Category: Covid-19

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These 3 factors have helped the African continent beat early COVID-19 predictions – World Economic Forum

October 3, 2020

While infections spread worldwide, COVID-19 cases have been declining across the African continent since July. The reason, according to the World Health Organization and other experts, is the result of a a combination of public health measures paired with strong socio-environmental factors.

Early on, some worried that a shortage of health professionals and equipment would make battling COVID-19 difficult - or even catastrophic. Others wondered if prevention measures, such as handwashing, could be easily be adapted to varying contexts where finding fresh running water can be difficult.

Years of experience battling previous pandemics, however, helped ensure the continents response was swift and more tailored to local needs and capacities than it might have been otherwise. Fraying global solidarity also galvanized many nations to seek out solutions themselves rather than wait for resources or support.

Africa has not witnessed an exponential spread of COVID-19 as many initially feared, Dr Matshidiso Moeti, World Health Organization (WHO) Regional Director for Africa, was quoted in the release.

The downward trend we have seen in Africa over the past two months is undoubtedly a positive development and speaks to the robust and decisive public health measures taken by governments across the region, said Moeti.

Africas younger population has helped keep case numbers - and deaths - down. Around 40% of the continents population is younger than 14, according to World Bank data. Algeria, one of the continents most affected countries also has one of the larger shares of older residents (6.5% of people 65 and older, around twice the share of the continent as a whole.)

What is more, African culture is more inclusive of older persons and many live with their families instead of care homes, which have proven to be extremely high-risk environments. Large shares of older populations helped drive death rates in countries around the world. At one point in the US, one third of all deaths came from nursing home residents and their workers.

Responding to the COVID-19 pandemic requires global cooperation among governments, international organizations and the business community, which is at the centre of the World Economic Forums mission as the International Organization for Public-Private Cooperation.

Since its launch on 11 March, the Forums COVID Action Platform has brought together 1,667 stakeholders from 1,106 businesses and organizations to mitigate the risk and impact of the unprecedented global health emergency that is COVID-19.

The platform is created with the support of the World Health Organization and is open to all businesses and industry groups, as well as other stakeholders, aiming to integrate and inform joint action.

As an organization, the Forum has a track record of supporting efforts to contain epidemics. In 2017, at our Annual Meeting, the Coalition for Epidemic Preparedness Innovations (CEPI) was launched bringing together experts from government, business, health, academia and civil society to accelerate the development of vaccines. CEPI is currently supporting the race to develop a vaccine against this strand of the coronavirus.

Travel challenges have helped limit the virus spread. Travel within the African continent can be more challenging than in other areas around the world due to the continents sheer size and the lower development of road networks. Additionally, the high-cost of inter-continental flights can make air travel less attractive.

To bridge those gaps, countries leveraged new technologies and approaches to adhere to health guidelines, keeping goods moving and people safe. For instance, a special system forged by the six nations of the East African Community helped truckers efficiently share COVID-19 test results to speed cross-border trade.

Meanwhile, lightweight drones helped get deliveries of supplies such as blood and PPE to hospitals and clinics to rural communities in Africa. Trips that might have taken an entire day by car can take 30 minutes or less by drone.

To date, the continent has seen 1.4 million cases and 36,000 deaths, a fraction of that other countries have experienced. Its recovery rate has been nearly 80%.

Still, the country must remain vigilant. Nearly 80% of those infected in Africa show no symptoms, Moeti recently explained. Progress has made some complacent.

As long as the virus is spreading, the risk for an uptick in spread and overwhelmed health systems is real. As Moeti explained, The slower spread of infection in the region means we expect the pandemic to continue to smoulder for some time, with occasional flare-ups.

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These 3 factors have helped the African continent beat early COVID-19 predictions - World Economic Forum

Titans up to 8 players positive for COVID-19 this week, source says – ESPN

October 3, 2020

A total of eight Tennessee Titans players have tested positive for COVID-19 this week after another player and two staff members tested positive Saturday, a source told ESPN's Adam Schefter.

In all, 16 members of the Titans organization -- the eight players and eight team personnel -- have tested positive since the team last played on Sunday.

On Friday, the Titans announced that wide receiver Adam Humphries and practice squad receiver Cameron Batson had been placed on the reserve/COVID-19 list. Also going on the reserve/COVID-19 list this week were starting nose tackle DaQuan Jones, linebacker Kamalei Correa, cornerback Kristian Fulton, long-snapper Beau Brinkley and practice squad tight end Tommy Hudson.

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Coach Mike Vrabel said Wednesday that some of the players who tested positive were experiencing flu-like symptoms.

Officials from the NFL and the NFL Players Association were in Nashville on Friday to check into the spread of the coronavirus on the team, sources told ESPN, confirming a report by NFL Network.

Other Titans players on the reserve/COVID-19 list are defensive back Greg Mabin, who was placed on the list Sept. 24, and offensive tackle Isaiah Wilson (Sept. 6). Prior to the Titans' 31-30 win over the Minnesota Vikings in Week 3, outside linebackers coach Shane Bowen's tested positive on Sept. 26.

On Thursday, the NFL announced that the Titans' game with the Pittsburgh Steelers would not be played during Week 4 due to the positive coronavirus tests on the Tennessee team. The Titans are now scheduled to play the Steelers in Week 7 on Oct. 25, the league said Friday. The Steelers were scheduled to play a road game against the Baltimore Ravens in Week 7 but will now play that game in Week 8.

The Minnesota Vikings again had no positive test results Saturday, a source told Schefter. They went back to work inside their facility Thursday and remain scheduled to visit Houston on Sunday as scheduled after losing 31-30 to the Titans last week. The Vikings .

ESPN's Turron Davenport and The Associated Press contributed to this report.

