Category: Covid-19

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Dr. Jerry Kruse: Learning to live with COVID-19 – The State Journal-Register

May 8, 2022

Dr. Jerry Kruse| Special to The State Journal-Register

Like Dodgers southpaw Sandy Koufax, the wily SARS-CoV-2 keeps throwing us one curveball after another. New variants arise swiftly, and news from the worlds of epidemiology and immunology keeps us on the edge of our seats Ive worn out at least three chairs in the past two years.

But we have learned a lot through the COVID-19 pandemic. There is good evidence for the following statements: 1) This virus is here to stay.2) New COVID-19 mutations will continue to arise. 3) Significant naturally acquired immunity, vaccine-acquired immunity and hybrid immunity have developed in the U.S.4) Vaccine-acquired immunity and hybrid immunity offer substantial protection against the development of severe illness and death due to COVID-19 infections.5) The vaccines will be the major influence for policy decisions as we live with SARS-CoV-2.

Almost 60% of Americans have, at one time or another, been infected with COVID-19. How do we know that? The incidence of people infected with COVID-19 can be calculated because anti-N antibodies are produced in response to infection, but are not produced in response to COVID-19 vaccines.

Earlier column: Dr. Jerry Kruse: Treating everyone equitably takes effort, empathy

Researchers measured anti-N antibodies, and, in the CDC publication MMWR, reported a stunning rise in the percentage of Americans infected during the omicron surge last winter. For all age groups combined, the percentage of Americans infected with COVID-19 rose from 28% in September 2021 to 58% in February 2022. The breakdown by age revealed that infections have occurred in 75% of those age 0 to 17 years, 64% of those age 18 to 49, and 41% of those age 50 and above.

Many of those who had been infected had received COVID-19 vaccines either before or after the infection, thus conferring hybrid immunity. These data give us a better foundation for new pandemic policies.

Where does the pandemic stand now?New COVID-19 cases continue to rise in the U.S. In New York, the state with the highest rate of new infections, the new BA.2.12.1 omicron variant is dominant.However, while cases are rising in number, there is not yet a surge.

The rate of new infections in Illinois has more than doubled over the past five weeks. In the Springfield area, new cases rose from 6 to 27 per 100,000. Again, there has been no surge, just a gentle, though consistent, rise.

One piece of good news is from Champaign County, the county with the highest COVID activity in Illinois over the last few months.Three weeks ago, the number of new cases per 100,000 in Champaign County stood at 65.Today, that number is 50. A surge may have been averted. Vaccines plus boosters plus natural infection are seemingly keeping a damper on severe infections and death.

So, back to immunity. Infection-acquired immunity is often short lived. Hybrid immunity confers protection similar to that of vaccine-acquired immunity.

More: Dr. Jerry Kruse: Resolve to do everything you can to help yourself, others stay healthy

The efficacy of vaccinations and boosters was reported in recent issues of the Journal of the American Medical Association and the New England Journal of Medicine. The following statement, made in regard to efficacy for the prevention of death and serious illness, is a summary of the data in the two articles:This means that … the absolute effectiveness of two vaccine doses is 90%, and the absolute effectiveness of two doses plus a booster is 99 to 100%.

In other words, the initial vaccine series reduced death and severe illness by about 90% for the original strain and delta variants, and boosters reduced severe illness and death due to omicron variants even further, to more than 95%.

We are rapidly learning how to live with SARS-CoV-2 and the disease it produces, COVID-19. Weve whiffed on a few curve balls. Yogi Berra said it best, Its tough to make predictions, especially about the future. Its a bit easier now, with immunity on our side.

Jerry Kruse, MD, MSPH, is dean and provost, SIU School of Medicine andCEO, SIU Medicine.

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Dr. Jerry Kruse: Learning to live with COVID-19 - The State Journal-Register

The CDC is investigating a Covid-19 outbreak on board a Carnival cruise ship – CNN

May 8, 2022

The Carnival Spirit, which sailed through the Panama Canal, departed Miami on April 17 and arrived in Seattle on May 3, according to a statement from the cruise line. The ship holds 2,124 guests and 930 crew members, Carnival said.

The ship's color status helps the CDC determine the scope of investigation, the agency said.

Carnival Spirit is one of 62 cruise ships currently sailing at orange status, the CDC said in a statement to CNN.

Both the cruise line and CDC said there were no severe outcomes or serious health issues among those who tested positive, and Carnival said most guests were asymptomatic.

"Our health and safety protocols exceed CDC guidelines and were closely followed including vaccination requirements and pre-cruise testing of all guests.Our crew are also vaccinated and wear masks," Carnival said in a statement to CNN.

"Our protocols are designed to flex up as needed and additional measures were implemented during the voyage," the statement added."In addition, all guests who were scheduled to continue on with the ship's next cruise to Alaska were tested and any guests and their traveling companions who tested positive were disembarked."

The ship departed Seattle for Alaska later on May 3, according to Carnival's statement.

The CDC is working with the cruise line as well as state and local health agencies to "enact existing Covid-19 agreements and protocols," the statement added.

Passengers say cruise ship was "overwhelmed"

Some passengers who were on board the Carnival Spirit alleged that crew members mishandled the Covid-19 outbreak on the ship.

