Category: Vaccine

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Tuesday briefing: Measles cases are rising and its about more than vaccine misinformation – The Guardian

January 24, 2024

First Edition newsletter

Tue 23 Jan 2024 01.35 EST

Good morning. Before a vaccine for measles was created, there were regular epidemics that caused approximately 2.6 million deaths worldwide each year. In England, the year before the vaccine was introduced in 1968, there were 460,000 cases of measles by the 1980s that number had dropped to about 10,000 suspected cases a year.

To drive home the importance of getting protected from this highly contagious infection, the government implemented a national vaccination campaign in 1994 the impact was immediately felt. There have been no measles epidemics since 1995 and in 2017, the World Health Organisation (WHO) declared England measles-free. So, how, in just seven years, is measles back at the top of the health agenda?

A combination of factors means measles cases are rising rapidly in England and Wales. Figures from NHS England suggest more than 3.4 million children under the age of 16 years are unprotected against measles, mumps and rubella.

The steady decline of MMR vaccine uptake has made measles outbreaks increasingly common. Certain regions are worst affected, particularly the West Midlands, where more than 300 cases were reported between 23 October and 15 January. After these outbreaks, the UK Health Security Agency (UKHSA) declared a national incident and warned that further outbreaks could spread across the country, even though 85% of children nationally have had their second dose of the MMR vaccine. This is because, to ensure herd immunity, 95% of the population has to be fully vaccinated.

To get a sense of why this is happening, for todays newsletter I spoke with Guardian science correspondent Nicola Davis. But first, the headlines.

Energy | More than 2 million people across the UK will be cut off from their gas and electricity this winter because they cannot afford to top up their prepayment meters, according to Citizens Advice.

Immigration and asylum | Rishi Sunaks plan to deport asylum seekers to Rwanda has received its first parliamentary defeat after the House of Lords voted for a motion that sought to delay ratification of the new treaty until the government can show the country is safe.

Weather | Two people have died and tens of thousands were left without power after Storm Isha wreaked havoc across the UK with gusts as high as 107mph.

Middle East | The White House has called on Israel to protect innocent people as Palestinian officials said the Israeli military had stormed al-Khair hospital in Gaza and placed another, al-Amal, under siege.

UK news | A coroner has ruled that a 13-year-old black boy, Christopher Kapessa, was deliberately pushed into a Welsh river by an older white boy as a dangerous prank. But the coroner, David Regan, said there was no evidence that the child who pushed Christopher had intended to cause his death or that there was a racist motive behind it.

Measles is a highly contagious infection. According to the NHS one person can infect nine out of 10 unvaccinated close contacts. The infection can have a number of serious complications, including pneumonia, blindness, seizures and meningitis. Babies under the age of one, young children, pregnant women and immunocompromised people are vulnerable to the more aggressive side effects.

***

When did this start?

Though the problems surrounding MMR vaccine coverage have become particularly amplified in recent months, it is not a new issue. In 1998, former physician Andrew Wakefield put forward a widely and since comprehensively debunked hypothesis linking the MMR vaccine to autism. What we saw after that was a drop in uptake because people were worried about this false link, says Nicola. It meant that quite a lot of people born in that time did not have two doses of the vaccine, leaving a lot of late teens and young adults vulnerable to measles in the late 2010s. Before the Covid pandemic hit, there were a number of outbreaks of mumps and measles in secondary schools and universities, in part because of Wakefields hypothesis.

There has also, separately, been a slow decline over the last decade in vaccine uptake, meaning that young children are now also vulnerable 60% of cases in current outbreaks are assumed to be in children under the age of 10. Any drop in uptake is a problem.

Measles is a nasty infection, so this is serious, Nicola says. About one in five kids who get the disease have been admitted to hospital for treatment. It can cause very serious infection about one in 1,000 people get inflammation of the brain and about one in 5,000 in countries like the UK can die.

***

Why are people not getting vaccinated?

Though vaccine misinformation has played a role in the decline, it is not the only factor. Most parents do get their children vaccinated, as we can see from the figures, Nicola says. Parental confidence in vaccines is high: a 2022 survey conducted by the UKHSA found that 95% of parents agree vaccines work, 91% think they are safe and 90% agree they trust vaccines so what is stopping parents from getting the jabs into their childrens arms?

The first issue Nicola pointed out was access and flexibility when it came to booking the appointment initially. She also noted that underinvestment in the NHS has meant that we dont necessarily have systems where people are being chased up, reminded and given that extra encouragement to get this done.

The irony of the measles conundrum is that the efficacy of the vaccine has meant that most people are not aware of how serious the infection can be, and therefore there is not much urgency when it comes to getting vaccinated. Most of us will never have actually seen measles and could mistakenly think that it is just a bit of a rash that clears up after a few days, not realising that this is a very serious and potentially fatal disease, Nicola says.

During the height of the pandemic, many parents were also nervous or hesitant to go into hospitals or other health settings to get children vaccinated for fear of getting infected with Covid and others simply did not know that these routine vaccinations were still happening at that point. So theres a melting pot of reasons for the decline, Nicola says.

