Reassortment incompetent live attenuated and replicon influenza vaccines provide improved protection against influenza in piglets – Nature.com

Cador, C. et al. Maternally-derived antibodies do not prevent transmission of swine influenza A virus between pigs. Vet. Res. 47, 86 (2016).

Article PubMed PubMed Central Google Scholar

Anderson, T. K. et al. A phylogeny-based global nomenclature system and automated annotation tool for H1 hemagglutinin genes from swine influenza A viruses. Msphere 1, e0027516 (2016).

Article CAS PubMed PubMed Central Google Scholar

Chauhan, R. P. & Gordon, M. L. A systematic review analyzing the prevalence and circulation of influenza viruses in swine population worldwide. Pathogens 9, 355 (2020).

Article CAS PubMed PubMed Central Google Scholar

Hennig, C. et al. Are pigs overestimated as a source of zoonotic influenza viruses? Porcine Health Manag. 8, 30 (2022).

Article PubMed PubMed Central Google Scholar

Abdelwhab, E. M. & Mettenleiter, T. C. Zoonotic animal influenza virus and potential mixing vessel hosts. Viruses 15, 980 (2023).

Article CAS PubMed PubMed Central Google Scholar

Pitzer, V. E. et al. High turnover drives prolonged persistence of influenza in managed pig herds. J. R. Soc. Interface 13, 20160138 (2016).

Article PubMed PubMed Central Google Scholar

Kessler, S., Harder, T. C., Schwemmle, M. & Ciminski, K. Influenza A viruses and zoonotic events-are we creating our own reservoirs? Viruses 13, 2250 (2021).

Article PubMed PubMed Central Google Scholar

Henritzi, D. et al. Surveillance of European domestic pig populations identifies an emerging reservoir of potentially zoonotic swine influenza A viruses. Cell Host Microbe 28, 614627.e6 (2020).

Article CAS PubMed Google Scholar

Sun, H. L. et al. Prevalent Eurasian avian-like H1N1 swine influenza virus with 2009 pandemic viral genes facilitating human infection. Proc. Natl Acad. Sci. USA 117, 1720417210 (2020).

Article CAS PubMed PubMed Central Google Scholar

Vincent, A. L., Ma, W. J., Lager, K. M., Janke, B. H. & Richt, J. A. Swine influenza viruses: a North American perspective. Adv. Virus Res. 72, 127154 (2008).

Article CAS PubMed Google Scholar

Kristensen, C. et al. Experimental infection of pigs and ferrets with pre-pandemic, human-adapted, and swineadapted variants of the H1N1pdm09 Influenza A virus reveals significant differences in viral dynamics and pathological manifestations. PLos Pathog. 19, e1011838 (2023).

Article CAS PubMed PubMed Central Google Scholar

Souza, C. K. et al. Antigenic distance between North American swine and human seasonal H3N2 influenza A viruses as an indication of zoonotic risk to humans. J. Virol. 96, e0137421 (2022).

Lopez-Moreno, G., Schmitt, C., Spronk, T., Culhane, M. & Torremorell, M. Evaluation of internal farm biosecurity measures combined with sow vaccination to prevent influenza A virus infection in groups of due-to-wean pigs. BMC Vet. Res. 18, 393 (2022).

Article PubMed PubMed Central Google Scholar

Diaz, A. et al. Association between influenza A virus infection and pigs subpopulations in endemically infected breeding herds. PLos ONE 10, e0129213 (2015).

Article PubMed PubMed Central Google Scholar

Keay, S. et al. Does vaccine-induced maternally-derived immunity protect swine offspring against influenza A viruses? A systematic review and meta-analysis of challenge trials from 1990 to May 2021. Animals 13, 3085 (2023).

Article PubMed PubMed Central Google Scholar

Van Reeth, K. & Ma, W. Swine influenza virus vaccines: to change or not to change-thats the question. Curr. Top. Microbiol. Immunol. 370, 173200 (2013).

PubMed Google Scholar

Deblanc, C. et al. Maternally-derived antibodies do not inhibit swine influenza virus replication in piglets but decrease excreted virus infectivity and impair post-infectious immune responses. Vet. Microbiol. 216, 142152 (2018).