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Titans up to 8 players positive for COVID-19 this week, source says - ESPN

‘Provocative results’ boost hopes of antibody treatment for COVID-19 – Science Magazine

October 2, 2020

Companies are developing COVID-19 treatments using monoclonal antibodies, Y-shaped immune proteins that target the pandemic coronavirus.

By Jon CohenSep. 30, 2020 , 5:15 PM

Sciences COVID-19 reporting is supported by the Pulitzer Center and the Heising-Simons Foundation.

A second company has now produced strong hints that monoclonal antibodies, synthetically produced versions of proteins made by the immune system, can work as treatments in people who are infected with the pandemic coronavirus but are not yet seriously ill.

The biotech Regeneron Pharmaceuticals has developed a cocktail of two monoclonal antibodies that attach to the surface protein of that coronavirus, SARS-CoV-2, and attempt to block it from infecting cells. Yesterday at an investor and mediawebcast, the firm revealed early results.

The company showed slides with detailed data from 275 infected people in a placebo-controlled trial that ultimately plans to enroll 2100 individuals who are asymptomatic or, at worst, moderately ill. The analysis divides patients into two groups: those who had detectable antibodies against SARS-CoV-2 at the trials start and those who did not, a so-called seronegative group. The monoclonal cocktail showed little effect on people who already had antibodies against the virus. But it appeared to help the seronegative patients, powerfully reducing the amount of virus found in nasopharyngeal swabs and alleviating symptoms more quickly. These are provocative results, says Myron Cohen of the University of North Carolina, Chapel Hill, who was not involved with the study but is helping Regeneron test its monoclonal cocktail as a preventive.

Cohen notes that Regenerons data look similar to those in a press release from Eli Lilly 2 weeks ago about early results from a trial of its single monoclonal antibody against SARS-CoV-2. Both of these reports go in the same direction, Cohen says. But he cautions that neither has been published, both trials are ongoing, and more data are needed to understand howor whetherthese experimental medicines can best help patients. Lilly, oddly, did not see an impact at the highest dose of antibody tested, and Regeneron saw no difference between its low- and high-dose preparations used in the study.

James Crowe, a viroimmunologist at Vanderbilt University who is working with AstraZeneca to develop COVID-19 monoclonal antibodies, welcomed Regenerons detailed preliminary results. I applaud Regeneron for releasing so much information, Crowe says. Theyre contributing to public health by releasing this as soon as possible. But he notes even people who did well on the monoclonal cocktail still had low levels of virus detectable after their treatment, which in theory could cause problems. I was surprised that there was any virus at all given that these are such potent antibodies, he says, adding that the residual virusdetected in the swab tests may not be capable of copying itself.

The monoclonal antibodies from the two companies are clones of potent SARS-CoV-2 antibodies that can neutralize the virus in test tube studies. Researchers plucked the genes for these antibodies from humans who recovered from COVID-19 or from mice artificially infected with the virus. The companies then put the genes in Chinese hamster ovary cells to bulk manufacturethe antibodies, which were given to the COVID-19 patients as infusions.

At the webcast that announced Regenerons results, George Yancopoulos, president and co-founder of the company, emphasized how the target population for the monoclonal cocktail are SARS-CoV-2 infected people who have not yet mounted their own immune response and have exceedingly high levels of the virus. What we really want to do is turn them into patients who have already started to effectively fight the virus, Yancopoulos said.

In the Regeneron data, the most dramatic drops in SARS-CoV-2 were seen in seronegative patients who had the highest levels of virus at the trials start. In comparison with patients who received the placebo, the results were clearly statistically significant.

Daniel Skovronsky, Lillys chief scientific officer, says the Regeneron data are quite confirmatory of their own. I dont expect there to be large differences between good neutralizing antibodies, Skovronsky says. Antibodies will work best in people who cant clear the virus on their own. One key difference between the two studies, he says, is that Lilly enrolled fewer seronegative people and still found an impactalthough the company, in contrast to Regeneron, is withholding details until it publishes results. Lilly also stressed that people receiving its antibody were shown to have fewer hospitalizations or emergency room visits: five out of 302 (1.7%) treated patients versus nine out of 150 (6%) in the placebo group. Yes, these are small numbers by some measures, Skovronsky says, but by other measures, there are significant differences in hospitalization.

Regeneron hasnt yet accumulated enough data to show the same protection. Its trial had only 12 patients who had COVID-19related medically attended visits. Although there was a trend toward more of these in the placebo group than treatment arms, only one was hospitalized.

Regenerons data raise difficult questions about when to use its cocktail. People who test positive for SARS-CoV-2 arent routinely screened for antibodies to it or for levels of the virus. If the decision is going to be made to deploy such a therapeutic solution in the patients who might benefit the most and need it most, were going to have to solve the problem of using the right point-of-care diagnostic tools, either for serology or high viral load, Yancopoulos said, noting that their partnersincluding Rocheare developing these types of assays.

Skovronsky says Lilly has a simpler plan: Offer monoclonals to people who test positive for the virus if they are in high-risk groups for developing severe disease, which include the elderly and people with underlying diseases such as diabetes or who are overweight. Running extra tests before treating people, as Regeneron suggests, is just not going to meet the needs of the population, he says

Both Lilly and Regeneron say they are discussing their data with regulators to see whether their monoclonal antibodies might warrant moving to widespread use more quickly through mechanisms like the U.S. Food and Drug Administrations emergency use authorization process. Additional studies of their monoclonal treatments are underway in hospitalized COVID-19 patients and, separately, as preventives in uninfected people.