***

Fighting the infection

The government has announced a national campaign to encourage parents of children between the ages of six and 11 to make an appointment with their GP to administer any missed MMR vaccines. The campaign will also target a million people in the West Midlands and London between the ages of 11 and 25 particularly as measles can be more serious if it is contracted in adulthood.

If the government and the NHS deal with all of the various components of this problem, they can stop the infection from becoming a full-blown health crisis. Conversely, any level of complacency will exacerbate the problem.

We have a safe and highly effective vaccine, we shouldnt have measles in the UK. So its about putting resources into getting jabs into the arms of those who are unvaccinated, Nicola says.

What does our heart rate really tell us about our health and state of being? Joel Snape talks to experts to find out. Nimo

Is this heralding a new era for India? The prime minister, Narendra Modi, has opened a controversial Hindu temple built on the ruins of an ancient mosque in a move that has been viewed as seeking to transform India from a secular democracy into a Hindu state. Nazia Parveen, acting deputy editor, newsletters

Matthew Cantor asks whether we are taking hypochondria seriously enough after a Swedish study found that those with long-term, serious anxiety over health die earlier than others. Nimo

In our latest instalment on Latin Americas water wars, Paloma de Dinechin meets the people of the Ixquisis valley who thought their most valuable resource would help lift their villages out of poverty. Instead, to their horror murder and violence followed. Nazia

Ill admit it: I love having a quick look into peoples windows as I stroll by, especially in fancy neighbourhoods. What can I say, Im a curious being. For the Atlantic (), Michael Waters turns the focus on to the wealthy who fling open their curtains, allowing people to gawp at their showroom-like homes. Nimo

Australian Open | So far in Tuesdays play, Coco Gauff of the US has beaten Ukraines Marta Kostyuk 7-6(6) 6(3)-7 6-2 to reach the final four of the womens singles for the first time. Earlier, Cameron Norrie finished happy with his games evolution as he narrowly lost 7-5, 3-6, 6-3, 4-6, 7-6 (3) against the sixth seed Alexander Zverev in the fourth round. And three games into her contest with Linda Noskova, Elina Svitolina was forced to retire with a back injury while trailing 0-3. The womens draw quickly became a free-for-all as Dayana Yastremska, a Ukrainian qualifier, picked off Victoria Azarenka, a two-time champion, 7-6 (8-6), 6-4.

Football | The Africa Cup of Nations hosts Ivory Coast are on the brink of a humiliating exit from their own tournament after a shock 4-0 defeat by Equatorial Guinea who were confirmed as the surprise group winners ahead of Nigeria, who beat Guinea-Bissau 1-0. Ghana are also set to miss out on the last 16 after drawing 2-2 with Mozambique, while Egypt scraped through despite being held to draw by Cape Verde in Group B.

Cricket | Virat Kohli has withdrawn from the first two of Indias five Tests against England for personal reasons, with the Board of Control for Cricket in India asking media and fans to respect his privacy and refrain from speculating about the nature of [those] reasons.

Medics urged not to report illegal abortions to police is the Guardians print lead today. The Financial Times splashes with Narrow voter ID rules expose Tories to claims of bias, elections chief warns. Breakthrough Alzheimers blood test will bring cure closer thats the Daily Express while the Daily Telegraph has Alzheimers blood test revolution for over-50s and the Times says Blood test can detect early sign of Alzheimers. Story of the moment for the Daily Mail is Starmer wades into culture wars on the side of the woke (he criticised the Tories war on the aforementioned). Weight loss horror the Daily Mirror covers the Devastating consequences of a womans botched surgery in Turkey. A counterpoised story in the Metro: Fat-busting balloon pill on NHS. UKs worst storms in a decade will become the norm warns the i.

New Hampshire primary: the last chance to stop Trump?

After the withdrawal of Ron DeSantis from the race, only Nikki Haley now stands between Donald Trump and the Republican nomination for the presidency. David Smith reports from Manchester, New Hampshire

A bit of good news to remind you that the worlds not all bad

Hurtling towards her 40s as a single mother, relying on benefits to support her three children, Zoe Smith, made the decision to quit the UK and return to Grenada, the island her paternal and maternal grandparents had left in the 1950s.

If I couldnt make it work in the UK, what chance did my children have in a country in which, on every indicator from education to employment, health to housing the odds of success as black citizens were clearly stacked against them?

Smith decided to leave the UK in the middle of the pandemic and when she finally landed after many cancelled flights she describes feeling a sense of overwhelming relief. Moving to Grenada has thrown up its challenges but her ultimate motivation is to raise her children in an environment where they could feel that freedom is their birthright.

Sign up here for a weekly roundup of The Upside, sent to you every Sunday

And finally, the Guardians puzzles are here to keep you entertained throughout the day with plenty more on the Guardians Puzzles app for iOS and Android. Until tomorrow.

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Tuesday briefing: Measles cases are rising and its about more than vaccine misinformation - The Guardian

Whooping cough cases in Wales show sharp increase – BBC.com

January 24, 2024

23 January 2024

Image source, Getty Images

Babies are given whooping cough vaccine as part of their six-in-one inoculation

Whooping cough cases have risen rapidly in Wales in the first few weeks of 2024.

There have already been 135 notified cases so far in January, compared with about 200 in the whole of 2023.

Public Health Wales (PHW) expert Dr Chris Johnson said, from what GPs had been reporting, it appeared to show the start of a relatively large wave.

He has urged all pregnant women and parents of babies and young children to ensure they are vaccinated.

PHW said whooping cough has waves of increased infection every three to four years and notifications had grown sharply in the past few weeks.

Dr Johnson, a consultant epidemiologist, said: "With rates suppressed during the lockdowns of the pandemic we are naturally seeing a resurgence this year."

Of the 53 cases notified in the most recent week, 12 were in Pembrokeshire, eight in Flintshire and six in Rhondda Cynon Taf but there were cases also in 12 other council areas.

Only Blaenau Gwent,, Merthyr Tydfil and Monmouthshire have not had any cases notified in the past six weeks.

The last whooping cough peak was in the year before Covid - 2019 - and before that a big surge came in 2012, when notifications averaged 180 a week in the run-up to Christmas.

Dr Johnson, who heads PHW's vaccine preventable disease programme, added: "Whooping cough is highly contagious and is spread by breathing in small droplets in the air from other people's coughs and sneezes."

Image source, Getty Images

Whooping cough is also known as pertussis and is a lung or breathing tube infection, which is contagious.

The name comes from a "whoop" sound which some sufferers get, when they gasp for breath between coughs and coughing can last for several weeks.

People are recommended to get rest and take plenty of fluids but may be prescribed antibiotics if in the infectious early stages.

The take-up for babies has reached 95% but there has been a very gradual drop-off over the decade.

There has been a slightly more marked drop in recent years to about 70% of pregnant women being vaccinated.

"It's really important, that because we haven't seen in Wales very, very serious or fatal cases for some time, that we don't become complacent and we keep those levels of protection high," said Dr Johnson.

He added babies under six months old were at most risk.

"It can be very serious and lead to pneumonia and permanent brain damage. Young babies with whooping cough are at risk of dying from the disease."

He said vaccine protection passes on to the unborn baby and protected it until the first routine immunisation at two months old.

Seasonal viruses like flu have been stable so far this winter, although patients testing positive with flu or Covid in hospital have increased a little since the start of December.

Respiratory syncytial virus (RSV) saw a winter peak in November among children - with cases in the community at a high intensity levels and hospital admissions peaking too. But numbers have been declining back to low levels.

The latest sample test for various viruses taken by hundreds of patients attending hospital each week showed about 8% were positive for flu and 12% had Covid.

With measles, there were nine cases in Wales in 2023, and none in the previous two years - and an outbreak in Cardiff ended in November.

PHW said although cases were low it was important children were protected from it.

"It's very easy to think of them as just like any other childhood illness," said Dr Johnson. "They aren't. Steps have been taken globally to eliminate measles, because it is such a dangerous and highly infectious disease.

"All the vaccines we offer routinely to children especially - but also those we offer to adults such as Covid and flu, they're there because these illnesses are serious, and can result in really unpleasant hospitalisation and death, but they're preventable."

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Whooping cough cases in Wales show sharp increase - BBC.com

Scottish study finds zero cases of cervical cancer among women vaccinated against HPV at 12-13 yrs – ThePrint

January 24, 2024

While previous studies on the HPV vaccines effectiveness have shown positive results, this is the first trial to have a cohort that is 100 percent without cancer. Scientists part of the study also found that one or two doses confer(s) immunity against invasive cancer when administered at a young age, while older women would require three doses for full protection.

The study was conducted by Public Health Scotland, the national health agency, in collaboration with University of Strathclyde and University of Edinburgh and published in the journal JNCI: Journal of the National Cancer Institute.

The cancer of the cervix does not present initial symptoms until it progresses over a span of five to ten years, after which it results in symptoms such as vaginal bleeding and pelvic pain. It is diagnosed through regular cervical screening and Papanicolaou test (pap smear).

Cervical cancer can be treated just like any other cancer through radiation, chemotherapy, immunotherapy, and surgery with a nearly 50 percent five-year post-diagnosis survival rate. Like with all cancers, early detection offers longer survival.

The HPV vaccines available today are known to protect against HPV-16 and HPV-18, two of the nine types of known strains, that cause nearly all cases of cervical cancer.HPV vaccines are also thought to protect from vaginal and anal cancers, vulvar cancer, and HPV throat cancers. They also prevent warts. Some vaccines can also protect against HPV-6 and HPV-11.

Vaccination is recommended for girls aged 9 and above, and is ideally recommended before a person becomes sexually active. No link to serious adverse effects have been found to date. Since they were first recommended in 2006, HPV vaccines have been included in 125 countries vaccination programmes for young adolescents.

Apart from preventive vaccines, researches and biopharmaceutical companies are also working to produce a therapeutic vaccine for cervical cancer.

(Edited by Amrtansh Arora)

Also Read: India denies nod to 1st-ever weekly insulin for diabetics, seeks more info from maker Novo Nordisk

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Scottish study finds zero cases of cervical cancer among women vaccinated against HPV at 12-13 yrs - ThePrint

Florida has low rate of nursing home residents getting new COVID shot – Tampa Bay Times

January 24, 2024

Floridas nursing home residents are among the most vulnerable to COVID-19. But less than a third of them have gotten new vaccines tailored to better combat virus variants even as deaths and infections continue to rise.

The state has the fifth-lowest percentage of nursing home residents up to date with COVID-19 shots in the U.S., according to federal data from the week ending Jan. 14.

Thats disappointing, said Jason Salemi, a University of South Florida epidemiologist. It is a simple way to improve our protection against the disease.

Only Arizona, Texas, Arkansas and South Carolina have lower rates than the Sunshine State. Centers for Disease Control and Prevention scientists report an urgent need to improve vaccination levels in nursing homes across the country.

The health agency recommended updated versions of the Pfizer-BioNTech and Moderna vaccines on Sept. 12. Since then, Florida nursing homes have reported at least 46 COVID-19 deaths and more than 4,200 cases among residents, according to a Tampa Bay Times analysis of Centers for Disease Control and Prevention data.

Those numbers pale in comparison to earlier surges of the pandemic. Prior vaccinations and exposures to the pathogen have blunted COVID-19s impacts, said Morgan Katz, an infectious disease expert at Johns Hopkins University.

But Floridas latest vaccine figures are concerning, she said.

The virus has more opportunities to spread and cause severe illness when fewer people get inoculated, said Katz, who has studied COVID-19 in nursing homes.

Since federal health authorities recommended the latest shots, nursing homes in Hillsborough, Pinellas and Pasco counties have seen at least five COVID-19 deaths and over 700 cases among residents, according to the Times analysis.

During the week ending Jan. 7, roughly three-quarters of local facilities reported that most of their residents were behind on their vaccines.

One Clearwater nursing home, Gulfside Health and Rehabilitation Center, saw 14 cases among residents, the areas highest infection count that week, according to federal data.

The facility reported that none of its residents were up to date with COVID-19 inoculation. It didnt respond to a request for comment.

Kristen Knapp, spokesperson for the Florida Health Care Association, which represents 80% of nursing homes statewide, said her group provides facilities with educational resources stressing the importance of vaccination. The industry is working to ensure residents health and safety, Knapp said.

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The Florida Agency for Health Care Administration, which regulates long-term care centers, didnt respond to a request for comment.

Its challenging to contain virus transmission in nursing homes, with visitors entering facilities and older adults socializing and eating together, Katz said. Staff must also provide close-quarters care for prolonged periods of time.

Roughly 8% of Floridas nursing home staff were up to date with COVID-19 vaccines during the week ending Dec. 31, reflecting a national trend, according to federal data. The U.S. Centers for Medicare & Medicaid Services ended its vaccine mandate for nursing home workers last summer.

The low number of inoculations among residents and staff could be due to vaccine fatigue and a perception that COVID-19 is now a mild ailment, Katz said.

Gov. Ron DeSantis appointee to Floridas surgeon general, Joseph Ladapo, has urged providers to stop using the Pfizer-BioNTech and Moderna vaccines, citing a debunked theory about DNA contamination. Salemi, the University of South Florida expert, said the benefits of getting vaccinated typically far outweigh the risks for nursing home residents.

Whether Floridas low standing reflects (a nursing homes) lack of diligence in providing access or a trend of residents opting not to be vaccinated is something that the state should assess, wrote AARP Florida spokesperson Rick DelaHaya in an email.

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Florida has low rate of nursing home residents getting new COVID shot - Tampa Bay Times

Capricor Therapeutics Shares Rise 7% After Collaboration for Covid-19 Vaccine – Morningstar

January 24, 2024

By Chris Wack

Capricor Therapeutics shares were up 7% at $4.42 after the company said its proprietary StealthX exosome-based multivalent vaccine for the prevention of SARS-CoV-2 has been selected to be part of Project NextGen.

The stock hit its 52-week low of $2.68 on Nov. 10, and is down 3% in the past 12 months.

Project NextGen is an initiative by the U.S. Health and Human Services Department to advance a pipeline of new, innovative vaccines providing broader and more durable protection for Covid-19.

As part of Project NextGen, the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, will conduct a Phase 1 clinical study with Capricor's StealthX vaccine, subject to regulatory approval. NIAID's Division of Microbiology and Infectious Diseases would oversee the study.

The StealthX vaccine is a proprietary vaccine developed internally by Capricor using exosomes that were engineered to express either spike or nucleocapsid proteins on the surface. Preclinical results from murine and rabbit models showed the StealthX vaccine resulted in robust antibody production, potent neutralizing antibodies, a strong T-cell response and a favorable safety profile.

Write to Chris Wack at chris.wack@wsj.com

(END) Dow Jones Newswires

January 24, 2024 10:48 ET (15:48 GMT)

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Capricor Therapeutics Shares Rise 7% After Collaboration for Covid-19 Vaccine - Morningstar

Why feds had compelling interest to act on vaccine disinformation – American Medical Association

January 24, 2024

Vaccines save lives, prevent disease and reduce stress on the nations health care system. Because of this, the government has a compelling interest in combatting vaccine misinformation to prevent factually incorrect statements from costing lives.

That is the argument put forth in an amicus brief (PDF) filed with the U.S. Supreme Court in the case Murthy v. Missouri by the AMA, American Academy of Pediatrics, American Academy of Family Physicians, American College of Physicians and American Geriatrics Society.

The brief notes that these organizations represent hundreds of thousands of medical professionals who have witnessed both the lifesaving promise of vaccination in clinical settings and the ability of misinformation to destroy that promise.

Additionally, based on decades of research and professional experience, these organizations believe that vaccines are among the most important public health interventions, and that widespread vaccine uptake has substantial public health benefits that cannot be achieved by any other means.

Meanwhile, the attorneys general of Missouri and Louisiana filed suit after individuals contended social media companies were coerced into censoring them after they posted content criticizing COVID-19 policies and mask and vaccine mandates.

The Biden administration, however, contends that its communication with social media companies was an attempt to mitigate the hazards of online misinformation by highlighting content that violated the companies own policies, according to SCOTUS Blog.

Find out about the cases in which theAMA Litigation Center is providing assistanceand learn about theLitigation Centers case-selection criteria.

Focused argument

The brief focuses on how disinformation diminished uptake of COVID-19 vaccines, which then limited the vaccines ability to save lives by controlling the spread of diseasethereby creating a compelling interest for the government to act.

Combatting vaccine misinformation is, at its simplest, the government trying to prevent factually incorrect statements from costing people their lives, the brief says.

Its argument on this point notes that vaccines approved by the Food and Drug Administration (FDA) are safe and that vaccinations save lives, reduce the prevalence of deadly diseases and lower the burden on the health care system.

It also argues that misinformation about vaccines led to declining immunization uptake, which meaningfully interferes with their lifesaving role in a well-functioning public health system, and that combatting vaccine misinformation diverts time and resources from clinical care.

The brief cites studies that found COVID-19 vaccinations prevented an estimated 235,000 COVID-associated deaths in the U.S. among vaccinated adults between Dec. 1, 2020, and Sept. 30, 2021, and reduced mortality by as much as 40% among hospitalized patients.

It also notes that greater strain on medical resources leads to worse health outcomes, and argues that vaccinations indirectly produced better health outcomes for patients with ailments unrelated to COVID-19 because an increased strain on hospitals and health professionals was avoided.

Incredulous claims go viral

Vaccine safety is subject to FDA scrutiny, which only grants its approval after scientists conduct extensive clinical trials. After vaccines are approved, government agencies continue to monitor their safety, the brief says.

In contrast, disinformation claims that people became magnetized after vaccination or that vaccinated individuals were implanted with a tracking microchip or became infertile were widely circulated without any proof of their validity.

None of these assertions are supported by credible evidence, the brief says, adding that some of these very claims were the subject of communications at issue in this case.

The declining vaccination uptake spurred by disinformation has also resulted in a resurgence of diseasessuch as measlesthat previously verged on eradication, the brief says.

A July 2023 district court ruling to limit administration communication with social media companies was upheld in part by the 5th U.S. Circuit Court of Appeals. In October, the Supreme Court froze the original district court order as modified by the appellate court until it could rule on the case itself, which could happen in June, according to SCOTUS Blog.

In another vaccine-related case, theLitigation Center of the American Medical Association and State Medical Societiesfiled an amicus brief with the 9th U.S. Circuit Court of Appeals urging it to uphold a permanent injunction preventing Montana officials from enforcing a 2021 law barring physicians from knowing the vaccination status of employees or patients who refuse to answer questions about it.

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Why feds had compelling interest to act on vaccine disinformation - American Medical Association

COVID-19 vaccine dosing impact on maternal and infant antibodies – Contemporary Obgyn

January 24, 2024

COVID-19 vaccine dosing impact on maternal and infant antibodies | Image Credit: Ralf - Ralf - stock.adobe.com.

Cord anti-Spike (anti-S) antibody levels are increased 10-fold in patients with 3 or more COVID-19 vaccination doses compared to patients with 2 doses, according to a recent study published in JAMA Network Open.

COVID-19 infection during pregnancy increases the risks of hospitalizations, intensive care unit admission, and mortality. To reduce infection in this population, vaccination is vital.Data has indicated COVID-19 vaccination during pregnancy reduces the risks of maternal morbidity, hospital admission, critical care admission, stillbirth, and neonatal demise.

The COVID-19 vaccine provides anti-S antibodies that are able to cross the placenta through active transplacental antibody transfer, similarly to vaccines against conditions such as influenza. However, there is little data on maternally derived antibodies in infants born preterm.

To determine how the timing of COVID-19 vaccine administration impacts immunity in preterm and full-term infants, investigators conducted an ongoing prospective cohort study. Participants were recruited between February 1, 2021, and January 31, 2023.

Participants included individuals with receipts of at least 2 doses of messenger RNA (mRNA)based COVID-19 vaccines, singleton pregnancy, no previous COVID-19 infection, paired maternal and cord samples, nondetectable antinucleocapsid antibody, no fetal genetic anomaly, and appropriate infant birth weight, Exclusion criteria included 1 dose or less of the COVID-19 vaccine and receiving a non-mRNA-based vaccine.

Data was available for maternal and cord anti-S IgG, number of vaccine doses, timing of doses, gestational age at delivery, and covariates. Electronical medical records were evaluated for clinical data.

Data on race, gender, ethnicity, insurance status, and body mass index (BMI) were also obtained.Preeclampsia and chronic hypertension diagnoses were defined by American College of Obstetricians and Gynecologists criteria and hypertension diagnosis at under 20 weeks gestation, respectively.

Elecsys Anti-SARS-CoV-2 immunoassays (Roche Diagnostics) were used to test paired maternal and infant cord samples. This immunoassay has 99.5% sensitivity and 99.8% specificity.

There were 220 participants included in the final analysis, aged a median 34 years and with a median gravidity of 2 and parity of 0. Of participants, 81.8% were White, 2.3% Black, 11.9% Asian, 0.5% Alaska Native, 6.4% Hispanic, and 92.3% non-Hispanic. Private insurance was reported in 93.2% of participants.

Of deliveries, 36 were preterm and 184 full-term.Median BMI was significantly increased in patients with preterm delivery, as well as rates of pregestational diabetes, preeclampsia, and chronic hypertension. Preterm infants were delivered at a median 35.1 weeks and full-term infants a median 39.5 weeks.

The odds of cesarean delivery and neonatal intensive care unit admission among preterm births were 66.7% and 63.9%, respectively, and the median birth weight was 2437 g. Among full-term infants, these rates were 34.8%, 5.4%, and 3453 g.

Receival of 2 COVID-19 vaccine doses before delivery was reported in 55% of participants and 3 or more in 45%. Of preterm deliveries, 69.4% of patients received 3 or more doses and 30.6% 2 doses. Among full-term deliveries, these rates were 40.2% and 59.8%, respectively.

The unadjusted geometric mean concentration (GMC) for maternal anti-S antibodies was 674 after 2 doses and 8159 after 3 or more doses. For cord anti-S antibodies, these numbers were 1000 and 9992, respectively.

Decreased cord to maternal antibody ratios were observed among preterm births compared to full-term births, at 1.18 and 1.40, respectively. However, a significant difference was not observed based on preterm vs full-term birth status in adjusted models.

These results indicated 2 or less doses of COVID-19 vaccination may not provide adequate protection for infants. Investigators recommended further research to determineoptimal COVID-19 vaccine dosing for maternal and infant protection.

Reference

Kachikis A, Pike M, Eckert LO, et al. Timing of maternal COVID-19 vaccine and antibody concentrations in infants born preterm. JAMA Netw Open. 2024;7(1):e2352387. doi:10.1001/jamanetworkopen.2023.52387

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COVID-19 vaccine dosing impact on maternal and infant antibodies - Contemporary Obgyn

Flu and COVID vaccines there’s still time! | The Standard Newspaper – Waukon Standard

January 24, 2024

Theres still time to receive the flu and COVID vaccines. A flu vaccine is the best way to help protect yourself and your loved ones against flu and its potentially serious outcomes. A flu shot can safely help prevent the flu and lessen flu symptoms if you do get sick. A flu shot also can help protect your baby from flu for several months after birth.

Every year flu puts thousands of children in the hospital. Getting your child a flu vaccine can lessen flus more serious symptoms - reducing the risk of serious illness and flu-related hospitalization if they do get sick.

The flu and COVID vaccines continue to be offered each Wednesday afternoon at Veterans Memorial Hospital Community and Home Care/Allamakee Public Health. Flu shots are recommended for all those who have not yet received the vaccine, and they will be effective throughout the rest of the flu season.

According to the Iowa Department of Health and Human Services, flu vaccines are proven to help prevent millions of illnesses and have been shown to reduce the risk of having to go to the doctor by 40-60%. COVID-19 vaccines help protect by creating an antibody response without having to experience potentially severe illness or post-COVID conditions. Although it is still possible to get sick after being vaccinated, flu and COVID immunizations are proven to help prevent severe illness, which can be lifesaving.

Allamakee Public Health offers Comirnaty (Pfizer) COVID vaccine. Anyone can receive Pfizer vaccine, even if Moderna vaccine was given in the past. According to the CDC, it is safe and effective to receive multiple immunizations, such as the flu and COVID-19 vaccines, during the same vaccination appointment. Medicare, Medicaid and most insurances do cover the cost of the flu and COVID vaccine.

The CDC now recommends that everyone age six months of age and older get vaccinated against the flu every year. For those who are at higher risk of developing serious flu complications, flu vaccination is especially important. These groups include: Adults 65 and older Adults with certain chronic health conditions, such as asthma, heart disease, diabetes, and chronic kidney disease Pregnant people Children younger than five years of age, but especially those younger than two years old.

For more information or to make an appointment for a vaccination, call the Veterans Memorial Hospital Community and Home Care Department at 563-568-5660. The Veterans Memorial Hospital Community and Home Care Department is located on the upper level of Veterans Memorial Hospital in Waukon.

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Flu and COVID vaccines there's still time! | The Standard Newspaper - Waukon Standard

New long COVID study results, a possible Paxlovid alternative, and RSV vaccine updates for babies – American Medical Association

January 24, 2024

AMA Update covers a range of health care topics affecting the lives of physicians, residents, medical students and patients. From private practice and health system leaders to scientists and public health officials, hear from the experts inmedicineon COVID-19, medical education, advocacy issues, burnout, vaccines and more.

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A check-in on COVID, flu and RSV cases, and an overview of new COVID and Long COVID studies. AMA's Vice President of Science, Medicine and Public Health, Andrea Garcia, JD, MPH, reports that the tripledemic wave is declining, but vaccination levels for COVID, flu and RSV among adults are still low. Plus, continued supply issues for the RSV vaccine for children, administration errors for the RSV vaccine, and two new studies that could inform future treatments for COVID and Long COVID. AMA Chief Experience Officer Todd Unger hosts.

Unger: Hello and welcome to the AMA Update video and podcast. Today, we have our weekly look at the headlines with the AMA's Vice President of Science, Medicine and Public Health, Andrea Garcia. I'm Todd Unger, AMA's chief experience officer. Andrea, welcome back.

Garcia: Thanks, Todd. It's great to be here.

Unger: Well, let's begin by checking in on the tripledemicthe mix of COVID, RSV and the flu. That has been swirling around. Andrea, are things looking any better this week?

Garcia: So far, yes. I mean, overall, respiratory virus season does seem to be easing up just a bit. We've now seen some of those numbers decrease for a second week in a row. If we look at the CDC data, that week ending January 13 showed 24 states and DC experienced high or very high levels of patients seeking care for respiratory illness symptoms. That's down from 37 states and territories the week ending January 6.

In line with those numbers, respiratory viruses seem to be putting less of a strain on our hospitals. COVID, flu and RSV accounted for a combined 6.3% of total emergency room visits in mid-January. That's down from about 7.9% the week prior and 9.9% that last full week of December.

The percentage positive test nationwide for COVID and RSV also decreased about one percentage point if we look at that week ending January 13, and positive tests for flu remained stable. So at least for right now, things generally seem to be turning a corner and trending in the right direction.

Unger: Well, that's good news. Is there anything that we need to keep an eye on?

Garcia: Well, wastewater data for COVID did find viral activity is still very high, with the South reporting an increase in recent weeks. And if we look at ER and outpatient visits, seven states in particular experienced very high levels of respiratory illness in that week ending January 13. Those are Alabama, Georgia, Louisiana, New Mexico, South Carolina, Tennessee and Wyoming.

So we'll need to keep an eye on those areas. And I think I would also just point out that with flu in particular, it's not unheard of for us to have two peaks in a season. So while numbers are heading down, we couldwe could see them go back up again.

Unger: Well then that's a good entree into this next question. Because we've talked about vaccination rates before. Are we still struggling with vaccination numbers?

Garcia: We are. And the CDC updated data last Friday, and vaccination rates for all three illnesses remain low in both children and adults. So for COVID, we're only seeing about 11% of children, 21.5% of adults between 18 and 65, and about 40.9% of adults over 65 receiving that updated vaccine. The numbers are slightly better for flu.

So around 47% of adults and children have received it, 73% of those over age 65. For both COVID and flu, seniors do have the highest uptake of the vaccine. And then, the vaccination rate for RSV, which is recommended under that shared clinical decision-making framework for adults 60 years and up, is hovering at around 21%.

Unger: Andrea, but RSV immunizations for children are another story. Tell us more about that.

Garcia: Yeah, we're still seeing shortages of the RSV immunization for infants. And demand there continues to outpace supply. As a reminder, we're talking about nirsevimab, which is that monoclonal antibody authorized in August for newborns and babies under one who are born during or entering their first RSV season, and then those children up to 24 months who remain at risk of severe RSV disease.

While the manufacturer does continue to make more of those immunizations available, there's currently enough to immunize about 40% of babies who are eligible for the drug. We do know that earlier this month, White House officials met with reps from the manufacturer to discuss ways to meet that patient demand this year as well as next RSV season.

Unger: That's a challenge. What are we hearing from physicians on this front?

Garcia: Well, many pediatricians offices that were lucky enough to receive the antibody, ran out of that drug in December. I think, aside from the shortage, the other complicating factor is that the drug is distributed in both the 50-milligram and 100-milligram doses, with the smaller ones set aside for infants weighing less than 11 pounds. It can be a bit of a guessing game, as you can imagine, for physicians to predict how much of each shot they need to order, because it's hard to know in advance how many babies they're going to see who weigh less than 11 pounds versus those who may require that larger dose.

Many of these immunizations are also being distributed directly through hospitals for newborns rather than through those individual pediatric practices. A smaller rollout is anticipated for next year, but we know RSV is still circulating. So we do still have a ways to go yet this season.

Unger: Well, we're also seeing a few complications in administering the RSV vaccine. Andrea, what's the story there?

Garcia: Well, Todd, vaccine administration errors are generally pretty rare, but they are routinely monitored through the Vaccine Adverse Event Reporting System, or VAERS. Since approval of the RSV vaccine, CDC and FDA have received some reports of the Pfizer and GSK RSV vaccines, which are approved for adults, being administered to young children. The agencies have also received reports of the GSK RSV vaccine being administered in error to pregnant people. That Pfizer RSV vaccine is the only vaccine approved for use during pregnancy. Thankfully, most of the reports had no adverse events, or if they did, they were classified as non-serious.

Unger: That's good. Andrea, all of these vaccines are new. Is that where confusion of this kind is coming from? And what do physicians do if their patients have been given the wrong vaccine?

Garcia: Well, these recommendations do vary. For infants and children, it's recommended they receive a dose of nirsevimab to ensure they're protected. The other option available to protect babies is that maternal vaccine. So the Pfizer RSV vaccine is recommended for use during pregnancy, for people who are at the 32 to 36 weeks of pregnancy during the months of September through January.

It's unclear why these errors happened, but as you said, these are new vaccines this year. It is recommended that facilities do take steps that can help reduce errors like automating prevention alerts in the EHR, ensuring proper education, and training on vaccine recommendations, and paying close attention to labeling following proper storage and administration best practices. If mistakes do occur, it should be reported to us as soon as possible. And if there are questions about vaccine administration errors, physicians can email [emailprotected].

Unger: Excellent. And you can see that on the screen there, [emailprotected]. Andrea, RSV isn't the only virus with breakthroughs. Researchers also continue to study COVID. And we heard about a promising new treatment just last week. Tell us more about it.

Garcia: Yeah, last Thursday, in the New England Journal of Medicine, Chinese researchers published positive trial results of simnotrelvir, which is an oral antiviral that can shorten the duration of mild to moderate COVID symptoms. According to the Center for Infectious Disease Research and Policy, unlike with Paxlovid or other antivirals, that were tested against COVID, this trial was conducted mostly on healthy young adults, none of whom had severe symptoms.

The formulation used in the study included ritonavir, which acted as a booster to the antiviral. And among patients who began that treatment within 72 hours of symptom onset, the length of COVID symptoms was, on average, 36 hours shorter in that treatment group than in the control group. The viral loads were also significantly lower among the treatment group by day five, dropping 30-fold more than the load seen in that control group. So this is good news, something we'll definitely be continuing to follow.

Unger: Absolutely. That sounds very promising. There's also been a new development with long COVID, Andrea. What can you tell us about that?

Garcia: Yeah, so scientists have identified a persistent change in a handful of blood proteins in people with long COVID, which indicates that an important part of the immune system remains on high alert for months after an acute infection. These findings were published last Thursday in the journal Science, and they could help explain what causes that persistent fatigue, brain fog and other debilitating symptoms of long COVID. Experts think this could help pave that way for diagnostic tests and, potentially, a long-waited treatment.

That study followed 113 COVID patients for up to a year after they were first infected along with 39 healthy controls. At the six-month mark, 40 patients had long COVID symptoms. So repeated blood samples in those patients turned up important differences in their blood. A group of proteins indicated that a part of the body's immune system, called the complement system, remained activated long after it should have returned to normal.

Unger: So what is the significance of that particular finding, Andrea?

Garcia: Well, one of the study's investigators explained to NBC News that when you have a viral or bacterial infection, the complement system becomes activated, and it binds to these viruses and bacteria, and then eliminates them. The system then returns to its resting state, where its regular job is to clear the body of dead cells. But if the complement system remains in its microbe-fighting state after the viruses and bacteria are eliminated, it starts damaging healthy cells. And the result is tissue damage and microclots in the blood, which can lead to those symptoms of long COVID. Understanding these mechanisms could help scientists confirm diagnosis and develop effective treatments. The next step here is likely more and larger trials.

Unger: That really sounds like some exciting developments for something that's been debilitating for so many people out there. And we've heard from you and seen your comments on the videos out there on YouTube. And so, we'll continue to track that.

Andrea, as usual, thanks so much for keeping us up to date. That wraps up today's episode. If you enjoyed this discussion, you can support more programming like it by becoming an AMA member at ama-assn.org/join.

We'll be back soon with another AMA Update in the meantime. You can find all our videos and podcasts at ama-assn.org/podcasts. Thanks for joining us today. Please take care.

Disclaimer: The viewpoints expressed in this video are those of the participants and/or do not necessarily reflect the views and policies of the AMA.

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Read the original here:

New long COVID study results, a possible Paxlovid alternative, and RSV vaccine updates for babies - American Medical Association

Elanco Animal Health shares how to choose the right vaccine for your herd – RFD-TV

January 24, 2024

Animal vaccines are not a one-size-fits-all, and experts at Elanco Animal Health want to help producers understand what factors to consider when developing a program.

Well, those would really include looking at disease history in the herd. How do you manage these animals, the type of housing, and certainly working with your local herd health veterinarian is going to really facilitate that and get a good plan put together. The type of production system you have. If youre calving, all year round, that would affect some things that you would do versus if you are calving in a specific season, like a 60-day calving season. Those are some things that we consider when were looking at what type of vaccine program were going to put together, said Bret Terhaar.

Terhaar says programs should be tailored to the specific herd, and it is important to store vaccines properly by keeping them cool and out of the sunlight.

January 24, 2024 01:10 PM

January 24, 2024 12:58 PM

January 24, 2024 12:49 PM

Original post:

Elanco Animal Health shares how to choose the right vaccine for your herd - RFD-TV

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