Scientists caution about CDC guidance on over-the-counter drugs for COVID-19 – University of Minnesota Twin Cities

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In its most recent guidelines on the use of over-the-counter (OTC) drugs for COVID-19, the US Centers for Disease Control and Prevention (CDC) says that mildly ill patients can relieve symptoms such as fever and sore throat with acetaminophen or ibuprofen, but a team led by Florida Atlantic University (FAU) researchers says it's not that simple..

In a review in the American Journal of Medicine, the investigators conclude that the decision to take acetaminophen (eg, Tylenol), aspirin, or ibuprofen (eg, Motrin, Advil) should be done on an individual basis under the guidance of a clinician.

This is because the drugs aren't risk-free, with overuse of acetaminophen tied to irreversible liver damage, liver failure, the need for liver transplant, and kidney damage, the authors noted.

While aspirin's anti-inflammatory properties may be useful in treating moderate to severe COVID-19, it carries the risk of bleeding, especially in the gastrointestinal (GI) tract. This is of particular concern in COVID-19, which may itself lead to bleeding and clotting abnormalities.

Compared with aspirin, ibuprofen, naproxen (eg, Aleve), and other non-steroidal anti-inflammatory drugs (NSAIDs) have greater adverse-event profiles, namely for gastroenteritis (inflammation of the GI tract) and peptic ulcers. As with acetaminophen, long-term use of these drugs can lead to liver and kidney toxicity.

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Scientists caution about CDC guidance on over-the-counter drugs for COVID-19 - University of Minnesota Twin Cities