Vaccines
not yet in
human trials
Vaccines
testing safety
and dosage
Vaccines
in expanded
safety trials
Vaccines
in large-scale
efficacy tests
Vaccines
approved
for use
Vaccines not yet in human trials
Vaccines
testing safety
and dosage
Vaccines in
expanded
safety trials
Vaccines
in large-scale
efficacy tests
Vaccines
approved
for use
Vaccines not yet in human trials
Vaccines
testing safety
and dosage
Vaccines in
expanded
safety trials
Vaccines
in large-scale
efficacy tests
Vaccines
approved
for use
Researchers around the world are developing more than 135 vaccines against the coronavirus. Vaccines typically require years of research and testing before reaching the clinic, but scientists are racing to produce a safe and effective vaccine by next year.
Antibody
produced in
response to a
vaccine
Antibody produced in
response to a vaccine
Antibody produced in
response to a vaccine
Work began in January with the deciphering of the SARS-CoV-2 genome. The first vaccine safety trials in humans started in March, but the road ahead remains uncertain. Some trials will fail, and others may end without a clear result. But a few may succeed in stimulating the immune system to produce effective antibodies against the virus.
Here is the status of all the vaccines that have reached trials in humans, along with a selection of promising vaccines still being tested in cells or animals.
The development cycle of a vaccine, from lab to clinic.
PRECLINICAL TESTING: Scientists give the vaccine to animals such as mice or monkeys to see if it produces an immune response.
PHASE I SAFETY TRIALS: Scientists give the vaccine to a small number of people to test safety and dosage as well as to confirm that it stimulates the immune system.
PHASE II EXPANDED TRIALS: Scientists give the vaccine to hundreds of people split into groups, such as children and the elderly, to see if the vaccine acts differently in them. These trials further test the vaccines safety and ability to stimulate the immune system.
PHASE III EFFICACY TRIALS: Scientists give the vaccine to thousands of people and wait to see how many become infected, compared with volunteers who received a placebo. These trials can determine if the vaccine protects against the coronavirus.
APPROVAL: Regulators in each country review the trial results and decide whether to approve the vaccine or not. During a pandemic, a vaccine may receive emergency use authorization before getting formal approval.
WARP SPEED: The U.S. governments Operation Warp Speed program has selected five vaccine projects to receive billions of dollars in federal funding and support before theres proof that the vaccines work.
COMBINED PHASES: Another way to accelerate vaccine development is to combine phases. Some coronavirus vaccines are now in Phase I/II trials, for example, in which they are tested for the first time on hundreds of people.
Vaccines that use one or more of the coronaviruss own genes to provoke an immune response.
PHASE IIWARP SPEEDModernas mRNA vaccine dazzled the stock market in May with Phase I data on just eight people, only to see its stock price drop when experts had a lukewarm reaction to the results. Part of Operation Warp Speed, the American company is eyeing Phase III trials in July and hopes to have vaccines ready by early 2021.
PHASE I PHASE IIWARP SPEEDThe German company BioNTech has entered into collaborations with Pfizer, based in New York, and the Chinese drug maker Fosun Pharma to develop their mRNA vaccine. In May, Pfizer announced human trials for the vaccine. Another beneficiary of Operation Warp Speed, Pfizer hopes to have a few million doses for emergency use in the fall if all goes well in the trials.
PHASE I PHASE IIImperial College London researchers have developed a self-amplifying RNA vaccine, which boosts production of a viral protein to stimulate the immune system. They began Phase I/II trials on June 15 and have partnered with Morningside Ventures to manufacture and distribute the vaccine through a new company called VacEquity Global Health.
PHASE IIn May, the American company Inovio published a study showing that their DNA-based vaccine produced antibodies in mice. Phase I trials are underway in the United States and will start in South Korea at the end of June.
PRECLINICALIn March, the Trump administration tried to entice CureVac to move its research from Germany to the United States. The company has not yet started human trials for Covid-19, but a rabies vaccine based on the same RNA design passed Phase I safety trials in January. The company said its German facility can make hundreds of millions of vaccines a year.
Vaccines that use a virus to deliver coronavirus genes into cells and provoke an immune response.
PHASE II PHASE IIIWARP SPEEDA vaccine in development by the British-Swedish company AstraZeneca and the University of Oxford is based on a chimpanzee adenovirus called ChAdOx1. The vaccine is beginning Phase II/III testing in England and Brazil. Supported by Operation Warp Speed, the project may deliver emergency vaccines by October. In June, AstraZeneca said their total manufacturing capacity stands at two billion doses.
