Category: Covid-19

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Virginia COVID-19 cases spike to daily high of nearly 10000; over 3600 in Northern Virginia – Inside NoVA

January 18, 2021

The number of new COVID-19 cases reported in Virginia soared to a one-day record Sunday of nearly 10,000, with over 3,600 of those in Northern Virginia.

Sunday's startling jump to 9,914 new cases reported statewide reflected an increase of more than 3,000 from the prior record of 6,757, set Saturday. No previous day had more than 5,800 new cases reported.

The Virginia Department of Health said the huge two-day weekend surge -- over 16,000 total cases -- was not due to a reporting lag, as has been the case at several other points during the pandemic.

"This increase is likely due to exposures during the holidays, similar to after Thanksgiving. VDH reminds Virginians to be vigilant and use the recommended guidance to prevent the spread of COVID-19," the department said.

The health department has emphasized that case numbers based on when patients first report symptoms is a more accurate measure of the spread of the virus. That data currently show a peak of 4,463 cases on Jan. 4, but those numbers tend to increase as more cases are reported and can lag for several weeks.

Regardless, the huge new numbers reported over the past two days drove the state's seven-day average to a new high of 5,778.4. In Northern Virginia, the 3,678 new cases reported Sunday -- more than 2 1/2 times the prior one-day record -- raised the region's seven-day average to a new high of 1,552.6.

Fairfax County alone reported 1,485 cases on Sunday, and Prince William County reported 1,356. Those two localities have the most total cases of any jurisdiction in the state.

Three other health regions in Virginia set one-day records for new cases on Sunday: the Central region at 2,107, the Eastern region at 1,784, and the Southwest region at 1,328. Only the Northwest region didn't set a one-day record.

The record case numbers come amid concern that vaccine shipments are not going to meet the state's expectations over the next few months. Gov. Ralph Northam has set a short-term goal of administering 25,000 vaccinations a day, growing to 50,000, but state health officials said during a news briefing Saturday that based on current information it could take months for the state to receive enough vaccine doses to meet that target.

As of Sunday morning, the health department's vaccine dashboardshows that the state has received 943,400 doses of the vaccine and administered 316,812. A total of just over 33,000 Virginians have received the two doses required for the vaccines to be fully effective, while about 283,000 have received at least one dose. The state has about 500,000 people in the first tier of vaccinations, which would require about 1 million doses. Over 4 million Virginians are in the first three tiers, requiring more than 8 million doses.

In new modeling released Friday, the Biocomplexity Institute at the University of Virginia said that if the vaccine rollout is slower than expected - coupled with "pandemic fatigue" - the state could see increasing numbers of new cases until April, when numbers would peak at 75,000 a week. If vaccines continue to roll out on schedule and Virginians follow mitigation guidelines, however, cases should peak at around 48,000 a week in early February.

The U.Va. report, however, is based on data through last Monday, so does not take into account the huge two-day surge seen this weekend.

Deaths related to COVID-19 continue to remain high statewide, with 50 reported Saturday and 23 on Sunday. In Northern Virginia, seven new deaths were reported Saturday and one on Sunday. Of those, two apiece were in Fairfax, Loudoun and Prince William counties, one in Alexandria and one in Arlington County.

SOURCE: Virginia Department of Health

Possibly the only slightly positive sign to come out of the weekend's COVID-19 reports is hospitalizations tracked by the Virginia Hospital and Healthcare Association. After peaking at 3,209 patients statewide on Wednesday, they have declined every day and stand at 3,058 on Sunday. That's actually two patients fewer than a week earlier, the first time a week-over-week decline has been seen in several months.

The state has reported the results of over 76,000 diagnostic tests in the past two days, and despite the high numbers of new cases, positivity rates continue to trend downward slowly from highs seen just after the new year.

SOURCE: Virginia Department of Health

LATEST COVID-19DATA

New Cases/Deaths

Northern Virginia: 3,678 new cases, 1 new death.

Statewide: 9,914 new cases, 23 new deaths.

Statewide Testing: 42,583 PCR diagnostic test results.

Overall Total

Northern Virginia: 126,316 cases, 1,512 deaths

Statewide: 439,305 cases, 5,729 deaths

Statewide Testing: 4.81 million PCR diagnostic tests(5.88 million when including antibody and antigen tests)

Multisystem Inflammatory Syndrome in Children (MIS-C) cases: 13

*Provided byVirginia Department of Health.The health department's COVID-19 data is updated each morning by 10 a.m. and includes reports by local health agencies before 5 p.m. the previous day.

Statewide Hospital and Nursing Home Data

Hospitalizations: 3,058 (down from 3,119 the previous day)

Peak Hospitalizations: 3,209 reached Jan. 13

Patients in ICU: 566 (up from 561 the previous day)

Patients Discharged: 35,276 total

*Provided byVirginia Hospital and Healthcare Association

For updated national and international COVID-19 data, visit theJohns Hopkins University coronavirus dashboard.

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Virginia COVID-19 cases spike to daily high of nearly 10000; over 3600 in Northern Virginia - Inside NoVA

One more dead from COVID-19 in Wisconsin; 50 newly hospitalized – WKOW

January 18, 2021

MADISON (WKOW) -- One more person was added Sunday to the total of those who have died in Wisconsin because of COVID-19, according to the latest numbers from the Wisconsin Department of Health Services.

Deaths for each day arereported by DHS HERE.

DHS also reported 50 people were newly-hospitalized.

As of Saturday afternoon, 911COVID-19 patientswere being treated in Wisconsin hospitals, down 42 from the day prior.

Of those, 212 are in the ICU, down 15 from the day before,according to the Wisconsin Hospital Association.

There have been 1,606 positive COVID-19 tests since yesterday in Wisconsin and 5,068 negative results.

(CLICK HERE FOR THE FULL DHS DASHBOARD)

The Department of Health Servicesdashboardshows the seven-day average of both positive tests by day and test by person.(CHART)

(App users, see the daily reports and charts HERE.)

Of all positive cases reported since the pandemic began, 490,043 or 93.9 percent, are considered recovered.

DHS now has a county-level dashboard to assess the COVID-19 activity levelin counties and Healthcare Emergency Readiness Coalition regions that measure what DHS calls the burden in each county.View the dashboard HERE.

The Wisconsin Department of Health Services updates the statistics each dayon its website around 2 p.m.

(Our entire coronavirus coverage is available here.)

The new strain of the coronavirus causes the disease COVID-19. Symptoms include cough, fever and shortness of breath. A full list of symptoms is available onthe Centers for Disease Control website.

In severe cases, pneumonia can develop. Those most at risk include the elderly, people with heart or lung disease as well as anyone at greater risk of infection.

For most, the virus is mild, presenting similarly to a common cold or the flu.

Anyone who thinks they may have the disease should call ahead to a hospital or clinic before going in for a diagnosis. Doing so gives the staff time to take the proper precautions so the virus does not spread.