Darren Siefertson, who is from Las Vegas, Nevada, told CNN he boarded the ship on April 17 from Miami and was informed by April 26 that there was a Covid-19 outbreak on the ship.

After testing positive, Siefertson said he was promised to be moved to an isolation cabin but ended up being forced to stay in the same room as his roommate.

Siefertson said when he called the medical center for an update, the center had already closed before its scheduled closing time, and no one was picking up the phone.

When Siefertson's cabin mate went to guest services to ask what they should do, he was told there were no more isolation cabins available, and he would have to stay in the same room as Siefertson.

Ship guests also complained that room service took "hours to get food to those who were in quarantine," Siefertson said.

"There were times we ordered our food at 1 p.m. and it didn't show up until 7 p.m.," Walter Babij, who was on the cruise with his wife, told CNN. Both Babij and his wife tested positive for Covid-19 while aboard the ship and quarantined in an isolation cabin.

"There were also a few times we didn't get our complete orders. We would have to call several times to track down our food. We were completely dependent on them," Babij said.

Siefertson also complained that a few days after testing positive, his cabin and two other cabins near him began to reek of sewage.

"You couldn't even call to ask someone to fix the problem because no one would pick up the phone and we couldn't leave our room, so I had to stay in this room that smelled like a toilet. It was terrible," Siefertson said. "Carnival said they managed the situation, but that is so not true. They were so overwhelmed."

Both Siefertson and Babij told CNN they felt the cruise line was "overwhelmed."

"I don't think they expected that level of cases and when it got to a certain level they didn't know what to do. It was a perfect storm," Babij said.

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The CDC is investigating a Covid-19 outbreak on board a Carnival cruise ship - CNN

COVID-19 deaths, hospitalizations and cases increase in Wisconsin – Milwaukee Journal Sentinel

May 8, 2022

Fauci: COVID-19 global pandemic not over

The seven-day average of new cases per day is around 47K, down from a peak of more than 800K in January. Dr. Fauci says the pandemic is still not over.

Damien Henderson, USA TODAY

The state is experiencing an uptick in new reported deaths, hospitalizations and cases as new data analysis shows that this is not just a pandemic of the unvaccinated.

The pandemics toll is no longer falling almost exclusively on those who chose not to or could not get shots, a Washington Post analysisthat was published late last month found.

During the omicron variant surge, the vaccinated made up 42% of deaths in January and February, compared with 23% of the dead in September, the peak of the delta wave, according to the Centers for Disease Control and Prevention.

Data still shows that the unvaccinated are more likely to suffer severe illness or death compared to the vaccinated, but it is clear that vaccinated people made up a significant portion of recent COVID deaths.

"Its still absolutely more dangerous to be unvaccinated than vaccinated,"Andrew Noymer, a public health professor at the University of California at Irvine who studies COVID-19 mortality, said to thePost.

"A pandemic of and by the unvaccinated is not correct. People still need to take care in terms of prevention and action if they became symptomatic," he added.

The vast majority of vaccinated deaths are among people who did not get a booster shot, according to state data provided to the Post. Health officials say this is all the more reason to get a booster dose.

Nationwide data also shows that the majority of COVID deaths are among elderly citizens.Nearly two-thirds of the people who died during the omicron surge were 75 and older, according to a Post analysis, compared with a third during the delta wave.

The U.S. is set to pass 1 million COVID-19 deaths in the coming days, according to Johns Hopkins University. The state Department of Health Services reported 12,919 confirmed COVID-19 deaths in Wisconsin, and another 1,545 are probable.

Accordingto the state DHS,36 confirmed deaths occurred this week, an increase of 25 deaths from the previous week.

Hospitalizations continued to increase throughout the week as well. Roughly 257 patients are hospitalized with COVID-19, up 133 patients from a month ago, according to the Wisconsin Hospital Association.

Similarly to what's been seen around the country, COVID-19 cases are also increasing, although seven-day averages are still lower than last fall.

Track COVID and the vaccine in Wisconsin: See the latest data on cases, deaths and administered doses

State and private labs regularly do further tests on a portion of positive COVID-19 samples to find the prevalence of different variants of the virus. The numbers below are just a fraction of the total number of variant cases.

Omicronvariant was identified in 100% of tests sequenced during the week starting April 3.

Contact Drake Bentley at (414) 391-5647 orDBentley1@gannett.com. Follow him on Twitter at @DrakeBentleyMJS.

Our subscribers make this reporting possible. Please consider supporting local journalism by subscribing to the Journal Sentinel at jsonline.com/deal.

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COVID-19 deaths, hospitalizations and cases increase in Wisconsin - Milwaukee Journal Sentinel

George Cheeks, the president of CBS, tests positive for coronavirus after attending the White House Correspondents’ Dinner. – The New York Times

May 8, 2022

Nearly 15 million more people died during the pandemic than would have in normal times, the World Health Organization said on Thursday, a staggering measure of Covids true toll that laid bare how vastly country after country has undercounted victims.

In Mexico, the excess death toll during the first two years of the pandemic was twice as high as the governments official tally of Covid deaths, the W.H.O. found.

In Egypt, excess deaths were roughly 12 times as great as the official Covid toll.

In Pakistan, the figure was eight times as high.

