Category: Monkey Pox Vaccine

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The Daily Explains: Navigating COVID-19, monkeypox and the flu this season – Daily Northwestern

October 5, 2022

Wintertime may look bleak in Chicago, but your health and wellness dont have to be. The public health landscape can often seem daunting, but The Daily is here to break down the three prevalent viruses to watch out for this season.

How an outbreak becomes an epidemic

Outbreaks can lead to epidemics or pandemics if case numbers rise quickly within a short period of time. These pandemics differ from seasonal variations in that people have little to no immunity given the novelty of the viruses.

On the other hand, the seasonal flu leads to an expected rise in cases that peaks between December and February. Scientists develop a new influenza vaccine yearly to target virus mutations and waning immunity over time, though previous infection and vaccination offer some immunity.

Though coronaviruses have also been around for a while, the COVID-19 pandemic originated from the SARS-CoV-2 strain. With mutations affecting the infectivity and severity of the disease, vaccine modifications have followed. Similarly to the seasonal flu, infections and booster doses strengthen immunity against COVID-19.

How each virus spreads

The key difference between the recent monkeypox outbreak, the seasonal flu and the COVID-19 pandemic is the rate at which transmission occurs.

Monkeypox primarily spreads through close, skin-to-skin contact, which can include direct contact to monkeypox rash or fluids from an infected person. The virus is therefore not as easily transmissible as COVID-19 and the flu, which primarily spread through respiratory droplets. Though the majority of monkeypox cases have been reported among men who have sex with other men, anyone who has close contact with an infected person can contract the virus.

COVID-19 and the flu spread in similar ways, but the smaller particle sizes of SARS-CoV-2 allow these respiratory droplets to stay in the air longer, increasing the rate of infection. This difference has made COVID-19 spread more rapidly than the flu.

COVID-19 also has a longer incubation period than the flu: someone who contracts the flu will typically experience symptoms within one to two days of exposure, while an individual with COVID-19 may not experience symptoms until within two days to two weeks. With this delay between symptom onset and viral exposure, people are more likely to spread SARS-CoV-2 before they quarantine or isolate.

Monkeypox has an even wider incubation period, ranging from five to 21 days.

Symptoms to watch out for

COVID-19 and the seasonal flu have many overlapping symptoms, including fever, fatigue, headache and nausea. However, unlike the flu, COVID-19 may also present with loss of taste or smell as well as shortness of breath.

Though monkeypox symptoms also include fever, headache and exhaustion, the more distinctive symptoms include rash and swollen lymph nodes. Symptoms typically persist for two to four weeks.

Prevention and possible treatment

Vaccines are currently available for all three viruses to increase immunity in case of exposure.

For COVID-19, vaccination eligibility differs by age. The Centers for Disease Control and Prevention recommend first receiving a two- or three-dose primary vaccination series of Pfizer, Moderna or Novavax, or the one-dose Johnson & Johnson vaccine.

Those 12 years or older should then receive a bivalent booster dose authorized Sept. 1 at least two months after their last COVID-19 vaccination. This updated dose provides protection against the original COVID-19 virus as well as the more infectious omicron BA.4 and BA.5 variants that comprise the majority of current infections.

Individuals between the ages of five and 11 are not yet eligible for the bivalent booster dose and should instead get the original monovalent booster dose at least five months after their last COVID-19 vaccination if they received the Pfizer primary-series vaccination.

The CDC has approved two vaccines for monkeypox, though vaccination is only recommended for those exposed to monkeypox or at high risk of exposure. Eligible individuals can either receive the two-dose Jynneos vaccination series or the single-dose ACAM2000 vaccine. Northwestern Medicine Student Health Service provides a list of local monkeypox vaccine providers on its website.

In terms of influenza vaccination, the CDC recommends individuals obtain the single-dose flu vaccine by the end of October. NU students can make a flu vaccine appointment at the Evanston campus, and all individuals can seek vaccination at nearby pharmacies like CVS and Walgreens.

In terms of treatment, a health care professional can prescribe antiviral medications for the influenza virus. For COVID-19 and monkeypox, professionals can prescribe antiviral medications to eligible, high-risk populations.

University policies and guidelines

NU currently does not have vaccination requirements for the flu or monkeypox but encourages vaccination against these viruses for eligible individuals. All community members are required to have at least primary-series vaccination unless granted an exemption.