Those needing emergency medical services should continue to use 911.

(County by county results are available here).

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One more dead from COVID-19 in Wisconsin; 50 newly hospitalized - WKOW

Equitable recovery from COVID-19: Bring global commitments to community level – World – ReliefWeb

January 18, 2021

Summary box

High level speakers at the December 2020 United Nations General Assembly pointed to the growing inequalities and stress to health, social, economic and democratic systems caused by COVID-19, calling for a range of collective interest driven responses and measures for a sustainable recovery.

The pandemic, lockdown and other responses, along with underfunded, poorly prepared and overstretched public sector social and health systems in many countries worsened many dimensions of family, womens, child and adolescent health and well-being that were already facing deficits, generating a rising health and social debt in communities, the true scale and long-term consequences of which are as yet unknown, especially for the most marginalised in society.

Rather than getting back to normal, recovery and reset demands change to tackle the inequalities, conditions, services, socioeconomic and environmental policies that made people susceptible and vulnerable to COVID-19.

While economic recovery should not replicate the features of the global economy that are generating pandemic and other crises, for global aspirations to translate into benefit for communities, families, young people and children, an equitable recovery should include significant investment in: (1) universal, public sector, primary health care-oriented health services; (2) redistributive, universal rights-based and life course based social protection; and (3) people, especially in early childhood and in youth, as drivers of change.

Who designs the reset influences the change, and within countries and internationally, opportunities must be provided for meaningful public engagement as a critical driver of an equitable recovery.

Introduction

One after the other, high-level speakers at the 2020 United Nations General Assembly (UNGASS) on COVID-19 pointed to growing inequalities and stresses to health, social, economic and democratic systems caused by the pandemic, calling for comprehensive, collective interest driven responses. They called for a sustainable recovery to include: debt relief and international financing; ensuring food security; universal access to vaccines, diagnostics and medicines for COVID-19 as global public goods; military ceasefires to reach populations in conflict areas; and halting ecological determinants of zoonotic pandemics.

These issues will be on international agendas into 2021 and beyond. However, global commitments must translate into benefit for local communities for any recovery to tackle the inequalities and conditions that made society vulnerable to COVID-19, particularly for those experiencing its worst impact.

In this commentary, we examine how COVID-19 has impacted on family and child health and well-being (FCHW) and the implications for a bottom-up recovery. We propose significant investment in universal, public sector, community-driven health and social protection systems to connect measures called for globally with those needed to ensure equitable recovery within communities.

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Equitable recovery from COVID-19: Bring global commitments to community level - World - ReliefWeb

NBA COVID19 Tracker: Attempting to keep up with cases and outbreaks in the NBA – SLC Dunk

January 18, 2021

In the last week the NBAs battle to play a season out in the wild with COVID19 started to look daunting. With every passing hour, either Shams or Woj was breaking news that another team was experiencing an outbreak amongst their players and personnel. Thirteen games have now been postponed due to COVID19 and more will most likely be on the way due to a new outbreak in the Minnesota Timberwolves locker room. It has become a head spinning task to keep up with all the notifications so I created a tracker to help out.

Below youll see that you can search by team to see the players that have been in Health and Safety Protocols. Those who qualify have to have been in the system for more more than 24 hours. Thats why you wont see Joe Ingles for the Utah Jazz, but you will see his teammate Juwan Morgan. Data was pulled from the NBAs injury report so it becomes a little messy when games are postponed. Teams will disclose who is in or out of the NBAs Health & Safety Protocols when a game is played, but when a game is postponed that information will not be disclosed. To get around that I used the qualification that states use whenever there are probable cases, if youre told to stay home and not be around people, youre a probable case. Players on teams with outbreaks that played any minutes in the game before postponement are cautiously overcomunted as quarantined.

If you notice any players who have been in the protocols but are not showing in the dashboard, just say so in the comments with the players name and when they were listed as having COVID this season or when they were listed in the NBAs Health and Safety Protocols.

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NBA COVID19 Tracker: Attempting to keep up with cases and outbreaks in the NBA - SLC Dunk

Phil Spector dies after getting COVID-19: Record producer and convicted murderer was 81 – Los Angeles Times

January 18, 2021

For all the hit songs he drove up the charts, for all the power and wealth he amassed, for all the admiration he drew as he rearranged the pop music landscape, there was a darkness deep in Phil Spectors soul that would forever shadow his genius.

Even as anthems such the Ronettes Be My Baby and the Righteous Brothers Youve Lost That Lovin Feelin erupted from radios across America, the acclaimed record producer was a brooding, manic man with a white-hot temper and a fondness for gunplay, all of which would manifest itself on a winter morning in 2003 when he fatally shot actress and nightclub hostess Lana Clarkson in the foyer of his castle-like mansion in Alhambra.

Dispatched to prison after being convicted of second-degree murder, Spector died Saturday while in custody in a Northern California hospital where he was being treated, according to the California Department of Corrections and Rehabilitation. He was 81.

Spector was hospitalized after becoming ill with COVID19, said a source familiar with his medical condition who wasnt authorized to speak publicly on the matter. Before he was transferred to a hospital, Spector had been an inmate at the California Health Care Facility in Stockton, which specializes in housing medically vulnerable people with existing health conditions, the corrections department said.

Its a sad day for music and a sad day for me, said Ronnie Spector, the producers former wife and muse. The magical music we were able to make together was inspired by our love. I loved him madly and gave my heart and soul to him.

But Ronnie Spector added: Unfortunately Phil was not able to live and function outside of the recording studio. Darkness set in. Many lives were damaged.

Though Spectors exact cause of death was not announced, California prisons have been hard hit by COVID-19 and are in the midst of another surge. At least 60 inmates have died from the disease since Dec. 25, including one of Americas most prolific serial killers, Samuel Little.

At the California Heath Care Facility in Stockton, where Spector was housed, 582 prisoners have tested positive, and at least 10 have died. The medical examiner in the San Joaquin County Sheriffs Office will investigate Spectors death, the corrections department said.

Decades removed from his days of glory, Spector was twice tried for Clacksons death, the first trial ending with a hung jury and the second with a conviction.

Clarkson died of a single gunshot wound to the mouth on Feb. 3, 2003, just three hours after meeting Spector at the House of Blues, the Sunset Strip music club where she worked as a hostess.

Prosecutors said Clarkson had her purse slung over her shoulder and was ready to leave Spectors hilltop home, known as Pyrenees Castle, when he shot her. They described her murder as the culmination of a very rich history of violence toward women, with at least five women alleging Spector had menaced them with guns in the decades leading up to the shooting.

Lana Clarkson was a warm, compassionate, kind, loving woman who would be 58 years old now, her family said Sunday in a statement. Her energy, brightness and love of life have sustained her family since her murder 18 years ago.

