Category: Covid-19

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Beyond COVID-19, where will biopharma focus in 2021? – FierceBiotech

January 23, 2021

Fighting the pandemic will remain a top priority in 2021, not least for the biopharma companies working on the next generation of therapeutics and vaccines against COVID-19. But just because were in a pandemic doesnt mean all other diseases have stopped plaguing humanity. We asked executives which areas might see a resurgence this year, and neurology emerged as a popular horse to bet on.

Part of that interest could be down to Biogens once-failed Alzheimers disease candidate, aducanumab, which is slated for an FDA decision by March 7.

I think neurology will continue to be a big focus, at least in the first half of the year, while aducanumab is out there and all eyes are on the PDUFA, said Shehnaaz Suliman, M.D., president and chief operating officer of Alector, which is working on immuno-neurology approaches to neurodegenerative disease. There was a recent spate of high-priority deals done in the neuro spaceit signals appetite in Big Pharma and Big Biotech to do big value-creating deals.

RELATED: JPM: Alector, Annexon, Athira on what an aducanumab approval could mean for Alzheimer's R&D

Multiple executives agreed that aducanumab would not be a best-in-class drug but that its approval would give the whole field a boost, encouraging interest and investment in neurodegenerative disease R&D. Recent data for a similar drug, Eli Lillys donanemab, also offered hope.

I think its important to continue to go after neurology," said Doug Love, president and CEO of Annexon Biosciences. We are an aging population, and, of course, patients are going to have neurodegenerative disorders We need to think smart and branch out beyond Alzheimers. There are lots of neurodegenerative diseases. There are lots of kinds of dementia we can target.

Its a good time to pursue these indications, Love said, adding, As the field advances with various biomarkers, we will understand earlier in the disease process if drugs are working.

Another reason traditionally big indications like neurology and cardiology are getting more interest is the availability of genetic sequencing and the ability to slice those disease areas up into more manageable segments. It provides a regulatory path for companies working in those areas that previously did not exist, said Rahul Ballal, Ph.D., CEO of Imara, a company working on treatments for sickle cell disease and other blood disorders.

RELATED: JPM: Biogen bullish on Alzheimer's drug approval, sees Lilly data as positive despite AdComm rejection

For a long time, people have run away from those spaces for all the reasons you know: low probability of technical success, large, heterogeneous patient populations, Ballal said. And I think what biotech is doing thats really exciting within the neurodegenerative space and within cardiovascular disease is they are applying a rare disease approach to those diseases by finding patients within the very large swaths.

Whichever areas receive the most interest in 2021, the entire industry should make sure that treatments reach every patient who needs them, said Nessan Bermingham, CEO of Triplet Therapeutics.

We look at whats happening with the (COVID-19) vaccine and whats happening with the rollout of care for individuals who have gotten COVID-19, and the disparities are very clear, Bermingham said. In the U.S. and from a global standpoint, were only going to see those be further emphasized. This is something, as a biotech industry, we need to be very conscious of.

Biopharma companies should think about pricing, distribution and access not just of cutting-edge immuno-oncology meds and gene therapies but also of things like basic care, real-time feedback from doctors, diagnostics and imaging.

As we think about the disparities we face, weve not changed that, and arguably with new therapies coming out, weve actually made those disparities worse, Bermingham added. I think as an industry, we need to go back to the concept of healthcare democracy: that everyone has the right to healthcare.

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Beyond COVID-19, where will biopharma focus in 2021? - FierceBiotech

OHA updates COVID-19 totals for cases, deaths, hospitalizations, negative tests in Oregon – KPTV.com

January 23, 2021

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OHA updates COVID-19 totals for cases, deaths, hospitalizations, negative tests in Oregon - KPTV.com

South Bay hospital allowed teachers to skip the line for COVID-19 vaccines – San Jos Spotlight – San Jos Spotlight

January 23, 2021

Teachers and staff at an affluent South Bay school district can skip the line and get a COVID-19 vaccine by pretending to be health care workers at the behest of Good Samaritan Hospital, according to an email obtained by San Jos Spotlight.