Individuals who suspect they have monkeypox should contact the health service for assessment and treatment. Students who test positive are required to self-isolate until fully healed in order to prevent transmission of the virus including using separate bathrooms, towels, clothing and linens from others. If living on campus, individuals must seek temporary off-campus housing for the duration of the isolation period, though the University has a limited number of isolation spaces available.

If students test positive for COVID-19, they will also be required to isolate for a minimum of five days. Students living on campus must complete their isolation period at 1835 Hinman Ave. NU recently updated its isolation housing policies for Fall Quarter.

While the University doesnt have isolation requirements for the flu, the CDC recommends isolation protocols similar to those outlined for COVID-19. Infected individuals should self-isolate until at least 24 hours after the absence of fever without fever-reducing medications.

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The Daily Explains: Navigating COVID-19, monkeypox and the flu this season - Daily Northwestern

Monkeypox studies suggest ways to reduce viral spread – University of Toronto

October 5, 2022

Less than three months since it launched, themonkeypox rapid research responseled by the University of TorontosEmerging and Pandemic Infections Consortium(EPIC) and three partner hospitals is generating results that could help curb transmission of the virus.

When monkeypox first arrived in Canada, we quickly learned about the stockpile of smallpox vaccine [which also protects against monkeypox], saidJesse Knight, a PhD student in U of TsInstitute of Medical Science in the Temerty Faculty of Medicine. Given that the vaccine supply was quite limited early on, it was important to use it quickly and efficiently to help reduce cases.

Knight is the first author on a new modellingstudythat looks at how to optimize the initial rollout of vaccine to prevent the most infections. The study,which hasnot yet been peer-reviewed,suggests that the greatest number of infections could be prevented by prioritizing vaccines to bigger cities with larger networks of communities at risk, the highest epidemic potential and largest number of initial cases.

Knight notes these results do not mean that areas outside of big cities should not receive vaccines, but rather they provide guidance on how to maximize immediate impact early in an epidemic of an extremely limited supply until more doses become available. Indeed, while Ontarios vaccination efforts initially centred on Toronto, they soon expanded to areas outside the city.

Darrell Tan and Sharmistha Mishra

The preliminaryfindings were co-authored by Knights academic supervisorSharmistha Mishraand collaboratorDarrell Tan, both clinician-researchers atSt. Michaels Hospital, Unity Health Toronto, and associate professors in U of Ts Temerty Faculty of Medicine.

Mishra and Tan are also co-leads of EPICs monkeypox rapid research response. EPIC is one of several U of T institutional strategic initiatives.

For their study, the researchers built a mathematical model that simulated the potential transmission of monkeypox virus in the context of sexual networks of gay, bisexual, and other men who have sex with men. The model reflects two interconnected sexual networks that can be thought of as communities within two cities one larger network like in Toronto and a smaller network in a medium-sized Ontario city and simulated the roll-out of 5,000 vaccine doses starting two months after the first case of monkeypox.

The team tested scenarios in which they changed the relative population size in each network (i.e., city), the interconnectedness between the two sexual networks (sex among individuals between cities), epidemic potential of the virus in each cityand the distribution of initial imported cases across cities.

A citys epidemic potential reflects how likely a person carrying the virus is to pass it on to othersby taking into account the density and configuration of the sexual network, access to prevention and careand the underlying social and structural contexts that shape sexual networks and shape access.

Early insights from these analyses helped inform vaccine prioritization by health units across Ontario, which to date has centred on community-based organizations, service providers, health unitsand public health teams at every level working together to mobilize access and deliver vaccines to gay, bisexual and other men who have sex with men who may be most at risk of infection, said Mishra.

From the start, Mishra said, community leadership has been at the forefront of the response, including the science with modeling questions, inputs, interpretationand application shaped by communities and the public health actors working to serve communities.

Knight hopes that this work will also have an impact on how vaccines are deployed globally.

Given our increasingly connected world, our findings really highlight the importance of global vaccine equity in responding to outbreaks, and also in preventing them in the first place," he said.

Vaccines can help break chains of transmission when deployed strategically, but another opportunity to stop transmission is in the environment where people infected with the virus may shed it onto surfaces and objects.

