Impact of the gut microbiome on immunological responses to COVID-19 vaccination in healthy controls and people … – Nature.com

World Health Organization (accessed 14 July 2023). https://covid19.who.int/.

Polack, F. P. et al. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N. Engl. J. Med. 383, 26032615 (2020).

Article CAS PubMed Google Scholar

El Sahly, H. M. et al. Efficacy of the mRNA-1273 SARS-CoV-2 vaccine at completion of blinded phase. N. Engl. J. Med. 385, 17741785 (2021).

Article CAS PubMed Google Scholar

Antonelli, M. et al. Risk factors and disease profile of post-vaccination SARS-CoV-2 infection in UK users of the COVID Symptom Study app: a prospective, community-based, nested, case-control study. Lancet Infect. Dis. 22, 4355 (2022).

Article CAS PubMed PubMed Central Google Scholar

Baden, L. R. et al. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N. Engl. J. Med. 384, 403416 (2021).

Article CAS PubMed Google Scholar

Carazo, S. et al. Estimated protection of prior SARS-CoV-2 infection against reinfection with the Omicron variant among messenger RNAvaccinated and nonvaccinated individuals in Quebec, Canada. JAMA Netw. Open 5, e2236670 (2022).

Article PubMed PubMed Central Google Scholar

Connors, J., Bell, M. R., Marcy, J., Kutzler, M. & Haddad, E. K. The impact of immuno-aging on SARS-CoV-2 vaccine development. Geroscience 43, 3151 (2021).

Article CAS PubMed PubMed Central Google Scholar

Soiza, R. L., Scicluna, C. & Thomson, E. C. Efficacy and safety of COVID-19 vaccines in older people. Age Ageing 50, 279283 (2021).

Article PubMed Google Scholar

Lynn, D. J. & Pulendran, B. The potential of the microbiota to influence vaccine responses. J. Leukoc. Biol. 103, 225231 (2018).

Article CAS PubMed Google Scholar

McDermott, A. J. & Huffnagle, G. B. The microbiome and regulation of mucosal immunity. Immunology 142, 2431 (2014).

Article CAS PubMed PubMed Central Google Scholar

Baradaran Ghavami, S. et al. Cross-talk between immune system and microbiota in COVID-19. Expert Rev. Gastroenterol. Hepatol. 15, 12811294 (2021).

Article CAS PubMed Google Scholar

Mezouar, S. et al. Microbiome and the immune system: from a healthy steady-state to allergy associated disruption. Hum. Microbiome J. 10, 1120 (2018).

Article Google Scholar

Li, D., Breiman, A., Le Pendu, J. & Uyttendaele, M. Anti-viral effect of Bifidobacterium adolescentis against noroviruses. Front. Microbiol. 7, 864 (2016).

PubMed PubMed Central Google Scholar

Chiang, B.-L., Sheih, Y., Wang, L., Liao, C. & Gill, H. Enhancing immunity by dietary consumption of a probiotic lactic acid bacterium (Bifidobacterium lactis HN019): optimization and definition of cellular immune responses. Eur. J. Clin. Nutr. 54, 849855 (2000).

Article CAS PubMed Google Scholar

Gill, H. S., Rutherfurd, K. J., Cross, M. L. & Gopal, P. K. Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019. Am. J. Clin. Nutr. 74, 833839 (2001).

Article CAS PubMed Google Scholar

Atarashi, K. et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science 331, 337341 (2011).

Article CAS PubMed Google Scholar

Chen, J. & Vitetta, L. Inflammation-modulating effect of butyrate in the prevention of colon cancer by dietary fiber. Clin. Colorectal Cancer 17, e541e544 (2018).

Article PubMed Google Scholar

Furusawa, Y. et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature 504, 446450 (2013).

Article CAS PubMed Google Scholar

Lynn, D. J., Benson, S. C., Lynn, M. A. & Pulendran, B. Modulation of immune responses to vaccination by the microbiota: implications and potential mechanisms. Nat. Rev. Immunol. 22, 3346 (2022).

Article CAS PubMed Google Scholar

Vitetta, L., Saltzman, E. T., Thomsen, M., Nikov, T. & Hall, S. Adjuvant probiotics and the intestinal microbiome: enhancing vaccines and immunotherapy outcomes. Vaccines 5, 50 (2017).

Article PubMed PubMed Central Google Scholar

Huda, M. N. et al. Stool microbiota and vaccine responses of infants. Pediatrics 134, e362e372 (2014).

Article PubMed PubMed Central Google Scholar

Harris, V. C. et al. Effect of antibiotic-mediated microbiome modulation on rotavirus vaccine immunogenicity: a human, randomized-control proof-of-concept trial. Cell Host Microbe 24, 197207.e194 (2018).

Article CAS PubMed Google Scholar

Harris, V. C. et al. Significant correlation between the infant gut microbiome and rotavirus vaccine response in rural Ghana. J. Infect. Dis. 215, 3441 (2017).

Article CAS PubMed Google Scholar

Pabst, O. & Hornef, M. Gut microbiota: a natural adjuvant for vaccination. Immunity 41, 349351 (2014).

Article CAS PubMed Google Scholar

Nakaya, H. I. et al. Systems biology of vaccination for seasonal influenza in humans. Nat. Immunol. 12, 786795 (2011).

Article CAS PubMed PubMed Central Google Scholar

Oh, J. Z. et al. TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination. Immunity 41, 478492 (2014).

Article CAS PubMed PubMed Central Google Scholar

Kim, D. et al. Recognition of the microbiota by Nod2 contributes to the oral adjuvant activity of cholera toxin through the induction of interleukin1. Immunology 158, 219229 (2019).

