Category: Covid-19

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Could you still have Covid-19 if you have symptoms but test … – CNN

February 9, 2023

CNN

It has been over three years since Covid-19 cases were first diagnosed in the United States. And while President Joe Biden announced last week that he intends to end the state of national emergency around Covid-19, this does not mean the pandemic is over.

Although much is now known about this coronavirus, many questions remain, especially as the virus continues to evolve and infect people on a large scale. There were more than 280,000 new coronavirus cases diagnosed in the last week, according to the US Centers for Disease Control and Prevention. This is almost certainly an undercount, given the many home tests not included as part of the official tally.

A frequent question from CNN readers and viewers is what it means if someone has Covid-19 symptoms but tests negative for the virus, especially if they have been exposed. Why does that happen? Should they test again and when? Are there other tests they should get, including for other viruses? How can someone find out if theyve already had Covid-19?

To help us with these questions, I spoke with CNN medical analyst Dr. Leana Wen, an emergency physician and professor of health policy and management at the George Washington University Milken Institute School of Public Health. She is also the author of Lifelines: A Doctors Journey in the Fight for Public Health.

CNN: Many people believe they have symptoms of Covid-19 but are testing negative. Why does that happen?

Dr. Leana Wen: There are several possibilities. First, Covid-19 often presents like other viral illnesses. Common symptoms include a fever, cough, runny nose, headache or body aches, a sore throat and diarrhea. These are types of symptoms also seen with other viral illnesses, including influenza and adenovirus. Its possible you may have symptoms youre identifying as evidence of a Covid-19 infection that are actually due to another virus.

Second, you may be testing too soon after being infected with Covid; there may not be enough virus present to trigger a positive result. Generally, it takes at least two days after exposure to develop symptoms and/or to have a positive result. Many times, though, there isnt enough virus to trigger a positive test until at least five days after exposure. This is why repeated testing is important, especially if you are taking home rapid antigen tests.

Third, the test may be a false negative. Home antigen tests are less accurate than PCR tests. If you have a high likelihood of contracting Covid-19 for example, if you were exposed to someone who had the coronavirus and now you have symptoms, but youre still testing negative from a home test you may wish to get a PCR test.

CNN: If someone were exposed to another person who has Covid-19, when should they get tested, and with what test?

Wen: If you were exposed to someone with Covid-19, you should wait until its been at least five days after exposure to get tested, according to the CDC. Either an antigen test or a PCR test could be used at this point. But because its still possible to develop symptoms after five days, the CDC recommends you wear a mask when in public indoor places for a total of 10 days. You should also monitor your symptoms; if you develop any, even after five days following a potential exposure, you should get tested again.

CNN: What if youve had direct exposure for example, from a spouse who has Covid-19 and have symptoms, but still get a negative test after five days?

Wen: If you took a rapid antigen test, Id recommend taking another one the next day. Its possible your viral load was not high enough the first time around. (This is also the guidance suggested by the U.S. Food and Drug Administration.)

If the repeat test is still negative, and its important for you to find out whether you have Covid-19, you could go take a PCR test. The PCR test is more accurate, though the caveat is that it picks up viral remnants. That means if its positive, it could mean you recently recovered from Covid-19.

If all these tests are negative, another possibility is that you have a different viral illness, and should still continue to wear a mask in public until 10 days after your exposure. Also, be careful around vulnerable individuals while you are symptomatic, even if its not from Covid-19. If you have a trip to a nursing home planned to visit your elderly aunt, for example, or youre planning to host dinner with an immunocompromised guest, you should postpone until your symptoms are gone and your 10-day quarantine period has completed.

CNN: If your Covid-19 test is negative, should you get tested for other viruses?

Wen: It depends. If you are a generally healthy person and have mild symptoms, testing is probably not required. You should use symptomatic management, meaning to drink lots of fluids, rest and take over-the-counter analgesics like acetaminophen or ibuprofen as needed.

