Category: Vaccine

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Officials pushing vaccination by end of October, but shot rollout still slow – Becker’s Hospital Review

October 25, 2023

Although both COVID-19 cases and flu are now both low nationwide, health officials are still encouraging individuals to get vaccinated before the end of October.

Cases for these respiratory viruses may be low at the moment, but the viral season as a whole is shaping up to be similar to last year's which at its worst saw between 15 and 25 new hospitalizations for every 100,000 people weekly CNN reported Oct. 23.

"I would say October is when you want to start thinking about getting it, anticipating that November, December, and January will be the rough period," Scott Roberts, MD, a Yale Medicine infectious diseases specialist stated in a news release in early October.

However, the fall vaccine rollout for COVID-19 the newly availableRSV shot has been less than ideal, running into supply issues.

Populations that are most vulnerable to severe illness the elderly in nursing homes and children are having the hardest time accessing these vaccines.

One of the major changes for the COVID-19 vaccination is the shift that occurred from federal government rollout to commercializationand now areinstead buying the vaccines from suppliers and wholesalers. So far 12 million Americans have received the updated COVID-19 vaccine, according to HHS data, CNN reported. Last year by Oct. 12, more than18 million people had received the new COVID-19 shot, the outlet reported.

For the other vaccines, drugmakers like Sanofi have publicly stated they are working to address the issues, but in some cases, like for its RSV shot, demand is outpacing supply.

"We're angry," Lauren Fitzpatrick, MD, who works at Parole, Md.-based Luminis Health Anne Arundel Medical Center, told CBS News Oct. 11. "As pediatricians, we're angry because it feels like we have an opportunity that may be missed."

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Officials pushing vaccination by end of October, but shot rollout still slow - Becker's Hospital Review

What Are The COVID-19 Vaccine Side Effects in 2023? – Verywell Health

October 25, 2023

Key Takeaways

With updated COVID-19 vaccines from Pfizer, Moderna, or Novavax rolling out this fall, many people who are planning to get the shot are wondering if theyll have side effects.

According to the Centers for Disease Control and Prevention (CDC), any vaccine can cause mild side effects, and they usually go away within a few days of getting a shot.

Stuart Ray, MD, an infectious disease specialist and a professor of medicine at Johns Hopkins University School of Medicine, told Verywell that some side effects come on right when you get a vaccine while others might show up later in the day or the next day.

A common example? Having a sore arm after you get your annual flu shot.

Heres what we know about COVID vaccine side effects in 2023, including what experts say you can do to minimize any side effects that you may have.

Hannah Newman, MPH, senior director of infection prevention at Northwell Lenox Hill Hospital in New York, told Verywell that common side effects of the updated COVID vaccine are similar to ones that people had with previous versions.

Possible side effects from COVID vaccines in 2023 include:

Ray explained that since a COVID vaccine is injected into a muscle in your arm (specifically, the deltoid muscle), its not unusual to feel a little pain. However, holding still during the injection, and then for the next few hours actively using that muscle, can help minimize the discomfort.

Its not as common as arm pain, but Ray said that some people may have a general feeling of being unwell (malaise), redness and swelling in their arm where the needle went in, or more muscle soreness after a COVID shot. Side effects like fever, chills, headaches, or noticeable swelling of lymph nodes around the arm (like in the armpit) are even less common.

According to Ray, side effects like arm discomfort come on when you get the shot and dont last very long. Muscle soreness, stiffness, or malaise may come on a few hours after you get the vaccine, and wont last more than a few days.

Its rare, but Ray said that more serious reactions to a vaccine (like anaphylaxis, a life-threatening allergic reaction) can come on immediately after getting the shot or may not show up for a day or so after.

Newman said that if you have side effects, theyll most likely be mild. How long COVID vaccine side effects last can vary, lasting only a few hours to a couple of days. And some people dont have COVID vaccine side effects at all.

You should call your provider or seek medical care right away if you:

According to Newman, everyones immune system responds differently to different vaccines, and that can influence whether or not they have side effects.

Ray said that some people who react to vaccines may have more reactive immune systems, possibly because there are genetic and environmental factors at play. However, more research is needed to understand why some people have side effects after vaccines and others dont.

There is some evidence for higher immune responses in people with more side effects, but this relationship is not super strong, said Ray. People who experience few side effects from the COVID-19 vaccine tend to have excellent immune responses, so its just an interesting trend worthy of deeper understanding.

If you do have side effects after getting a vaccine, Newman said it means that your immune system is working and building a response. However, even if you dont experience side effects, your body is still building protection.

Ray said that individual immune responses and differences in the formulation of the newest COVID vaccine could explain why some people may get side effects this time around even if they didnt have side effects when they got vaccinated before.

The reaction to a vaccine is a complex combination of the persons own immune system plus other factors including precise formulation of the vaccine, said Ray. We do not completely understand this complex mixture of factors, but people tend to have similar reactions to a series of vaccinations.

According to Ray, since COVID vaccine formulations vary a little from brand to brand, there could be minor differences in side effects.

For example, Ray said that Pfizer and Moderna COVID shots are mRNA vaccines that tend to be very effective and also relatively reactogenic, meaning that they may cause more side effects than other, less effective vaccines,

However, Ray added that the shots are still more or less considered equal as long as these differences are not majorthat is, all the shots offer protection and are safe.

Newman said that all three of the currently available vaccine brandsPfizer, Moderna, and Novavaxhave had similar side effects reported: injection site tenderness, fatigue, headache, and muscle pain.

Novavax seems to have a lower risk of causing more serious side effects like inflammation of the heart muscle (myocarditis) or swelling of the membrane around the around (pericarditis), but Newman said that the risk is not zero.

This is a rare side effect that can occasionally occur, especially in young men, said Newman, adding that there is also a risk of these conditions after infection with the COVID-19 virus as well.

Ray said that the immune response to the Novavax COVID vaccine compares to the one stimulated by mRNA vaccines, and there might be fewer side effects. However, we cant be too sure about these comparisons because we dont have a large head-to-head comparison in the same population.

Newman said that getting a COVID shot, flu vaccine, and/or the RSV vaccine on the same day should not raise your risk of having more side effects.