Article CAS PubMed PubMed Central Google Scholar

Kim, D. et al. Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin. Nat. Med. 22, 524530 (2016).

Article CAS PubMed PubMed Central Google Scholar

Turroni, F. et al. Exploring the diversity of the bifidobacterial population in the human intestinal tract. Appl. Environ. Microbiol. 75, 15341545 (2009).

Article CAS PubMed PubMed Central Google Scholar

Koff, W. C. et al. Development and deployment of COVID-19 vaccines for those most vulnerable. Sci. Transl. Med. 13, eabd1525 (2021).

Article CAS PubMed Google Scholar

Pellini, R. et al. Initial observations on age, gender, BMI and hypertension in antibody responses to SARS-CoV-2 BNT162b2 vaccine. EClinicalMedicine 36, 100928 (2021).

Article PubMed PubMed Central Google Scholar

Stefan, N., Birkenfeld, A. L. & Schulze, M. B. Global pandemics interconnectedobesity, impaired metabolic health and COVID-19. Nat. Rev. Endocrinol. 17, 135149 (2021).

Article CAS PubMed Google Scholar

Mller, L. et al. Age-dependent immune response to the Biontech/Pfizer BNT162b2 coronavirus disease 2019 vaccination. Clin. Infect. Dis. 73, 20652072 (2021).

Article PubMed Google Scholar

Dandachi, D. et al. Characteristics, comorbidities, and outcomes in a multicenter registry of patients with human immunodeficiency virus and coronavirus disease 2019. Clin. Infect. Dis. 73, e1964e1972 (2021).

Article CAS PubMed Google Scholar

Geretti, A. M. et al. Outcomes of coronavirus disease 2019 (COVID-19) related hospitalization among people with human immunodeficiency virus (HIV) in the ISARIC World Health Organization (WHO) clinical characterization protocol (UK): a prospective observational study. Clin. Infect. Dis. 73, e2095e2106 (2021).

Article CAS PubMed Google Scholar

Hoffmann, C. et al. Immune deficiency is a risk factor for severe COVID19 in people living with HIV. HIV Med. 22, 372378 (2021).

Article CAS PubMed Google Scholar

Chang, M. et al. Changes of gut microbiota in pregnant sows induced by 5-Aminolevulinic acid. Res. Vet. Sci. 136, 5765 (2021).

Article CAS PubMed Google Scholar

Mak, J. W. Y. Modulation of gut microbiota to enhance health and immunity (accessed 2 July 2023). https://clinicaltrials.gov/ct2/show/NCT04884776 (2020).

Falahi, S. & Kenarkoohi, A. Host factors and vaccine efficacy: implications for COVID19 vaccines. J. Med. Virol. 94, 13301335 (2022).

Article CAS PubMed Google Scholar

Chen, J., Vitetta, L., Henson, J. D. & Hall, S. The intestinal microbiota and improving the efficacy of COVID-19 vaccinations. J. Funct. Foods 87, 104850 (2021).

Article CAS PubMed PubMed Central Google Scholar

Zhao, T. et al. Influence of gut microbiota on mucosal IgA antibody response to the polio vaccine. npj Vaccines 5, 47 (2020).

Article CAS PubMed PubMed Central Google Scholar

Praharaj, I. et al. Influence of nonpolio enteroviruses and the bacterial gut microbiota on oral poliovirus vaccine response: a study from South India. J. Infect. Dis. 219, 11781186 (2019).

Article CAS PubMed Google Scholar

Ichinohe, T. et al. Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proc. Natl Acad. Sci. USA. 108, 53545359 (2011).

Article CAS PubMed PubMed Central Google Scholar

Hagan, T. et al. Antibiotics-driven gut microbiome perturbation alters immunity to vaccines in humans. Cell 178, 13131328.e1313 (2019).

Article CAS PubMed PubMed Central Google Scholar

Wells, J. M. Immunomodulatory mechanisms of lactobacilli. Microbial Cell Factories 115 (BioMed Central, 2011).

Wexler, H. M. Bacteroides: the good, the bad, and the nitty-gritty. Clin. Microbiol. Rev. 20, 593621 (2007).

Article CAS PubMed PubMed Central Google Scholar

Wright, E. K. et al. Microbial factors associated with postoperative Crohns disease recurrence. J. Crohns Colitis 11, 191203 (2017).

Article PubMed Google Scholar

Chilton, P. M., Hadel, D. M., To, T. T., Mitchell, T. C. & Darveau, R. P. Adjuvant activity of naturally occurring monophosphoryl lipopolysaccharide preparations from mucosa-associated bacteria. Infect. Immun. 81, 33173325 (2013).

Article CAS PubMed PubMed Central Google Scholar

Fix, J. et al. Association between gut microbiome composition and rotavirus vaccine response among Nicaraguan infants. Am. J. Tropical Med. Hyg. 102, 213 (2020).

Article Google Scholar

Zafar, H. & Saier, M. H. Jr Gut Bacteroides species in health and disease. Gut Microbes 13, 1848158 (2021).

Article PubMed PubMed Central Google Scholar

Domingo, M.-C. et al. Cloacibacillus sp., a potential human pathogen associated with bacteremia in Quebec and New Brunswick. J. Clin. Microbiol. 53, 33803383 (2015).

Article PubMed PubMed Central Google Scholar

Dong, T. S. et al. Gut microbiome profiles associated with steatosis severity in metabolic associated fatty liver disease. Hepatoma Res. 7, https://doi.org/10.20517/2394-5079.2021.55 (2021).

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Impact of the gut microbiome on immunological responses to COVID-19 vaccination in healthy controls and people ... - Nature.com