Monoclonal antibodies are more difficult to make than many drugs and often are extremely expensive, which means that supply could outstrip demand and many countries might not be able to afford them. The U.S. governments Operation Warp Speed has invested $450 million in Regeneron to produce up to 300,000 doses of its cocktail by the end of the year, which would be distributed to Americans free of charge. A substantial fraction of those are already available, Yancopoulos saidalthough its not yet clear what constitutes a single dose of the companys cocktail. Nonetheless, Regeneron, which is partnering with Roche to increase production capability, says it hopes to ramp up to produce 250,000 doses per month.

Skovronsky says if the lowest dose Lilly is testing works, it could have up to 1 million doses by the end of the year. Lilly is partnering with Amgen to scale up production to several million doses next year. Were rooting for Regenerons success, just as Regeneron is rooting for Lillys success, he says. None of us can make enough antibodies to meet the need.

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'Provocative results' boost hopes of antibody treatment for COVID-19 - Science Magazine

COVID-19 Daily Update 9-30-2020 – West Virginia Department of Health and Human Resources

October 2, 2020

TheWest Virginia Department of Health and Human Resources (DHHR) reportsas of 10:00 a.m., September 30, 2020, there have been 561,113 total confirmatory laboratory results receivedfor COVID-19, with 15,848 total cases and 350 deaths.

DHHR has confirmed the deaths of a 56-year old male from FayetteCounty, a 68-year old male from Kanawha County, a 95-year old male from BooneCounty, an 81-year old female from Putnam County, and a 68-year old male fromKanawha County. As we recognize and honor the lives of these WestVirginians, we also extend our sincere condolences to their families, saidBill J. Crouch, DHHR Cabinet Secretary.

CASESPER COUNTY: Barbour(81), Berkeley (1,025), Boone (232), Braxton (13), Brooke (114), Cabell (852),Calhoun (25), Clay (37), Doddridge (27), Fayette (630), Gilmer (48), Grant(161), Greenbrier (128), Hampshire (108), Hancock (150), Hardy (91), Harrison(392), Jackson (271), Jefferson (439), Kanawha (2,747), Lewis (38), Lincoln(172), Logan (622), Marion (285), Marshall (179), Mason (143), McDowell (87),Mercer (427), Mineral (174), Mingo (385), Monongalia (2,049), Monroe (151),Morgan (56), Nicholas (112), Ohio (375), Pendleton (53), Pleasants (18),Pocahontas (59), Preston (157), Putnam (583), Raleigh (528), Randolph (259),Ritchie (13), Roane (53), Summers (55), Taylor (129), Tucker (35), Tyler (16),Upshur (87), Wayne (406), Webster (7), Wetzel (58), Wirt (12), Wood (375),Wyoming (119).

Pleasenote that delays may be experienced with the reporting of information from thelocal health department to DHHR. As case surveillance continues at the localhealth department level, it may reveal that those tested in a certain countymay not be a resident of that county, or even the state as an individual inquestion may have crossed the state border to be tested.Suchis the case of Webster County in this report.

Pleasevisit the dashboard located at http://www.coronavirus.wv.gov for more information.

Free COVID-19 testinglocations are available today in Fayette, Kanawha, Logan, Monongalia, Putnam,Taylor, and Wayne counties:

Fayette County, September30, 4:00 PM 7:00 PM, Gateway Center, 2 Greyhound Lane, Smithers, WV

Kanawha County, September30, 3:00 PM 7:00 PM, George Washington High School, 1522 Tennis Club Road,Charleston, WV

Logan County, September30, 10:00 AM 2:00 PM, Old 84 Lumber Building, 100 Recovery Road, Peach Creek,WV

Monongalia County,September 30, 9:00 AM 4:00 PM, West Virginia University, Student RecreationCenter, 2001 Rec Center Drive, Morgantown, WV

Putnam County, September30, 1:00 PM 5:00 PM, Old Buffalo High School, 81 High School Road, Buffalo,WV

Taylor County, September30, 12:00 PM 2:00 PM, First Baptist Church of Grafton, 2034 Webster Pike (USRt. 119 South), Grafton, WV

Wayne County, September30, 9:00 AM 1:00 PM, Wayne County Health Department, 217 Kenova Ave, Wayne,WV 25570

Testing is available to everyone,including asymptomatic individuals. For upcoming testing locations, pleasevisit https://dhhr.wv.gov/COVID-19/pages/testing.aspx.

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COVID-19 Daily Update 9-30-2020 - West Virginia Department of Health and Human Resources

Steuben County reports 500th COVID-19 case, more cases at the Corning Center – WETM – MyTwinTiers.com

October 2, 2020

CORNING, N.Y. (WETM) Steuben County has reported more than 500 cases of COVID-19 since March.

On Thursday the county reported 15 new cases of COVID-19, giving them 513 confirmed cases and 159 active patients. This news comes as the county reported its 50th COVID-19 death, a resident of the Corning Center.

Twelve of the new cases are residents of the Corning Center, and the other three are residents of Bath, Painted Post, and Corning.

One individual traveled to a state on the advisory list and participated in a large gathering while there, according to the health department. Another person reported being in close contact with another case.

The individuals reported visiting the following locations within their investigation timeframe:

9/23/20 9/25/20 SKIP of New York in Painted Post

Hospitalizations continue to be on the rise daily due to COVID-19, said Public Health Director, Darlene Smith. Positive individuals who are not elderly and who do not have serious underlying medical conditions are being hospitalized. COVID-19 is proving to be extremely serious and dangerous during this surge in cases. Do absolutely everything you can to protect yourself and your loved ones and prevent the further spread of this deadly virus.

All residents should continue to monitor themselves for COVID-19 symptoms of fever, cough, shortness of breath, chills or repeated shaking with chills, muscle pain, headache, sore throat, and new loss of taste or smell and contact their healthcare provider for instructions if feeling ill.