PHASE IIThe Chinese company CanSino Biologics is testing a vaccine based on an adenovirus called Ad5, in partnership with the Institute of Biology at the countrys Academy of Military Medical Sciences. In May they published a paper in the Lancet, the first time Phase I trial data from any Covid-19 vaccine appeared in a scientific journal.
PRECLINICALWARP SPEEDResearchers at Beth Israel Deaconess Medical Center in Boston are testing an adenovirus called Ad26 in monkeys. Johnson & Johnson, picked by Operation Warp Speed, announced in June that they would start Phase I/II trials in late July.
PRECLINICALThe Swiss company Novartis will manufacture a vaccine based on a gene therapy treatment developed by the Massachusetts Eye and Ear Hospital. A virus called an adeno-associated virus delivers coronavirus gene fragments into cells. Phase I trials are set to begin in late 2020.
PRECLINICALWARP SPEEDThe American company Merck announced in May it would develop a vaccine from vesicular stomatitis viruses, the same approach it successfully used to produce the only approved vaccine for Ebola. The company is partnering with IAVI.
Vaccines that use a coronavirus protein or a protein fragment to provoke an immune response.
PHASE I PHASE IIIn May, the Maryland-based Novavax started a Phase I/II trial on a vaccine made up of microscopic particles carrying fragments of coronavirus proteins. The Coalition for Epidemic Preparedness Innovations is investing $384 million in the project.
PHASE IClover Biopharmaceuticals has developed a vaccine containing a protein from coronaviruses. The vaccine would be taken in conjunction with a so-called adjuvant, made by British drugmaker GSK, to further stimulate the immune system.
PRECLINICALAfter the SARS epidemic in 2002, Baylor College of Medicine researchers began developing a vaccine that could prevent a new outbreak. Despite promising early results, support for the research disappeared. Because the coronaviruses that cause SARS and Covid-19 are very similar, the researchers are reviving the project in partnership with the Texas Childrens Hospital.
PRECLINICALA vaccine in development by the University of Pittsburgh, called PittCoVacc, is a skin patch tipped with 400 tiny needles made of sugar. When placed on the skin, the needles dissolve and deliver virus proteins into the body.
PRECLINICALA vaccine from Australias University of Queensland delivers viral proteins altered to draw a stronger immune response. In June, the university and the company CSL announced a partnership to start Phase I trials, which could lead to millions of doses a year starting in 2021. GSK is providing an adjuvant to further stimulate the immune system.
PRECLINICALThe French company Sanofi will produce viral proteins using engineered viruses that grow inside insect cells. GSK will supplement these proteins with adjuvants that stimulate the immune system. Sanofi has said it could produce at least 600 million doses a year if the vaccine succeeds in trials.
PRECLINICALVaxarts vaccine is an oral tablet containing different virus proteins. In June, the American company announced it was preparing for Phase I trials in summer 2020.
Vaccines that use a weakened or inactivated version of the coronavirus to provoke an immune response.
PHASE I PHASE IIThe private Chinese company Sinovac Biotech is testing an inactivated vaccine called CoronaVac. On June 13 the company announced that Phase I/II trials on 743 volunteers found no severe adverse effects and produced an immune response. Sinovac is preparing Phase III trials in China and Brazil and is building a facility to manufacture up to 100 million doses annually.
PHASE I PHASE IIThe state-owned Chinese company Sinopharm has started Phase I/II trials on two inactivated vaccine viruses. The company has announced it has built a facility in Beijing to make up to 200 million vaccines per year.
PHASE IResearchers at the Institute of Medical Biology at the Chinese Academy of Medical Sciences, which has invented vaccines for polio and hepatitis A, are running a Phase I trial of an inactivated virus vaccine for Covid-19.
Vaccines already in use for other diseases that may also protect against Covid-19.
PHASE IIIThe Bacillus Calmette-Guerin vaccine was developed in the early 1900s as a protection against tuberculosis. The Murdoch Childrens Research Institute in Australia is conducting a Phase III trial, and several other trials are underway to see if the vaccine partly protects against the coronavirus.
Additional reporting by Sui-Lee Wee.
Sources: World Health Organization, National Institute of Allergy and Infectious Diseases, National Center for Biotechnology Information, New England Journal of Medicine
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