Spectors subsequent second-degree-murder trials laid bare the producers erratic mood swings, darkening depression and isolation from an industry he once seemed to rule. He was ultimately sentenced to 19 years to life in prison. Stripped of his flamboyance and tassel of dark hair, he appeared to be just another senior citizen in prison photos a balding man with a pair of hearing aids.

But in his prime, Spector was brash, driven and as much a star as the artists he produced. He made the top 10 14 times between 1958 and 1965, created a signature sonic avalanche in the studio known as the Wall of Sound and record by record revolutionized popular music.

In the studio, Spector awoke pop music from its early-1960s doldrums and crafted a sound that would influence record-making for generations, informing the music of such acts as the Beach Boys, Bruce Springsteen, the Beatles, the Rolling Stones and David Bowie.

Though Spector appeared to be out of steam when his first hit era ended in 1966, he returned from seclusion in 1970 to collaborate with the Beatles, producing solo works by John Lennon and George Harrison and reassembling the music that became the groups Let It Be album.

Nobody, its fair to say, ever wrought deeper changes in the way the rock industry looked, felt, behaved.... To come out of a vacuum and force such changes at such speed, with such totality even now its hard to conceive the force and self-belief it must have taken, author Nik Cohn wrote after spending time with Spector in 1969.

Spector was praised by friends for his wit, passion and intelligence, but he was also identified early as a complex and troubled man. In an interview with journalist Mick Brown less than two months before Clarksons slaying, Spector talked about psychological struggles, saying that he was taking medication for schizophrenia and characterizing himself as bipolar. He said he had devils inside him.

People tell me they idolize me, want to be like me, but I tell them, you dont want my life, Spector said. Ive been a very tortured soul. I have not been at peace. I have not been happy.

Harvey Philip Spector was born Dec. 26, 1939, in the Bronx. His father, Benjamin, an ironworker, died by suicide when his son was 9, and three years later his mother, Bertha, moved to an apartment in Los Angeles Fairfax District with Spector and his older sister, Shirley.

Sickly and slightly built, Spector was a social misfit during his first years at Fairfax High School, and at home he endured a stormy relationship with his mother and his sister, who later was committed to a mental institution.

The three bickered constantly, often blaming one another for Benjamins suicide. Bertha was controlling and protective, discouraging her son from having company and going out. Later, she would frequently sit in the studio lounge with a sandwich for him during his recording sessions, but he would ignore her presence.

A natural musician, Spector was at ease with the accordion, French horn and guitar and played at parties and dances with schoolmates and other friends. After graduating from Fairfax High in 1957, he continued to work on music while he studied to be a court reporter at Los Angeles City College.

He approached the owners of Gold Star, a small recording studio at the corner of Santa Monica Boulevard and Vine Street in Hollywood, and paid to record an original song with some Fairfax friends and a younger member of their circle, singer Annette Kleinbard.

The group, the Teddy Bears, hooked up with the small label Dore Records and recorded To Know Him Is to Love Him, an atmospheric, melancholy ballad written by Spector. The title sentiment ran deeper for Spector than for most of the records teenage fans. He took it from the inscription on his fathers grave: To know him was to love him.

The single got off to a slow start; but in 1958, it hit No. 1 on the charts, with sales of more than 1 million.

The Teddy Bears soon faded away. Spector, determined to focus on producing, signed with the respected record business veteran Lester Sill, who sent him to New York.

There, Spector established important alliances with such figures as Atlantic founder Ahmet Ertegun, publishing kingpin Don Kirshner and many of the songwriters who would later supply him with hit material, including the teams of Carole King and Gerry Goffin, Barry Mann and Cynthia Weil, and Jeff Barry and Ellie Greenwich.

Spector produced three top 10 hits Ray Petersons Corrine, Corrina, Gene Pitneys Every Breath I Take and the Paris Sisters I Love How You Love Me. In 1961, he and Sill founded Philles Records, a company designed to give the partners full creative control and distribution independence.

Their first signing was the Crystals, a vocal quintet from Brooklyn whose Philles hits included Theres No Other (Like My Baby) and Uptown.

Hes a Rebel, Spectors first No. 1 record with Philles, was also credited to the Crystals, though the singers were actually an L.A. session trio known as the Blossoms. That billing illustrated Spectors priorities: The song and the production took precedence over the artists.

During his 1962 flurry of hits, Spector honed his fabled Wall of Sound methodology. Up to half a dozen guitars strummed chords in unison. Then came two, and sometimes three or more, pianos. In the small Gold Star studio, the instruments bled together, the texture so thick that the horn and string arrangements were almost subliminal, absorbed into the great sonic mass.

A firm drumbeat and dramatic flourishes castanets, chimes, maracas added to the grandeur. Yet Spector was able to keep the focus on the lyrics of youthful love and desire, sung with soulful fervor by his interchangeable vocalists, including the Crystals Barbara Alston and LaLa Brooks, the Blossoms Darlene Wright (later Darlene Love) and the Ronettes Veronica Bennett, better known as Ronnie.

He fostered a core of studio musicians who became known as the Wrecking Crew, many of them highly respected jazz and session players. Among his regulars were Don Randi, Glen Campbell, Leon Russell, Hal Blaine, Sonny Bono and Oscar-winning arranger Jack Nitzsche.

A driven, demanding perfectionist, Spector presided over sessions that were part party, part endurance test, part psychodrama. He would take the tapes home and labor on the mixing process for weeks.

The record often regarded as Spectors first masterwork was 1963s Be My Baby by the Ronettes, a New York trio whose lead singer, Bennett, utterly fascinated the producer.

Spector bought out Sill in 1962 to become Philles sole owner. In six years, he had gone from high school nobody to the hottest name in popular music.

Spector reveled in his celebrity, dressing flamboyantly, flaunting his success and delighting in public confrontations. He hobnobbed with the Beatles and the Rolling Stones in London, surrounded himself with bodyguards and was the subject of one of Tom Wolfes earliest pieces of new journalism, The First Tycoon of Teen, a portrait of youthful excess.

Things tailed off commercially for Philles in 1964, but Spector came roaring back with a white soul-singing duo from Orange County called the Righteous Brothers. Their epic lament Youve Lost That Lovin Feelin' reached No. 1 in early 1965 and eventually was proclaimed the most played song in the history of radio.

Three more Righteous Brothers hits led Spector to his culminating work of the 60s, a record whose ambition and grandeur cemented his artistic legacy and whose commercial failure drove him into seclusion.

Ike & Tina Turners River Deep Mountain High subjected singer Tina Turner to his most ornate and tempestuous production, and she responded with a fierce, frenzied performance. The idiosyncratic record took his sound as far as it could possibly go, and when it stalled at No. 86 on the U.S. chart in 1966, Spector walked away. Philles became inactive, and its owner retreated to his Spanish-style mansion in Beverly Hills near the Sunset Strip.