There has not been an association of more side effects or more severe side effects when multiple vaccines are given at one time, said Ray.

Getting more than one vaccine on the same day doesnt seem to be any worse overall than getting them on separate days. However, Ray said that if you plan to get them all at once, try to remember where you got each injection.

Its worth remembering where you got each injection so that if you have an intense local reaction to one of them, youll have a better chance of knowing which one it was, said Ray, though its still not likely youll have any problem.

Suellen Hopfer, PhD, associate professor of Health, Society & Behavior at the University of California, Irvine, told Verywell there are a few things you can do to help with COVID vaccine side effects. Here are some general tips to keep in mind:

To try to prevent side effects, Hopfer recommends getting a good nights sleep the night before and getting your shot in the morning if you can, which studies have suggested may enhance the immune response and possibly lead to fewer side effects.

And remember, if your side effects are getting worse or not getting better within a few days, call your provider.

Side effects from COVID vaccines are generally mild and go away within a few days. Resting up the night before and staying active and hydrated after you get the shot may help with any temporary discomfort you have. If youre concerned about side effects, call your provider.

The information in this article is current as of the date listed, which means newer information may be available when you read this. For the most recent updates on COVID-19, visit ourcoronavirus news page.

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What Are The COVID-19 Vaccine Side Effects in 2023? - Verywell Health

LDH to host drive-thru vaccine clinic in Shreveport – Louisiana Department of Health – Louisiana.gov

October 25, 2023

The Louisiana Department of Health (LDH) Office of Public Health (OPH) in Region 7 (Northwest Louisiana) is preparing residents for flu season by hosting a drive-thru vaccine clinic on Wednesday, October 25 from noon to 6 p.m. at Ochsner LSU Health St. Mary Medical Centers Fountain, 1 St. Mary Place, Shreveport.

Flu vaccines are available at no cost to individuals. However, if you have insurance, bring your insurance card for billing purposes.

Ochsner LSU Health St. Mary Medical Center will also offer skin cancer screenings at the event.

Additional flu vaccination clinics will be offered around the region later this fall. Region 7 serves the parishes of Bienville, Bossier, Caddo, Claiborne, DeSoto, Natchitoches, Red River, Sabine and Webster.

Flu vaccine guidance

The Centers for Disease Control and Prevention (CDC) and LDH recommend that all individuals ages 6 months and older receive a flu shot by the end of October. The flu shot is particularly encouraged among high-risk populations such as pregnant women, children below the age of 5, adults ages 65 and up, and immunocompromised children and adults with chronic health conditions such as diabetes, heart disease and asthma.

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LDH to host drive-thru vaccine clinic in Shreveport - Louisiana Department of Health - Louisiana.gov

What to Know About the RSV Vaccine – Geisinger

October 25, 2023

When youre preparing for respiratory illness season, you probably get a flu shot. Maybe a COVID-19 vaccine. And if youre looking for a way to safeguard your family against RSV, protecting everyone just got easier with an FDA-approved RSV vaccine and monoclonal antibody treatment.

RSV (or respiratory syncytial virus) is a highly contagious lung infection. It can cause serious complications, especially in young children and adults with a weakened immune system, says Stanley Martin, MD, system director of infectious diseases at Geisinger.

Those most at risk for contracting RSV include:

RSV spreads through direct contact with a sick person or through infected respiratory droplets in the air. The virus can also live for hours on hard surfaces. It can enter the body through the eyes, nose or mouth. That means you could be infected by touching a contaminated object, then rubbing your eye.

The vaccine is a single injection to help prevent respiratory syncytial virus. This safe, effective immunization can not only reduce your risk of getting RSV, but it can also lower the risk of serious illness that requires hospitalization.

Like other shots, it works by introducing an inactive protein into the body. After you receive the injection, your immune system starts working to produce antibodies, Dr. Martin says. Those antibodies help protect against RSV.

For infants, a monoclonal antibody can be given to build immunity against RSV. This isnt the same as a vaccine, he explains. The antibody treatment gives antibodies directly to the body to help fight off an RSV infection.

The RSV shot is recommended for:

The monoclonal antibody is recommended for:

For maximum protection, think about timing.

If youre over 60 and considering the vaccine, start by having a conversation with your healthcare provider. They can look at your risk factors to help you decide if the shot is right for you.

Pregnant people between weeks 32 and 36 of pregnancy are recommended to consider the upcoming respiratory viral season (typically September through January) to prevent RSV in their babies once theyre born.

The antibody treatment for infants can provide protection for at least five months, says Dr. Martin. If given at the right time, it can last through RSV season.

Want to learn more about the RSV vaccine or antibody treatment? Talk to your healthcare provider. They can help you decide if its right for you or your family.

Side effects of the RSV vaccine include:

The most common side effects of the antibody treatment are pain, redness or swelling at the injection site, says Dr. Martin. Whether you received the vaccine or treatment, most side effects are mild and go away in a day or two.

Wondering where to get the RSV vaccine? To schedule an RSV shot for yourself or an antibody treatment for your child, contact your healthcare provider or schedule an appointment through MyGeisinger.

After you get your shot, youll be protected. And youll help protect everyone around you. That means youll have more time to focus on feeling your best.

The science behind your flu shot Know the symptoms of RSV Think you cant get COVID and RSV at the same time? Think again.

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What to Know About the RSV Vaccine - Geisinger

UM Leads $12.3M Contract to Advance TB Vaccine – University of Montana

October 25, 2023

UM researcher Walid Abdelwahab is a co-principal investigator on a $12.3 million contract to develop a vaccine adjuvant for use in a tuberculosis vaccine.

MISSOULA The National Institutes of Health recently awarded a $12.3 million contract to the University of Montana to develop a novel vaccine adjuvant for use in a tuberculosis vaccine. Adjuvants are substances that boost the effectiveness of vaccines.

The five-year award went to UMs Center for Translational Medicine and its partners. The contract is titled Development of UM-1098: A Novel Synthetic Th17 Inducing Adjuvant and Delivery System.

The development and clinical evaluation of safe and effective adjuvants is urgently needed for the advancement of vaccines to combat the ongoing threat of bacterial and fungal infections, including tuberculosis, pertussis and others, said Jay Evans, director of the UM center. TB affects a significant portion of the global population, and the only licensed vaccine, BCG, has limited effectiveness. Thus the development of an effective vaccine is critical to end the global TB epidemic.