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Steuben County reports 500th COVID-19 case, more cases at the Corning Center - WETM - MyTwinTiers.com

Covid-19 and school reopenings, explained in 10 facts – Vox.com

October 2, 2020

Americas largest school district, New York City, brought some 300,000 students back for in-person learning on Tuesday, even as Covid-19 rates in the city began to tick up. Meanwhile, schools in Miami announced a return to fully in-person learning this month, after a disastrous rollout of online education earlier in the fall. Then there are schools from Kentucky to New Jersey that have switched from in-person to remote learning in recent weeks due to Covid-19 cases.

Like everything about the response to the coronavirus in America, school reopenings have been a patchwork, with states and districts each following their own guidelines some informed by public health guidance, some less so. As millions of Americans try to make decisions about their childrens education, or their own work as teachers or school staff, they face a terrifying lack of information: Theres no nationwide data on the number of Covid-19 cases in K-12 schools.

Still, we are starting to get a picture or perhaps a rough sketch of what education looks like in this time helped along largely by data collection efforts by the New York Times and the Covid-19 School Response Dashboard.

We are beginning to have a sense of how common Covid-19 is in schools that have reopened, and what schools are doing to reduce the spread of the virus. We know that rates among staff are markedly higher than those among students not a surprise given previous evidence that adults are more likely to contract the virus, but significant nonetheless. And we know that, at least for now, hybrid learning models employed in many districts to make schools safer have not completely eliminated the risk.

With schools having just started in some places and concerning signs of a new surge as summer moves to fall the coming weeks may bring answers to some of the biggest questions about Covid-19 and schools.

One key indicator will be whether the overall rate of cases in schools increases from week to week, Emily Oster, an economics professor at Brown University who co-created the dashboard, told Vox: If theyre 0.75 percent this week, are they 3 percent next week, and 6 percent the week after that? That would be very worrisome.

And while we dont yet have much of a longitudinal view, the 10 facts below offer a guide to what we know so far and what we need to find out.

Part of the difficulty in fully understanding Covid-19 risk in schools is that approaches to pandemic education are incredibly varied. While some states, like California, have issued guidelines barring districts from opening if transmission is too high and others, like Florida, have pressured schools to open regardless of transmission decisions have often been left up to individual districts themselves. Efforts to map reopening around the country end up looking like patchwork quilts.

Still, we have some nationwide data about reopening plans at the beginning of the school year. In a nationally representative survey of 477 districts conducted in late August by the Center on Reinventing Public Education (CRPE), 49 percent planned to open fully in-person. Meanwhile, 26 percent planned to be fully remote, and 12 percent planned to open on a hybrid model, with students in-person on some days and remote on others. And 85 percent of districts planned to offer some fully remote option for families, even if they also offered in-person instruction.

Around the country, district reopening plans vary widely based on population density, the CRPE survey found. Rural districts were most likely to plan a fully in-person start, with 65 percent indicating such a plan compared with 24 percent of suburban districts and 9 percent of urban ones. And nearly four out of five urban districts planned to start the year fully remote.

Districts with a high percentage of students living in poverty were also more likely than others to plan for a remote start. Just 24 percent of districts with the lowest rate of poverty in the CRPE survey planned to start remotely, compared with 41 percent of the highest-poverty districts.

In some cases, this may have to do with virus risk, as communities with high levels of poverty have also been disproportionately affected by the coronavirus. Its also possible that the expense of hybrid learning, which requires complex scheduling and potentially more staff, may be prohibitive for high-poverty districts as the CRPE report notes, high-poverty districts were much less likely to plan for logistically complex and likely more expensive hybrid learning.

The divide between high- and low-poverty districts is concerning, the report notes, because students in poverty face disproportionate barriers to successful remote learning, from a lack of adequate space at home for schoolwork to parents who need to work outside the home and cant supervise their childrens schooling. Schools around the country are going above and beyond to help students in poverty with remote learning, but so far, many lack the help they need from states and the federal government.

Its an absolute tragedy that our communities that are getting hit most by the pandemic are then getting hit once again by the effects of schools being closed, Brandon Guthrie, a professor of global health and epidemiology at the University of Washington, told Vox.

The CRPE report paints a picture of what districts were planning at the beginning of the school year. But schools are changing their plans constantly in the face of changing viral conditions and, sometimes, political pressures.

For example, when EdWeek surveyed districts in July, about 13 percent planned for all-remote learning. When the publication conducted the survey again at the end of August, that figure jumped to around 23 percent.

But some districts shifted in the opposite direction 9 percent told EdWeek in July that they would be fully in-person, while 13 percent said so by the end of August.

Sometimes, these changes are a response to rising or falling case counts in the community. A school district in Mifflinburg, Pennsylvania, for example, decided to reopen for full in-person learning after planning for a hybrid model for some students because cases in the county declined, according to EdWeek. Other districts, such as one in State College, Pennsylvania, have shifted to a fully remote schedule as case counts in the area increase.

In other situations, however, districts have been forced to change plans after orders from the state. The Miami-Dade County public schools, for example, had planned to reopen for in-person learning in mid-October. But under pressure from the state, where Republican Gov. Ron DeSantis has threatened to withhold funding if schools do not reopen, it moved up this date to October 5.

For districts doing at least some in-person learning, the big question is how likely students and teachers are to contract Covid-19. And if you read the news around this question, youre likely bombarded with numbers of cases: one case at one school, six cases at another, and cases in 100 different New York City schools before in-person classes even started.

But without knowing how many students and staff, total, are in the buildings reporting cases, its impossible to know how prevalent the virus really is in schools. While even one case of a potentially serious illness is important and requires a response, its also true that one case out of 10 students probably requires a different response than one out of 100,000.

When reports of outbreaks come out, thats the numerator; we dont actually know what is the denominator, Marilyn Tseng, an epidemiologist at Cal Poly San Luis Obispo, told Vox.