Those estimates, calculated by a global panel of experts assembled by the W.H.O., represent what many scientists see as the most reliable gauge of the total impact of the pandemic. Faced with large gaps in global death data, the expert team set out to calculate excess mortality: the difference between the number of people who died in 2020 and 2021 and the number who would have been expected to die during that time if the pandemic had not happened.

Their calculations combined national data on reported deaths with new information from localities and household surveys, and with statistical models that aimed to account for deaths that were missed.

Most of the excess deaths were victims of Covid itself, the experts said, but some died because the pandemic made it more difficult to get medical care for ailments such as heart attacks. The previous toll, based solely on death counts reported by countries, was six million.

Much of the loss of life from the pandemic was concentrated in 2021, when more contagious variants tore through even countries that had fended off earlier outbreaks. Overall deaths that year were roughly 18 percent higher an extra 10 million people than they would have been without the pandemic, the W.H.O.-assembled experts estimated.

Developing nations bore the brunt of the devastation, with nearly eight million more people than expected dying in lower-middle-income nations during the pandemic.

Its absolutely staggering what has happened with this pandemic, including our inability to accurately monitor it, said Dr. Prabhat Jha, an epidemiologist at St. Michaels Hospital and the University of Toronto, who was a member of the expert working group that made the calculations. It shouldnt happen in the 21st century.

The figures had been ready since January, but their release was stalled by objections from India, which disputes the methodology for calculating how many of its citizens died.

Nearly a third of the excess deaths globally 4.7 million took place in India, according to the W.H.O. estimates. The Indian governments own figure through the end of 2021 is 481,080 deaths.

But India was far from the only country where deaths were substantially underreported. Where excess deaths far outstripped the number of reported Covid fatalities, experts said the gap could reflect countries struggles to collect mortality data or their efforts to intentionally obscure the toll of the pandemic.

In some countries, flaws in government reports were widely known. Russia, for example, had reported roughly 310,000 Covid deaths by the end of 2021, but the W.H.O. experts indicated that the excess death toll was nearly 1.1 million. That mirrored earlier estimates from a Russian national statistics agency that is fairly independent of the government.

Aleksei Raksha, an independent demographer who quit the Russian state statistics service after complaining of the failure to count Covid deaths properly, said that informal orders had been given to local authorities to ensure that in many cases, Covid was not registered as the primary cause of death.

Excess deaths have established the true picture, Mr. Raksha said. Russia demonstrated a dismal performance in fighting the pandemic.

In other nations, W.H.O. experts used what limited data was available to arrive at estimates jarringly at odds with previous counts, though they cautioned that some of those calculations remained highly uncertain. In Indonesia, for example, the experts leaned heavily on monthly death data from Jakarta, the capital, to estimate that the country had experienced over a million more deaths than normal. That figure would be seven times as high as the reported Covid death toll.

Siti Nadia Tarmizi, a spokeswoman for the governments Covid-19 vaccination program, acknowledged that Indonesia had suffered more deaths than the government had reported. She said the problem stemmed in part from people not reporting relatives deaths to avoid complying with government rules for Covid victims funerals. But she said that the W.H.O. estimates were far too high.

In Pakistan, Dr. Faisal Sultan, a former health minister, defended the governments death reports, saying that studies of the number of graveyard burials in major cities did not reveal large numbers of uncounted victims of the pandemic.

For still other countries that suffered grievously during the pandemic, the W.H.O. estimates illuminated even more startling figures hiding inside already devastating death counts. In Peru, for instance, the expert estimate of 290,000 excess deaths by the end of 2021 was only 1.4 times as high as the reported Covid death toll. But the W.H.O. estimate of 437 excess deaths for every 100,000 Peruvians left the country with among the worlds highest per capita tolls.

When a health care system isnt prepared to receive patients who are seriously ill with pneumonia, when it cant provide the oxygen they need to live, or even provide beds for them to lay in so they can have some peace, you get what youve gotten, said Dr. Elmer Huerta, an oncologist and public health specialist who hosts a popular radio show in Peru.

In the United States, the W.H.O. estimated that roughly 930,000 more people than expected had died by the end of 2021, compared with the 820,000 Covid deaths that had been officially recorded over the same period.

In Mexico, the government has itself kept a tally of excess deaths during the pandemic that appears roughly in line with the W.H.O.s. Those estimates about double the countrys reported Covid death toll reflected what analysts there described as difficulties counting the dead.

We responded badly, we reacted slowly. But I think the most serious of all was to not communicate the urgency, the wanting to minimize, minimize, said Xavier Tello, a public health analyst based in Mexico City. Because Mexico wasnt or isnt testing for Covid, a lot of people died and we dont know if they had Covid.

The W.H.O.s calculations include people who died directly from Covid, from medical conditions complicated by Covid, or because they had ailments other than Covid but could not get needed treatment because of the pandemic. The excess death estimates also take into account expected deaths that did not occur because of Covid restrictions, such as reductions in traffic accidents or isolation that prevented deaths from the flu and other infectious diseases.

Calculating excess deaths is complex, the W.H.O. experts said. About half of countries globally do not regularly report the number of deaths from all causes. Others supply only partial data. In the W.H.O.s African region, the experts said that they had data from only six of 47 countries.