We knew very little about fomite [surface] transmission of monkeypox prior to this outbreak, saidChristopher Kandel, an infectious disease physician atMichael Garron Hospital, Toronto East Health Network, and assistant professor in the Temerty Faculty of Medicinesdepartment of medicine.

To study the risk of environmental transmission of monkeypox, Kandel andSharon Sukhdeo, aninfectious diseasesresident at U of T, teamed up with EPIC faculty membersAllison McGeer, who is atMount Sinai Hospital and is a professor in the Temerty Faculty of Medicine and at the Institute of Health Policy, Management and Evaluation (IHPME) in the Dalla Lana School of Public Health,Adrienne Chan, who is atSunnybrook Health Sciences Centre and is an associate professor in the Temerty Faculty of Medicine and the Dalla Lana School of Public Health,andMatthew Muller, who is atSt. Michaels Hospital and is an associate professor in the Temerty Faculty of Medicine and at IHPME.

For the first part of their study, the team swabbed a mixture of high- and low-touch surfaces in hospital exam rooms where patients with monkeypox had received care. They tested the same surfaces again after the rooms had been cleaned.

Their preliminary results showed detectable levels of monkeypox DNA on many high-touch and a few low-touch surfaces. Encouragingly, the researchers could not detect the virus on the majority of surfaces after cleaning. Where they did detect the virus after cleaning, levels were significantly reduced.

Kandel notes that while they were able to detect monkeypox DNA, their methods cant determine whether the detected virus was infectious.

As a next step, the researchers will expand their study to look at environmental transmission within households. They will ask people who are self-isolating with monkeypox to swab objects and surfaces in their home at different timepoints, which will provide insight into how long an infected person sheds the virus and whether common at-home cleaning products can effectively disinfect contaminated surfaces.

There are so many questions that need to be answered, said Kandel. With these studies, well have a much better understanding of monkeypox transmission, including how infectious people are and how long isolation should last to best protect others.

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Monkeypox studies suggest ways to reduce viral spread - University of Toronto

Should we be concerned about monkeypox at ACL? – KUT

October 5, 2022

Austin City Limits Music Festival kicks off this weekend, and people are excited to dance, drink and watch their favorite artists perform. But with many attendees traveling from out of town and possible skin-to-skin contact in the crowds, some might be wondering if the festival will worsen the spread of monkeypox.

As of Sept. 30, Travis County has had 186 confirmed cases. Texas has reported the fourth highest number of monkeypox cases in the U.S. since the outbreak began earlier this year. Nationally, though, cases have been on the decline since late August.

Dr. Michael Stefanowiczs, associate director of sexual health programs at CommUnityCare Health Centers and a UT Dell Medical School assistant professor, said health care professionals havent seen any outbreaks of monkeypox associated with large public gatherings, but he can understand why people may feel anxious.

Large gatherings, or superspreader events, worsened and prolonged the COVID-19 pandemic. However, Stefanowiczs said, in the U.S., monkeypox is mostly spreading through sexual contact.

For ACL and other large-scale events, it is not no-risk, but it is categorically low-risk, Stefanowiczs said.

Stefanowiczs said ACL attendees are more likely to contract COVID-19 at this years festival than monkeypox. And the good news is more than 82% of people in Travis County have received at least one coronavirus vaccine.

We have the tools that we need to mitigate and reduce risk, and those tools include knowledge, he said.

Monkeypox is spread through close contact with an infected person, or by touching clothing or linens that were in contact with the infected persons rash or body fluids, according to Austin Public Health. Symptoms include high fever, swollen lymph nodes, muscle aches, headaches, chills and a pimple or blister-like rash.

APH recommends limiting skin-to-skin contact with strangers and avoiding direct contact with monkeypox rashes and scabs and body fluids from a person with monkeypox.

Stefanowiczs urges people to be proactive if they experience any symptoms and to isolate at home as soon as possible to reduce the risk of transmitting the virus.

The sooner you isolate, the lower the risk of exposing others, he said. And thats true whether your symptoms are concerning monkeypox, COVID-19 or the flu.

Stefanowiczs said these are all vaccine-preventable illnesses and encourages all those who are eligible to get their COVID-19 vaccines and boosters as well as the monkeypox JYNNEOS vaccine.

