Here's how mRNA viruses like COVID-19 mutate, and why certain viruses are harder to develop vaccines for. USA TODAY
If you think the COVID-19 vaccine rollout seems chaotic and incomprehensible, that the numbers don't add up and allocationsdon't make sense, you're not alone.
Even people who study this for a living are at a loss.
None of us know whats going on, said Dr. Amesh Adalja, a senior scholar at the Johns Hopkins Center for Health Security.
He has been trying to understand howfigures from the Centers for Disease Control and Prevention, the White House and the states fit together, but he cant.
I dont understand why theres not more transparency, he said. They could easily hold a webinar every day to go through the numbers this is how many boxes we shipped, this is how many boxes are coming next week. The more they dont do that, the more acrimony thats created between states and the federal government.
Overallthe trends are positive, but the pace will need to intensify significantly to meet deadlines the White House announced this week.
The White House says winter weather affecting parts of the country has slowed down vaccinations. This comes as the Biden administration admits if Johnson & Johnson vaccine gets approved, it will be slow rollout. (Feb. .17) AP Domestic
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Since Jan. 25, COVID-19 vaccine distribution from the federal government has increased 57%. As of this week, it'sup to 13.5 million doses shipped a week.
"We are on track to have enough vaccine supply for 300 million Americans by the end of July,"Jeff Zients, White House COVID-19 response coordinator, said in a task force briefing Wednesday.
To get the scheduled two doses of the authorized vaccines to 300 million people, distribution from the federal government will need to ramp up by about one-third. At the current level, it would take until September.
Given how fast things have been increasing, that seemsfeasible. But no actual data on future increases has been announced by the White House.
If things appear to be on track, why is there so much chaos at the state level, with long lines, people unable to get appointments and clinics closing because of lack of vaccine?
There are severalreasons. One is a lack of federal transparency about vaccine supply and shipments and continued fluctuation of vaccine deliveries, all of whichconfuse and confound states.
Public health officials are frustrated over thelack of clarity. It's impossible to know exactly how much vaccine is being shipped and to where and to whom it hasbeen administered information they need so they can plan.
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Vaccine is delivered, and tallied,through several separate programs, including ones for states, nursing homes and long-term-care facilities,Federally Qualified Health Centersandprivate pharmacies. Some doses are controlled by states themselves andsome by federal programs.
The National Governors Association sent a public letter to President Joe Biden this week asking for more clarity, including"visibility into the federal vaccination efforts at the facility level happening in our borders."
The letter cited "the anxiety created by the demand and supply of the vaccine" and asked for better reporting to avoid confusion.
States also shoulder a share of the blame.Experts say theyopened up vaccinations to ever-widening groups too quickly, eventhough supplies werein short supply.
We knew all along there would be a limited number of doses at the beginning and we would have to prioritize, said Dr. Marcus Plescia, chief medical officer of the Association of State and Territorial Health Officials."Somewhere in there, the vaccine got overpromised."
That hasn't always happened.
The CDCs Advisory Committee on Immunization Practices spent months creating a carefully designedseries of vaccine eligibility tiers from the most vulnerable to the least.
Since Jan. 25, COVID-19 vaccine distribution from the federal government has increased 57%.(Photo: John Locher, AP)
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Some state officials promptly ignored the recommendations and began opening up vaccinationto broader groups of people, Plesciasaid.
The immunization advisory committee guidelinesfrom December saidfront-line heath care workers and long-term-care facility residents would be first in linein what was known as Phase 1a.Next wouldcome front-line essential workers and people 75 and older, in Phase 1b. People 65 and older and people with high-risk medical conditions would be in a larger Phase 1c.
Just one week after the first COVID-19 vaccine wasdistributed, Florida Gov. Ron DeSantis overrode the committee guidelines and unilaterally declaredhis state was prioritizing people 65 and older.
That resulted in long lines, seniors waiting overnight for vaccine, crashing appointment websites and general chaos as Florida's more than 4 million seniors clamored to getvaccinated.
In 35 states plus the District of Columbia,people65 and older can seek an appointment now, according to the White House. But other stateshaven't moved beyondvaccinating essential workers and those 75 and above.
Wisconsin's Legislature is debating this week whether to add teachers to Phase 1a.
Early finger-pointing that states were going too slow may have driven the rush for speed and bypassing of the guidelines.In any case, he said, vaccine got overpromised.
We suddenly skipped through the ACIP guidelines and told all these people they were eligible, he said. "I dont know if that was the most judicious thing to do. It probably would have been better if wed held our ground."
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Other states, such as Georgia,have resisted widely broadening who is eligible for vaccines, saidGlen Nowak, director of the University of Georgia's Center for Health and Risk Communications and a former communication director for the National Immunization Program at the CDC.
The governor there has been consistent saying there isn't yet enough vaccine for the first priority groups, so he's not going to open it up yet. "He's saying'I hear you, I want to do that,but we don't have enough vaccine right now,'" Nowak said.
To make the rollout seem as if it's under control, states need to manage expectations. "Broadening it isn't going to help, it's going to make things worse," he said.
Whats needed are honest messages that widespread vaccination cant happen overnight. Though not everyone will get a vaccine immediately, everyone will get one eventually, said Dr. Gregory Poland, director of the Mayo Clinic's Vaccine Research Groupand editor-in-chief of the journal Vaccine.
The cure is tincture of time, he said. But, he acknowledged, thats easy for me to say now that Ive now gotten both my doses.
A big part of the problem, since before the first doses of the vaccine were shipped, has been the lack of clear, consistent communication, experts say. That hasmade the job of explaining what's happening now with the vaccine supply even harder.
Even the man who played a key role in making COVID-19 vaccines possible, Moncef Slaoui, says messaging was a major failure of Operation Warp Speed's otherwise stellar work.
The rollout "was a huge communications failure, honestly," Slaoui said at a recent New York Academies of Science conference.
USA TODAY analysis: What went wrong with COVID-19 vaccine distribution and how it has tarnished the 'miracle'
There was no way everyone in America was going to be immunized immediately, he said, but that message didn't get out. Millions of Americans have expressed anger and frustration about something Slaoui and his team thought they had clearly explained.
"Every single time we said, 'We will produce enough vaccine doses to immunize the U.S. population by the summer of 2021.' It is understood in that statement that it's going to take six, seven months to have enough vaccine to immunize everybody," he said."But, in fact,I think we should have communicated much, much better that there will not be enough vaccine for everybodyimmediately."
It's going to take time to overcome that deficit of trust and information, said Dr. Kelly Moore,deputy director of the nonprofit Immunization Action Coalition.
"We will never recapture the opportunities that were lost tobuild a solid foundation for the vaccination program before vaccines began rolling out," she said,"but were getting back on track, and the signs give me hope.
Contact Elizabeth Weise at eweise@usatoday.com
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