Scientists also noted that excess death rates were not necessarily indicative of a countrys pandemic response: Older and younger populations will fare differently in a pandemic, regardless of the response. And the W.H.O. experts said that they did not account for the effects of heat waves or conflicts.

Where death figures were missing, the statisticians had to rely on modeling. In those cases, they made predictions based on country-specific information like containment measures, historical rates of disease, temperature and demographics to assemble national figures and, from there, regional and global estimates.

W.H.O. officials used the release of their calculations to plead for greater investment in death reporting.

When we underestimate, we may underinvest, said Dr. Samira Asma, the W.H.O.s assistant director general for data, analytics and delivery for impact. And when we undercount, we may miss targeting the interventions where they are needed most.

W.H.O. officials cited Britain as an example of a country that had accurately recorded Covid deaths: Their analysis found that about 149,000 more people than normal had died during the pandemic, nearly identical to the number of Covid deaths Britain reported.

The disagreement over Indias Covid deaths spilled into public this week when the Indian government on Tuesday abruptly released mortality data from 2020, reporting an 11 percent increase in registered deaths in 2020 compared with average annual deaths registered over the two prior years.

Analysts saw the release as an attempt to force the W.H.O. to reconsider its calculations on the eve of publication. Indian health officials said their figures showed that the country had lost fewer people to Covid than outside estimates suggested.

But scientists believe that most of the countrys excess mortality occurred in 2021, during a grievous wave caused by the Delta variant. And even Indias 2020 figures gave additional credence to the W.H.O. estimates, said Dr. Jha, who has also studied excess deaths in India.

The Indian government wanted to deflect the news, he said, but theyre confirming, at least for 2020, the W.H.O. numbers.

Other experts said that Indias refusal to cooperate with the W.H.O. analysis was rooted in the countrys history of ignoring how data can inform policymaking.

Its natural to miss some of the Covid deaths, said Dr. Bhramar Mukherjee, a professor of biostatistics at the University of Michigan School of Public Health who has been working with the W.H.O. to review the data. But, she added, Nobodys been this resistant.

The Ministry of Health in New Delhi did not respond to requests for comment. W.H.O. officials said that Indias 2020 death figures were released too late to be incorporated into their calculations but that they would carefully review the data.

Nations that report Covid deaths more accurately have also been at the center of disputes over the reliability of excess death estimates. In Germany, for example, the W.H.O. experts estimated that 195,000 more people than normal had died during the pandemic, a significantly higher toll than the 112,000 Covid deaths recorded there.

But Giacomo De Nicola, a statistician at Ludwig Maximilian University of Munich, who has studied excess deaths in Germany, said that the countrys rapidly aging population meant that the W.H.O. analysis might have underestimated the number of people who would have been expected to die in a normal year. That, in turn, could have produced overestimates of excess deaths.

He said that the W.H.O.-assembled experts had accounted for trends in mortality, but not directly for changes in the age structure of the population. While Germany experienced excess deaths, he said, the W.H.O. estimate for the country seems very high.

Overall, the W.H.O. calculations were more conservative than separate analyses released earlier by The Economist and the Institute for Health Metrics and Evaluation.

Some experts said that the W.H.O. analysis benefited from relying more heavily than other estimates on actual data, even where it was incomplete, as opposed to statistical modeling.

Oscar Lopez, Karan Deep Singh, Sofa Villamil, Christopher F. Schuetze, Ivan Nechepurenko, Richard C. Paddock, Muktita Suhartono, Mitra Taj, Julie Turkewitz, Merna Thomas and Salman Masood contributed reporting.

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George Cheeks, the president of CBS, tests positive for coronavirus after attending the White House Correspondents' Dinner. - The New York Times

COVID-19 Infection Has More Than 50 Long-Term Effects – Medscape

May 8, 2022

MADRID, Spain Clinical experiences in approaching COVID-19 from different perspectives, results obtained by various therapeutic options and, above all, the challenges posed by a new healthcare reality long COVID were all the focus of a recent discussion at the 7th International Congress of the Spanish Society of Precision Health.

In this forum, titled Precision Health: A COVID-19 Professional Debate, Mayca Gonzlez, MD, a specialist in microbiology and an expert in age management medicine at the University of Granada, reviewed the most recent data regarding long COVID. "According to the latest evidence, 9 out of 10 COVID-19 patients (87%) discharged from hospital experience at least one symptom 60 days after illness onset, with 32% reporting one or two symptoms and 55% presenting three or more. Additionally, more than 50% of symptomatic cases have at least one symptom of the disease 1 year after infection."

Another study found that 12.8% of the infected study participants continued to have dyspnea after 6 months, even in the absence of a pneumonia diagnosis, Gonzlez added.

Research on this topic has also shed light on the main risk factors for developing long COVID. "First of all, gender, age, and even the number of symptoms" are risk factors, said Gonzlez. "Therefore, women and people between 40 and 54 years of age are more likely to suffer from long COVID. It is also known that the more severe the acute illness, the greater the number of symptoms that appear after post-infection.

"Having a body mass index equal to or greater than 25, reporting three to seven symptoms of COVID-19 in the acute phase, and patients with more than five symptoms during the first week of the disease are factors associated with being prone to suffer from long COVID. All this sets up a health problem that will undoubtedly be a major challenge from now on."