Part of the goal of the Covid-19 dashboard has been to figure out those denominators in order to draw conclusions about prevalence and risk. Oster and her team collected data from public and private schools, as well as districts so far, they have 703 schools on board, with a total of 126,785 students and 47,489 staff going to buildings in person.

This group of schools is not a nationally representative sample; schools and districts have to opt in, and those that choose to share their data are not a perfect sampling of schools in America. However, by enrolling whole districts in the project, the team hopes to be able to draw at least some large-scale conclusions. And by allowing schools to report data anonymously, they hope to encourage schools to share their numbers even if those numbers are high.

Despite its limitations, the Covid dashboard made a splash when it was released last week, in part because it provided something available nowhere else: an estimate of the Covid-19 infection rate in American schools. Among schools participating in the project, about 0.071 percent of students had a confirmed infection in the period between August 31 and September 13. At that rate, a school of 1,350 students could expect to see about one student case in a two-week period, Oster wrote in a recent New York Times op-ed.

Those are just the confirmed cases if you add in suspected cases of the virus, the rate rises to 0.51 percent.

Those rates arent particularly high, especially given rates of Covid-19 in some communities. Still, they clearly show that kids are bringing the virus into schools, and that schools can expect cases to tick up. Ultimately, what you think of a 0.071 percent rate of confirmed infection may depend on how you weigh the benefits of in-person school against the risk of a child contracting the coronavirus. As Oster put it, all these kinds of numbers are in the eyes of the beholder.

Whatever you think about the rate of student infection, one thing is clear: The rate for teachers and staff is higher. In the Covid dashboard sample, 0.19 percent of teachers and other adults in schools had a confirmed infection between the end of August and mid-September. When you add in suspected cases, the rate rises to 0.61 percent.

The difference between staff and student infection rates adds to an existing body of evidence suggesting that opening schools poses a greater risk to adults than to children. From data in the US and abroad, we know that if you have limited control measures in place, and have transmission going on in the school, that it is likely that teachers would become infected, Guthrie said.

A study of schools open in the UK this summer, for example, found 70 cases among students (out of about 843,430 total students) and 128 among staff (out of about 519,590 total staff members). The majority of cases linked to in-school outbreaks, as opposed to out-of-school transmission, appeared in staff as well.

The dashboard data underscores the fact that adults in schools appear to contract Covid-19 at a higher rate than children something especially concerning since they are also more likely to become seriously ill from the virus.

One thing that the dashboard makes clear is that even if the infection rate is relatively low, cases do happen, and schools and districts have to adjust to this reality.

For example, Woodcliff Lake Middle School in New Jersey closed for 14 days after a staff member tested positive on September 10, according to NJ.com. And in Cherokee County, Georgia, schools opened for full in-person instruction on August 3 but by the end of the week, several schools had to close and nearly 1,200 students and staff were in quarantine, according to the New York Times.

Quarantines and temporary closures are likely to be routine during the pandemic, but they pose numerous problems for schools. In Lumpkin County, Georgia, quarantined students cannot simply switch to remote learning because remote and in-person learning are on different tracks, according to the Times. And in Greater Clark County, Indiana, schools have struggled to stay open due to the number of staff in quarantine, which at one point reached 59.

Its not clear how schools will continue to handle these ongoing challenges, especially with overstretched state and local budgets making extra staffing difficult. But one thing better data could provide is the ability to plan. One function of the Covid dashboard, Oster says, is to help school officials know what to expect if and when they open in person. Over time, the data could help superintendents answer the question, When I reopen, what should I expect is the number of kids that are going to get sick, Oster says and plan accordingly.

The schools and districts that have generally chosen hybrid models where students are in-person for some part of the week and remote for the rest have done so under the theory that these are safer. Using a hybrid schedule, a school can reduce the number of students in the building at any one time and allow for better social distancing.

Indeed, the Covid dashboard showed that as of September 22, schools with hybrid models had lower student infection rates than schools that were fully in-person, with 24 cases per 100,000 students in fully in-person school, compared with 14 cases per 100,000 in hybrid schools.

However, infection rates among staff were actually higher at hybrid schools 52 cases per 100,000, compared with 21 cases per 100,000 for fully in-person schools.

There are a number of possible reasons for the discrepancy. For one thing, Oster notes, schools may be more likely to use a hybrid model in places where case numbers are already high, leading to more cases within schools.

But hybrid models may also have their own risks. You do really need to think about what is happening while kids are not in the classroom, Guthrie said. Those kids are not all isolated at home with their families. Instead, younger children may be in child care centers or with babysitters, while older kids may be hanging out with friends. And all of those exposures have to be factored in to the risks of any model.

And while there havent been any outbreaks yet that can be conclusively tied to hybrid learning, there are reasons to raise it as a concern, Guthrie said.

The Covid dashboard also tracks the mitigation strategies schools are using in an effort to reduce viral spread. The most common were at-home symptom screenings, with 96 percent of schools reporting use of this method, and masks, with 96 percent of schools requiring them for students and 95 percent requiring them for staff. Next up was increased ventilation, at 85 percent.

The prevalence of masks is encouraging news since theres increasing evidence that wearing a face covering can help stop the spread of the virus. The more that we learn about aerosol transmission, I think the more support there is for universal masking, Guthrie said.

Other interventions, however, are less common. Only 62 percent of schools reported requiring students to keep 6 feet apart, a strategy supported by experts throughout the pandemic as a way to reduce risk. And just 5 percent of schools reported testing staff before the first day of school.

As of now, we dont yet know which strategies are the most effective for stopping transmission within schools. What is clear, however, is that private schools have been able to put in place more strategies than public schools. As of September 22, for example, 92 percent of private schools in the dashboard sample were reporting increased ventilation, compared with just 52 percent of public schools. And 81 percent of private schools reported having some or all classes outdoors, compared with 32 percent of public schools.