Article CAS PubMed Google Scholar

Everett, H. E. et al. Vaccines that reduce viral shedding do not prevent transmission of H1N1 pandemic 2009 swine influenza A virus infection to unvaccinated pigs. J. Virol. 95, e01787-20 (2021).

Shin, S., Park, S. H., Park, J. H., Kim, S. M. & Lee, M. J. Age-dependent dynamics of maternally derived antibodies (MDAs) and understanding MDA-mediated immune tolerance in foot-and-mouth disease-vaccinated pigs. Vaccines 10, 677 (2022).

Article CAS PubMed PubMed Central Google Scholar

Vono, M. et al. Maternal antibodies inhibit neonatal and infant responses to vaccination by shaping the early-life B cell repertoire within germinal centers. Cell Rep. 28, 17731784.e1775 (2019).

Article CAS PubMed Google Scholar

Deblanc, C. et al. Evaluation of the pathogenicity and the escape from vaccine protection of a new antigenic variant derived from the European human-like reassortant swine H1N2 influenza virus. Viruses 12, 1155 (2020).

Article CAS PubMed PubMed Central Google Scholar

Ryt-Hansen, P. et al. Substantial antigenic drift in the hemagglutinin protein of swine influenza A viruses. Viruses 12, 248 (2020).

Article CAS PubMed PubMed Central Google Scholar

Ryt-Hansen, P. et al. Acute Influenza A virus outbreak in an enzootic infected sow herd: impact on viral dynamics, genetic and antigenic variability and effect of maternally derived antibodies and vaccination. PLos ONE 14, e0224854 (2019).

Article CAS PubMed PubMed Central Google Scholar

Trovo, N. S., Khan, S. M., Lemey, P., Nelson, M. I. & Cherry, J. L. Comparative evolution of influenza A virus H1 and H3 head and stalk domains across host species. mBio 15, e0264923 (2023).

Article PubMed Google Scholar

Platt, R. et al. Comparison of humoral and cellular immune responses to inactivated swine influenza virus vaccine in weaned pigs. Vet. Immunol. Immunopathol. 142, 252257 (2011).

Article CAS PubMed Google Scholar

Rahn, J., Hoffmann, D., Harder, T. C. & Beer, M. Vaccines against influenza A viruses in poultry and swine: Status and future developments. Vaccine 33, 24142424 (2015).

Article CAS PubMed Google Scholar

Vincent, A. L. et al. Influenza A virus vaccines for swine. Vet. Microbiol. 206, 3544 (2017).

Article CAS PubMed Google Scholar

Chan, L. et al. Review of influenza virus vaccines: the qualitative nature of immune responses to infection and vaccination is a critical consideration. Vaccines 9, 979 (2021).

Article CAS PubMed PubMed Central Google Scholar

Graaf, A. et al. Cold-passaged isolates and bat-swine influenza a chimeric viruses as modified live-attenuated vaccines against influenza a viruses in pigs. Vaccine 40, 62556270 (2022).

Article PubMed Google Scholar

Lee, J. et al. Bat influenza vectored NS1-truncated live vaccine protects pigs against heterologous virus challenge. Vaccine 39, 19431950 (2021).

Article CAS PubMed PubMed Central Google Scholar

Gracia, J. C. M., Pearce, D. S., Masic, A. & Balasch, M. Influenza A virus in swine: epidemiology, challenges and vaccination strategies. Front. Vet. Sci. 7, 647 (2020).

Article Google Scholar

Ciminski, K., Thamamongood, T., Zimmer, G. & Schwemmle, M. Novel insights into bat influenza A viruses. J. Gen. Virol. 98, 23932400 (2017).

Article CAS PubMed PubMed Central Google Scholar

Juozapaitis, M. et al. An infectious bat-derived chimeric influenza virus harbouring the entry machinery of an influenza A virus. Nat. Commun. 5, 4448 (2014).

Article CAS PubMed Google Scholar

Ma, W. J., Garcia-Sastre, A. & Schwemmle, M. Expected and unexpected features of the newly discovered bat influenza A-like viruses. PLos Pathog. 11, e1004819 (2015).

Article PubMed PubMed Central Google Scholar

Yang, J. et al. Pathogenicity of modified bat influenza virus with different M genes and its reassortment potential with swine influenza A virus. J. Gen. Virol. 98, 577584 (2017).