COVID-19 vaccines and boosters are available at local doctor's offices, pharmacies and clinics. You can find a vaccine provider near you at Vaccines.gov.

Monkeypox vaccines are available to those who are at high risk of developing infection. You can check your eligibility for a vaccine and schedule an appointment here.

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Should we be concerned about monkeypox at ACL? - KUT

Monkeypox vaccine side effects: What’s that lump and should you worry?

October 1, 2022

Dr. Fauci explains why people are not protected from monkeypox

Dr. Anthony Fauci, the director of the National Institute of Allergy and Infectious Diseases, talked to USA TODAY about protection against monkeypox.

Ariana Triggs and Becky Kellogg, USA TODAY

If you've gotten vaccinated for monkeypox, you may befamiliar with "the lump."

Ever since the viral outbreak reached the U.S. this summer, many people have taken to social media to report side effects of the Jynneos vaccine, which can be injected intradermally (into the skin) or throughthe more traditional subcutaneous method (below the skin).

One common complaintis a red bumpat the injection sitelasting for two to three weeks, if notlonger. But experts reassure that it's nota "weird" or "permanent" reaction.

A temporary lump on your armis normal forany vaccination,but "it is particularly expected with the Jynneos vaccine," says Anthony Fortenberry, chief nursing officer at Callen-Lorde Community Health Center. "This is a super common side effect."

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Induration, or an area of hardness at the injection site, is part of the body's immune response to vaccines.

"The body recognizes the viral material as foreign and sends immune cells to react against it,"says Dr. AdityaChandorkar, an assistant professor in the division of infectious diseases and international medicine at the University of Minnesota. "One of the consequences of this reaction (is) some degree of local reaction, leading to a lump/swelling.

"Its important to note that the presence or absence of the swelling is not a marker for how well the person is going to be protected by the vaccine."

Some people have reported tenderness, itching, pain or bruising on or around the lump. "That generally does resolve on its own," Fortenberry says. "You do want to avoid scratching it because that can cause further inflammation, delay healingand also cause infection, so you want to be cautious. And if it's causing pain, the recommendations are over-the-counter Tylenol or Motrin" to help with inflammation.

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"Having a large, painless lump at the site of the injection is fairly common," Chandorkar says. "The original (Jynneos) vaccine studies reported some degree of local swelling in over half of the people who received the vaccine." Anecdotally, "most people have reported the lump going away after a week to two weeks. In almost all cases, the lump should go away by itself, and people should not need to see their physician."

If the bump is still present after more than two weeks, that's no cause for alarm. In fact, it's "really common," Fortenberry says, and should not deter people from receiving their second Jynennos dose four weeks after the first.

"So many people are having inflammation at the site for many weeks," Fortenberrysays. "For inflammation to occur for up to four weeks is such an expected side effect that clinical guidance (at vaccination sites) addresses that, by asking nurses to administer the shoton the other arm."

"Other side effects include muscle pain, headache, fatigue and nausea," Chandorkar says. "Although fevers and chills are reported, they are not the norm. They are only seen in 1% to 10% of patients."

The Jynneos vaccine produces side effects that"are comparable to most other vaccines," he adds. "(Reactionsare) generally far milder than what some experienced with the COVID-19 vaccines."

You should speak to a medical professional ifyou experiencefevers or chills for more than one to two days after getting the Jynneos vaccine,says Dr. Peter Hotez, co-director of the Center for Vaccine Development at Texas Childrens Hospital and dean of the National School of Tropical Medicine at Baylor College of Medicine.

As for the lump, "if the pain becomes problematic, or if you see the redness worsen or spreading, including streaks of redness, you should contact your doctor," Hotez says.

Fortenberry stresses that severe adverse reactions to the Jynneos vaccine are "extremely rare," but you should call 911 immediately if you experiencedifficulty breathing, hives, swelling of the face or throat, a fast heartbeat, dizziness, or weakness after getting vaccinated.

Although side effects such asthe lump might seem like a nuisance, they're much better than the alternative of getting monkeypox, which is an extremely painful infection with symptomsthat can lasttwo to fourweeks andrequiresquarantine.

"The best way to ensure you won't become infected is to get vaccinated," Hotez says. "Monkeypox, although rarely fatal, is a serious and debilitating infectious disease, and could require hospitalization."