According to the World Health Organization, 1.6 million people died from TB in 2021. Worldwide, TB is the 13th leading cause of death and second leading infectious killer after COVID-19 (above HIV and AIDS).

Drs. Evans and Walid Abdelwahab are the co-principal investigators on the contract, along with their colleagues Drs. David Burkhart, Asia Riel and Blair DeBuysscher with Center for Translational Medicine. The project also includes researchers from the University of Chicago (Dr. Shabaana Khadar), the Texas Biomedical Research Institute (Dr. Smriti Mehra) and Missoula-based Inimmune Corp., a corporate development partner (Drs. Kendal Ryter and Shannon Miller).

Evans said vaccine development for TB and other bacterial and fungal pathogens has been hampered by the lack of appropriate adjuvants and effective formulations. This new contract builds upon a recently completed $13 million NIH Adjuvant Discovery Contract, which identified the lead candidate being advanced toward human clinical trials in the current award.

This funding represents tremendous support for our continuous research efforts in advancing safe and efficient adjuvants and formulation strategies for further development of vaccine candidates against TB, Abdelwahab said. This contract is a strong endorsement of our exceptional vaccine research team at UM.

The project involves a large vaccine research team at UM with more than two decades of research on improving vaccines through the use of adjuvants and novel delivery systems to ensure vaccines are safely and efficiently delivered to the targeted cells. The UM research will involve both undergraduate and graduate students, providing them with an opportunity to do research on a new vaccine that may have a profound impact on global health.

There is extraordinary research ongoing at UM that could positively impact the lives of countless people, Evans said. Our Vaccine Research Team is dedicated to nurturing and cultivating an interactive research community at UM, specifically geared toward advancing these technologies to help individuals and communities in Montana and across the globe.

Inimmune is a biotech company located at the Universitys business incubator, MonTEC. It will assist with vaccine manufacturing efforts and advancement of this new technology to human clinical trials. The Inimmune efforts will be led by Ryter, the companys vice president of manufacturing and development.

Inimmune is very excited to be chosen as a collaborator to advance this exciting new technology, Ryter said. Adjuvants and immunomodulators that effectively drive a Th17-biased immune response are not part of the standard vaccine tool kit, and we see this approach as having tremendous potential in developing therapies for some of the most difficult to treat and impactful infectious diseases in the world, such as TB.

Founded in 2016, Inimmune focuses on the discovery and development of new immunomodulatory therapeutics for treatment of allergic diseases, cancer and infectious disease. Learn more at https://inimmune.com/.

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Contact: Jay Evans, research professor, UM Center for Translational Medicine director, 406-381-0573, jay.evans@umontana.edu.

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Epidemic: What good is a vaccine when there is no rice? – News-Medical.Net

October 25, 2023

The 1970s was the deadliest decade in the "entire history of Bangladesh," said environmental historian Iftekhar Iqbal. A deadly cyclone, a bloody liberation war, and famine triggered waves of migration. As people moved throughout the country, smallpox spread with them.

In Episode 7 of "Eradicating Smallpox," Shohrab, a man who was displaced by the 1970 Bhola cyclone, shares his story. After fleeing the storm, he and his family settled in a makeshift community in Dhaka known as the Bhola basti. Smallpox was circulating there, but the deadly virus was not top of mind for Shohrab. "I wasn't thinking about that. I was more focused on issues like where would I work, what would I eat," he said in Bengali.

When people's basic needs like food and housing aren't met, it's harder to reach public health goals, said Bangladeshi smallpox eradication worker Shahidul Haq Khan.

He encountered that obstacle frequently as he traveled from community to community in southern Bangladesh.

He said people asked him: "Theres no rice in peoples stomachs, so what is a vaccine going to do?"

To conclude this episode, host Cline Gounder speaks with Sam Tsemberis, president and CEO of Pathways Housing First Institute.

He said when public health meets people's basic needsfirst, it gives them the best shot at health.

Senior Fellow & Editor-at-Large for Public Health, KFF Health News @celinegounder

Cline is senior fellow and editor-at-large for public health with KFF Health News. She is an infectious diseases physician and epidemiologist. She was an assistant commissioner of health in New York City. Between 1998 and 2012, she studied tuberculosis and HIV in South Africa, Lesotho, Malawi, Ethiopia, and Brazil. Gounder also served on the Biden-Harris Transition COVID-19 Advisory Board.

Sam Tsemberis Founder, president, and CEO of Pathways Housing First Institute @SamTsemberis

Shohrab Resident of the Bhola basti in Dhaka Iftekhar Iqbal Associate professor of history at the Universiti Brunei Darussalam Shahidul Haq Khan Former World Health Organization smallpox eradication program worker in Bangladesh

Podcast Transcript

Epidemic: "Eradicating Smallpox"

Season 2, Episode 7: What Good Is a Vaccine When There Is No Rice?

Air date: Oct 24, 2023

Editor's note: If you are able, we encourage you to listen to the audio of "Epidemic," which includes emotion and emphasis not found in the transcript. This transcript, generated using transcription software, has been edited for style and clarity. Please use the transcript as a tool but check the corresponding audio before quoting the podcast.

[Ambient sounds from a ferry play softly.]

Cline Gounder: Im on a boat in southern Bangladesh, headed toward Bhola, the countrys largest island.

We're traveling by ferry on calm waters. But my head spins and my stomach roils just a bit as I imagine how these same waters nearly destroyed Bhola Island.

[Tense instrumental music begins playing.]

It was 1970.

In November, under an almost-full moon and unusually high tides.

The island was hit by one of the most destructive tropical storms in modern history: the Bhola cyclone.

[Shohrab speaking in Bengali fades under English translation.]

Shohrab: There were floods. Back then there werent any embankments to stop the water from rising.

Cline Gounder: Counterclockwise winds, torrential rains, and treacherous waves swept entire villages into the sea. People held onto whatever they could to keep their heads above water.

[Shohrab speaking in Bengali fades under English translation.]

Shohrab: I remember at that time the water level rose so high that people ended up on top of trees. The water had so much force. Many people died.