Spector was hit hard by the 1966 drug overdose death of controversial comedian Lenny Bruce, a close friend and artistic hero. He sampled the film world, serving briefly as producer of his friend Dennis Hoppers ill-fated The Last Movie. He later appeared as a cocaine dealer with Hopper and Peter Fonda in Easy Rider.

After he divorced, Spector married Bennett in 1968. It was a turbulent relationship, and the singer would later allege that she was virtually a prisoner in their home, subjected to abuse and threats by her combustible husband. The couple divorced in 1974. A well-known teetotaler through his early career, Spector began to drink heavily.

He finally returned to music and produced Lennons 1970 single Instant Karma, then stepped in to salvage the music the Beatles had recorded for their final album.

The group had abandoned the tracks as the members moved toward their breakup, and Spector snipped, spliced and augmented the recordings, adding strings and horns to several songs. His lush orchestration on The Long and Winding Road was a polarizing arrangement. McCartney hated it, and the reviews were mixed, but the song was a No. 1 single, and the album, Let It Be, also topped the charts.

Spector stayed on in London and produced Lennons first two solo albums as well as George Harrisons All Things Must Pass and the Grammy-winning The Concert for Bangladesh. But by now, Spector was no longer the star in the studio. Though there were distinctive Spector touches, especially in Harrisons debut, he tailored his technique to the music, abandoning his big sound on Lennons Plastic Ono Band and Imagine.

Back in L.A., Spector undertook the production in Los Angeles of Lennons album Rock n Roll, which turned into a chaotic, alcohol-fueled fiasco infamous for Spectors firing a gun at the studio ceiling.

Spector struck a partnership with Warner Bros. Records in the mid-70s and worked with Cher, Darlene Love and Dion DiMucci. More notably, he produced Leonard Cohens Death of a Ladies Man, the raucous, contentious sessions yielding an eccentric hybrid of Cohens poet-pop and Spectors bombast.

His last complete album production was the Ramones 1980 release, End of the Century. He then withdrew again.

In his first formal interview in 14 years in 1991, Spector explained his seclusion and his efforts to emerge in the late 80s.

I needed to get a focus, he told The Times. For a long time, I just didnt know how I wanted to spend my life.... It was after Elvis died and John [Lennon] ... and there was all that disco, and you just sort of lose interest for a while.

I just said, Im going to turn this around. Cause if I really am any kind of genius, I should be able to do [at least] that.

Spectors return began tentatively, when he appeared at a 1988 Nashville ceremony honoring To Know Him Is to Love Him, whose recording by Emmylou Harris, Linda Ronstadt and Dolly Parton was named BMIs song of the year.

In 1989, he was inducted into the Rock and Roll Hall of Fame, and he compiled Back to Mono, a box set anthology of his recordings that came out in 1991.

Though deeply affected by the death of his 10-year-old son, Phillip Jr., from leukemia, Spector seemed socially outgoing again, without the bodyguards and confrontational attitude that had punctuated his forays in public as a younger man. He began hosting an annual party at an old-fashioned bowling alley in suburban Montrose, and he regularly held court in his home with friends.

But everything darkened again the night of Feb. 2, 2003, when Spector went out on the town in West Hollywood and Beverly Hills. Witnesses recalled Spector downing cocktails as he moved from restaurant to restaurant.

He ended the evening at the House of Blues on the Sunset Strip, where Clarkson worked as a hostess. At closing time, she helped him to his car, and after some persuasion she agreed to accompany him to his home after her shift.

On the way to Spectors castle-like estate in Alhambra, Clarkson told his driver, Adriano De Souza, that she planned to leave after one drink.

De Souza was sitting in the black Mercedes-Benz in the estates driveway when he heard a popping sound about 5 a.m.

According to his trial testimony, Spector emerged from the house holding a handgun.

I think I killed somebody, he said.

When L.A. County sheriffs deputies arrived, Spector had to be subdued with a Taser.

Nobodys taking my gun, he reportedly said.

Clarksons body was sprawled in a chair. Her broken teeth lay scattered around the foyer and a nearby stairway, and blood was smeared on the wood railing of the stairway and the back door handle. Detectives also discovered blood on a mans coat in an upstairs dressing room and found a blood-soaked cloth in a bathroom near the foyer, court papers said.

Spector was booked on suspicion of murder and released on $1-million bail.

According to testimony before a Los Angeles County grand jury, Spector told police that he shot the actress by accident, but later changed his story and said she had killed herself.

Clarkson had appeared in small roles on television series including Threes Company, Night Court and The A-Team, and was a cult heroine after playing the title role in the 1985 period adventure Barbarian Queen.

At Spectors trial for second-degree murder in April 2007, defense attorney Bruce Cutler argued that Clarkson was despondent over the state of her career and contended that her death was an accidental suicide.

Prosecutors disputed that portrayal and emphasized Spectors history of threatening women with guns, but the jury deadlocked. A second trial opened in 2008, and this time Spector was convicted.

On May, 30, 2009, he received a mandatory life sentence, with eligibility for parole in 2028. He was 69 at the time.

Before Spectors sentencing, Clarksons mother, Donna, a constant presence at both trials, told the judge that her heartbreak over her daughters death was intensified because of the way she was portrayed in court.

Donna Clarkson, dressed in a black suit adorned with a ribbon of leopard skin her daughters favorite fashion accent said she often wanted to interrupt the proceedings to defend her daughters memory.

I am very proud of Lana and the wonderful and special person she was, she said. Her voice choking, she added: All our plans together are destroyed. Now I can only visit her in the cemetery.

I miss you so, she whispered.

Four months after Spector was sentenced, Sony Music Entertainment and EMI Music Publishing announced a licensing deal to reissue records from the Philles catalog through Sonys Legacy Recordings.

Despite that revival, Spector knew too well that a bad ending could overshadow a revolutionary body of work.

I dont want to be Elvis, or Lenny Bruce, he said in an interview in the early 1990s. Do you think people will remember their genius or the way they died on the bathroom floors?

Cromelin is a former Times staff writer. Times staff writers Harriet Ryan, Anna Gorman and Steve Marble contributed to this article.

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Phil Spector dies after getting COVID-19: Record producer and convicted murderer was 81 - Los Angeles Times

France may demand rapid COVID-19 test from Irish truck drivers: Irish minister – Reuters

January 18, 2021

DUBLIN (Reuters) - France is considering requiring rapid COVID-19 tests from Irish truck drivers operating on a logistics route that has become key since Britains exit from the European Union, Irelands transport minister said on Sunday.

Large numbers of Irish trucks have begun transporting goods via ferries to France in recent weeks to avoid delays in the more traditional route to continental Europe via Britain, which withdrew from EU trading rules on Jan. 1.

The new measures would be targeted at a more infectious variant of the coronavirus first discovered in England but that has become widespread in Ireland.