Gonzlez stressed that studies have shown that there are more than 50 long-term effects of COVID-19, the most prevalent being fatigue (58%), headache (44%), attention disorders (27%), and hair loss (25%).

Among all the research projects carried out on this topic, Gonzlez highlighted a study published in January that, in her opinion, is one of the most relevant to date "because it delves into the pathophysiologic circumstances behind symptoms at all levels, something that we did not fully know until now.

"For example, it has been shown that dyspnea, hypoxia, fatigue, 'ground-glass' opacities, and pulmonary fibrosis are due to damage to the lung parenchyma [primarily] mediated by the virus and secondarily due to immunological microvascular damage. On the other hand, at a cardiovascular level, up to 20 cardiovascular conditions can occur 1 year after overcoming COVID-19. This allows us to foresee that these patients will be a significant demand on health systems in the coming years."

Regarding the digestive and intestinal system, Gonzlez highlighted a hitherto unknown mechanism: the involvement of the vagus nerve and the intestinal microbiota.

"There are studies that suggest a pattern of persistent or recurrent viremia in some patients, causing a clinical evolution of nonspecific symptoms associated with personal limitations," she said. "This could lead us to think about the possibility that the virus would have a reservoir at this level. Along the same lines, research currently in progress points to a possible involvement of the vagus nerve as the cause of the manifestations of long COVID. We must not forget that this nerve connects the brain and the gastrointestinal tract, in addition to controlling heart rate, sweat production, and the gag reflex."

In her analysis of this pilot study carried out by a group of Spanish researchers, Gonzlez commented that two thirds (228) of the 348 participants involved had at least one symptom suggestive of vagus nerve dysfunction. Upon further evaluation of these 228 patients, in the first 22 subjects with vagus nerve dysfunction, 20 were women with a median age of 44 years.

"The study also reflects that the most frequent vagus nerve dysfunction related symptoms were diarrhea (73%), tachycardia (59%), dizziness (45%), dysphagia (45%), and dysphonia (45%); 86% of the patients had three different vagus nerve dysfunction related symptoms. Six of the 22 patients displayed alteration of the vagus nerve in the neck shown by ultrasound, including both thickening of the nerve and mild inflammatory reactive changes," she noted.

Another important fact of this research was that 10 of the patients showed abnormal breathing patterns and reduced maximum inspiratory pressures, which, according to Gonzlez, indicated the weakness of the respiratory muscles connected to the vagus nerve. "Seventy-two percent also had oropharyngeal dysphagia or difficulty swallowing, and eight patients showed reduced or impaired ability to move food from the esophagus to the stomach and acid reflux."

At the same conference, Wilson Martnez,MD, a specialist in sports and exercise medicine, addressed the role of physical exercise in the recovery of people who have suffered from COVID-19. "It should be kept in mind that many patients with mild or severe COVID-19 do not fully recover and have a wide variety of chronic symptoms for months or weeks after infection that are often neurological, cognitive, or psychiatric in nature. This is what is known as post-COVID-19 syndrome, reported by between 10% and 20% of patients."

In his presentation, The Value of Exercise in the Post-COVID Patient, Martnez reviewed the most recent studies that show the link between exercise and the benefits for health in general and against SARS-CoV-2 and its consequences in particular. "In these investigations," he told the audience, "exerkines are discussed, understanding as such the substances that are produced or generated with the practice of physical activity (including hormones and metabolites) with healthy benefits at different levels. There is a varied repertoire of exerkines in the systemic circulation, and it is known that the higher the intensity and momentum with which exercise is performed, provided it is done properly, that these exerkines manifest in a more positive way."

In the context of COVID-19, Martnez explained this positive impact "taking into account that SARS-CoV-2 affects the angiotensin-converting enzyme-2 receptor, and this in turn involves the appearance of fibrosis, inflammation, vasoconstriction, reduced neurogenesis, and cardiovascular damage. This activation of a series of vascular signaling chains that occurs with exercise makes it possible to counteract a good number of the symptoms of the post-COVID-19 syndrome, acting in a certain sense like a polypill."

Specifying the potential benefits of exercise in post-COVID-19 syndrome, Martnez highlighted that there is an improvement in the psychological component, since it reduces stress, which translates into an improvement in mood and a feeling of well-being.

"At the neurological level, it stimulates brain plasticity, improves cognitive abilities, decreases allostatic load and optimizes sleep quality," he explained. "As for the cardiovascular system, angiogenesis occurs, improving the vascular system and cardiovascular function, lowering blood pressure, normalizing dysautonomia, and notably increasing mitochondrial biogenesis.

"In the respiratory system, it decreases dyspnea and improves oxygen consumption and lung function. In muscles, it improves exercise tolerance, increases muscle strength and muscle mass, with better intramuscular coordination. In relation to the immune system, it decreases inflammatory cytokines and increases anti-inflammatory cytokines, generally improving immune function," Martnez continued.

Martnez stressed that there is no known drug that produces all these benefits. "Unfortunately, we are not taught or used to prescribing exercise. Based on all this evidence, it is obvious that it should be incorporated into the prevention of and approach toward not only COVID-19 and post-COVID-19, but in general, for the care of cardiovascular and metabolic health, both to prevent diseases and as an adjuvant in many pathologies."