Teachers cant get vaccines in Santa Clara County yet. The county is in the beginning part of Phase 1B, but its only vaccinating people 75 and older. Education and childcare workers come after health care workers and people 65 and older.

But teachers at the Los Gatos Union School District dont have to wait, their Superintendent Paul Johnson told them. They can get their vaccines now at the behest of the hospitals top leadership.

The reason the teachers get to skip the line, Johnson said in the email, is because they helped raise money in the spring for meals for health care workers at Good Samaritan Hospital.

The COO of the hospital says we can access the appointments through here and has cleared LGUSD staff to sign up under the healthcare buttons, Johnson wrote in the email to faculty and staff obtained by this news organization. This is a wonderful gesture by our Good Sam neighbors and I encourage you to take advantage of this within the next few hours.

Johnson said in the email that the plan was approved by Good Samaritans chief operating officer. He said the hospital would like to offer vaccines to the school district because they have not forgotten the kindness of the staff raising money for meals for health care workers.

In an interview with San Jos Spotlight, Johnson said its not a quid pro quo and that Good Samaritans offer is not connected to the money the district raised.

My understanding is Good Sam was cleared for the next tier, so teachers didnt jump in line, Johnson said. You would have to talk to Good Sam about offering to other districts outside of Los Gatos.

Sarah Sherwood, spokesperson for Good Samaritan Hospital, said that the hospital chose to offer vaccines to the Los Gatos teachers because the hospital had extra appointments one day.

We had some open time slots to fill and welcomed 65 Los Gatos teachers into the clinic to receive their vaccines, following county guidelines, Sherwood said. Now, with no additional open time slots, we need to continue to vaccinate the population of 75+.

Sherwood said the hospital is updating its website to make the vaccination schedule clearer.

It is our full intention to vaccinate as many people as possible, Sherwood said. It is our hope that we will be able to vaccinate many more in the near future.

According to the California Department of Public Health, counties can allocate vaccine doses on the assumption that immunization will be accepted by some but not all who are offered the vaccine, and then continue to offer vaccinations in progressive priority tiers.

For example, the department says, if a county has maximized use of the vaccine to administer individuals in Phase 1A, they should move to Tier 1 of Phase 1B while continuing to offer vaccines to those in higher priority groups.

We are very grateful that Good Sam reached out to our district and offered to help our LGUSD staff (teachers and support staff) get vaccinated, Johnson said. Teachers are essential workers, and as we transition back to in-person instruction, we are thankful that they are able to have access to vaccines to protect the students and community.

Los Gatos schools have not resumed in-person classes. The district has plans to open once cases in Santa Clara County fall below 25 cases per 100,000 residents. According to the states COVID-19 dashboard, the county averaged 67 cases per 100,000 this week.

Teachers wont be required to get vaccinated, Johnson added, and its a personal choice. He said the district only received guidance from Good Sam on how to navigate their sign-up system.

The state last week began vaccinating residents 65 and older, but health care providers in Santa Clara County, including Kaiser, are only vaccinating people 75 and up due to a vaccine shortage.

Due to the short supply of vaccines, Good Samaritan reported to the county that its only vaccinating eligible health care workers in the first phase of the states COVID-19 vaccine rollout plan.

Santa Clara County is receiving about 30,000 vaccines a week from the state and federal government. County supervisors have said its not enough and voted to send a letter to state health officials demanding more doses.

According to the Santa Clara County vaccine dashboard, Good Samaritan Hospital had received 6,585 first and second doses of the vaccine as of Jan. 22, and had administered 3,674 doses.

The Santa Clara County Board of Education did not respond to a request for comment.

Santa Clara County Public Health officials say they are looking into the matter after an inquiry from this news organization.

Contact Madelyn Reese at [emailprotected] and follow her @MadelynGReese on Twitter.

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South Bay hospital allowed teachers to skip the line for COVID-19 vaccines - San Jos Spotlight - San Jos Spotlight

A recent COVID-19 infection could impact your availability to get the vaccine – WBRC

January 23, 2021

COVID-19 in the last 90 days plus being treated with convalescent plasma or monoclonal antibodies, Hicks said. Other than that, its if we have limited doses. You can wait to give somebody else the courtesy of going in front of you, because you do have some level of protection with antibodies. Maybe wait your turn in line and let someone else go, because the thought is if you had COVID in the last 90 days, you have some level of antibodies protection. So give somebody else a shot before you.