That disparity may reflect the fact that many private schools have resources that public schools lack, as Anya Kamenetz and Daniel Wood note at NPR, especially in a time of state and local budget cuts. And theyre concerning because they threaten to further entrench the inequalities that have been evident throughout the pandemic, since private schools tend to serve a whiter and wealthier student body than public ones.

Though the sample sizes are small for now, private schools in the dashboard sample are seeing much lower infection rates than their public counterparts, Oster said. My guess is even as we grow the sample that will continue to be true.

One of the biggest questions around reopening schools is how much the decision impacts community spread of Covid-19 for example, theres been concern that allowing students back in person could lead to a spike affecting even those without school-age kids, including potentially vulnerable populations like those over 65.

So far, evidence from other countries suggests this isnt a huge concern in places where community transmission rates are already very low, Guthrie said. Countries like Germany, for example, were able to reopen schools without a large spike in cases, though it remains to be seen what will happen now that many parts of Europe are experiencing a second wave of infections.

In the US, schools have reopened in many places with relatively high levels of transmission, such as Georgia, which welcomed students back to school even as case counts rose. While such openings have already led to quarantines, its not yet entirely clear what theyve meant for overall rates of the virus or whether reopenings in less hard-hit areas have led to resurgences.

Some data, however, is encouraging. In Florida, where many schools reopened amid or on the heels of a summer surge in cases, a recent USA Today analysis showed that case counts among children 5 to 17 actually declined through late September, even though schools opened in August. And spikes in individual counties appeared to be driven by colleges, not K-12 schools.

However, the analysis also found that after schools reopened, the rate of decline in cases which peaked in July began to slow. That could mean that cases are about to rebound due to school reopenings, but its just not showing up in the data yet.

Its one of those things where its not a problem until there is a problem, Katherine Auger, a professor of pediatrics at the University of Cincinnati College of Medicine, told USA Today.

The example of Florida is a reminder that as the US enters the seventh month of the pandemic, theres still much we dont know about Covid-19 and schools. Indeed, one thing nearly all experts agree on is the need for more data to draw real conclusions on the risks to students, staff, and the broader community.

If there were some more standardized effort across jurisdictions, where we could get the true denominator data, it would help people make better decisions, Tseng said. But we dont have that.

And over the next several months, as fall turns to winter and districts around the country continue trying to educate students in the face of the pandemic, for better or for worse, were going to have a lot to learn, Guthrie said.

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Judge temporarily halts state health department from releasing names of businesses with COVID-19 cases – Milwaukee Journal Sentinel

October 2, 2020

An American Foods Group employee walks past a sign that says Heroes trabajan aqu, meaning Heroes work here, on April 28 in Green Bay.(Photo: Sarah Kloepping/USA TODAY NETWORK-Wisconsin)

A judge temporarily blockedthe state health department from releasing the names of businesses linked to COVID-19 cases on Thursday, after Wisconsin Manufacturers & Commerce sued to stop the release of the informationto media outlets.

The state's largest business lobbying group argued Thursday that the records are protected by patient confidentiality laws and that disclosure will "irreparably" harm businesses by "effectively blacklisting them."

The order from Waukesha County Circuit Judge Lloyd V. Carter will remain in effect for five days.

Track COVID-19 in Wisconsin: See the latest numbers and trends

The Milwaukee Journal Sentinel requested state Department of Health Services data on facilities associated with COVID-19 cases on June 6.

The department announced in July that it would release the names of businesses with outbreaksbut backtracked after business groups and Republican lawmakers pushed back against the idea.

After a Journal Sentinel attorney contacted DHS on Sept. 16 on the status of its open records request, the agency told the newspaper it would provide a response by Friday.

A lack of information has helped keep workers, area residents and the public in the dark about the extent of the outbreaks and the risks they face.Many workers at food processing plants with outbreaks told the Journal Sentinel they learned about cases at their companies through coworkers.

As of Thursday, DHS is actively investigating 440 workplaces with positive cases, a tally that does not includehealth care facilities, schools or long-term care facilities.

Journal Sentinel editor George Stanley pointed to the organization's previous reporting on long-term care facilities, meatpacking plants and other businesses that failed to protect their employees or inform the public about COVID-19 outbreaks.

"All we aim to do is let people know where outbreaks are occurring not identify anybody who is sick," Stanley said. "These health records belong to the taxpayers and not to any business lobbying group."

In a news conference Thursday, Gov. Tony Evers, who said he had not yet seen the WMC lawsuit, said lawyers had assessed the public records requests and determined it is a legitimate release that were doing.

We have an obligation to the public to obey the law in that area, and we will be releasing to people in the media that have asked for that information in the very near future, Evers said.

In an email Thursday, DHS spokesperson Elizabeth Goodsitt said the agency would not post the names of the businesses on their website "because we do not think that has public health value."

In a statement, WMC President Kurt Bauer said the release has the potential to spread false and misleading information that will damage the brands of Wisconsin employers.

Bauer said the release could have a chilling effect on businesses by making themafraid to work with their local health departments for fear of having their names published.

The release of the names of facilities would reduce the effectiveness of contact tracing, reduce the confidence level workers have in their employers and actually increase the likelihood of spreading the virus, Bauer said.

The Muskego Area Chamber of Commerce and New Berlin Chamber of Commerce & Visitor Bureau are also plaintiffs along withWMC in the lawsuit.

Three states Oregon, Coloradoand Kansas currently publish names of businesses with outbreaks, using different thresholds,as doOzaukeeand Washington counties, which share a health department.

Public health and open records experts have argued in favor of transparency.

In July, the American Public Health Association and the Johns Hopkins Center for Health Security issued a report recommending that states publish the names of group facilities such as nursing homes and essential workplaces with outbreaks.