Transport Minister Eamon Ryan told RTE that France was considering demanding a PCR COVID-19 test, which can take several days, from most Irish travellers. Ireland is demanding similar tests from all arriving passengers.

France is also considering demanding a much quicker antigen test, which can give results in minutes, from Irish truck drivers.

If the French government comes back with that requirement, we would have to manage that and make sure we can do it in a way that doesnt disrupt supply chains, Ryan told RTE radio. That would be demanding but I am confident we will be able to do it.

A demand from France for COVID-19 tests from British drivers caused significant delays and trade disruption in December.

France on Friday announced that people travelling from non-EU countries to France would be required to present negative PCR COVID-19 test, but that an antigen test would be sufficient from British truck drivers.

Ireland is a member of the European Union, but not of the Schengen free travel area.

Frances European Affairs minister Clement Beaune said on Sunday that Paris would be holding consultations this week to strengthen control measures within the European area.

But he warned it may be difficult to accept rapid antigen tests from Irish drivers.

Between France and Ireland, PCR tests work because we have the same ones; antigenic tests do not work because Ireland does not yet recognise them, he said.

Reporting by Conor Humphries; Additional reporting by John Irish; Editing by Toby Chopra and Susan Fenton

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France may demand rapid COVID-19 test from Irish truck drivers: Irish minister - Reuters

Watch New Yorkers Share Stories of Those They Lost to COVID-19 – THE CITY

January 18, 2021

Kenneth Alston Jr. sang a hymn for his grandmother Etta B. Alston.

Digna Lebron read a poem she wrote for her son, nicknamed Tito.

Maryann McKenzie talked about how COVID-19 took her partner in crime her 33-year-old son Luke.

These were just a few of the people who joined THE CITYs MISSING THEM Memorial Event last month to honor New Yorkers lost to the pandemic. They signed on to Zoom and told stories of their loved ones, lit candles, read poems, shared photos, laughed, cried and connected with hundreds of other folks there to listen.

The event marked an extension of THE CITYs effort also called MISSING THEM to find every New Yorker who died due to COVID-19 and write an obituary for them. Nearly 26,000 New Yorkers have died due to the virus, with cases on the rise again since November.

This collaborative project powered by volunteers, journalism schools, cultural institutions and New York residents has verified nearly 2,000 names, or less than 8% of those who died in the city, and has produced nearly 300 obituaries.

Over the course of the three-day virtual event, held Dec. 11 to Dec. 13, we set out to provide folks with different spaces to connect with one another, to honor their loved ones and share the many griefs brought on by the pandemic.

The free virtual gatherings, organized with community partners, included eight sessions.

The response was overwhelming: About 750 people joined via Zoom including members of 29 families who shared stories of the loved ones lost. Here are a few:

You can view all of the stories shared here.

The main focus of the event was to bring families together to share stories of their loved ones and to provide a community to bear witness. We also wanted to offer a variety of ways for folks to participate and sometimes just listen.

Our opening night featuring poetry readings from Ellen Bass, Ross Gay and Aracelis Girmay saw folks tune in from across the five boroughs, as well as California, Oregon, Wyoming, Vermont, North Carolina, New Jersey, Washington, Massachusetts, Idaho, Canada, Thailand and more.

The readings were followed by the presentation of a poem written by New Yorkers from Brooklyn Public Librarys Poetry of Comfort class. The community poem was created based on dozens of obituaries written by THE CITYs MISSING THEM writers.

We also held two theatrical performances over Zoom.

On the afternoon of Dec. 12, before families shared stories, actor and director Reza Salazaar, along with six actors, performed a virtual play, titled MISSING THEM, inspired by more than a dozen interviews conducted by reporters who wrote obituaries for the digital memorial.

The next afternoon, the theater company What Will The Neighbors Say? performed Our Grief Our Lives, a play based on stories written by community members during an event workshop just 24 hours earlier.

The WWTNS? team had guided about 50 folks through a series of writing exercises to help them write their own stories. Folks were encouraged to write letters to their pre-pandemic March self, explore different objects around them, and make a list of what they did the day before.

Then, in the span of just about 24 hours, WWTNS? took that material, with permission, and turned it into a script that was presented by professional actors.

We also held a roundtable to discuss mental health, wellness and trauma during the pandemic with panelists Rev. Willard Ashley, psychologist Julie Colwell and meditation teacher Francesca Maxim. You can watch the discussion here and get more mental health resources here.

THE CITYs MISSING THEM project is part of a growing movement to create memorials and hold vigils to remember those who died due to COVID-19 in New York.

We heard from artist Andrea Arroyo, who developed CoVIDA, as well as from representatives from the Morris Jumel Mansion, Care For The Homeless , Urban Pathways and Naming The Lost Memorials. You can see pictures of the work the group have done and the people theyve brought together here.

Over the course of the weekend, more than 60 lives lost to COVID-19 were honored either by family members or through performances. Since the event, weve heard from dozens of people about how important it is to provide spaces like this for families to share and for people to listen.

It was only about 60, though, of the more than 25,000 weve lost so far. Its our hope to continue this MISSING THEM series of storytelling events that bring families, friends, neighbors and New Yorkers together to share and celebrate the lives of all weve lost.

This has been a very moving experience, one attendee wrote in the Zoom chat. Id just like to express my thanks to everyone who has spoken so movingly about their loved ones. I lost a colleague ... in March and I still feel the loss. Being here with everyone has helped me with my own sense of loss. Goodnight to all.

If youd like to share a story of someone youve lost due to COVID-19 at the next MISSING THEM Memorial Event (timing still to be determined), fill out the questionnaire below, leave us a voicemail at (646) 494-1095 or text remember to 73224.

If youd like to help out in some other way, email us at memorial@thecity.nyc.

Partners for THE CITYs MISSING THEM Memorial Event included Brooklyn Public Library, What Will The Neighbors Say?, Reimagine End of Life, Interfaith Center of New York, Morris Jumel Mansion, Care For The Homeless , Urban Pathways, Naming The Lost Memorials and a number of independent actors and performers.

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Watch New Yorkers Share Stories of Those They Lost to COVID-19 - THE CITY

A more contagious strain of COVID-19 hasn’t been found in Alaska yet. But it could be lurking. – Anchorage Daily News

January 18, 2021

Alaska has yet to detect a new, highly contagious variant of the coronavirus, but that doesnt mean the strain isnt already here, state health officials said.

The new strain, which was originally identified in the United Kingdom, hadnt been detected in Alaska as of Saturday, according to state health officials.

Researchers estimate that the U.K. variant spreads about 50% more between people compared with the more common strain. That means someone infected with the variant has a higher likelihood of spreading it to someone else close by.

What does this mean in terms of mitigation strategies? state epidemiologist Dr. Joe McLaughlin asked on a recent call with reporters. Basically, what it means is people just need to remain vigilant.

