Category: Flu Vaccine

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Boost Your Immunity and Your Wallet! Get Free Flu Shot and $100 … – University of Arkansas Newswire

October 21, 2023

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Participants needed for a study examining the effects of the immune system on social perception in the workplace. People's immune system is activated when they are sick or experiencing a stressor, and recent research suggests that it affects people's social behavior as well. Because people often have to make important decisions about hiring and promotions while they are sick or stressed, it is important to examine how the immune system affects people's thought processes about others. In this study, researchers are seeking participants who will be given the flu vaccine to temporarily activate their immune system.

Participants will attend two lab sessions at the UAMS-NorthWest Campus in Fayetteville. Sessions will be 1-1.5 hours long and will take place on two consecutive weekdays at approximately the same time each day. During the first session, half of the participants will get the flu shot and half will get a shot with salt water but no vaccine or medicine (these participants will get the actual flu shot at the end of the second session). Participants will also get their blood drawn, provide a saliva sample and complete tasks and questionnaires about social perception the way people view other people. Participants will also be asked to give their impression of different social interactions. At the second session, participants will again get their blood drawn, provide a saliva sample and complete tasks and questionnaires about social perception.

Eligibility:

Adults ages 18 to 40

Have not gotten the flu vaccine since August 2023

No history of allergic reactions to vaccines

People who have diagnosed illnesses that suppress their immune system should not participate in the study

All potential participants will go through a phone screening to check eligibility

If you are interested and would like more information, please fill out an interest form orvisit sparklab.uark.edu/flushotstudy.

Email IDMstudy@uark.edu if you have questions.

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Boost Your Immunity and Your Wallet! Get Free Flu Shot and $100 ... - University of Arkansas Newswire

The Holy Grail: A ‘Universal’ Flu Vaccine | American Council on … – American Council on Science and Health

October 21, 2023

Flu and COVID-19 are examples of respiratory diseases that require repeated vaccine boosters to prevent illness. They are a reminder that we need better vaccines that offer improved durability andenhanced breadth of protection against new variants. This article will discuss progress in developing universal flu vaccines, and Part 2 (to follow) will focus on COVID-19 vaccines with similar properties.

Although annual seasonal flu vaccines are invaluable tools for controlling the spread and severity of influenza, they do not provide immunity against every strain of the virus, which constantly mutates, sometimes radically. Numerous attempts over many years to develop flu vaccines that would not require yearly shots to protect against new variants have not succeeded. They would, however, be an important public health advance. Many Americans fail to get flu shots, and the CDC estimates that from 2010 to 2020, between 12,000 and 52,000 people died of flu in the United States annually.

There aretwo ways that flu viruses commonly evolve. One is called "antigenicdrift," which is caused by changes in the surface proteins of the virus, hemagglutinin (HA) and neuraminidase (NA). Those mutations usually produce viruses closely related to one another, which means that antibodies elicited by exposure to one flu virus will likely recognize other viruses that arose from antigenic drift.

Another, more drastic type of change is called "antigenicshift," a major genetic change that gives rise to new, significantly different HA and/or NA proteins in flu viruses that enable them to infect humans. This is more likely to occur when there is co-infection by different viruses for example, human and avian flu viruses simultaneously infecting an animal host giving rise to reassortment of viral RNAs, the formation of a new hybrid virus containing parts from the genomes of two distinct viruses in a mixed infection. The new viruses may be sufficiently different that most people do not have immunity to them.

Such a "shift" occurred in the spring of 2009, when an H1N1 flu virus with genes from viruses originating from North American swine, Eurasian swine, humans, and birds emerged, infecting people, spreading quickly, and causing a pandemic.

Antigenic drift (the two circular genomes at the top) and shift(the reassortment of RNA segments, below), respectively, are illustrated here:

Figure legend: (A) Antigenic Drift (the two circular genomes at the top): Gradual accumulation of mutations in the genome of viruses leads to emergence of new virus variants. Mutations in the HA (blue) and NA (red) can affect the antigenic epitopes leading to antigenically new variants. (B) Antigenic Shift (the four figures below (A)): The exchange/reassortment of genetic segments between two or more infecting viruses in a host cell can lead to emergence of antigenically distinct, new subtypes. Courtesy: Wikimedia Commons.

Therefore, every spring, a group of scientific experts gets together to try to predict which strains are likely to be prevalent during the following flu season (which begins in the fall), and they select three or four of these strains to include in the next seasonal vaccine. Using a variety of platforms, drug companies then produce their versions of the vaccine in preparation for distribution in late summer or early fall.