If you have underlying medical conditions, you might be particularly concerned about influenza. There are antiviral treatments available, and you should consider speaking with your doctor about flu testing and if you are eligible for them.

Some physicians practices are now routinely testing for Covid-19, influenza and respiratory syncytial virus (RSV). When in doubt, speak with your doctor. And make sure to call your doctor if you develop worsening or particularly concerning symptoms, such as shortness of breath, chest pain or an inability to keep down fluids.

CNN: How can someone find out if theyve already had Covid-19?

Wen: There is an antibody blood test to the SARS-CoV-2 Nucleocapsid available from commercial laboratories like Quest Diagnostics and Labcorp. This specifically looks for prior infection.

If it comes back positive, it means that you had Covid-19 at some point. It does not tell you when. So if you want to find out if a particular bout of recent symptoms was from the coronavirus, this test wouldnt help. And remember, having had Covid-19 in the past doesnt mean that you cant get sick from it again.

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Could you still have Covid-19 if you have symptoms but test ... - CNN

COVID-19 public health emergency may end, but need remains for …

February 9, 2023

COVID-19 was the greatest challenge I faced as the U.S. surgeon general.It tested our nations resolve, and yet we made great strides in countering this threat.

Key to this was Operation Warp Speed, which developed and delivered lifesaving vaccines in record time, showing whats possible when government and industry collaborate for the common good.

Vaccines are critical and effective tools in our fight against COVID-19, but they cannot be our only tool. It is clear that when the virus evades vaccines (or when people choose not to take them), therapeutics become our best line of defense to prevent hospitalizations and death. As new elusive variants emerge faster than we can develop vaccines to fight them, new therapies become a more critical lifeline.

Coming off the heels of President Joe Bidens recent announcement to end the COVID-19 national and public health emergencies in May, it is more critical than ever to continue shifting the treatment paradigm and address the persistent unmet need for patients who are still at the greatest risk.

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COVID-19 remains the third leading cause of death in the United States, behind only cancer and heart disease. Even as it becomes more endemic, hundreds of Americans are still dying daily, with most deaths now among the elderly, those with risk factors for severe COVID-19 and immunocompromised individuals.

For high-risk patients, monoclonal antibodies have been critical in saving lives.Unfortunately they are no longer effective against the most common currently circulating variants and have been pulled from the market.

As we continue to see new COVID-19 variants and subvariants emerging in shorter time intervals and with unpredictable levels of severity, we are continually reminded that we are just one mutation away from the possibility of another pandemic.

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And while bivalent vaccines have shown promise, only about 16% of the eligible U.S. population has opted to receive them, leaving more opportunities for this virus to continue evolving beyond our protective means.

Driven by the commitment to save lives, we must continue with urgency and focused efforts on innovative industry and government collaboration particularly through accelerated development and provision of innovative oral COVID-19 antiviral treatments. This is a critical part of pandemic preparedness, now and in the future.

Like other antivirals, Paxlovid is designed to stop a virus from making copies of itself. Paxlovid is authorized for emergency use but not fully approved by the Food and Drug Administration. Pfizer is working on the necessary paperwork.

Unfortunately, treatment development is not keeping pace with this ever-changing virus. Medical professionals across the United States have told me that they are desperate for new therapeutic choices, including easy-to-take oral treatments that can be prescribed soon after the onset of COVID-19 symptoms and prevent severe disease and hospitalization.

While existing antivirals are a much-needed foundation, they are not an option for many patientsand have limitations for already high-risk population groups, including drug-drug interactions and reduced efficacy for people with compromised immune systems.

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Collectively among industry and government sectors, its still our responsibility to ensure these treatments get in the hands of patients as swiftly as possible to lessen the severity of COVID-19 and reduce mortality for those at greater risk.

The U.S. Food and Drug Administration shares these beliefs, and it is essential that the emergency use authorization, which allows the agency to respond more quickly, continue for new treatments when the criteria for issuance is met.