And if you have any fears of potential side effects, don't hesitate to discuss them with medical personnel at your vaccination site.

"They have all the information necessary to provide reassurance and make sure everyone has very clear expectations around the vaccine," Fortenberry says. "We encourage everyone to complete their vaccine series if they're eligible for a second dose. Don't let side effects prohibit you from going back for your second dose and getting full immunity.It's super important to err on the side of reaching out to a medical provider if you have questions or concerns that's what we're here for.

"You don't have to manage this on your own with the internet."

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Monkeypox vaccine side effects: What's that lump and should you worry?

8 monkeypox vaccine questions and where to get it – Nebraska Medicine

October 1, 2022

As of Sept. 15, there are 24 monkeypox cases in Douglas County.

Infectious diseases nurse practitioner Nikki Regan, MSN, APRN, NP-C, is leading monkeypox vaccine education and outreach in Nebraska Medicine clinics.

Get answers to the most common questions about the monkeypox vaccine. You can also protect yourself from monkeypox in other ways.

Yes. The JYNNEOS vaccine is approved for prevention of both monkeypox and smallpox. "Smallpox and monkeypox are in the same family of viruses," explains Regan. This vaccine has shown effectiveness in previous outbreaks of smallpox and monkeypox.

"We simply don't have enough to vaccinate the entire population," says Regan. "There's a lot of demand for it, so we're reserving vaccines for people at highest risk."

Monkeypox vaccines are available for the prevention of monkeypox both before and immediately after an exposure:

Post-exposure: You can get the vaccine up to 14 days after close contact with someone with monkeypox. Get the vaccine as soon as possible after exposure to get the best chance of preventing monkeypox or having a less severe illness. "Getting vaccinated within a couple days of exposure reduces the risk of developing monkeypox," says Regan.

Pre-exposure: Pre-exposure prophylaxis or PrEP vaccinations are the majority of vaccinations right now. "Every health department has its own prioritization criteria. Here in the Omaha area, we are prioritizing people at high risk of monkeypox exposure including men or transgender people who have sex with men, especially if they have multiple partners or recent sexually transmitted infections," says Regan. "Check with your local health district to see how it's being distributed in your area."

How to get the monkeypox vaccine: Take the Douglas County Health Department survey. If you are eligible, they will reach out to you about where to get your vaccine. If you live outside of Douglas County, check with your provider or local health department.

The JYNNEOS vaccine is a two-dose series, given 28 days apart.

"The vaccine has a virus that's been weakened so it can't replicate in your body," says Regan. "The weakened virus can't make the person sick, and it can't spread to other people either. The weakened virus is there for the immune system to see it and build some protection against it. Then, if the person is exposed to the real monkeypox virus later, the immune system remembers it and prevents the infection."

That red, raised bump on your arm after receiving the vaccination is perfectly normal. It's not permanent and should go away after several weeks.

The shallow injection of the vaccine causes a wheal, which looks like a small bubble and gradually fades. Providers are giving the monkeypox vaccine intradermally (between the skin) rather than subcutaneously (into fatty tissues) to increase supply. Intradermal injection has increased the vaccine supply fivefold.

"We place a small amount of vaccine right under the top layer of the skin, which causes a wheal kind of like a little bubble," says Regan. "It can be irritating and itchy and sometimes causes bruising, but this is minor and temporary." Other common vaccine side effects include tiredness and headache.

The monkeypox vaccine causes a red, raised bump called a wheal. A wheal shouldn't leave a scar, but it can feel itchy.

In most cases, you can get a JYNNEOS vaccine at the same time you get other vaccines, except the COVID-19 vaccine. If you get the JYNNEOS vaccine, wait four weeks before getting a COVID-19 vaccine.

Yes, the monkeypox vaccine JYNNEOS is free. The federal government is currently distributing the vaccine.

Yes, the vaccine can prevent monkeypox or lessen the severity of your disease if you get vaccinated soon after a known exposure. Ideally, you should get vaccinated as soon as possible ideally within four days, but it can be given up to 14 days after exposure.

You can also get the vaccine before exposure as a preventive step if you're eligible.