However, sometimes their predictions are inaccurate, and unexpected changes in the dominant strains of the virus cause immune escape and decreased vaccine efficacy. An effective universal flu vaccine could address these problems by protecting vaccinees against a wide variety of strains and ideally providing durable long-term immunity.

Such a vaccine would have two advantages: It would stop the guessing game about which flu strains will become dominant, and people would not need to be vaccinated yearly. Several clinical research trials to develop universal vaccines are underway; two of the more promising ones are described below.

The results of a small clinical trial of a candidate were published in July in the journal Lancet Infectious Diseases. The active, immunogenic moiety of the OVX836 vaccine, which is made by a French company called Osivax, is a recombinant H1N1 nucleoprotein, a protein in viral particles that is not very prone to the mutations that change surface antigens and characterize new strains. Therefore, used as a vaccine, it should be better able to elicit immunity to new virus strains that have arisen by antigenic drift or shift.

In the single-center trial conducted in Belgium, three doses of the OVX836 vaccine induced dose-dependent cell-mediated immune responses. There were four cases of influenza A in the 33-patient placebo group and two in the 104 patients who received the vaccine. The vaccine had a favorable safety profile. But vaccines are typically tested in tens of thousands of subjects before regulatory approval, so its still in its early days.

Another clinical trial of an experimental universal flu vaccine, developed by researchers at the NIHs National Institute of Allergy and Infectious Diseases, began enrolling volunteers earlier this year. This very small Phase 1 trial will test the vaccine, designated H1ssF-3928 mRNA-LNP and consisting of messenger RNA (mRNA) encapsulated in lipid nanoparticles (LNP), for safety and its ability to induce an immune response.

The trial will enroll up to 50 healthy subjects aged 18 through 49. Three groups of study participants will receive various doses of the vaccine, and another group will receive a current quadrivalent seasonal influenza vaccine. That will allow a direct comparison between the immunogenicity and safety of the candidate vaccine and available seasonal flu vaccines.

Another complementary approach is to enhance vaccines with adjuvants, chemicals that boost the immune response, making it more rapid and stronger and making possible smaller doses of the immunogen.

The bottom line is that there are several lines of research underway to develop flu vaccines that would be effective against new viral variants that arise. Given the health and economic burdens of flu and Americans resistance to getting yearly shots, the availability of universal vaccines would be an important advance.

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The Holy Grail: A 'Universal' Flu Vaccine | American Council on ... - American Council on Science and Health

Flu shots widely available in Eagle County, but COVID-19, RSV … – Vail Daily

October 21, 2023

As we head into winter, many people are thinking about vaccines to protect against the various respiratory diseases that circulate through the season.

The good news is that flu shots are widely available, and insurers generally pay for those vaccines. The vaccines are also free for certain patients.

Rebecca Larson, deputy director of the Eagle County Department of Public Health and Environment, wrote in an email that the countys MIRA bus will provide free flu shots through October. That vaccine is recommended for people 6 months old and older.

Alana Hurst, the director of Urgent Care and Clinical Support at Colorado Mountain Medical, wrote that facility has a large quantity of vaccinations, including a supply of high dose vaccines for people 65 and older.

Patients can walk in for a shot at Colorado Mountain Medicals offices in Avon, Dillon, Eagle and Vail

The facility will hold flu and COVID-19 vaccine clinics from 9 a.m.-3 p.m. on Oct. 14 in Dillon, Oct. 21 in Eagle and Nov. 11 in Eagle.

While the flu vaccine is available just about anywhere, including local pharmacies, the story is different for the latest COVID-19 vaccine, this one from Moderna. While most people can get both a flu shot and a COVID-19 vaccine during the same visit, supplies are more limited for the COVID-19 shot.

Colorado Mountain Medical has about 600 doses of the COVID-19 vaccine, and Larson wrote that the vaccine isnt yet widely available in the community. Larson added that health officials expect the supply to improve in the next month or so.

In fact, Eagle County Public Health isnt yet able to offer the new COVID-19 vaccine. Once those vaccines are available, Eagle County Health will only offer the shots to children and adults served by Medicaid, those without insurance, or those whose insurance doesnt cover the cost of the vaccine.

While the federal government covered the cost of the first few rounds of the COVID-19 vaccine, that cost is now borne by private insurers. Private-pay patients will pay about $150 for the shot.

Supplies are even more limited for the vaccine for the respiratory syncytial virus, known as RSV.

Colorado Mountain Medical isnt yet offering that vaccine, and Eagle County Public Health isnt offering the vaccine since it isnt part of the federal vaccine program for children, or for adults without insurance.

