Survivors of Severe COVID Face Persistent Health Problems – UC San Francisco

Anil Makam, MD, MAS, works with a patient in an ICU room at Zuckerberg San Francisco General Hospital in San Francisco. Makams research looks at the long-term effects of severe COVID-19 illness among the sickest of survivors early in the pandemic. Photo by Erin Lubin

UC San Francisco researchers examined COVID-19 patients across the United States who survived some of the longest and most harrowing battles with the virus and found that about two-thirds still had physical, psychiatric, and cognitive problems for up to a year later.

The study, which appears April 10, 2024, in the journal Critical Care Medicine, reveals the life-altering impact of SARS-CoV-2 on these individuals, the majority of whom had to be placed on mechanical ventilators for an average of one month.

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64% of study participants reported having a persistent impairment after one year, including:

Physical 57% Respiratory 49% Psychiatric 24% Cognitive 15% Continued use of supplemental oxygen 19%

Nearly half, or 47%, had more than one type of problem.

Too sick to be discharged to a skilled nursing home or rehabilitation facility, these patients were transferred instead to special hospitals known as long-term acute care hospitals (LTACHs). These hospitals specialize in weaning patients off ventilators and providing rehabilitation care, and they were a crucial part of the pandemic response.

Among the 156 study participants, 64% reported having a persistent impairment after one year, including physical (57%), respiratory (49%), psychiatric (24%), and cognitive (15%). Nearly half, or 47%, had more than one type of problem. And 19% continued to need supplemental oxygen.

The long-term follow up helps to outline the extent of the medical problems experienced by those who became seriously ill with COVID early in the pandemic.

We have millions of survivors of the most severe and prolonged COVID illness globally, said the studys first author, Anil N. Makam, MD, MAS, an associate professor of medicine at UCSF. Our study is important to understand their recovery and long-term impairments, and to provide a nuanced understanding of their life-changing experience.

Researchers recruited 156 people who had been transferred for COVID to one of nine LTACHs in Nebraska, Texas, Georgia, Kentucky, and Connecticut between March 2020 and February 2021. They questioned them by telephone or online a year after their hospitalization. The average total length of stay in the hospital and the LTACH for the group was about two months. Their average age was 65, and most said they had been healthy before getting COVID.

In addition to their lingering ailments from COVID, the participants also had persistent problems from their long hospital stays, including painful bedsores and nerve damage that limited the use of their arms or legs.

Many of the participants we interviewed were most bothered by these complications, so preventing these from happening in the first place is key to recovery, Makam said.

Although 79% said they had not returned to their usual health, 99% had returned home, and 60% of those who had previously been employed said they had gone back to work.

They were overwhelmingly grateful to have survived, often describing their survival as a miracle. But their recovery took longer than expected.

The results underscore that it is normal to for someone who has survived such severe illness to have persistent health problems.

The long-lasting impairments we observed are common to survivors of any prolonged critical illness, and not specific to COVID, and are best addressed through multidisciplinary rehabilitation, Makam said.

Authors: Additional UCSF co-authors include Oanh Kieu Nguyen, MD, MAS, Eddie Espejo, MA, Cinthia Blat, MPH, W. John Boscardin, PhD and Kenneth E. Covinsky, MD, MPH.

Funding: The work was supported by grants from the National Institutes of Health/National Institute on Aging (K23AG052603), the UCSF Research Evaluation and Allocation Committee (Carson and Hampton Research Funds) and the National Association of Long Term Hospitals. The authors had no conflicts of interest to disclose.

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Survivors of Severe COVID Face Persistent Health Problems - UC San Francisco