"It is within our power, and within our grasp, to prevent that from occurring," Fauci, director of the National Institute of Allergy and Infectious Diseases, told CNN on Monday.
The way to do it, he said, is by utilizing mitigation measures such as wearing masks indoors and in schools, as well as increasing vaccination rates.
The idea of vaccine mandates for schools and businesses has sparked debate through much of the country, but with the spread of the Delta variant, more leaders are adopting such methods.
And the evidence shows that vaccine mandates do get more people vaccinated, and the more vaccinated people there are in a community, the more protected the community is, Centers for Disease Control and Prevention Director Dr. Rochelle Walensky told ABC News on Monday.
Those mandates have been implemented by the federal government for its employees, and President Joe Biden stressed the importance of people getting vaccinated Monday while receiving his booster shot.
"This is a pandemic of the unvaccinated. That's why I'm moving forward with vaccination requirements wherever I can," he said.
Dr. Scott Gottlieb, a former Food and Drug Administration commissioner, estimated that the Delta wave of the pandemic could run its course by Thanksgiving, and Covid-19 could eventually become more of a seasonal nuisance than a devastating pandemic. But Fauci said that is dependent on getting a lot more people vaccinated.
Many places are still impacted by the spread.
North Carolina has received 25 Advanced Life Support ambulances as the state experiences "greatly increased" calls for service during the Covid-19 pandemic. The ambulances each have a two-person crew of EMS providers, according to a news release from the North Carolina Department of Public Safety. The ambulances were provided in response to a request to the Federal Emergency Management Agency.
"These ambulances and crews will provide necessary relief to our extremely busy EMS systems," North Carolina Emergency Management Director Will Ray said. "While it's not the full complement we requested, we know medical resources are extremely limited across the nation right now, and we are grateful for this assistance from our federal partners."
Pfizer/BioNTech submit initial data on vaccine for kids ages 5 to 11
A formal submission to request EUA for the vaccine is expected to follow in the coming weeks, the companies said in a statement.
This is the first submission of data to the FDA for a Covid-19 vaccine for younger children. The Pfizer/BioNTech vaccine is approved for people age 16 and older and has an EUA for people ages 12 to 15.
Last week, Pfizer released details of a Phase 2/3 trial that showed its Covid-19 vaccine was safe and generated a "robust" antibody response in children ages 5 to 11.
FDA officials have said that once vaccine data was submitted, the agency could authorize a vaccine for younger children in a matter of weeks -- not months -- but it would depend on the timing and quality of the data provided.
Fauci hopes the vaccines can be given to children ages 5 to 11 by the end of October, he told MSNBC on Tuesday.
Vaccine mandates argued in court
Mask and vaccine mandates have drawn intense debates.
But, a Maricopa County judge ruled the ban unconstitutional Monday in a move Gov. Doug Ducey called "an example of judicial overreach."
The ruling was made because the Covid-19 measures were inserted into the state budget bill, and legislators are precluded from "combining unrelated provisions into one bill to garner votes," according to the court filing.
One of Tennessee's largest school districts plans to implement a mandatory mask mandate Tuesday ordered by a federal judge, and the school district is preparing for potential protests.
"Students who refuse to wear a mask will be allowed in the school building, but please know they will not be in their regular classroom," Superintendent for Knox County Schools, Bob Thomas, said. Parents will be allowed to take their child home for refusing to wear a mask, but the student's absence will be counted as unexcused, a message to families said.
The injunction was then dissolved by a federal appeals court Monday, allowing the city's schools to enforce vaccine mandates among educators once again. The cohort of teachers and paraprofessionals who requested the injunction lost their appeal, their attorneys said.
The deadline for school employees to receive at least one Covid-19 vaccine dose has been extended to the end of Friday, meaning only those who complied will be able to work the following Monday (October 4), the city's Department of Education said after the ruling.
Those getting a first dose of a two-dose vaccine must later prove they got the second dose within 45 days of the first, according to the order.
"Vaccinations are our strongest tool in the fight against Covid-19 -- this ruling is on the right side of the law and will protect our students and staff," city education department spokeswoman Danielle Filson told CNN in a statement.
"With thousands of teachers not vaccinated, the city may regret what it wished for," attorney for the teachers and paraprofessionals who asked for the injunction, Mark Fonte, said in a statement to CNN. "Our children will be left with no teachers and no security in the schools."
The union had also filed a motion requesting the requirement be put on hold while it negotiated terms of its members' employment, but Judge Jackie Corwin said the importance of protecting the citizens and officers outweighs the union's right to bargain for employment terms and conditions.
Access to boosters will likely expand, but for most people there is no rush, experts say
Health experts have been discussing vaccine boosters as another way to increase protection against the virus, but they are not currently accessible to everyone.
Booster doses of Pfizer's Covid-19 vaccine are now available to people 65 and older and some adults with underlying medical conditions or those at increased risk for a breakthrough infection.
"The frequency and type of side effects were similar to those seen after the second vaccine doses and were mostly mild or moderate and short-lived," the CDC director said during a White House Covid-19 briefing.
While boosters will likely become available to more people in the United States, not everyone will need one right away, Fauci said Monday.
Many people are still well protected from their initial Covid-19 vaccination, while certain categories of people, such as the elderly and those in long-term care facilities, may be ready for a boost six months after their initial vaccination, Fauci told CNN.
"If you're a person who ultimately might get a booster that will make you optimally protected, you don't necessarily need to get it tomorrow," Fauci said.
And boosters for people who got a Moderna or Johnson & Johnson vaccine will be addressed with urgency, Walensky told ABC.
"I want to reiterate that this is a very slow wane. There is no urgency here to go and get your booster immediately. You know, walk don't run to your booster appointment," she said. "We will come and look at the data for Moderna and J&J in very short order."
CNN's Lauren Mascarenhas, Naomi Thomas, Jason Hoffman, Deidre McPhillips, Rebekah Riess, Jason Hanna, Jamie Gumbrecht, Devon Sayers, Amy Simonson and Jennifer Henderson contributed to this report.
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