The RSV vaccine is recommended for older adults those 60 and older with health conditions that could be worsened by a bad respiratory virus. Infants younger than 8 months those who werent yet born during the last RSV season should also be vaccinated. The RSV vaccine is expensive as much as $300 per dose for private-pay patients but insurers usually cover that cost.

Still, Larson wrote, the RSV vaccine is a new one, so there will be a slow rollout from health care providers.

Want the news to come to you? Get the top stories in your inbox every morning. Sign up here: VailDaily.com/newsletter

Once the RSV vaccine is available, patients may get that shot at the same time they get flu and COVID-19 shots. But, Larson wrote, many health care providers recommend getting the RSV shot either two weeks before or after their flu and COVID shots.

As always, if you are laid low by a respiratory virus, stay home, and wash your hands, pretty much all the time.

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Flu shots widely available in Eagle County, but COVID-19, RSV ... - Vail Daily

Sanford Health hosting flu vaccination events in Minot – Sanford Health News

October 21, 2023

Erin Horn Sanford Health Media Relations 701-516-4903/erin.horn@sanfordhealth.org

MINOT, N.D. (Oct. 2, 2023) Sanford Health is hosting several flu vaccination events in Minot, North Dakota.

Vaccines will be provided within Sanford Health Hwy 2 Clinic, at 801 21st Ave. SE, every Thursday throughout the month of October from 5 p.m. 8 p.m.

Seasonal vaccines are available for adults and children ages six months and older.

Appointments are recommended, but not required. Please visit mysanfordchart.org to schedule a flu vaccine at one of these special events or call 701-456-6001.

Fall is the perfect time to get your flu shot. The vaccine offers protection throughout the entire flu season and is the best way to protect yourself and your community from the flu.

Who should receive a flu shot? Everyone ages six months and older should get a flu vaccination annually to reduce the risk of becoming ill with influenza or transmitting it to others. Certain groups are at higher risk and are strongly recommended to receive the vaccine, including:

Visit sanfordhealth.org to learn more about the safety and effectiveness of vaccines and get answers to commonly asked questions.

The Sanford Bismarck region provides health care to central and western North Dakota, eastern Montana and northern South Dakota. It includes 21 clinics in Bismarck, Mandan, Minot, Dickinson and Watford City, as well as a Level II trauma center located in Bismarck.

About Sanford Health Sanford Health, the largest rural health system inthe United States, is dedicated to transforming the health care experience and providing access to world-class health care in Americas heartland. Headquartered inSioux Falls, South Dakota, the organization serves more than one million patients and 220,000 health plan members across 250,000 square miles. The integrated health system has 47 medical centers, 2,800 Sanford physicians and advanced practice providers, 170 clinical investigators and research scientists, more than 200 Good Samaritan Society senior care locations and world clinics in 8 countries around the globe. Learn more about Sanford Healths commitment to shaping the future of rural health care across the lifespan atsanfordhealth.orgorSanford Health News.

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Sanford Health hosting flu vaccination events in Minot - Sanford Health News

The new vaccines and you: Americans better armed than ever against the winter blechs – NBC Montana

October 21, 2023

The new vaccines and you: Americans better armed than ever against the winter blechs

by Amy Maxmen, KFF Health News

Last years triple-demic marked the beginning of what may be a new normal: a confluence of respiratory infections RSV, influenza, and COVID-19 will surge as the weather cools each year. (Getty Images)

HELENA, Mont.

Last years triple-demic marked the beginning of what may be a new normal: a confluence of respiratory infections RSV, influenza, and COVID-19 will surge as the weather cools each year.

Like blizzards, the specific timing and severity of these outbreaks are hard to forecast. But their damage can be limited in more ways than ever before. More protective vaccines against influenza are on the horizon. And new vaccines against respiratory syncytial virus, or RSV, were approved this year, as were updated COVID vaccines. Although the first days of rollout for the Moderna and Pfizer vaccines saw hiccups, with short supplies at some pharmacies and billing confusion with some insurers, the shots now are generally available at no cost.

Whats more, after enduring the worst pandemic in a century, people are more attuned to protecting themselves and those around them. Wearing face masks and staying home when sick can stop the spread of most respiratory infections. The rate of flu vaccinations has climbed over the past five years.

It seems like the pandemic reminded them of how important vaccination is, said Brian Poole, a microbiologist at Brigham Young University in Utah. In a study of college students, Poole and other researchers found that flu vaccination rates have nearly tripled since 2007, from 12% to 31% in the respiratory infection season of 2022-23. Only a minority of students expressed vaccine fatigue.