JYNNEOS is safe for people with eczema. ACAM2000, a vaccine that is approved for smallpox and available for the prevention of monkeypox under an Expanded Access Investigational New Drug protocol, is a live virus vaccine that is not safe for people with eczema and some other conditions.

"JYNNEOS is the primary vaccine being administered for the current monkeypox outbreak in the United States," says Regan. "ACAM2000 is an alternative vaccine that contains a live replicating virus called vaccinia. It can spread to other parts of your body and other people, so you have to be extra cautious caring for the vaccine injection site."

The ACAM2000 vaccine is not safe for people with these conditions:

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8 monkeypox vaccine questions and where to get it - Nebraska Medicine

CDC warns of severe illnesses from monkeypox as Ohio reports death of a monkeypox patient – CNN

October 1, 2022

CNN

The US Centers for Disease Control and Prevention issued a new warning to health care providers Thursday about severe illnesses in people with monkeypox.

The alert comes as Ohio reported that an individual with monkeypox has died the third known death of a patient with monkeypox in the United States.

Ohio listed the death in an update to its online monkeypox outbreak dashboard Thursday. The Ohio Department of Health on Friday said an adult male with monkeypox had died, and the individual had other health conditions. The CDC told CNN it is aware of the death.

The first US death due to monkeypox was confirmed this month in Los Angeles County. The county public health department and the CDC said the person had a severely weakened immune system and had been hospitalized. No further information will be made public, the department said.

A person in Harris County, Texas, who had monkeypox died in August, but the virus role in that death has not been confirmed.

Deaths from monkeypox are extremely rare, and babies, pregnant women and people with weakened immune systems are at greater risk. Among more than 67,000 cases reported globally in the current outbreak, there have been 27 deaths, according to the World Health Organization.

More than 25,000 cases of monkeypox have been reported in the United States, but recent case trends suggest that the outbreak is slowing in the US.

Falling case numbers might be a reflection of rising numbers of people vaccinated against the virus. This week, the CDC announced that its expanding eligibility for the Jynneos monkeypox vaccine to higher-risk people who have not been exposed to the virus.

According to data posted by the CDC on Wednesday, men at high risk for monkeypox because they have sex with other men or because they live with HIV were 14 times more likely to be infected if they were unvaccinated compared with those who were at least two weeks past their first dose of the vaccine.

The CDC said Thursday that some people in the US who were infected with monkeypox during the ongoing outbreak have had severe manifestations of the illness, extended hospitalizations or substantial health problems.

The agencys health alert notes that severe monkeypox can happen in anyone, and most people diagnosed during this outbreak have had mild or moderate illness. Most people whose illness has been severe have had HIV with substantial immunosuppression, it says.

Some of the severe illnesses have included:

The advisory urges health-care providers to be aware of risk factors for severe monkeypox and says anyone with suspected or confirmed monkeypox should be tested for HIV. Providers should also check whether the persons immune system may be weakened by another condition or by a medication.

Monkeypox treatment in people who have weakened immune systems should involve stopping any medications that may be affecting the immune system, providing antiretroviral therapy for those with HIV, and possibly using medications such as tecovirimat, known as Tpoxx.

The CDC says people who were exposed to monkeypox through sexual contact should get tested for HIV and other sexually transmitted diseases.

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CDC warns of severe illnesses from monkeypox as Ohio reports death of a monkeypox patient - CNN

UB partners with ECDOH to host monkeypox vaccine clinic – UBNow: News and views for UB faculty and staff – University at Buffalo

October 1, 2022

The Erie County Department of Health (ECDOH) is offering a monkeypox vaccine clinic for eligible members of the UB community from 11 a.m. to 5 p.m. Oct. 7 at UBs new Student Health Services facility, 4350 Maple Road, Amherst. The clinic is open to UB students, faculty, staff, alumni and others at high risk of exposure to monkeypox.

Appointments are strongly recommended; walk-ins are welcome.

Current New York State monkeypox (Jynneos) vaccine eligibility includes the following New Yorkers:

In addition to UB-hosted clinics, ECDOH is also holding off-campus monkeypox clinics that may be conveniently located for some UB students, faculty and staff.

For a list of these clinics, their locations and schedules, visit ECDOHs website.

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UB partners with ECDOH to host monkeypox vaccine clinic - UBNow: News and views for UB faculty and staff - University at Buffalo

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