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Despite the now anticipated end in May or sooner of the public health emergency declaration, and the unpredictable nature of COVID-19, our collective commitment to develop and deliver efficacious treatments should continue as a pillar of pandemic preparedness.

We learned valuable lessons from COVID-19 thus far, so we must apply them to the next phase of antiviral development to create oral COVID-19 treatment options that can help us finally put this pandemic in the history books where it belongs.

Dr. Jerome Adams

Dr. Jerome Adams, a former U.S. surgeon general, is a distinguished professor and executive director of health equity initiatives at Purdue University and a member of the USA TODAY Board of Contributors. Follow him on Twitter:@JeromeAdamsMD

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This article originally appeared on USA TODAY: As COVID-19 emergency ends, accelerate oral antiviral treatments

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COVID-19 public health emergency may end, but need remains for ...

Heres What the End of the COVID-19 Public Health Emergency Could Mean …

February 9, 2023

Top federal health officials told lawmakers on Wednesday about their plans for ending the COVID-19 public health emergency. The Centers for Disease Control and Prevention director, in particular, made several requests of Congress on data and workforce priorities as it undergoes an overhaul.

President Biden said during his State of the Union on Tuesday night, COVID no longer controls our lives. This comes after the White House announced last week the administration is planning to COVID-19 national emergency and public health emergency on May 11. Both have been in place since 2020 and have allowed for a series of flexibilities for the federal governments response.

Id like to be clear that we plan to address this emergency and work towards the safety and security of all Americans 24/7 regardless if theres a public health emergency in place, said Dr. Rochelle Walensky, CDC director, during a joint hearing by the House Energy and Commerce Committees subcommittees on Oversight and Investigations and Health.It is the case that when the public health emergency comes down we lose some of our ability to see the data. We will lose testing dataWe will lose other data as well and were actively working right now to set up data use agreements, so that we will have the data that we need.

One of her requests to Congress is for more authority so the agency doesnt have to sign dozens of data use agreements, which takes months. She said this will be important for COVID-19, but also other public health emergencies.

Dr. Lawrence Tabak, acting director of the National Institutes of Health, said the effects of the ending of the public health emergency on NIH will be modest, noting they will have to work with their grant community for slight changes.

Dr. Robert Califf, commissioner of the Food and Drug Administration, also said the effects on the FDA will be modest. FDA has worked on guidance for transitioning devices that fall within enforcement policies issued during the COVID-19 [public health emergency] or that received [emergency use authorizations] to help facilitate a clear and predictable path to market for interested developers, he said in his prepared statement. FDA intends to facilitate continued access to devices for patients and healthcare providers during the transition and while marketing submissions are under review.

The White House made the announcement about the ending of the emergencies in response to legislation brought forth by Republicans that would have ended them immediately. An abrupt end to the emergency declarations would create wide-ranging chaos and uncertainty throughout the health care system for states, for hospitals and doctors offices, and, most importantly, for tens of millions of Americans, said a statement of administration policy.

Even as the emergencies are ending, during his address on Tuesday night Biden also re-upped the administrations call for more funding to support monitoring COVID-19 variants and support the development of new vaccines and treatments. The administration has been repeatedly asking for more funding for a year, but to no avail.

As the CDC has been undergoing internal reforms based on challenges identified earlier in the pandemic, Walensky told lawmakers her agency could use more workforce authorities such as danger pay, overtime pay and tax-free loan repayment in order to enhance its workforce capacity. A report released last month from a bipartisan working group launched by the Center for Strategic and International Studies outlined other workforce-related recommendations to revamp the CDC, which would align it with the authorities that the U.S. Agency for International Development and the Federal Emergency Management Agency have.

During the hearing, lawmakers also pressed the health officials on trust in science, gain-of-function research (something highly scrutinized by Republicans) in light of a recent report from the Government Accountability Office and vaccines. On Thursday, the House Energy and Commerce Committee will vote on its oversight plan for the 118th Congress, which includes much COVID-19 response oversight.

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Heres What the End of the COVID-19 Public Health Emergency Could Mean ...

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