Georges Benjamin, executive director of the American Public Health Association, said the information helps the public be moreaware of whether they may be at risk of exposure.

For example, he said, someone who attended a barbecue with friendswillbe more likely to get tested if he orshe learns theres been an outbreak at his friends' workplace.

Transparency enhances our ability to do effective disease containment, Benjamin said. The less transparent we are, the more difficult it is.

Bill Lueders, president of the Wisconsin Freedom of Information Council, said the public has a right to the data to gauge how well public health officials and businesses are responding to outbreaks.

The objections of the business community are predicated on the worst assumptions about the people of Wisconsin that they are too stupid and too mean to be provided with this information without flipping out, Lueders said.

In Washington and Ozaukee counties, the health department publishes the names of facilities with outbreaks but not the number of cases, partly in order to protect the privacy of employees at smaller facilities. Businesses that havent had additional cases in 14 days are removed from the dashboard.

Kirsten Johnson, the director of the Washington Ozaukee Health Department, said the local business community has been very cooperative about working with them.

Johnson said the health department wants people to be aware of where the virus has been present so they could be aware if they had been potentially exposed.

We are hopeful that giving the information to the community helps people make good decisions, she said.

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NIH to assess and expand COVID-19 testing for underserved communities – National Institutes of Health

October 2, 2020

News Release

Wednesday, September 30, 2020

The National Institutes of Health has awarded nearly $234 million to improve COVID-19 testing for underserved and vulnerable populations. A part of the Rapid Acceleration of Diagnostics (RADx) initiative, the RADx Underserved Populations (RADx-UP) program will support 32 institutions across the United States and will focus on populations disproportionately affected by the pandemic. These groups include African Americans, American Indians/Alaskan Natives, Latinos/Latinas, Native Hawaiians, older adults, pregnant women and those who are homeless or incarcerated.

It is critical that all Americans have access to rapid, accurate diagnostics for COVID-19, especially underserved and vulnerable populations who are bearing the brunt of this disease, said NIH Director Francis S. Collins, M.D., Ph.D. The RADx-UP program will help us better understand and alleviate the barriers to testing for those most vulnerable and reduce the burden of this disease.

The program aims to understand COVID-19 testing patterns better among underserved and vulnerable populations; strengthen the data on disparities in infection rates, disease progression and outcomes; and develop strategies to reduce these disparities in COVID-19 testing. To accomplish these goals in rapid fashion, the RADx-UP program is supporting projects with established community partnerships that can use their existing research infrastructures to swiftly implement strategies and interventions to increase access and uptake of COVID-19 testing among underserved and vulnerable populations.

The RADx-UP program has three primary components supported by these NIH grants to increase availability, accessibility and acceptance of testing among underserved and vulnerable populations:

Long-term community engagement efforts established by these researchers and programs provide an essential mechanism for discovering the factors that lead to COVID-19 related disparities, said Eliseo J. Prez-Stable, M.D., director of the National Institute on Minority Health and Health Disparities. These existing partnerships will serve as the foundation for swift implementation of interventions to promote greater health equity.

In the coming months, the RADx-UP program will award additional funding, pending availability of funds, to address the evolving needs of the pandemic response, integrate new scientific and/or technologic advances such as vaccines, novel therapeutics and new testing approaches, and expand the studies and/or populations being reached.

About the Rapid Acceleration of Diagnostics (RADxSM) initiative: The RADx initiative was launched on April 29, 2020, to speed innovation in the development, commercialization and implementation of technologies for COVID-19 testing. The initiative has four programs: RADx Tech, RADx Advanced Technology Platforms, RADx Underserved Populations and RADx Radical. It leverages the existing NIH Point-of-Care Technology Research Network. The RADx initiative partners with federal agencies, including the Office of the Assistant Secretary of Health, Department of Defense, the Biomedical Advanced Research and Development Authority, and U.S. Food and Drug Administration. Learn more about the RADx initiative and its programs: https://www.nih.gov/radx.

About the National Institutes of Health (NIH):NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

NIHTurning Discovery Into Health

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NIH to assess and expand COVID-19 testing for underserved communities - National Institutes of Health

COVID-19: What you need to know about the coronavirus pandemic on 1 October – World Economic Forum

October 2, 2020

Confirmed cases of COVID-19 have now passed 33.9 million globally, according to the Johns Hopkins Coronavirus Resource Center. The number of confirmed deaths stands at just over 1 million.

The Czech government has announced a state of emergency from next Monday to tackle a rapid rise in COVID-19 cases.

Iran's COVID-19 death toll has risen above 26,000, according to state media.

Retail sales in Germany rose much more than expected in August, while unemployment fell further in September, raising hopes for a stronger economic recovery in Europe's biggest economy.

The UAE has seen its highest daily total of COVID-19 infections since the start of the outbreak.

The prevalence of COVID-19 infections is much higher in England than at the end of August, but there are signs growth is slowing, according to an Imperial College study.

Brazil has registered over 1,000 new coronavirus deaths, bringing its total to 143,952. There have been more than 4.8 million confirmed cases in the country.

Global confirmed cases are approaching 34 million.

Image: Our World in Data

A new study has examined the impact of school reopenings on rising coronavirus cases, finding generally no clear link between the two.

Its been assumed that opening schools will drive infections, and that closing schools will reduce transmission, but the reality is much more complex, said Randa Grob-Zakhary, Founder and Chief Executive at Insights for Education, the organization that conducted the analysis.

The Geneva-based educational foundation said lockdown closures would leave a "pandemic learning debt" of 300 billion missed school days, of which 84% would be lost by children in poorer countries.

Grob-Zakhary said: "The key now is to learn from those countries that are reopening effectively against a backdrop of rising infections."