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A recent COVID-19 infection could impact your availability to get the vaccine - WBRC

Ohio State provides overview of COVID-19 vaccine information – The Ohio State University News

January 23, 2021

President Kristina M. Johnson sent the following email to The Ohio State University community today (Jan. 22).

Dear Students, Faculty and Staff:

I write to share an overview of the current available information about how the COVID-19 vaccine is being distributed under the guidelines from the Centers for Disease Control and Prevention and the state of Ohio.

Supplies of the vaccine remain low, and manufacturers are ramping up production. At this time, Ohio is scheduled to receive a total of 100,000 doses per week, which represents less than 1% of the states total population. We expect that additional vaccine manufacturers will be approved in the coming weeks, which will add to vaccine supply. Because of the limited availability, the early distribution is being phased in according to priority populations, which are detailed below.

Like the flu vaccine, we expect that eventually you will be able to receive a vaccine for COVID-19 through a variety of providers, including hospitals, retail pharmacies and health departments, depending on your health insurance, your medical provider, your location in the state and other factors. Including the Schottenstein Center, there are 60 COVID-19 vaccination locations in Franklin County alone and more are planned to be added.

We are working in close coordination with Governor Mike DeWine as well as state and local health experts. We will continue to share updates, and the latest information is also on the Safe and Healthy Buckeyes website. We will be holding a series of virtual town halls on COVID-19 the first Monday of each month through April. The first town hall is Monday, February 1, at 5:30 p.m. and will focus on information about the vaccine. We will share details of how to join the town halls soon through the Safe and Healthy Buckeyes website and onCampus.

Below is a summary of the current plans for vaccine distribution by the Wexner Medical Center in Columbus, along with general information and links for further vaccine information and guidelines from the state of Ohio. For those living outside Columbus, the state has created an online tool to help Ohioans identify vaccine distribution sites in their communities. Additional information about the states vaccine distribution plan is available on the Ohio Department of Health website.

The initial phase of distribution at the Wexner Medical Center is nearly complete and focused on health care personnel, support employees (e.g., environmental services, security, etc.) and health sciences students who provide patient care, consistent with state and federal guidance.

Vaccination scheduling opportunities will follow the states phased distribution plan. The time frames below are subject to change based on vaccine availability.

The state also has plans to begin vaccinating patients with certain severe congenital and developmental disorders that increase the risk of severe COVID-19 disease and student-facing employees of K-12 schools in the coming weeks.

As more information becomes available on when additional populations can receive a vaccine, we will communicate this information to you, and the state will share it publicly at coronavirus.ohio.gov/vaccine.

For those individuals currently eligible to receive a vaccine, an appointment is required, and the option to schedule an appointment is only available once the criteria are met.

Eligible Wexner Medical Center patients who have seen a provider in the last three years will receive an automated phone call, a MyChart email and/or regular mail with details on how and when to schedule. Eligible Wexner Medical Center patients are encouraged to schedule an appointment through their MyChart account. Individuals who are not patients of the Wexner Medical Center or those who do not have a MyChart account can call 614-688-VAXX (8299) for assistance. Vaccinations will take place at the Schottenstein Center. More information, including frequently asked questions, is available on the Wexner Medical Center website.

While this progress is promising, it remains critically important to keep following public health protocols even if you receive the vaccine. That means continuing to wear masks, practicing physical distancing, avoiding large gatherings and consistently cleaning your hands. Together As Buckeyes, we will continue to do our part to have a safe and healthy spring semester and beyond.

Sincerely yours,

Kristina M. Johnson, PhD

President

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Ohio State provides overview of COVID-19 vaccine information - The Ohio State University News

How the winter COVID-19 surge overwhelmed California – Los Angeles Times

January 23, 2021

In the spring, while New York suffered untold devastation from the COVID-19 pandemic, California was so successful in keeping the virus at bay that at least one expert called it the California miracle.