Just because officials havent identified new, emerging strains in Alaska yet doesnt mean that, for example, the U.K. strain is not here yet, McLaughlin said. It could be here; we just havent detected it yet.

Existing health practices mask-wearing, hand-washing and staying 6 feet from others are super important, he said. If the U.K. strain is circulating in Alaska and people forget to follow those measures or stop altogether, theres a much bigger chance that the virus could hop to someone else within range, he said.

Scientists dont think that the new strain can make someone sicker, but theres a ripple effect if greater transmission of the virus occurs within the community. More COVID-19 cases can drive up the number of people seeking medical care. That, in turn, can strain the health care system and lead to more deaths.

While its good that Alaskas COVID-19 cases have recently decreased compared with previous months, its still possible that the new variant could drive up those numbers once again, Lorne Carroll, a public health nurse in Homer, said recently.

We should all assume that these variants are circulating pretty broadly in the United States, Jayme Parker, chief of the section of public health labs, said last week.

The state of Alaska has been sequencing COVID-19 cases since March, which is a way to look for the new variants. But now, the state is trying to ramp up its search, Parker said. The state lab is trying to join forces with university scientists in Anchorage and Fairbanks in order to increase capacity.

The United Kingdom has sequenced around 5% to 6% of its cases, Parker said. Thats still fairly low, but the process is both expensive and laborious. In the U.S., there isnt as much visibility on which variants may be circulating here because less than half of 1% of cases have been sequenced.

But in Alaska, roughly 4% to 5% of cases have been sequenced, Parker said. That puts Alaska on par with the U.K.s sequencing efforts and more than four times ahead of what the country is doing nationally.

Lisa Smith, who oversees the sequencing department at the state virology lab in Fairbanks, said the specimens they sequence only come from state public health labs in Anchorage and Fairbanks which test roughly a third of all samples getting collected in the state. But, Smith said, even among those samples, they put an emphasis on choosing specimens from across Alaska, as a way to know whats circulating in different corners of the state.

Parker, with the state public health labs, emphasized that while scientists expect the coronavirus to continue producing new variants, the same strategies that worked originally to stop virus spread will continue to do so. Thats why its important, she said, to keep wearing masks, physically distancing and continue good hand washing.

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A more contagious strain of COVID-19 hasn't been found in Alaska yet. But it could be lurking. - Anchorage Daily News

Immunological characteristics govern the transition of COVID-19 to endemicity – Science

January 16, 2021

Abstract

We are currently faced with the question of how the CoV-2 severity may change in the years ahead. Our analysis of immunological and epidemiological data on endemic human coronaviruses (HCoVs) shows that infection-blocking immunity wanes rapidly, but disease-reducing immunity is long-lived. Our model, incorporating these components of immunity, recapitulates both the current severity of CoV-2 and the benign nature of HCoVs, suggesting that once the endemic phase is reached and primary exposure is in childhood, CoV-2 may be no more virulent than the common cold. We predict a different outcome for an emergent coronavirus that causes severe disease in children. These results reinforce the importance of behavioral containment during pandemic vaccine rollout, while prompting us to evaluate scenarios for continuing vaccination in the endemic phase.

Humans have regularly been threatened by emerging pathogens that kill a substantial fraction of all people born. Recent decades have seen multiple challenges from acute virus infections including SARS, MERS, Hendra, Nipah and Ebola. Fortunately, all were locally contained. When containment is not immediately successful, as is likely for the novel betacoronavirus SARS CoV-2 (CoV-2) (1, 2), we need to understand and plan for the transition to endemicity and continued circulation, with possible changes in disease severity due to virus evolution and build-up of host immunity and resistance.

CoV-2 is an emerging virus that causes COVID. The virus has a high basic reproductive number (R0) and which is transmissible during the asymptomatic phase of infection, both of which make it hard to control (3). However, there are six other coronaviruses with known human chains of transmission, which may provide clues to future scenarios for the current pandemic. There are four human coronaviruses (HCoVs) that circulate endemically around the globe; they cause only mild symptoms and are not a significant public health burden (4). Another two HCoV strains, SARS CoV-1 and MERS, emerged in recent decades and have higher case fatality ratios (CFRs) and infection fatality ratios (IFRs) than COVID-19 but were contained and never spread widely (5, 6).

We propose a model to explore the potential changes in both transmission and disease severity of emerging HCoVs through the transition to endemicity. We focus on CoV-2 and discuss how the conclusions would differ for emerging coronaviruses more akin to SARS and MERS. Our hypothesis is that all HCoVs elicit immunity with similar characteristics, and the current acute public health problem is a consequence of epidemic emergence into an immunologically nave population in which older age-groups with no previous exposure are most vulnerable to severe disease. We use our estimates of immunological and epidemiological parameters for endemic HCoVs to develop a quantitative model for endemic transmission of a virus with SARS-CoV-2 -like characteristics, including the age-dependence of severity. Our model explicitly considers three separate measures for immune efficacy that wane at different rates (fig. S1).

Building on ideas from the vaccine modeling literature, immunity may provide protection in three ways (7). In its most robust form, sterilizing immunity can prevent a pathogen from replicating, thereby rendering the host refractory to reinfection. We term this property immune efficacy with respect to susceptibility, IES. If immunity does not prevent reinfection, it may still attenuate the pathology due to reinfection (IEP) and/or reduce transmissibility or infectiousness (IEI). Indeed, experimental reexposure studies on endemic HCoVs provide evidence that the three IEs do not wane at the same rate (8, 9). Callows experimental study (8) shows that reinfection is possible within one year (relatively short IES); however, upon reinfection symptoms are mild (high IEP) and the virus is cleared more quickly (moderate IEI). Details on the derivation of the model can be found in section 2 of the supplementary materials (SM).

We reanalyze a detailed dataset that estimates age-specific seroprevalence based on both IgM (acute response) and IgG (long-term memory) against all four circulating HCoVs in children and adults (10) to estimate parameter ranges for transmission and waning of immunity (see Fig. 1A). The rapid rise in both IgM and IgG seroprevalence indicates that primary infection with all four endemic HCoV strains happens early in life, and our analysis of these data gives us an estimate for the mean age of primary infection (MAPI) between 3.4 and 5.1 years, with almost everyone infected by age 15 (see SM section 1 for details). The absence of detectable IgM titers in any individual over the age of 15 years suggests reinfections of adults causes a recall response, indicating that while CoV specific immunity may wane it is not lost. Whether immunity would wane to nave levels in the absence of high pathogen circulation remains an open question.