Regarding what type of activity is most recommended in these patients, Martnez pointed out that "there is sufficient evidence to suggest that adapted and supervised training with aerobic and strength endurance exercises can be an effective multisystemic therapy for post-COVID-19 syndrome."

In this sense, Martnez stressed the need to value the importance of strength training. "Although a good part of the population practices aerobic activity, the percentage drops when it comes to strength routines, especially among women, since they associate it with the risk of excessive bodybuilding. In the case of post-COVID-19, this training is essential, since one of the most worrying signs of this syndrome is the loss of muscle mass.

"A little more research is required in this field, but without a doubt, it is a perfect tool to counteract and manage the multiple signs and symptoms that persist after having suffered from COVID-19," Martnez concluded.

Gonzlez and Martnez have disclosed no relevant financial relationships.

Follow Carla Nieto of Medscape Spanish edition on Twitter @carlanmartinez.

This article was translated from the Medscape Spanish edition.

For more news, follow Medscape on Facebook, Twitter, Instagram, YouTube, andLinkedIn

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COVID-19 Infection Has More Than 50 Long-Term Effects - Medscape

Model finds COVID-19 deaths among elderly may be due to genetic limit on cell division – University of Washington

May 8, 2022

Health and medicine | Public Health | Science | UW News blog

May 6, 2022

This illustration represents the core theory in a new modeling study led by the University of Washington: The circles represent the immune systems aging, in which its ability to make new immunity cells remains constant until a person (represented by the human figures) reaches middle-age or older and then falls off significantly. The central blue figure represents an immune system T cell that attacks the virus.Michele Kellett and James Anderson/University of Washington

Your immune systems ability to combat COVID-19, like any infection, largely depends on its ability to replicate the immune cells effective at destroying the SARS-CoV-2 virus that causes the disease. These cloned immune cells cannot be infinitely created, and a key hypothesis of a new University of Washington study is that the bodys ability to create these cloned cells falls off significantly in old age.

According to a model created by UW research professor James Anderson, this genetically predetermined limit on your immune system may be the key to why COVID-19 has such a devastating effect on the elderly. Anderson is the lead author of a paper published March 31 in The Lancet eBioMedicine detailing this modeled link between aging, COVID-19 and mortality.

When DNA split in cell division, the end cap called a telomere gets a little shorter with each division, explains Anderson, who is a modeler of biological systems in the School of Aquatic and Fishery Sciences. After a series of replications of a cell, it gets too short and stops further division. Not all cells or all animals have this limit, but immune cells in humans have this cell life.

The average persons immune system coasts along pretty good despite this limit until about 50 years old. Thats when enough core immune cells, called T cells, have shortened telomeres and cannot quickly clone themselves through cellular division in big enough numbers to attack and clear the COVID-19 virus, which has the trait of sharply reducing immune cell numbers, Anderson said. Importantly, he added, telomere lengths are inherited from your parents. Consequently, there are some differences in these lengths between people at every age as well as how old a person becomes before these lengths are mostly used up.

Anderson said the key difference between this understanding of aging, which has a threshold for when your immune system has run out of collective telomere length, and the idea that we all age consistently over time is the most exciting discovery of his research.

Depending on your parents and very little on how you live, your longevity or, as our paper claims, your response to COVID-19 is a function of who you were when you were born, he said, which is kind of a big deal.

To build this model the researchers used publicly available data on COVID-19 mortality from the Center for Disease Control and US Census Bureau and studies on telomeres, many of which were published by the co-authors over the past two decades.

Assembling telomere length information about a person or specific demographic, he said, could help doctors know who was less susceptible. And then they could allocate resources, such as booster shots, according to which populations and individuals may be more susceptible to COVID-19.

Im a modeler and see things through mathematical equations that I am interpreting by working with biologists, but the biologists need to look at the information through the model to guide their research questions, Anderson said, admitting that the dream of a modeler is to be able to actually influence the great biologists into thinking like modelers. Thats more difficult.

One caution Anderson has about this model is that it might explain too much.

Theres a lot of data supporting every parameter of the model and there is a nice logical train of thought for how you get from the data to the model, he said of the models power. But it is so simple and so intuitively appealing that we should be suspicious of it too. As a scientist, my hope is that we begin to understand further the immune system and population responses as a part of natural selection.

Co-authors include Ezra Susser, Mailman School of Public Health, Columbia University; Konstantin Arbeev and Anatoliy Yashin, Social Science Research Institute, Duke University; Daniel Levy, National Heart, Lung, and Blood Institute, National Institutes of Health; Simon Verhulst, University of Groningen, Netherlands; Abraham Aviv, New Jersey Medical School, Rutgers University.

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For more information, contact Anderson at jjand@uw.edu.

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Model finds COVID-19 deaths among elderly may be due to genetic limit on cell division - University of Washington

Uptick in COVID-19 cluster related to Hawaii proms – KHON2

May 8, 2022

HONOLULU (KHON2) Officials are noticing an uptick in clusters associated with large school events that are happening just as prom season has begun for many schools.

The Hawaii State Department of Health had an investigation on outbreaks of COVID-19 and Influenza A in April that were associated with two high school proms on Oahu.

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DOH said the first investigation started after a school reported to the department that 37 students who attended the prom stated they were sick with common respiratory symptoms.

There were over 300 students and chaperones who attended the prom. Six attendees tested positive for coronavirus, said DOH.