So when the coronavirus began to proliferate with unprecedented fury in November, transforming California into the epicenter of the pandemic, health experts and residents struggled to understand what had gone wrong.

Now, with the crisis showing signs of easing, the main reason for the catastrophic surge is coming into focus: a false confidence that the pandemic could be kept in check. For the public, that complacency showed up in fatigue and frustration over safety restrictions. Officials, for their part, were caught off-guard by how rapidly, and how broadly, the virus spread once the numbers began to climb.

By Christmas, so many patients struggling to breathe needed to be hospitalized in California that emergency rooms in large swaths of the state closed to ambulances as doctors stuffed patients in hospital corridors. The holiday surge has so far killed more than 18,100 Californians, more than doubling the states total death toll from the pandemic in less than three months.

We never, never planned for something like this to happen, California Health and Human Services Secretary Dr. Mark Ghaly said in a recent interview. The states mask mandates, business closures and stay-at-home orders, he said, were all designed to try to avoid this.

There are many possible theories as to why California was hit so hard starting in the late fall, including the introduction of more contagious strains of the virus, dry weather that made transmission easier and a higher percentage of the population being vulnerable to the disease because relatively few Californians had been infected up to that point.

But most experts point to changes in behavior: people beginning to abandon staying home, social distancing while out and other precautions that experts say curb transmission of the coronavirus.

In the fall, masking dipped in California while social distancing fell to the lowest levels since the pandemic began, according to one analysis. Meanwhile, the numbers of Californians attending gatherings with 10 or more people reached the highest level since before March, according to a USC survey.

And when a coronavirus wave started building in late October, Californians didnt cut down on their risky activities as quickly as they had earlier in the pandemic. Instead, the state faced the alarming prospect of a series of amplifying events with Halloween, Thanksgiving, Hanukkah and Christmas, followed by New Years.

The complacency caught officials off-guard and in turn sealed the states fate, as the prevalence of the virus crossed a tipping point into explosive growth, experts say.

California Health and Human Services Secretary Dr. Mark Ghaly at a news conference in 2020 with Gov. Gavin Newsom.

(Randall Benton / Associated Press)

Had we had the same level of compliance that existed with the first wave, we could have avoided the magnitude, said UCLA epidemiologist Dr. Robert Kim-Farley. This wave has turned into a tsunami.

Though people let their guard down across the nation as the pandemic wore on, California requires a higher degree of compliance to stave off a New York-style disaster, given the states high rates of poverty and its relatively low number of hospital beds, experts say.

Some attribute the waning cooperation simply to fatigue. Others argue that a dizzying array of health orders exhausted and confused Californians and sparked backlash.

Though epidemiologists warned the nation of a deadly winter wave fueled by colder weather, they didnt predict that temperate California would become the prime example. For the six-day period that ended on New Years Day, California had the highest per capita COVID-19 death rate in the nation.

Did I expect to see December and January this bad? Yes. But I expected to see it throughout the United States, said UC Berkeley public health professor Dr. John Swartzberg. Thats what I think the shocker has been.

To be clear, even after the awful surge, California maintains a comparatively low per-capita COVID-19 death rate overall, ranking 37th out of the 50 states. And, following several weeks of horror, the state appears to have finally turned the corner as coronavirus cases and hospitalizations begin to drop, though new variants of the virus have raised fresh concerns.

In the eyes of Ghaly, who leads the states response to the pandemic, what went wrong in California comes down to COVID fatigue, or what he sometimes calls COVID resentment.With Halloween and the championships of the Lakers and Dodgers, lonely Californians exploited an opportunity to socialize, he said. Even his own mother, who lives in San Francisco, began pleading with him to let her visit him and his kids in Los Angeles.

She calls every day. And she says, But when is it ready? When can I come visit? Ghaly said. So I cant even imagine where you dont have the same level of information its not constantly in your face how hard it must be to not gather.

Officials, too, were feeling hopeful in the fall that they had figured out how to manage the pandemic. In L.A. County, nail salons and indoor malls reopened. Some local officials anticipated that indoor restaurant dining and indoor gyms would reopen later in the fall.