(A) Mean proportion seropositive for IgG (green, top lines) and IgM (purple, bottom lines) against the four endemic HCoV strains [dots connected by dashed lines; vertical lines represent the 95% CI; data from Zhou et al. (10)]. The mean age of primary infection (MAPI) based on IgM data with 95% CI is shown in text inside each panel (see SM for details). (B) MAPI as a function of waning of sterilizing immunity (, y axis) and transmissibility of reinfections (, x axis). The MAPI was calculated from the equilibrium dynamics of the model shown in fig. S1 and supplementary equations 3 to 9 with a plausible basic reproductive number (R0 = 5) and 0 < < 2 and 0 < < 1. See SM section 2.1 for details. The white band in indicates the plausible combinations of values of and consistent with the MAPI for HCoVs estimated in (A). [See fig. S1 for parallel figures calculated at extreme plausible values for R0 (i.e., R0 = 2 and R0 = 10).]

For most people to be infected so early in lifeyounger even than measles in the pre-vaccine erathe attack rate must exceed transmission from primary infections alone. The model shows a high attack rate can arise from a combination of high transmissibility from primary infections (i.e., high R0), waning of sterilizing immunity and significant transmission from reinfections in older individuals. The rapid waning of sterilizing immunity is also reported in experimental HCoV infections of humans which showed that reinfection is possible 1 year after an earlier infection, albeit with milder symptoms (IEP) and a shorter duration (IEI) (11). Figure 1B shows the plausible combinations of waning immunity and transmission from reinfected individuals that are required to produce the MAPI observed in Fig. 1A, based on steady-state infection levels (see SM section 2.1 for details). Table 1 shows the ranges of the parameters used in our simulations.

Characteristics of coronavirus-immune interactions and relevant parameter ranges.

At the beginning of an outbreak, the age distribution of cases mirrors that of the population (Fig. 2A). However, once the demographics of infection reaches a steady state, our model predicts primary cases occur almost entirely in babies and young children, who in the case of COVID-19, experience a low CFR and a concomitantly low infection fatality ratio (IFR). Reinfections in older individuals are predicted to be common during the endemic phase and contribute to transmission, but in this steady-state population, older individuals, who would be at risk for severe disease from a primary infection, have acquired disease-reducing immunity following infection during childhood. The top panel of Fig. 3B illustrates how the overall IFR for CoV-2 drops dramatically, eventually falling below that of seasonal influenza (approximately 0.001) once the endemic steady-state is reached.

Transition from epidemic to endemic dynamics for emerging HCoVs, simulated from an extension of the model presented in fig. S1 that includes age structure. Demographic characteristics (age distribution, birth, and age-specific death rates) are taken from the United States, and seasonality is incorporated via a sinusoidal forcing function (see SM section 2.2). Weak social distancing is approximated by R0 = 2. (See figs. S9 to S11 for strong social distancing results, R0 < 1.5.) (A) Daily number of new infections (black line, calculations in SM section 2.3). An initial peak is followed by a low-incidence endemic state (years 5 to 10 shown in the inset). A higher R0 results in a larger and faster initial epidemic and more rapid transition to endemic dynamics. The proportion of primary cases in different age groups changes over time (plotted in different colors), and the transition from epidemic to endemic dynamics results in primary cases being restricted to younger age groups. Parameters for simulations: = 1 and = 0.7. (B) Time for the average IFR (6-month moving average) to fall to 0.001, the IFR associated with seasonal influenza. Gray areas represent simulations where the IFR did not reach 0.001 within 30 years. The time to IFR = 0.001 decreases as the transmissibility (R0) increases and the duration of sterilizing immunity becomes shorter. Results are shown for = 0.7. See SM section 2.3 and figs. S4 to S7 for sensitivity analyses and model specifications.

The age dependence of the IFR determines how the overall IFR changes during the transition from epidemic to endemic dynamics for emerging CoVs. (A) Age dependence of the IFRs for the three emerging CoVs. Primary infections with MERS and CoV-1 are consistently symptomatic and the IFR and CFR are therefore assumed to be the same. CoV-1 and CoV-2 have J shaped profiles, with a monotonic increase in IFR with age. The age-specific IFR for MERS is U shaped, with high mortality in the young and old age groups. Details of the statistical smoothing are described in SM section 6. (B) The overall IFR changes during the transition to endemic dynamics. These calculations assume deaths due to reinfections are negligible. We relax this assumption to allow for a slower build-up of immunity and possible death due to secondary infection in figs. S5 to S9 and show the qualitative results do not change.

The time it takes to complete the shift in IFR as endemicity develops depends on both transmission (R0) and loss of immunity ( and ), as is shown in Fig. 2B and fig. S4. The transition from epidemic to endemic dynamics is associated with a shift in the age-distribution of primary infections to lower age groups (Fig. 2A). This transition may take anywhere from a few years to a few decades depending on how fast the pathogen spreads. The rate of spread, measured by R0, is determined by a combination of viral properties and the frequency of social contacts, and may therefore be reduced by social distancing. The top panel shows the effect of reducing R0 to 2, whereas the middle and bottom panels show the dynamics for higher R0, which are more akin to those of CoV-2 in the absence of control measures. If transmission is high, the model predicts a high case load and death rate in earlier years following emergence (Fig. 2 and fig. S5). In Fig. 2B we see that, as might be expected, longer lasting sterilizing immunity slows down the transition to endemicity.

These results are robust to a more biologically realistic distribution for the duration of sterilizing immunity and the possibility that the generation of protective immunity requires more than one infection (see SM section 3 and figs. S5 to S9).

Slowing down the epidemic through social distancing measures that reduce R0 to close to one flattens the curve, thus delaying infections and preventing most deaths from happening early on, affording critical time for the development of an effective vaccine (fig. S10). If vaccine-induced IES and IEP immunity is similar to that induced by HCoV infections, the vaccine may usher in the endemic regime more quickly. The model code (see acknowledgments) provides a flexible scaffolding for studying alternative vaccination scenarios. Notably, the model predicts that once the endemic state is reached, mass vaccination may no longer be necessary to save lives (see SM section 4 and fig. S11).

We can extend our predictions to two other potentially emerging coronavirus infectionsSARS and MERS. Our model predicts that in the endemic state the IFR of a circulating CoV depends primarily on the severity of childhood infections. In the case of CoV-1, which is more pathogenic than CoV-2, we still expect a low disease burden in the endemic phase because CoV-1, like CoV-2, has a low IFR in the young (Fig. 3). However, data suggest not all emerging HCoVs follow this optimistic pattern; the overall IFR of an endemic MERS-like virus would not decrease during the transition to endemicity as seen in Fig. 3B, and this is because disease severity (and IFR) is high in children, the age group expected to experience the bulk of primary cases during the endemic phase. In the endemic phase, a vaccination program against MERS would therefore be necessary to avoid excess mortality (fig. S11).