Of the six that tested positive, one was unvaccinated, four had only completed their primary series and one was up to date on all vaccinations. There were four individuals that tested positive for Type A influenza, with one of them testing positive for both influenza and coronavirus.

Out of the 37 symptomatic individuals, 35 students said they received a COVID-19 test. However, the DOH believed that with limited influenza testing and home test reporting, the true number of infections could likely be higher than what was reported.

About 57% of the prom attendees had received a primary series of the coronavirus vaccine.

Attendees stated mask use and social distancing were not practiced or enforced at the event.

The second cluster had 16 COVID-19 cases at a high school prom with over 600 students and chaperones.

DOH said 10 attendees tested positive for coronavirus and three attendees were symptomatic and epidemiologically linked. Of the 13 primary cases, five had received a primary series only and five were up to date on all COVID vaccinations. The other three attendees vaccination status was unable to be determined.

Mask use was required indoors at the event except during food service.

Both schools required the attendees to be vaccinated with the primary series or submit a negative COVID-19 test. However, the DOH said that both proms being held indoors could have contributed to a higher risk of COVID transmission among the attendees.

Since April 1 the state of Hawaii investigated 27 clusters associated with schools and school-sanctioned events. Of the reported clusters, 30% were related to high school proms.

Get more coronavirus news: COVID vaccines, boosters and Safe Travels information

The DOH identified COVID-19 clusters when three or more confirmed or probable cases of coronavirus are linked to a particular site or event within one 14-day incubation period.

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Uptick in COVID-19 cluster related to Hawaii proms - KHON2

Two COVID-19 deaths reported this week, bringing county total to 62 – The Ithaca Voice

May 8, 2022

TOMPKINS COUNTY, N.Y.COVID-19 has claimed the lives of two more Tompkins County residents this week, the first two deaths from the coronavirus locally since the end of March.

Sadly, TCHD was notified of the death of a Tompkins County resident. Our condolences go out to the family of this individual, read a tweet from the Tompkins County Health Department Friday. A similar message was passed along earlier in the week with the first death.

The pandemic has been fairly quiet recently in Tompkins County, though that is partially because testing and contact tracing have been greatly reduced, either by the government or by peoples own level of caution. Over the last week or so, COVID-19 hospitalizations have hit double digits once again in Tompkins County, the first time since January 2022 that those numbers have sustained that level.

The health department is no longer publishing active case numbers, so it is difficult to tell how many people are currently ailing from COVID-19 in Tompkins County. Recent wastewater testing shows that COVID-19 is trending upward (more on that in a subsequent article), but exact numbers are nigh impossible to pin down. However, the health department lists the level of community transmission at 464 currently, meaning that the number of positive tests over the last week per 100,000 people (conveniently, Tompkins County has just about 100,000 people) is 464. That number is trending upward as well, though not nearly as high as this past December and January.

It is unclear whether or not the two people who passed away this week were vaccinated or not.

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Two COVID-19 deaths reported this week, bringing county total to 62 - The Ithaca Voice

COVID-19, Vaccines, and Global Health Inequities – Pulitzer Center on Crisis Reporting

May 8, 2022

The Pulitzer Center is seeking applications for enterprise and underreported stories about COVID-19 inequities and other U.S. and global health system failures. Were interested in systemic barriers to all sorts of care, including, but not limited to, COVID-19 vaccines and treatment. Were also interested in stories about misinformation and politicization that impede improved access to care and preparation for future health crises. This opportunity is open to all newsrooms and independent journalists in the United States and abroad.

COVID-19 laid bare what was clear to many already: With some exceptions, health systems around the world are woefully underresourced or inaccessible to many who arent wealthy.

COVID-19 spread rapidly among essential but often lower-paid U.S. workers who were unable to shelter and work at home. Despite lessons learned from the pandemic, even routine health care remains beyond reach for many in the worlds richest country. A disturbing number of U.S. residents also continue to shun vaccines, influenced by misinformation.

Globally, millions of people in low- and middle-income countries are unable to access vaccines. And some also harbor fear of inoculation. The pandemic and other crises have also contributed to a global surge in mental health problems, yet mental health care often remains taboo and unaffordable.

Were interested in reporting projects about underreported COVID-19 and non-COVID-19 health inequities, as well as solutions in the works.For inspiration, here are a few recent projects we supported:

We aim to support teams that reflect the communities they report on. We hope this grant can help our partner organizations advance their diversity, equity, and inclusion goals and commitments.

We accept grant proposals on a rolling basis.

Please refer to Tips for Writing a Successful Pulitzer Center Grant Proposal for more information on how to apply.

The COVID-19, Vaccines, and Global Health Inequities grant is funded by the Rockefeller Foundation and general operating support.

Who is eligible to apply?

This opportunity is open to U.S. residents and journalists around the world. We are open to proposals from freelance journalists, staff journalists, or groups of newsrooms working in collaboration with a project idea. We want to make sure that people from many backgrounds and perspectives are empowered to produce journalism. We strongly encourage proposals from journalists and newsrooms who represent a broad array of social, racial, ethnic, underrepresented groups, and economic backgrounds.

When will you be notifying applicants on whether they've been selected?