The public followed their lead. Californians perceived risk of catching the coronavirus fell to the lowest level since the pandemic began, while the percentage of Californians who had close contact with people they didnt live with peaked, according to the USC survey.

At the same time, Californians were moving around their communities at levels not seen since before the statewide stay-at-home order in March, according to cellphone mobility data analyzed by the Institute for Health Metrics and Evaluation.

The spread of the coronavirus began to quicken in the state, due to a false sense of security aided by low case numbers, said IHME epidemiologist Ali Mokdad.

You pay a price for your success, he said. The advice should be: This is here to stay. ... This virus is so stubborn. You make a tiny little mistake, it will go after that mistake.

Nurse Cristina Marco and chaplain Kevin Deegan with COVID-19 patient Domingo Benitez at Providence Holy Cross Medical Center.

(Francine Orr / Los Angeles Times)

When officials began warning in late October for people to limit their activities as coronavirus cases began to surge, the pleas increasingly fell on deaf ears.

Some Californians were distrustful of officials after Gov. Gavin Newsom ate at the French Laundry restaurant in defiance of his own health orders. Others were angry after months of unemployment with little economic help from the federal government or were simply fed up with living an isolated, walled-in version of their lives.

And after months of relative quiet in the hospitals, for many, the risk no longer seemed imminent.

On Nov. 16, a frustrated Dr. Wilma Wooten, the San Diego County health officer, said she had hoped a warning issued a month earlier about the resurgence of the pandemic would mark a change in the publics personal and collective behavior. It is quite obvious, however, that it did not.

Some of the inertia felt California-specific, said UC San Francisco epidemiologist Dr. Kirsten Bibbins-Domingo. Whereas other states reopened schools and many outdoor, low-risk activities when case numbers were low, Californias more restrictive orders created a feeling of being in lockdown for 10 months, she said.

I think Californians are more fatigued. Theyre fatigued in a way thats uniquely Californian, she said. We dont experience the fruits of all of the good work that weve done because were never quite open and so it feels hard to close down, even [when were] hearing what is a real message from our public health officials: that were in a crisis right now.

There is a relatively small window in which for officials to act to stop a devastating surge of the coronavirus, since each new infection makes it more likely that more people will become infected. California officials, seeing the writing on the wall, rushed to put in place policies in November and December to try to slow the spread.

But the orders engendered far wider criticism than had been seen up to that point. Of particular contention were a statewide curfew for most of the state banning many activities after 10 p.m., a ban on outdoor dining, closure of playgrounds which was eventually reversed amid backlash and the prohibition of most outdoor gatherings of any size. That malls remained open while going on a masked walk with a friend violated the health order became fodder for jokes, and frustration.

While many experts have backed these rules, others wonder if they ended up fueling a backlash. University of Florida epidemiologist Cindy Prins said she thinks California may have benefited from being more liberal with its rules for outdoor spaces.

Were all running a big experiment, because I dont think we know exactly what the right point is to have people be compliant, she said. I dont think all closed is the way to go. I dont think all open is the way to go. Im not sure where the happy medium is.

Some law enforcement officials in Sacramento, Orange, Fresno, Riverside and San Bernardino counties said they would not enforce Newsoms stay-at-home orders.

In L.A. County, some local politicians were incensed at the outdoor dining ban and began accusing county scientists of not following the science. County Supervisor Janice Hahn, who voted against the ban, said it became the final straw for residents: Up until that point, I felt like we had the publics trust, she said in an interview.

The loud debate around these orders dissolved the united front needed to gain adherence to public health measures, experts say.

By late December, 40,000 Californians were testing positive for the coronavirus each day and 20,000 were in the hospital. While the pushback to the regulations had been much more severe in the southern part of the state, the surge was too a sign of how important widespread cooperation with the rules can be, experts say.

Assemblyman Carlos Villapudua bumps elbows with Assemblywoman Blanca Rubio in the California state Capitol on Tuesday.

(Gina Ferazzi / Los Angeles Times)

The flood of new cases has exacted a horrific toll, with more than 500 Californians dying every day at the peak, and hospitals so crowded ill patients have had to wait as long as 17 hours to even just enter the emergency room.