There is, however, one dangerous departure from the past. Vaccination has become politicized, with college students and older adults who identify as Republican or conservative being less likely to get COVID vaccines, as well as vaccinations against flu. Before 2018, studies found that political affiliation had no influence on vaccine uptake. But as measures to limit COVID, such as school and church closures, became controversial, some political leaders downplayed the effects of COVID even as the pandemics U.S. death toll soared above 1 million.

That messaging has led to a disbelief in public health information. The Centers for Disease Control and Prevention reports data showing that COVID hospitalizations nearly tripled in the latest surge, with more than 40,000 hospitalizations in the first two weeks of September compared with about 13,600 in the same period of July. But in a recent KFF poll, half of Republicans did not believe in the surge, compared with just 23% of Democrats.

Messaging to minimize the toll of COVID also makes vaccines seem unnecessary, with 24% of Republicans leaning toward getting the updated COVID shot versus 70% of Democrats in the KFF poll. A larger share of vaccine-eligible adults said they planned to get, or have gotten, the flu shot and a new RSV vaccine.

Its important to recognize that the flu, COVID, and respiratory viruses still kill a lot of people, and that the vaccines against those viruses save lives, said David Dowdy, an epidemiologist at Johns Hopkins University in Baltimore. Flu vaccines prevent up to 87,000 hospitalizations and 10,000 deaths each year in the United States. I like to highlight that, Dowdy added, as opposed to making up terms like triple-demic to make people cower in fear.

Dowdy predicted this fall and winter will be better than the past few, when patients with COVID, influenza, or RSV filled hospitals. Even so, he estimated that more people will die than in the seasons before COVID appeared. About 58,000 people died from the flu last season, and hundreds of thousands more were sickened, staying home from school and work. This year, the flu doesnt appear to be kicking off unusually early, as it did last year with cases picking up in November, rather than in January. And more people are partially immune to COVID due to vaccines and prior infections.

The effectiveness of flu vaccines varies depending on how well its formula matches the virus circulating. This years vaccine appears more protective than last years, which reduced the risk of hospitalization from the flu by about 44% among adults. This year, researchers expect an effectiveness of about 52%, based on data collected during South Americas earlier flu season. Its benefit was higher for children, reducing hospitalizations by 70%.

The flus toll tends to be uneven among demographic groups. Over the past decade, hospitalization rates due to the flu were 1.8 times as high among Black people in the United States as among white individuals. Just 42% of Black adults were vaccinated against the flu during that period, compared with 54% of white or Asian adults. Other issues, ranging from a lack of paid sick leave and medical care to a prevalence of underlying conditions, probably contribute to this disparity. People who have asthma, diabetes, or cardiovascular issues or are immunocompromised are at higher risk of a severe case of flu.

Sean OLeary, an infectious disease pediatrician and the chair of the American Academy of Pediatrics committee on infectious diseases, urges parents to vaccinate their kids against influenza and COVID. Children hospitalized with co-infections of the two viruses last year were put on ventilators an intense form of life support to allow them to breathe far more often than those hospitalized for the flu alone. And COVID is surging now, OLeary said. Hospitalizations among children under age 18 increased nearly fivefold from June to September. Almost all of our kids who have died have been completely unvaccinated against COVID, he said.

The FDA greenlighted new RSV vaccines from the pharmaceutical companies GSK and Pfizer this year. On Sept. 22, the CDC recommended that pregnant mothers get vaccinated to protect their newborns from RSV, as well as infants under 8 months old. The disease is the leading cause of hospitalization for infants in the United States. The agency also advises people age 60 and older to get the vaccine because RSV kills between 6,000 to 10,000 older adults each year.

Rather than vaccination, the CDC advised a new long-acting antibody treatment, nirsevimab, for children between 8 to 19 months old who are at risk of RSV. However, the price could be cost-prohibitive anticipated at $300 to $500 a dose and many hospitals lack the staff needed to administer it. Although insurers cover it, the American Academy of Pediatrics warns that reimbursement often lags for a year. We dont have the infrastructure in place to ensure all children can access the product, said its president, Sandy Chung, in a statement. And that is alarming.

If the wrinkles can be ironed out, said Helen Chu, an infectious disease specialist at the University of Washington in Seattle, better tools could arrive as early as next year. Pfizer, Moderna, and other pharmaceutical companies are developing mRNA vaccines against influenza and RSV that may more precisely target each years circulating virus.

Todays flu and RSV vaccines are produced using traditional vaccine platforms, such as within chicken eggs, that are more cumbersome to handle, and therefore the vaccines take longer to develop each year. And President Joe Biden has awarded companies $1 billion to develop COVID vaccines that provide longer protection.

The future is going to be all three vaccines together, Chu said, but that will be a while yet.

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The new vaccines and you: Americans better armed than ever against the winter blechs - NBC Montana

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