Article CAS PubMed Google Scholar

Ricklin, M. E. et al. Partial protection against porcine influenza A virus by a hemagglutinin-expressing virus replicon particle vaccine in the absence of neutralizing antibodies. Front. Immunol. 7, 253 (2016).

Article PubMed PubMed Central Google Scholar

Finkelshtein, D., Werman, A., Novick, D., Barak, S. & Rubinstein, M. LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus. Proc. Natl Acad. Sci. USA 110, 73067311 (2013).

Article CAS PubMed PubMed Central Google Scholar

Walz, L., Kays, S. K., Zimmer, G. & von Messling, V. Neuraminidase-inhibiting antibody titers correlate with protection from heterologous influenza virus strains of the same neuraminidase subtype. J. Virol. 92, e01006e01018 (2018).

Article PubMed PubMed Central Google Scholar

Halbherr, S. J. et al. Vaccination with recombinant RNA replicon particles protects chickens from H5N1 highly pathogenic avian influenza virus. PLos ONE 8, e66059 (2013).

Article CAS PubMed PubMed Central Google Scholar

Kalhoro, N. H., Veits, J., Rautenschlein, S. & Zimmer, G. A recombinant vesicular stomatitis virus replicon vaccine protects chickens from highly pathogenic avian influenza virus (H7N1). Vaccine 27, 11741183 (2009).

Article CAS PubMed Google Scholar

Simon-Grif, M. et al. Swine influenza virus infection dynamics in two pig farms; results of a longitudinal assessment. Vet. Res. 43, 24 (2012).

Article PubMed PubMed Central Google Scholar

Loeffen, W. L., Heinen, P. P., Bianchi, A. T., Hunneman, W. A. & Verheijden, J. H. Effect of maternally derived antibodies on the clinical signs and immune response in pigs after primary and secondary infection with an influenza H1N1 virus. Vet. Immunol. Immunopathol. 92, 2335 (2003).

Article CAS PubMed Google Scholar

Kitikoon, P. et al. The immune response and maternal antibody interference to a heterologous H1N1 swine influenza virus infection following vaccination. Vet. Immunol. Immunopathol. 112, 117128 (2006).

Article CAS PubMed Google Scholar

Vincent, A. L. et al. Live attenuated influenza vaccine provides superior protection from heterologous infection in pigs with maternal antibodies without inducing vaccine-associated enhanced respiratory disease. J. Virol. 86, 1059710605 (2012).

Article CAS PubMed PubMed Central Google Scholar

Allerson, M. et al. The impact of maternally derived immunity on influenza A virus transmission in neonatal pig populations. Vaccine 31, 500505 (2013).

Article CAS PubMed Google Scholar

Andraud, M. et al. Evaluation of early single dose vaccination on swine influenza A virus transmission in piglets: from experimental data to mechanistic modelling. Vaccine 41, 31193127 (2023).

Article CAS PubMed Google Scholar

Rajao, D. S. et al. Heterologous challenge in the presence of maternally-derived antibodies results in vaccine-associated enhanced respiratory disease in weaned piglets. Virology 491, 7988 (2016).

Article CAS PubMed Google Scholar

Fu, Y. G. et al. Infection studies in pigs and porcine airway epithelial cells reveal an evolution of A(H1N1)pdm09 influenza A viruses toward lower virulence. J. Infect. Dis. 219, 15961604 (2019).

Article CAS PubMed Google Scholar

Sunwoo, S. Y. et al. A universal influenza virus vaccine candidate tested in a pig vaccination-infection model in the presence of maternal antibodies. Vaccines 6, 64 (2018).

Article CAS PubMed PubMed Central Google Scholar

McNee, A. et al. A direct contact pig influenza challenge model for assessing protective efficacy of monoclonal antibodies. Front. Immunol. 14, 1229051 (2023).

Article CAS PubMed PubMed Central Google Scholar

Corzo, C. A. et al. Relationship between airborne detection of influenza A virus and the number of infected pigs. Vet. J. 196, 171175 (2013).

Article PubMed Google Scholar

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Reassortment incompetent live attenuated and replicon influenza vaccines provide improved protection against influenza in piglets - Nature.com