Critics, including Florida Gov. Ron DeSantis, have said that the disaster in California is proof that mask mandates and stay-at-home orders dont work. Experts say they can be effective, but California simply requires a much higher rate of compliance with these measures than a state such as Florida due to its innate vulnerabilities.

California has the nations third-lowest ratio of hospital beds to residents, so the threshold for pushing ICUs to the brink is relatively low. The state is also home to several cities that are major travel hubs, reliant on public transportation, with a high percentage of residents living in poverty and in overcrowded homes, where the virus is more likely to spread due to the close quarters.

While 55% of Californias residents live in counties with high social vulnerability score a measure of how severely affected a region may be by a natural disaster or disease outbreak fewer than a quarter of Floridians do.

That California could somehow avoid a large COVID-19 surge without a China-style lockdown was naive, said UC Irvine public health professor Andrew Noymer. There is some randomness in when outbreaks hit Illinois worst surge came in November while Californias hit in December but there wont be safety from the pandemic until herd immunity via a vaccine is achieved, he said.

This virus will find a way, Noymer said. No place in the United States is just going to somehow evade this.

This week, however, hope arrived in the form of small percentages. The number of people in the hospital with COVID-19 in California has begun to decline, as have new case numbers.

The shifts are probably due to Californians decline in activity, which began to gradually decrease in November and hit a low the lowest since May in December, due to a combination of local and state rules, increased warnings and the publics natural tendency to become more cautious after witnessing the devastation around them, experts say.

As is usually the case with the pandemic, the consequences of peoples actions dont become evident for several weeks.

Ghaly said he thinks this progress shows that the state can control the pandemic, a spot of good news in a surge where the story has often been that things have only gone wrong.

Overall too, California has tallied 90 deaths for every 100,000 Californians since the pandemic began, compared with 212 per 100,000 people in New York, 158 out of 100,000 in Illinois and 119 out of 100,000 in Florida. In other words, if California had the same death rate as Florida, California would have a cumulative death toll of more than 47,000, instead of the 35,000 it does today.

Its hard to find successes in this, but ... improvements are successes, Ghaly said. What weve done in California has worked for us, and has done what Id hoped it had done, which is saved a lot of lives.

Times staff writers Sean Greene and Deborah Netburn contributed to this report.

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How the winter COVID-19 surge overwhelmed California - Los Angeles Times

Louisiana Department of Health announces COVID-19 testing for week of January 25-30 | Department of Health | State of Louisiana – Louisiana Department…

January 23, 2021

The COVID-19 testing schedule for sites operated by the Louisiana Army National Guard (LANG) for the week of January 25 to January 30 is listed below. Sites are closed during state holidays and inclement weather.

The more contagious U.K. variant of COVID-19 has been identified in Louisiana, and all Louisianans need to take precautions to protect themselves and their loved ones. Avoid gatherings of individuals not part of your households, work from home remotely when possible, wear a mask, practice social distancing and good hand hygiene, and stay home if sick. If you have been exposed or have symptoms of COVID-19, get tested. And, when it is your turn, consider getting the COVID-19 vaccine.

Pre-registration for COVID-19 testing is encouraged by going toHealth.QuestDiagnostics.com/STLOU. Testing is for ages 3 and older. There is no cost, and no identification is needed. Test results are available by calling1-866-MYQUEST (1-866-697-8378), but note that wait times can be lengthy. Test results are also available through the Quest online portal or app.

If you are unable to make it to a LANG testing location, no-cost testing is available by appointment atselect Walgreens locationsthrough a partnership between Walgreens and the Department of Health. These locations offer testing 7 days a week to people ages 3 and older. Appointments are required; make yours atwalgreens.com/covid19testing.

Region 4:Acadiana

Symptoms of COVID-19 include:

Test site details

Save the number 877-766-2130 in your phone

Anyone who receives a call from 877-766-2130 is urged to answer, as the call is from a contact tracer who will keep an individual's information private. Personal information is used to quickly identify anyone a COVID-positive individual may have been in close contact with to help contain the spread of the coronavirus. Everyone called by a contact tracer is advised to monitor themselves for signs of illness for 14 days from when they first came in contact with the COVID-19 person.