We begin reviewing applications as soon as they are received and typically notify applicants within a month if they're being considered for support. If there is some urgency to the field reporting, the applicant should state the reason in the application.

What is the budget range for proposals?

We do not have a budget range. We will consider projects of any scope and size, and we are open to supporting multiple projects each year.

Do you pay stipends or salaries for freelance journalists?

We expect news organizations to pay freelance journalists for their work, though in exceptional cases, we may consider stipends to cover a reporter's time, if provided in the budget with an explanation. It is OK to include costs of contractors, such as data researchers, illustrators, or data visualization/story designers in your proposal and budget. Please do not include stipends for journalists/team members who are in the employ of newsrooms or are being paid by a publisher.

Email Pulitzer Center Senior Editor Susan Ferriss at sferriss@pulitzercenter.org. We check emails daily and look forward to hearing from you.

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COVID-19, Vaccines, and Global Health Inequities - Pulitzer Center on Crisis Reporting

Should you get a second COVID-19 booster dose? Top docs on Staten Island weigh in. – SILive.com

May 8, 2022

STATEN ISLAND, N.Y. Nearly eight months after the United States Food and Drug Administration (FDA) gave the green light to administer COVID-19 booster doses, the number of new supplemental vaccinations being given has fallen precipitously after a winter spike, federal data shows.

Now, around a month after a second booster was authorized, top doctors on Staten Island are urging eligible residents to consider bolstering their protection against severe disease.

The Centers for Disease Control and Prevention (CDC) previously backed a plan to provide second booster doses for people over the age or 50 and those who are 12 and older who also have underlying conditions that put them at greater risk for severe infection. The FDA approved those guidelines in late March.

However, while data indicated a second booster dose strengthened the bodys protection against severe infection after defenses created by an initial booster began to dissipate, research found that reinforced deterrent to severe disease quickly began to wane.

The rapid drop off in protection has caused controversy among experts over the strategy of continually using booster doses.

Still, as new infections have again begun to rise, forcing New York City into a yellow, or medium, alert level for community transmission, health officials continue to urge Staten Islanders especially those who are at higher risk to not underestimate the virulence of COVID-19.

FIRST BOOSTER VERY EFFECTIVE

The first booster dose has by far been shown to be very effective in terms of limiting ones ability to get very sick. Were not seeing people get as sick as opposed to those who are not boostered or have no vaccine, said Dr. Theodore Strange, chairman of medicine at Staten Island University Hospital (SIUH). The second booster has been more controversial.

Noting a diminished antibody response to a second booster dose, Strange still affirmed that the fourth shot was effective for people with depleted immune systems, including those who are going through chemotherapy or have diabetes, adding, it definitely did show a benefit to those at highest risk.

He is recommending his older patients get the latest booster dose and said he is also planning to get a fourth shot.

Dr. Philip Otterbeck, chairman of medicine at Richmond University Medical Center in West Brighton, said strong evidence supports the authorization of a second booster dose for older and immunocompromised people.

While federal health authorities recommend anyone over the age of 50 receive the additional shot, Otterbeck said people over 60 should especially consider it because that was the particular group that tended to benefit from the second booster in international studies.

Otterbeck said he has received the first booster dose and will get the second when he is eligible.

The exteriors of Staten Island University Hospital in Ocean Breeze and Richmond University Medical Center in West Brighton are shown in an undated composite. (Staten Island Advance/Jason Paderon)

MORE BOOSTERS IN FUTURE?

It remains unclear if more booster doses will be recommended in future months and years, if the virus will begin to be treated in a similar fashion to the way the common flu is handled with yearly shots or if the approach of continuing to administer booster doses will bring diminished returns over time.

Despite being more than two years into the pandemic, a litany of questions remain on the fronts of vaccine protection and long-term effects of the disease that has officially killed more than one million people in the United States and more than 2,300 Staten Islanders.

Anybody who thinks theyre an expert at this, theyre not an expert. Were all experts, but none of us are experts, said Strange, who added that additional research is especially needed to better understand how long protection from booster doses lasts.

I think we need to continue to watch it and follow the science, said Strange.

While highly infectious variants of the coronavirus, like omicron and its sub-lineage BA.2, have locally caused new spikes in positive cases, hospitals are not being strained as they were in earlier stages of the pandemic.

Just a few dozen people hospitalized on Staten Island had COVID-19, with some of those individuals admitted for reasons unrelated to their infection. Tools like vaccinations and therapeutics, along with improved understanding of how to manage the disease, have helped ameliorate COVID-19 treatment and prevent deaths.

FUTURE SURGES?

Still, Strange expressed concern that a noticeable shift in public attitude toward the pandemic, coupled with loosening restrictions, could create a recipe for future surges that claim the lives of more borough residents.

Im still concerned another variant will come along as we let our guard down with masking and other things, said Strange, who said that while he does not feel stringent lockdowns are needed, persistent testing and isolation strategies in condensed hotspots should remain.

Otterbeck echoed those sentiments and said the future phases of the pandemic will largely depend on the emergence and virulence of new variants.

COVID is probably not going to be going away, at least anytime soon, said Otterbeck. But, we need to learn to work with it and make sure were doing everything we can to protect the people of Staten Island and of course the people in this country.

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Should you get a second COVID-19 booster dose? Top docs on Staten Island weigh in. - SILive.com

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