Cline Gounder: The Bhola cyclone killed some 300,000 people. And for those who survived, there wasnt much left to return to. Hundreds of thousands of people lost their homes, their farms, and their access to food.

The man whose voice youve been hearing was one of the survivors.

[Shohrab speaking in Bengali fades under English translation.]

Shohrab: My name is Shohrab. I am 70 years old.

Cline Gounder: Shohrab was a teenager when the cyclone hit. And in the days and weeks after the storm, he and his family joined a mass migration of people who fled southern Bangladesh.

They traveled about a hundred miles north from Bhola Island to the streets of Dhaka, the busy capital of Bangladesh.

There, they settled in a makeshift community, a kind of unsanctioned encampment dubbed the Bhola basti.

In Bengali that word,"basti," means settlement or "slum," in some translations.

The residents forged a community, but soon, the poor people there and what they built would be seen as a threat to the effort to keep smallpox in check.

Not just in South Asia but around the world.

Im Dr. Cline Gounder. This is "Epidemic."

["Epidemic" theme music plays.]

[Ambient sounds from the Bhola basti, including voices of people speaking Bengali, play softly.]

Cline Gounder: More than 50 years after the cyclone, Shohrab lives in the same area in Dhaka.

I interviewed him at a tea stall near his home. It's the kind of place where men gather to gossip and share stories over hot drinks.

Inside there's a colorful display of snacks and sweets hanging from the ceiling. Just outside we sat on well-worn wooden benches.

And as we sip our tea, he tells me about life in the encampment in the 1970s

[Sparse music plays softly.]

[Shohrab speaking in Bengali fades under English translation.]

Shohrab: I used to rent a place there. Five or six of us used to live in one room. Sometimes it was eight people in a room.

Cline Gounder: To cover his portion of the rent he worked as a day laborer, doing odd jobs here and there. Over time the basti became home.

But Shohrabs new home was likely seen as an eyesore by outsiders and by the Bangladeshi government.

Such settlements often lack running water, or electricity, or access to proper sanitation. Those conditions spotlight suffering and for local leaders that spotlight can be uncomfortable.

But, public health experts had a different concern: that the settlement of Bhola migrants in Dhaka would become a deadly stronghold for smallopox. Cramped and unsanitary living conditions put the residents at high risk.

I ask Shohrab if he remembers seeing or hearing about people with smallpox when he first arrived.

[Shohrab speaking in Bengali fades under English translation.]

Shohrab: I wasnt thinking about that. I was more focused on issues like where would I work, what would I eat, etc.

Cline Gounder: As he tried to rebuild his life, other things like food and shelter were more urgent.

[Music fades to silence.]

Widening beyond that one migrant encampment in Dhaka, researchers say the picture was similar in cities and villages all across the country.

Bangladesh was hit with a series of crises. Environmental historian Iftekhar Iqbal says each brought human suffering and that each was a blow to the smallpox eradication effort.

Iftekhar Iqbal: Seventies was really a time when, the coming of the smallpox couldnt come at a, at a more unfortunate time.

Cline Gounder: In 1970 the Bhola cyclone hit. In 1971, just four months later, the country fought a bloody liberation war. Then, in 1974, heavy rain and flooding triggered a famine. And in 1975 there was a military coup.

Iftekhar Iqbal: The 1970s was the deadliest decade in the history of Bangladesh.

Cline Gounder: This period is when the country became Bangladesh winning its independence from Pakistan in the liberation war. But residents of the young nation faced cascading upheaval and turmoil. And too much death.

[Instrumental music plays softly.]

On the global stage stopping smallpox was important, but many in Bangladesh were just trying to make it to the next day.

Daniel Tarantola: No. 1 priority is food and food and food. And the second priority is food and food and food.

This was an area where survival was always in question.

Cline Gounder: That's Daniel Tarantola.

He's from France and arrived in the region with the mission of helping to eradicate smallpox, but he says the people in front of him needed help with many other things.

Besides hunger, some of the villages he visited were dealing with two epidemics: smallpox and cholera.

Daniel Tarantola: And we were not equipped to do anything but smallpox containment and smallpox eradication. By design or by necessity, we didnt have the means to do anything much more than that.

Cline Gounder: Over the course of this season weve talked about big, complicated issues like stigma and bias, distrust, or First World arrogance that threatened to derail the smallpox eradication campaign. We've documented the public health workers who found a way around those roadblocks.

But sometimes the need is so big, so entrenched, that your inability to meet it can be demoralizing. I sometimes felt that during my own fieldwork: battling HIV and tuberculosis in Brazil and southern Africa, and during an Ebola outbreak in Guinea, West Africa.

Daniel Tarantola says in South Asia the best he could do was focus on the task at hand.

Daniel Tarantola: Meaning that you had to set up a program to eradicate smallpox or at least eliminate it from Bangladesh and at the same time not get if I can use the word distracted, um, by other issues that prevailed in Bangladesh.

[Music fades out.]

Cline Gounder: Those were tough emotional realities for health workers and the people they wanted to care for.

But

Daniel Tarantola: The level of resilience of this population is absolutely incredible given the number of challenges that they have had to survive.

Cline Gounder: One of the main ways people survived the upheaval in Bangladesh was by picking up and moving away from the things trying to kill them.

Remember how Shohrab fled to Dhaka after the cyclone?

Well, mass migration is a survival strategy but one that can worsen disease.

When the cyclone refugees from Bhola landed in that under-resourced basti in Dhaka, all smallpox needed was an opportunity to spread.

[Solemn music begins playing.]

That opportunity came in 1975 when the Bangladeshi government decided to bulldoze the Bhola basti.

Daniel Tarantola says it was a bad idea.

Daniel Tarantola: We knew there was smallpox transmission in this particular area and therefore they should wait until the outbreak subsides before dismantling the shanties.

Cline Gounder: Government officials did not wait for the outbreak to subside. They bulldozed the basti anyway.

Daniel Tarantola: That resulted in a wide spread of smallpox.

Cline Gounder: Here's environmental historian Iftekhar Iqbal again.

Iftekhar Iqbal: This eviction is considered one of the policy errors that led to the second wave of postwar smallpox.

Cline Gounder: In the wake of that eviction in 1975, thousands of people scattered. Some surely returned back home to Bhola.

[Music fades out.]

Cline Gounder: Public health's failure the government's failure to meet the basic need for safety, for food and housing, delayed the goal to stop the virus.

Shahidul Haq Khan, the Bangladeshi public health worker and granddad we met in Episode 4, says he learned that lesson over and over as he urged people to accept the smallpox vaccination.

Their frustration with him and by extension public health was clear.

[Shahidul speaking in Bengali fades under English translation.]

Shahidul Haq Khan: There was no rice in peoples stomachs, so what is a vaccine going to do? "You couldn't bring rice? Why did you bring all this stuff?" That was the type of situation we had to deal with.

[Atmospheric music begins playing.]

Cline Gounder: What good is a vaccine when there is no rice?

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Epidemic: What good is a vaccine when there is no rice? - News-Medical.Net

65 Million People Suffer From Long Covid. Our Experts Say New Vaccines Are The Best Defense – Forbes

October 23, 2023

By Melissa Delaney, Forbes Staff

Heart palpitations. Anxiety. Fatigue. Dizziness. Difficulty breathing. One in five American adults and more than 65 million people worldwide have spent months or even years suffering from the persistent, crippling symptoms of long Covid, and 155 Americans die each day from Covid-19-related conditions.

The only way to prevent long Covid is to not be infected, said Matthew Binnicker, director of clinical virology at the Mayo Clinic and a Forbes contributor. That makes a new series of updated vaccines an essential tool in our ongoing fight against Covid-19, he wrote. They reduce the chance of getting Covid-19 and long Covid and can mitigate the impact of both. And shots are especially important heading into the winter months, when Covid-19, flu and RSV rates spike.

As transmission, hospitalizations and deaths from the virus rose this fall, the U.S. Food and Drug Administration in September approved two updated vaccines for emergency use, and the Centers for Disease Control and Prevention recommends that everyone over the age of 6 months gets a shot.

Developed by Moderna and Pfizer-BioNTech, the vaccines are based on the messenger RNA technology in earlier versions, but the mRNA has been altered to trigger the production of antibodies that protect against the latest subvariants of the omicron strain, Dave Wessner, a biology professor at Davidson College in North Carolina, explained in a Forbes article.

For the foreseeable future, Wessner wrote, we probably can expect updated Covid-19 shots to be released periodically.

These new shots, along with the protein-based Novavax vaccine, which received approval earlier this month, should target the still-evolving omicron subvariants and can be effective at reducing severe disease and hospitalization, said Forbes contributor Dr. Omer Awan.

Covid-19 vaccines have been game-changers in a pandemic that shuttered businesses and schools, separated families and friends, overwhelmed hospitals and has killed nearly 7 million people worldwide. Yet vaccine rates have laggedfewer than 70% of the U.S. population was fully vaccinated and only 17% had received updated boosters as of the CDCs final update in Maydespite the monumental accomplishments of developing, approving and rolling out the groundbreaking vaccines, said Dr. Stephen Thomas, director of the Institute for Global Health and Translational Sciences at SUNY Upstate Medical University.

The development of mRNA vaccines was the result of years of work by Dr. Katalin Karik and Dr. Drew Weissman, despite the headwinds of skepticism by some who thought it wasnt a practical way to build a vaccine. Earlier this month, they were awarded the Nobel Prize in Physiology or Medicine for their decades-long research, which served as the foundation for the Covid-19 vaccines. Their approach offered hope for immunity without the need to inject patients with an actual virus.

Drs. Karik and Weissmans decades of perseverance paved the way for the technology needed to combat and pull the world out of the Covid-19 pandemic, said Dr. Mill Etienne, chief of neurology at WMCHealths Good Samaritan Hospital and associate professor of neurology and medicine at New York Medical College.

Forbes experts share what you need to know about the effects of long Covid and the updated vaccines essential in protecting yourself from the worst-case scenarios:

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65 Million People Suffer From Long Covid. Our Experts Say New Vaccines Are The Best Defense - Forbes

Is the Novavax COVID Vaccine Better than mRNA Vaccines? What We Know So Far – Scientific American

October 23, 2023

Scientific American is part of Springer Nature, which owns or has commercial relations with thousands of scientific publications (many of them can be found at http://www.springernature.com/us). Scientific American maintains a strict policy of editorial independence in reporting developments in science to our readers.

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Is the Novavax COVID Vaccine Better than mRNA Vaccines? What We Know So Far - Scientific American

Pfizer jacks up price of five-day course of COVID drug Paxlovid to $1,400 – New York Post

October 23, 2023

Business

By Ariel Zilber

Published Oct. 20, 2023, 11:45 a.m. ET

Pfizer plans to charge COVID patients around $1,400 for a five-day course of the antiviral drug Paxlovid nearly triple the amount the US government paid during the coronavirus pandemic, according to a report.

The pharmaceutical giant sent a letter dated Wednesday to pharmacies and clinics announcing the $1,390 price tag for the drug, which was the first oral treatment for COVID approved by the Food and Drug Administration, according to The Wall Street Journal.

The US government had been paying $529 to Pfizer for the five-day course.

Those with health insurance will likely pay much less than new, jacked-up price.

Pfizer is also expected to offer price discounts and help patients with out-of-pocket charges, according to The Journal.

Pfizer has reaped handsome profits from COVID-related treatments, including its mRNA vaccines.

But critics note that the company could not have brought the inoculation to market without significant funding of mRNA technology by taxpayers.

According to the Congressional Budget Office and other experts, the federal government has spent anywhere from $18 billion to $39.5 billion on developing the COVID vaccines.

While the US government directly gave funds to Johnson & Johnson and Moderna to develop their respective vaccines, Pfizers German partner, BioNTech, received a $445 million grant from its government.

The breakthroughs made in mRNA research is credited by many as the reason that Pfizer was able to bring its vaccine to market as quickly as it did, according to experts.

Pricing for Paxlovid is based on the value it provides to patients, providers, and health care systems due to its important role in helping reduce COVID-19-related hospitalizations and deaths, a Pfizer spokeswoman told The Post.

The spokeswoman added that all Paxlovid doses marked with the emergency use authorization label will remain free of charge to all patients until the end of 2023.

In addition, Paxlovid will remain available free of charge through 2024 to Medicare, Medicaid, and uninsured patients through a US Government patient assistance program (PAP) operated by Pfizer, the company spokesperson said.

Critics, however, blasted the company for gouging the public.

Eric Feigl-Ding, an epidemiologist who made frequent media appearances during the pandemic, wrote on the X social media platform that Pfizer is getting too greedy and that the cost increase was shameful.

David Hoskins wrote on X: Pfizer made $31,400,000,000 in profits in 2022, so of course it needs to jack up the price of a lifesaving medication 2.6 times in 2023.

Shares of Pfizer were down by some 1.25% as of 10:40 a.m. Eastern time on Thursday.

In March, Moderna, the makers of one of the COVID vaccines, announced that it would price one dose of the shot at around $130 more than four times what the US government paid to make the vaccine available at no cost.

Last month, Pfizer BioNTech set the list price for their jointly manufactured COVID vaccine at $120 per dose.

By contrast, the US government paid $19.50 per dose of the Pfizer/BioNTech vaccine in the initial contract that was signed in 2020 and $30.50 per dose for the updated vaccine that was released by the company last year.

Earlier this week, Pfizer reduced its full-year forecast for sales of Paxlovid by about $7 billion, and for the vaccine it developed with BioNTech by about $2 billion due to a plunge in use of pandemic-related products.

The company said that it had to take back 7.9 million unused Paxlovid doses from the US government.

It said it would make cuts this year and next and take a write-down.

In light of the forecast, Pfizer said it plans to embark on a $3.5 billion cost-cutting spree.

On an early Monday call with analysts, Pfizer CEO Albert Bourla said he expects around 17% of the US population will get updated COVID shots during the current vaccination campaign, in line with last year, but far below rates seen when vaccines first emerged in the spring of 2021.

The US is in the middle of COVID fatigue, where everyone wants to forget about the disease, he said.

Moderna, in a statement on Monday, maintained its current revenue forecast of $6 billion to $8 billion for its COVID vaccine for 2023.

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Pfizer jacks up price of five-day course of COVID drug Paxlovid to $1,400 - New York Post

RFK Jr. spent years stoking fear and mistrust of vaccines. These people were hurt by his work – The Associated Press

October 23, 2023

When 12-year-old Braden Fahey collapsed during football practice and died, it was just the beginning of his parents nightmare.

Deep in their grief a few months later, Gina and Padrig Fahey received news that shocked them to their core: A favorite photo of their beloved son was plastered on the cover of a book that falsely argues COVID-19 vaccines caused a spike of sudden deaths among healthy young people.

The book, called Cause Unknown, was co-published by an anti-vaccine group led by Robert F. Kennedy Jr., President John F. Kennedys nephew, who is now running for president. Kennedy wrote the foreword and promoted the book, tweeting that it details data showing COVID shots are a crime against humanity.

The Faheys couldnt understand how Bradens face appeared on the books cover, or why his name appeared inside it.

Braden never received the vaccine. His death in August 2022 was due to a malformed blood vessel in his brain. No one ever contacted them to ask about their sons death, or for permission to use the photo. No one asked to confirm the date of his death which the book misdated by a year. When the Faheys and residents of their town in California tried to contact the publisher and author to get Braden and his picture taken out of the book, no one responded.

We reached out in every way possible, Gina Fahey told The Associated Press in an emotional interview. We waited months and months to hear back, and nothing.

How could a member of one of the most influential political dynasties in American history be involved in such a shoddy, irresponsible project, the Faheys wondered?

Bradens story is just one example of how Kennedy, son of the late Sen. Robert F. Kennedy, has used his famous name to disseminate false information about vaccines and other topics in a time when spreading conspiracy theories has become a powerful way to grow a constituency. An AP examination of his work and its impact found Kennedy has earned money, fame and political clout while leaving people like the Faheys suffering.

Now, Kennedys decision to drop his Democratic bid for president and run as an independent gives him a new spotlight in an election thats currently heading toward a rematch between President Joe Biden and former President Donald Trump. Theres concern in both parties that he could emerge as a spoiler who could affect the outcome of the campaign in unexpected ways. And at a time when Republicans in the 2024 race also are sowing doubt about vaccine effectiveness, it threatens to further promote harmful misinformation that already has cost lives.

One mom told AP about how she had delayed important care for her child because she believed Kennedys vaccine falsehoods. A former elected leader described being harassed by Kennedys followers. Doctors and nurses recounted how his work has hurt people in the U.S. and abroad.

Kennedys campaign did not respond to several emails seeking comment for this article, but after AP contacted Kennedy and others involved in the book last week, the president of Skyhorse Publishing, which co-published it, texted the Faheys, offering to talk. Gina Fahey told AP she felt he reached out only after it became clear the situation could harm his reputation.

Theres still that lack of compassion that was always there from the beginning, she said, adding that she is hesitant to engage with them now because she doesnt trust their intentions. Its only now that theyre reaching out, days prior to knowing this story is going to be released.

Bradens parents have read vicious comments from people who falsely blame vaccines for their sons death. They say seeing Bradens memory being misrepresented by Kennedy and others has been deeply painful.

When you barely feel like you can even come up for air, you just get smacked back down again by this, Gina Fahey said.

Its very manipulative. And you know, hes making money off of our tragedies, she said, adding, How could you want somebody running our country that operates like that?

Many years before anti-vaccine activists exploited the pandemic to bring their ideas to the American mainstream, Kennedy, an environmental lawyer, was among the most influential spreaders of fear and distrust around vaccines. He has long advanced the debunked idea that vaccines cause autism. He has said vaccines had caused a holocaust, and has traveled the world spreading false information about the pandemic.

In recent years, Kennedy has used his name and rhetorical skills to build his anti-vaccine group, Childrens Health Defense, or CHD, into an influential force that spreads false and misleading information. An AP investigation previously revealed how Kennedy had capitalized on the pandemic to build CHD into a multimillion-dollar misinformation engine.

One of the ways Kennedy and CHD have made money is through the sale of books. Kennedys longtime publisher, Skyhorse, joined with CHD to create a book series that has published titles including Vax-Unvax, Profiles of the Vaccine Injured, and the book that included Braden Fahey, Cause Unknown.

Written by Edward Dowd, a former executive at BlackRock, that book is built on the false premise that sudden deaths of young, healthy people are spiking. Experts say these rare medical emergencies are not new and have not become more prevalent.

We are just not seeing anything that suggests that, said Dr. Matthew Martinez, of Atlantic Health System in Morristown Medical Center, who researches cardiac events among professional athletes.

The AP found dozens of individuals included in the book died of known causes not related to vaccines, including suicide, choking while intoxicated, overdose and allergic reaction. One person died in 2019.

AP asked Kennedys campaign, CHD, Dowd and Skyhorse president Tony Lyons several questions about the book, including why they chose to feature Braden, why they didnt speak to his family first and what steps they took to fact check.

The only person to respond was Lyons, who also co-chairs the Kennedy Super PAC American Values 2024.

In emails, Lyons did not address why Braden specifically was chosen for the cover but defended his inclusion by saying that news stories and his obituary did not mention his cause of death.

Hundreds of deaths are cited in the book, though Lyons said it only attributes nine of them to the vaccine. Lyons said Bradens death and others are never explicitly attributed to the vaccine, and that the book explores many possible reasons for deaths that have appeared in headlines since 2021.

Still, the book several times refers to its thesis that mass administration of COVID-19 vaccines caused a spike in deaths. Bradens parents said his appearance in the context of the book implies he died of the vaccine, putting his death in a false light.

Lyons said he was unaware of the Faheys efforts to contact his company and asked AP to share with them his contact information. He said he would make some corrections in future editions, including to Bradens date of death, but said they were studying whether to remove him from the book or the cover.

Lyons told the AP that Childrens Health Defense has a publishing deal with Skyhorse, though he would not say how much money CHD has received through it.

Kennedy also has a consulting deal with Skyhorse that personally paid him $125,000 since August 2022 for scouting out books for the company, according to a financial disclosure he filed. Lyons said that deal has so far resulted in 27 books of different genres including childrens books, mysteries and cookbooks, but declined to name them.

Lyons also praised Kennedys record of environmental work, such as protecting New Yorks Hudson River, and other work hes done to take on powerful corporate interests and what Kennedy sees as government corruption. Those are also topics Kennedy has focused on during his presidential campaign.

The platform Kennedy built for himself has an impact. In a study of verified Twitter accounts from 2021, researchers Francesco Pierri, Matthew DeVerna and others working with Indiana Universitys Observatory on Social Media found Kennedys personal Twitter account was the top superspreader of vaccine misinformation on Twitter, responsible for 13 percent of all reshares of misinformation, more than three times the second most-retweeted account.

The messages Kennedy shares have convinced a significant slice of the public, some of whom attend his campaign events proudly wearing pins with crossed-out syringes or repeating Kennedys talking points about vaccine ingredients.

Kennedys anti-vaccine organization has a lawsuit pending against a number of news organizations, among them The Associated Press, accusing them of violating antitrust laws by taking action to identify misinformation, including about COVID-19 and COVID-19 vaccines. Kennedy took leave from the group when he announced his run for president but is listed as one of its attorneys in the lawsuit.

Many people have staked their lives and the lives of their families on the views espoused by Kennedy and others who oppose vaccines.

The AP spoke to mothers who once identified as anti-vaccine and counted themselves among Kennedys most devoted followers.

I thought he was heroic, because he was saying the things publicly that other people were too afraid to say, said Lydia Greene.

Greene, who lives in the Canadian province of Alberta, declined all vaccines for her son after buying into the claims by Kennedy and other anti-vaccine gurus that vaccines cause autism. When her son started to show signs of autism, Greene discounted it out of hand.

I couldnt even see his autism because in the anti-vax movement, autism is the worst outcome that can happen to a child. And when they talk about their vaccinated autistic kids, its often with a tone of resentment and how they talk about how their life is ruined, their marriage is ruined, and its just this kid is damaged, Greene said. And so when my son was different, I couldnt see that stuff about him.

She said she did not recognize his condition until she came out of the rabbit hole of anti-vax.

I realized I had wasted so much valuable time where he should have been in occupational therapy, speech therapy, evidence-based therapy for autism, Greene said.

Kennedys Childrens Health Defense produces articles, newsletters, books, podcasts, even TV shows on its own CHD.TV. Greene said those articles often validate anxious parents fears no matter how irrational while making them feel like someone powerful is listening.

Today, Greene believes the group exploited her.

Thats what CHD does, Greene said. They find parents when theyre vulnerable. And hack into that.

Because of his national profile, Kennedys work has ripple effects beyond the most devoted anti-vaccine activists.

Medical professionals told the AP that vaccine disinformation spread by Kennedy and other influencers makes the patients they serve wary about lifesaving vaccinations.

Sharon Goldfarb, is a family nurse practitioner in Berkeley, California, who spent the worst of the pandemic caring for people on societys margins: people with no homes; people who were living in the country illegally; people with serious mental health needs. She has seen firsthand the consequences of vaccine misinformation and refusal.

Its disturbing because he has a huge family name, Goldfarb said. When youre a trusted public figure and you have a trusted family name, you have to answer to a higher authority. I just dont get it.

Dr. Todd Wolynn, a Pittsburgh pediatrician who works to clarify the facts about vaccines on social media, said despite Kennedys lack of clinical experience, he has an outsized influence on his followers.

He uses a very big platform to amplify disinformation that leads people down a path to make a decision thats not evidence based, Wolynn said. And as a result, it puts their own lives, the lives of their children, the lives of their family, in harms way.

Though Kennedy did not respond for this story, he has long said that he is not anti-vaccine, and only wants vaccines to be rigorously tested. The Centers for Disease Control and Prevention explains that vaccines undergo thorough testing before they are authorized or approved in the U.S. and they are monitored for safety after they are introduced to the public.

COVID-19 vaccines were initially developed under the Trump administration, through the program Operation Warp Speed. But what his Republican-led administration viewed at the time as a point of pride has since become a topic of criticism in Republican circles, including among GOP presidential candidates who have expressed skepticism about the immunizations.

The Republican candidate and biotech entrepreneur Vivek Ramaswamy said in a July podcast interview that if hed had the facts he would not have gotten vaccinated against COVID-19. The administration of fellow GOP candidate Florida Gov. Ron DeSantis has broken with CDC guidance to advise Floridians under 65 not to get the latest COVID-19 booster.

That kind of rhetoric, along with the conspiracy beliefs that Kennedy has shared about other subjects, like 5G, can impact the smooth running of societies, said Daniel Jolley, a University of Nottingham social psychology professor, who has published several papers on conspiracy thinking and its impacts.

While skepticism is important, proper evaluation of the evidence is key, Jolley said. Anyone pushing conspiracy theories while running for president makes the theories seem normal.

Its that kind of rhetoric that I think is really damaging, Jolley said. You worry when you think about the next pandemic or the next event or the next issue thats going to come our way.

Jolley wonders: Will people listen to doctors or experts next time?

Kennedys role in legitimizing anti-vaccine activism has not been limited to the U.S. Perhaps the most well-known example was in 2019 on the Pacific island nation of Samoa.

That year, dozens of children died of measles. Many factors led to the wave of deaths, including medical mistakes and poor decisions by government authorities. But people involved in the response who spoke to AP said Kennedy and the anti-vaccine activists he supported made things worse.

In June 2019, Kennedy and his wife, the actress Cheryl Hines, visited Samoa, a trip Kennedy later wrote was arranged by Edwin Tamasese, a Samoan local anti-vaccine influencer.

Vaccine rates had plummeted after two children died in 2018 from a measles vaccine that a nurse had incorrectly mixed with a muscle relaxant. The government suspended the vaccine program for months. By the time Kennedy arrived, health authorities were trying to get back on track.

He was treated as a distinguished guest, traveling in a government vehicle, meeting with the prime minister and, according to Kennedy, many health officials and the health minister.

He also met with anti-vaccine activists, including Tamasese and another well-known influencer, Taylor Winterstein, who posted a photograph of herself and Kennedy on her Instagram.

The past few days have been profoundly monumental for me, my family and for this movement to date, she wrote, adding hashtags including #investigatebeforeyouvaccinate.

A few months later, a measles epidemic broke out in Samoa, killing 83 people, mostly infants and children in a population of about 200,000.

Public health officials said at the time that anti-vaccine misinformation had made the nation vulnerable.

The crisis of low vaccination rates and skepticism created an environment that was ripe for the picking for someone like RFK to come in and in assist with the promotion of those views, said Helen Petousis-Harris, a vaccinologist from New Zealand who worked on the effort to build back trust in the measles vaccine in Samoa.

Petousis-Harris recalled that local and regional anti-vaccine activists took their cues from Kennedy, whom she said sits at the top of the food chain as a disinformation source.

They amplified the fear and mistrust, which resulted in the amplification of the epidemic and an increased number of children dying. Children were being brought for care too late, she said.

Kennedys campaign did not respond to emails seeking comment about Samoa, though he says on his campaign website that he had no role in the outbreak. He also said in an interview for a forthcoming documentary, Shot in the Arm, that he bears no responsibility for the outcome.

I had nothing to do with people not vaccinating in Samoa. I never told anybody not to vaccinate. I didnt, you know, go there for any reason to do with that.

But people who worked on the Samoan measles response told AP the credibility he gave to anti-vaccine forces when he met with them had an impact.

Moelagi Leilani Jackson, a Samoan nurse who worked on the vaccination campaign to stem the scourge of measles, said she remembered that after Kennedys visit, the anti-vaccine influencers got louder.

I feel like they felt they had the support of Kennedy. But I also think that Kennedy was very well, he came in and he left, she recalled. And other people picked up the pieces.

A few weeks after his trip to Samoa, Kennedy appeared in Sacramento, California, where lawmakers were debating a bill to make it more difficult to get a vaccine exemption. The bill was sponsored by Democratic state Sen. Richard Pan, a pediatrician.

As a crowd gathered outside the capitol, Kennedy stood to speak. Two large posters behind him featured Pans image, with the word LIAR stamped across his face in blood-red paint. Pan told AP he felt the staging was intended to incite the crowd against him.

So hes rallying to have people attack me, essentially, personally, said Pan, who is no longer in office.

Within months, one anti-vaccine extremist assaulted Pan, streaming it live on Facebook. Another threw blood at Pan and other lawmakers.

Kennedy has repeatedly brought up the Holocaust when discussing vaccines and public health mandates, comparisons that Pan said amount to an indirect call to violence against health advocates.

Who creates an atmosphere where they think whats appropriate is to actually physically assault a legislator? Its people like Robert F. Kennedy Jr. Pan said.

Pan said its one of many instances when Kennedy has whipped people up against public health advocates. Kennedy also wrote a bestselling book attacking infectious disease expert and former top government scientist Dr. Anthony Fauci, who has received death threats.

Those attacks have prompted criticism from Kennedys sister Kerry Kennedy, who invoked the Kennedy family history of political violence their father and uncle were both assassinated when she told the AP in 2021: Attacking doctors and scientists is irresponsible because many have received death threats. This can deter people from those professions. Our family knows that a death threat should be taken seriously.

Kerry Kennedy and three other siblings on Oct. 9 issued a statement denouncing Kennedys independent candidacy, calling it dangerous and perilous to the country.

Pan said that Kennedys rhetoric, which often demonizes scientists and health care professionals, is part of a strategy to intimidate and silence them.

When you call something a holocaust, it is incitement to violence, Pan said.

The real consequence of Robert F. Kennedy Jr. is we have dead children, and we have people who are in good faith doing their best to try to protect people, including children, who are basically being threatened and even assaulted because of his rhetoric and his lies, said Pan, who is now running for mayor of Sacramento, a nonpartisan position. That harms America.

Associated Press video journalist Terry Chea contributed to this report.

The Associated Pressreceives support from several private foundations to enhance its explanatory coverage of elections and democracy. See more about APs democracy initiative here. The AP is solely responsible for all content.

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RFK Jr. spent years stoking fear and mistrust of vaccines. These people were hurt by his work - The Associated Press

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