The key result from our new model framework that explicitly recognizes that functional immunity to reinfection, disease and shedding are different is that, in contrast with infections that are severe in childhood, CoV-2 could join the ranks of mild, cold-causing endemic human coronaviruses in the long run. A critical prediction is that the severity of emergent CoVs once they reach endemicity depends only on the severity of infection in children (Fig. 3) because all available evidence suggests immunity to HCoVs has short IES and moderate IEI, leading to frequent reinfection throughout adulthood (11, 12) but strong IEP such that childhood infection provides protection from pathology upon reinfection in adulthood, as evidenced by the rarity of severe infections or detectable IgM titers in adults. Strain-specific virulence factors, such as the shared cellular receptor, ACE-2, to which CoV-1, CoV-2 and the endemic strain NL63 all bind (1316), may affect the CFR during the emergence phase but have little impact on the severity of disease in the endemic phase. Because the four endemic HCoVs have been globally circulating for a long time and almost everyone is infected at a young age, we cannot ascertain how much pathology would result from a primary or even secondary case of any of these in an elderly or otherwise vulnerable person.

The key insights come from how our model explicitly incorporates different components of immunological protection with respect to susceptibility, pathology and infectivity (IES, IEP and IEI) and their different rates of waning. In our analysis we hypothesized that these components of immunity for CoV-2 are comparable to those of endemic HCoVs, and this needs to be determined. Additionally, during the transition to endemicity, we need to consider how the IEs depend on primary and secondary infections across ages (17) and how responses differ between vaccination and natural infection.

Longitudinal analysis of CoV-1 patients provides an opportunity to measure the durability of immune memory in the absence of reexposure. The only long-term study we know of that follows CoV-1-specific antibodies suggests they wane faster compared with antibodies to other live viruses and vaccines such as measles, mumps, rubella and smallpox (18) and fall below the threshold of detection in six years (19). In contrast to antibody responses, memory T cells persist for much longer periods (19, 20) and confer protection in animal model systems (21).

We further consider the effects of strain variation both for natural infection and vaccination. Strain variation and antibody escape may occur in endemic strains (22), however the fact that symptoms are mild suggests that immunity induced by previously seen strains is nonetheless strong enough to prevent severe disease. Indeed among HCoVs, frequent reinfections appear to boost immunity against related strains (12). However, the effect of strain variation may differ for vaccine-induced immunity, especially in light of the narrower epitope repertoire of many currently authorized vaccines.

If frequent boosting of immunity by ongoing virus circulation is required to maintain protection from pathology, then it may be best for the vaccine to mimic natural immunity insofar as preventing pathology without blocking ongoing virus circulation. Preliminary results suggest the adenovirus-based vaccine is better at preventing severe than mild or asymptomatic infections (23), and it will be important to collect similar data for the other vaccines. Should the vaccine cause a major reduction in transmission, it might be important to consider strategies that target delivery to older individuals for whom infection can cause higher morbidity and mortality, while allowing natural immunity and transmission to be maintained in younger individuals. During the transition to endemicity, primary CoV-2 infections will frequently occur in older individuals, and we need to determine if immunity induced by infection or vaccination in adulthood is similar to that produced by natural infections in childhood. Thus far, there have been few reinfections reported with CoV-2, and disease severity has varied (24); the only population-level study of reinfection of which we are aware estimates a low rate of reinfection within the first six months after primary infection and mild disease upon reinfection (25), but further analysis and monitoring are vital.

The findings presented here suggest that using symptoms as a surveillance tool to curb the viruss spread will become more difficult, as milder reinfections increasingly contribute to chains of transmission and population level attack rates. In addition, infection or vaccination may protect against disease but not provide the type of transmission-blocking immunity that allows for shielding (26) or the generation of long-term herd immunity (2).

The details of the change in overall IFR through the transient period will be impacted by a wide array of factors, such as age-specific human contact rates (27) and susceptibility to infection (28), as well as improvement in treatment protocols, hospital capacity, and virus evolution. The qualitative result of mild disease in the endemic phase is robust to these complexities, but quantitative predictions for the transient phase will depend on a careful consideration of these realities and how they interact with the dynamics of infection and components of immunity (29).

The changes in the IFR over time predicted by the model have implications for vaccination strategy against current and future emerging HCoVs. Social distancing and an effective vaccine are critical for control during a virgin epidemic and the transition out of it, but once we enter the endemic phase, mass vaccination may no longer be necessary. The necessity for continual vaccination will depend on the age-dependence of the IFR. If primary infections of children are mild (CoV-1 and CoV-2), continued vaccination may not be needed as primary cases recede to mild childhood sniffles. If, on the other hand, primary infection is severe in children (as for MERS), then vaccination of children will need to be continued.

From an ecological and evolutionary perspective, our study opens the door to questions regarding the within-host and between-host dynamics of human immunity and pathogen populations in the face of IEs with different kinetics. It also opens the question of how these IEs interplay with strain cross-immunity, which is likely relevant within the alpha- and beta-coronaviruses. Considering data and model predictions from emergence through endemicity of HCoVs revealed a framework for understanding immunity and vaccination that may apply to a variety of infections, such as RSV and seasonal influenza, which share similar age distributions and immune responses.

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Immunological characteristics govern the transition of COVID-19 to endemicity - Science

Volunteer for COVID-19 Vaccination Response | Georgia Department of Public Health – Georgia.gov

January 16, 2021

NEWS RELEASE

FOR IMMEDIATE RELEASE:

Jan. 15, 2021

Volunteer for COVID-19 Vaccination Response

Atlanta The Georgia Department of Public Health (DPH) is receiving offers from medical professionals and other individuals looking for ways to help with the COVID-19 vaccination response.An effective response relies on volunteers who are pre-credentialed and organized. Georgia Responds is Georgias health and medical volunteer program which matches the skills and credentials of medical and non-medical volunteers to help stop the spread of COVID-19 in Georgia.

Licensed medical volunteers including doctors, nurses, pharmacists and advanced EMS personnel (EMT Intermediate and above) may be used to administer vaccination. Nonmedical volunteers may be used in administrative roles such as registering individuals for vaccination, data input,language interpretation, other administrative areas as needed, and providing guidance and assistance at vaccination administration sites.

To volunteer, log on to https://dph.georgia.gov/georgia-responds and click on the Register Now box. Registering only takes a few minutes. Prospective volunteers will be asked for their name, address, contact information and occupation type. In order to be eligible for some assignments, responders are encouraged to complete a profile summary, which includes skills and certifications, training, medical history, emergency contact and deployment preferences.

Once your skills and credentials are reviewed, you will be notified by a DPH representative.

Even as the COVID vaccine becomes available, all Georgians play a critical role in helping to slow the spread of COVID-19 by adhering to the following guidance:

For updates on the COVID-19 situation as it develops, follow @GaDPH, @GeorgiaEMA, and @GovKemp on Twitter and @GaDPH, @GEMA.OHS, and @GovKemp on Facebook.

For information about COVID-19, visit https://dph.georgia.gov/novelcoronavirus or https://www.cdc.gov/coronavirus/2019-ncov/index.html.

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Volunteer for COVID-19 Vaccination Response | Georgia Department of Public Health - Georgia.gov

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