scholar

Catal, M. et al. The effectiveness of COVID-19 vaccines to prevent long COVID symptoms: staggered cohort study of data from the UK, Spain, and Estonia. Lancet Respir. Med. 12, 225236 (2024).

Article PubMed Google Scholar

Al-Aly, Z., Bowe, B. & Xie, Y. Long COVID after breakthrough SARS-CoV-2 infection. Nat. Med. 28, 14611467 (2022).

Article CAS PubMed PubMed Central Google Scholar

Huapaya, J. A. et al. Vaccination ameliorates cellular inflammatory responses in SARS-CoV-2 breakthrough infections. J. Infect. Dis. 228, 4658 (2023).

Article CAS PubMed PubMed Central Google Scholar

Zhu, X. et al. Dynamics of inflammatory responses after SARS-CoV-2 infection by vaccination status in the USA: a prospective cohort study. Lancet Microbe 4, e692e703 (2023).

Article CAS PubMed PubMed Central Google Scholar

Fan, Q. et al. Clinical characteristics and immune profile alterations in vaccinated individuals with breakthrough Delta SARS-CoV-2 infections. Nat. Commun. 13, 3979 (2022).

Article CAS PubMed PubMed Central Google Scholar

Vanderheiden, A. et al. CCR2 signaling restricts SARS-CoV-2 infection. mBio 12, e0274921 (2021).

Article PubMed Google Scholar

Shuai, H. et al. Emerging SARS-CoV-2 variants expand species tropism to murines. EBioMedicine 73, 103643 (2021).

Article CAS PubMed PubMed Central Google Scholar

Pan, T. et al. Infection of wild-type mice by SARS-CoV-2 B.1.351 variant indicates a possible novel cross-species transmission route. Signal Transduct. Target. Ther. 6, 420 (2021).

Article CAS PubMed PubMed Central Google Scholar

Leger, M. et al. Object recognition test in mice. Nat. Protoc. 8, 25312537 (2013).

Article CAS PubMed Google Scholar

Vasek, M. J. et al. A complementmicroglial axis drives synapse loss during virus-induced memory impairment. Nature 534, 538543 (2016).

Article CAS PubMed PubMed Central Google Scholar

Rosen, S. F. et al. Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination. Genome Med. 14, 108 (2022).

Article CAS PubMed PubMed Central Google Scholar

Brannock, M. D. et al. Long COVID risk and pre-COVID vaccination in an EHR-based cohort study from the RECOVER program. Nat. Commun. 14, 2914 (2023).

Article CAS PubMed PubMed Central Google Scholar

Notarte, K. I. et al. Impact of COVID-19 vaccination on the risk of developing long-COVID and on existing long-COVID symptoms: a systematic review. EClinicalMedicine 53, 101624 (2022).

Article PubMed PubMed Central Google Scholar

Bricker, T. L. et al. A single intranasal or intramuscular immunization with chimpanzee adenovirus-vectored SARS-CoV-2 vaccine protects against pneumonia in hamsters. Cell Rep. 36, 109400 (2021).

Article CAS PubMed PubMed Central Google Scholar

Antunes, M. & Biala, G. The novel object recognition memory: neurobiology, test procedure, and its modifications. Cogn. Process. 13, 93110 (2012).

Article CAS PubMed Google Scholar

Yang, A. C. et al. Dysregulation of brain and choroid plexus cell types in severe COVID-19. Nature 595, 565571 (2021).

Article CAS PubMed PubMed Central Google Scholar

Fullard, J. F. et al. Single-nucleus transcriptome analysis of human brain immune response in patients with severe COVID-19. Genome Med. 13, 118 (2021).

Article CAS PubMed PubMed Central Google Scholar

Lee, M. H. et al. Neurovascular injury with complement activation and inflammation in COVID-19. Brain 145, 25552568 (2022).

Article PubMed Google Scholar

Lage, S. L. et al. Persistent oxidative stress and inflammasome activation in CD14highCD16 monocytes from COVID-19 patients. Front. Immunol. 12, 799558 (2021).

More here:

Vaccination reduces central nervous system IL-1 and memory deficits after COVID-19 in mice - Nature.com

Related Posts
Tags: