The first case, a man with underlying health conditions, went to hospital in early April after developing a cough, fever and body aches. He later died from the disease.
But two other men in the same hospital, both aged 60, have also tested positive for the coronavirus sparking a broad contact tracing effort from health officials, to detect further infections before it can spread further. Dozens of people have been tested.
Hospitals can either serve as a source of prevention or amplification of transmission, said Dr Saskia Popescu, an infectious disease epidemiologist at the University of Maryland School of Medicine.
Ive spent a lot of time studying Mers healthcare-transmission cases and using those lessons to strengthen healthcare bioprep and honestly, THIS is why we invest in infection prevention programs, she wrote on X, formerly Twitter.
Mers was first detected in 2012, when it jumped from camels to humans in Saudi Arabia, and it has since spread to 27 other countries. Globally, 2,204 cases and 860 deaths have been reported, according to the WHO the vast majority, more than 80 per cent, have been in Saudi Arabia.
Earlier this year, the country also reported a fatal case in Taif a city 500 miles west of Riyadh, by the Red Sea earlier this year.
There have been several large chains of transmission in healthcare facilities including the largest outbreak outside of the Middle East, in South Korea in 2015. The country confirmed 185 cases and 38 fatalities as the coronavirus swept through 24 hospitals.
While several Mers treatments and vaccines are in clinical development, unlike Covid-19 none have been carried through clinical trials and approved by regulators.
[This is] a good reminder that we dont have any proven antiviral treatments, vaccines or rapid diagnostics for Mers, said Dr Tom Fletcher, an infectious disease specialist at the Liverpool School of Tropical Medicine.
The WHO said the latest cases do not change the overall risk assessment, though it expects that additional cases of Mers-CoV infection will be reported from the Middle East and/or other countries where Mers-CoV is circulating in dromedaries.
The health analytic firm Airfinty, which monitors disease outbreaks globally, said there was a high threat for the city Riyadh.
Mers-CoV [is] still around and still a threat, Prof Peter Horby, director of the Pandemic Sciences Institute at the University of Oxford said on X. [Saudi Arabia] has great experience of detecting and controlling health-care associated MERS transmission other places are less aware and less prepared.
Prof David Heymann, Professor of Infectious Disease Epidemiology at the London School of Hygiene and Tropical Medicine, said there had been no change in epidemiology with these infections.
He added: The index case is not the first case but was likely infected from the first case they are looking for that case now.
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