If a resource need is identified through the contact tracing interview, the case is flagged for follow-up from a resource coordinator social worker who can connect individuals with resources including medication, masks, food assistance and even help locating alternative housing.

If someone calls from a number other than 877-766-2130, claims to be a contact tracer and asks for personal information, hang up immediately.If you have a positive lab result and have not yet heard from a contact tracer, you can call our team directly at 877-766-2130.

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Louisiana Department of Health announces COVID-19 testing for week of January 25-30 | Department of Health | State of Louisiana - Louisiana Department...

Doctor looks to boost COVID-19 vaccine confidence by showing scans of infected lungs – WISHTV.com

January 23, 2021

INDIANAPOLIS (WISH) A doctor in Indianapolis is sharing some powerful pictures hoping to boost confidence in the COVID-19 vaccine after recently receiving both doses.

The photos are side by side lung scans comparing a healthy lung versus one infected with COVID, showing the damage the virus can cause.

The one to the right is a scan of a healthy lung and is black which shows the lung is full of good and healthy air. Thats according to Dr. Lauren Ladd a radiologist at IU Health Methodist Hospital who says the left scan is filled with areas of grey, which show the virus.

As a radiologist, Dr. Ladd admits shes outside her area of expertise in the realm of infectious disease, but she has also read and studied hundreds of pages of information on vaccine technology and the Pfizer research data.

Now that Dr. Ladd has had both doses of the vaccine, she wants others to know she believes science heals.

I think this is the best way for us to get back to a normal life. I want my 4-year-old and 2-year-old to be able to hug their grandparents without worrying my parents are going to end up sick in the hospital, said Dr. Ladd, also mentioned she looks forward to not having to look at the lung scans of COVID patients.

But in the meantime, if you have had COVID-19 with or without symptoms its a good idea to visit your doctor to determine if a lung scan is right for you.

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Doctor looks to boost COVID-19 vaccine confidence by showing scans of infected lungs - WISHTV.com

Experts still focus on COVID-19 testing as preventative measure for spread – Wink News

January 23, 2021

COLLIER COUNTY

There is a new push for widespread testing as Americans who are eligible wait on vaccinations.

One health care provider in Southwest Florida says its now offering free testing, and medical experts say this is key to keeping people out of the hospital.

It goes back to pre-symptomatic or asymptomatic spread. If you dont know youre infected, you cant isolate. Without that step, the virus can keep spreading.

Julie Pedretti is the COVID-19 community relations director for Healthcare Network. She says testing remains an important piece of stopping the spread, because its going to take time for the country to reach herd immunity.

Its going to take many, many months before we can get to that 80% vaccine rate, Pedretti said. Until then, we cannot let our guard down.

Some testing sites have shut down or scaled back because of vaccination programs. Thats where Pedrettis team comes in.

We know that the Department of Health is very busy with vaccines, so were ramping up our testing events, Pedretti said.

Help is on the way from the federal government as well. President Joe Bidens pandemic response plan calls for widespread testing.

How exactly they get rolled out is not fully understood at the moment, but I believe that there will probably be a focus on schools, said Dr. Michael Mina, an epidemiologist at Harvard. There will probably be a focus on essential businesses, and I hope that theres also a focus on getting these tests into homes.

Harry Owens got his first shot, but it was not without a lot of patience.

We waited in line, I guess about maybe 7:45, something like that, they started to come around and give out tickets, Owens said. I was 795 out of 800.

At 64, Owens wife cant get the vaccine yet, and neither can his children nor his grandchildren.

Thats why Owens applauds the renewed focus on testing.

Theres a lot of people out there who are younger than 65 that arent able to get that shot soon anyway, Owens said. I think from that standpoint, I think its very important.

Healthcare Network is offering free COVID-19 testing Saturday at the Nichols Community Center in Golden Gate from 9 to 11 a.m. You dont need an appointment, but you do need to bring a mask and your ID.

Isnt it just better to know whether you have COVID or not? Pedretti said. Whether you would test positive or not? So you can protect yourself and your loved ones and the rest of the community.