The COVID Response Alliance for Social Entrepreneurship is hosted by the Schwab Foundation for Social Entrepreneurship, with the support of Yunus Social Business and GHR Foundation and integrates the perspectives of social entrepreneurs through a strategic partnership with Catalyst 2030.

It identifies five principles that should lie at the heart of any COVID-19 response effort:

The Alliance has released a COVID Social Enterprise Action Agenda, outlining 25 concrete recommendations for key stakeholder groups to support social entrepreneurs during COVID-19. These align around the following streams:

1. Intermediaries and networks to surface the needs of the social entrepreneurs they serve on the ground and provide them with fitting support2. (Impact) investors to adapt their investment priorities and processes, and provide flexible capital and must-have technical assistance 3. Corporations to stand with the social entrepreneurs in their supply chains and ecosystems, and join forces with them to shape a new tomorrow 4. Funders and philanthropists to expand and expedite their financial support to social entrepreneurs and intermediaries, taking risks reflective of todays unprecedented times 5. Government institutions at all levels to recognize social entrepreneurs as a driving force in safeguarding jobs and in building a greener and equitable society, and to back them accordingly

Salesforce.com has said it has adapted some of its business software for healthcare organizations and governments to help them distribute future COVID-19 vaccines.

Work.com for Vaccines will help cities, states and healthcare groups track inventory, build online appointment portals and monitor patients after vaccination.

All these vaccines have various levels of quality and efficacy. We all know that theyre not all the same, Salesforce.com Chief Executive Marc Benioff told Reuters in an interview. And so technology will be really critical in separating the wheat from the chaff in the vaccine.

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COVID-19: What you need to know about the coronavirus pandemic on 1 October - World Economic Forum

Wisconsin reports record number of Covid-19 hospitalizations after task force warned of ‘rapid worsening’ – CNN

October 2, 2020

With 646 Covid-19-related hospitalizations Wednesday, Wisconsin reported just 18% of hospital beds are available, according to the state's Covid-19 website. Almost a third -- 32% -- of those hospitalized are in the intensive care unit.

The White House task force called on the state to increase social distancing "to the maximal degree possible," less than a week before President Donald Trump's scheduled campaign rallies in hot-spot metro areas La Crosse and Green Bay.

"Over the course of the past two to three weeks we have noticed a marked rise in Covid patients coming into our hospitals in Green Bay," said Dr. Paul Casey, medical director of the emergency department at Bellin Hospital. "And this comes in the wake of what we thought we thought we were doing well."

Casey evoked the images of overflowing emergency rooms seen in cities like New York and Detroit earlier in the pandemic.

"For the first time in 17 years that I've been here, we've had to put patients in hallway beds," Casey told CNN's Erin Burnett.

"I never envisioned having to do that in a small community like Green Bay, but we've done it not twice, but three times in the last 10 days."

Wisconsin had the third-highest rate of new cases per capita last week and had a test-positivity rate of between 8% and 10%, the seventh highest in the country, the task force said in a report dated Sunday and obtained by CNN.

"To the maximal degree possible, increase social distancing mitigation measures until cases decline," the letter reads.

Evers said Tuesday that Covid-19 cases in the state were "picking up speed."

The state's seven-day average of new daily cases hit its record for the pandemic Tuesday at 2,225, according to Johns Hopkins University. That is up from 630 six weeks ago.

"No party, no bar, no gathering is worth it," Evers said.

The Midwest averaged 156 cases per 1 million people, against 124 in the South, 88 in the West and 51 in the Northeast, Johns Hopkins data shows.

26 states report higher 7-day averages of new cases

This comes as at least 26 states -- mostly in the country's northern half -- were reporting higher seven-day averages of new daily cases Wednesday than a week ago.

Wyoming, which last week set a single-day record for new Covid-19 cases, loosened rules around restaurants after the governor said data showed dine-in restaurants have "not significantly contributed" to spread of the virus in the state.

For the country as a whole, although cases rates are down from a summer surge, they recently have inched up.

New daily cases over a week averaged about 42,000 as of Tuesday. That's down from a peak average of 67,317 on July 22 -- but it also is up about 22% since September 12, when it was at a two-month low of 34,307.

New York City battling test-positivity spikes as more schools set to reopen

Mayor Bill de Blasio said Wednesday that officials are especially watching nine ZIP codes with test-positivity rates between 3% and 6% -- well above the entire city's seven-day rolling average of 1.46%.

The city health department has said it was deploying 11 mobile testing units to areas with high test-positivity rates.

Restaurants in areas with spiking rates will get special attention, de Blasio said.

"There is going to be a very rigorous inspection effort in those ZIP codes, and we are going to be looking carefully to make sure every restaurant is following the rules," de Blasio said Wednesday.

Possible Moderna vaccine timeline

Moderna, which has developed a vaccine together with the National Institutes of Health, could have a vaccine widely available by late March or early April, if trials prove its vaccine candidate to be safe and effective, Modern CEO Stphane Bancel said Wednesday.

"I think a late Q1, early Q2 approval is a reasonable timeline, based on what we know from our vaccine," Bancel said at a conference hosted by the Financial Times.

The company could apply for emergency use of the vaccine by late November, but not sooner, given that the company must have two months of safety data after trial participants receive a second dose, Bancel said.

The CEO said he believes the vaccine will be mainly available to high-risk populations, like health care workers and the elderly, under emergency use authorization from the US Food and Drug Administration.

The company is working to ramp up production in the meantime.

"We are trying to really get ahead of the game, so that if the safety is good, efficacy is good, manufacturing will not delay the availability of a vaccine on an emergency use basis first," said Bancel.

CNN's Amanda Watts, Betsy Klein, Gregory Lemos, Kristina Sgueglia, Andy Rose, Rebekah Riess. Shawn Nottingham and Lauren Mascarenhas contributed to this report.

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