MORE: National Strategy for the COVID-19 Response and Pandemic Preparedness

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Experts still focus on COVID-19 testing as preventative measure for spread - Wink News

What If You Never Get Better From Covid-19? – The New York Times

January 23, 2021

Anecdotally, at least, some long-haulers are experiencing the type of viral reactivation Klimas describes. In late October, seven months after contracting the coronavirus, Lauren Nichols developed shingles a reactivation of the virus that causes chickenpox. The episode, which featured burning, out of this world nerve pain, sent her to the emergency room. A lesion developed on the cornea of her left eye, threatening her vision. Antiviral medication helped bring the shingles under control. Nichols, an administrator of a long-Covid support group, told me that reactivation of Epstein-Barr, cytomegalovirus and other herpesviruses occurs in a small but significant percentage of long-haulers on the site.

A similar argument over what drives chronic symptoms persistent infection versus lingering inflammation from a past infection appears prominently in the study of Lyme disease. Some people infected with Borrelia burgdorferi, the tick-borne bacterium that causes Lyme, fail to recover even after antibiotic treatment. Patients may refer to this illness as chronic Lyme disease, but doctors prefer to call it post-treatment Lyme disease syndrome, because theyre not sure an infection is still really there. As in ME/CFS research, the debate over the root cause of this post-Lyme illness has for years polarized the field.

There are other similarities as well. The Lyme problem is underrecognized but immense. Every year, an estimated 329,000 people are infected by B. burgdorferi. About 10 percent of those treated with antibiotics develop lasting symptoms, including fatigue, pain and occasionally nervous-system conditions like dysautonomia heart rate, blood pressure and other basic bodily functions in disarray. It appears to strike women more than men, it has long been dismissed as psychological and the long-term illness is often judged worse than the acute infection.

Like ME/CFS, post-Lyme syndrome has no biological marker that allows for concrete diagnosis. The three nonmutually exclusive ideas about what causes long-term symptoms roughly correspond with those for ME/CFS: a persistent infection (or perhaps merely debris from the Lyme spirochetes); an autoimmune or inflammatory dysfunction triggered by the infection that continues after the bacteria are gone; or changes in the nervous system that mirror Jarred Youngers angry microglia idea, but that are described by Lyme researchers as central nervous system sensitization. Perhaps the infection changes how the brain works in such a way that once-easily bearable stimuli pain, light, sound become unbearable.

The parallels between ME/CFS and Lyme reinforce the notion that many different infections including the Lyme spirochete can trigger debilitating long-term syndromes. Its a lesson that we as a society have perhaps forgotten, Allen Steere, a Lyme expert and rheumatologist at Harvard Medical School, told me. Now we have millions infected, and it becomes apparent to people that this type of problem can follow.

Its a maddening prospect, but long Covid may not be a single syndrome at all. It could, as seems to be the case with ME/CFS, be an array of problems connected in various ways with an initial trigger in Covids case, the invasion of the human body by a virus thought to be originally native to bats. ME/CFS doctors and researchers have faced this sort of frustrating complexity for years. Its an unavoidable challenge in managing a condition, be it ME/CFS or long Covid, whose diagnosis is based almost entirely on the subjective reporting of symptoms. There are, after all, many ways to produce symptoms like fatigue, brain fog and even dysautonomia. As Peter Rowe puts it, treating ME/CFS is like peeling an artichoke. Youre trying to remove treatable layers of problems and see what the essence is, he told me.

In the case of ME/CFS, scientists have identified a few more leaves of the proverbial artichoke a grab bag of treatable, somewhat obscure conditions that seem to be associated with it. One is mast cell activation syndrome, which can produce fatigue, pain and problems with thinking and memory; infection can sometimes initiate it. Another is small-fiber neuropathy, a condition in which the bodys nerves begin to misfire and can die off, causing pain, fatigue and disruption to basic bodily functions like breathing. Infections can sometimes trigger it, and given the current description of long-Covid symptoms, Anne Louise Oaklander, a pioneer in understanding this neuropathy, suspects it will be found to occur among long-haulers as well. Small-fiber neuropathy is usually treatable, Oaklander told me, and in some cases curable.

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What If You Never Get Better From Covid-19? - The New York Times

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