Category: Covid-19

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Novavax’s Updated COVID-19 Vaccine Now Available as Only Option in Poland – University of Nebraska Medical Center

December 14, 2023

Novaxx

Novavaxs updated protein-based non-mRNA COVID-19 vaccine is now available for use in Poland for the prevention of COVID-19 in individuals aged 12 and older. Doses have been distributed by the appropriate Polish authorities and made available for this seasons vaccination campaign. The Novavax vaccine is currently the only updated COVID-19 vaccine option available in Poland.

We are pleased that our updated vaccine is available in time for the upcoming Christmas and winter holiday season. We are honored to support both the Polish government and the countrys healthcare workers to help protect Polish citizens and their loved ones against COVID-19. Starting today, individuals across the country can receive an updated vaccine.

Non-clinical datashowed that Novavaxs updated COVID-19 vaccine induced functional immune responses against XBB.1.5, XBB.1.16 and XBB.2.3 variants. Additional non-clinical data demonstrated that Novavaxs vaccine induced neutralizing antibody responses to subvariants BA.2.86, EG.5.1, FL.1.5.1 and XBB.1.16.6 as well as CD4+ polyfunctional cellular (T-cell) responses against EG.5.1 and XBB.1.16.6. These data indicate Novavaxs vaccine can stimulate both arms of the immune system and may induce a broad response against currently circulating variants.1,2

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Novavax's Updated COVID-19 Vaccine Now Available as Only Option in Poland - University of Nebraska Medical Center

VDH: COVID cases and deaths up, hospitalizations down – Vermont Biz

December 14, 2023

by Timothy McQuiston, Vermont Business Magazine COVID-19 cases rose and hospitalizations fell last week. There were also 8 fatalities reported by the Vermont Department of Health, for a pandemic total of 1,075. Fatalities had been running at about five per week during the fall, mostly among the very elderly.

The VDH reported December 6, 2023, that COVID-19 hospitalizations were down 6 last week to a statewide total of 41. COVID-19 activity remains in the "Low" range, according to the VDH. Reported cases last week were 353, up 63 for the week.

VDH reported 15 COVID-related deaths in March, 20 in April, 10 in May, 10 in June (these are fewest since the summer of 2021), 11 in July, 15 in August, 17 in September, 25 in October, 19 in November and 1 so far December (there were 33 in October 2022 and 47 in October 2021 and zero in October 2020, which was the last month since the beginning of the pandemic to record no COVID-related fatalities).

Of the total deaths to date, 864 have been of Vermonters 70 or older. There have been 3 deaths of Vermonters under 30 since the beginning of the pandemic, as of December 2 (the most recent data available).

CDC states that already an estimated 97% of Americans have some level of immunity, from either vaccination or infection or both, which they said will help keep down new transmission and lessen serious outcomes.

(see data below)

Report Timeframe: November 26 to December 2, 2023

The hospitalizations dataset contains day-level data reported from all Vermont hospitals each Tuesday. Reported numbers are subject to correction.

The number of reportable COVID-19 cases is still available in this report, below. Laboratory-confirmed and diagnosed COVID-19 cases and COVID-19 outbreaks must still be reported to the Vermont Department of Health.

There were 8 outbreaks last week, 1 at schools, and 7 at long-term care facilities (LTC).

Vermont Department of Health recommendations: Preventing COVID-19 (healthvermont.gov)

Vermont has the second lowest fatality rate in the US (124.2 per 100K; Hawaii 101.6/100K). Mississippi (434.9/100K) and Oklahoma (431.8/100K) have the highest rates. The US average is 289.9/100K (CDC data).

There has been a total of 1,158,185 COVID-related deaths to date in the US (CDC) and 6,985,964 globally (WHO).

Following an analysis of COVID-19 data, the VDH reported in January 2023 a cumulative 86 additional COVID-associated deaths that occurred over the course of the pandemic but had not been previously reported. Most of those deaths occurred in 2022.

COVID-19 Update for the United States

Early Indicators

Test Positivity

% Test Positivity

11.5%

(November 26 to December 2, 2023)

Trend in % Test Positivity

+0.9% in most recent week

Emergency Department Visits

% Diagnosed as COVID-19

1.9%

(November 26 to December 2, 2023)

Trend in % Emergency Department Visits

+4% in most recent week

These early indicators represent a portion of national COVID-19 tests and emergency department visits. Wastewater information also provides early indicators of spread.

Severity Indicators

Hospitalizations

Hospital Admissions

22,513

(November 26 to December 2, 2023)

Trend in Hospital Admissions

+17.6% in most recent week

Deaths

% of All Deaths in U.S. Due to COVID-19

3.0%

(November 26 to December 2, 2023)

Trend in % COVID-19 Deaths

+25% in most recent week

Total Hospitalizations

6,544,614

CDC | Test Positivity data through: December 2, 2023; Emergency Department Visit data through: December 2, 2023; Hospitalization data through: December 2, 2023; Death data through: December 2, 2023. Posted: December 11, 2023 3:38 PM ET

The Delta variant took off in August 2021, which resulted in the heaviest number of deaths before vaccines and their boosters helped alleviate serious COVID cases. Multiple Omicron variants are now circulating and appear more virulent than previous variants, but perhaps not more dangerous, according to the CDC.

AP April 5, 2023: WHO downgrades COVID pandemic, says it's no longer a global health emergency

Walk-in vaccination clinics run by the state closed on January 31, 2023. Learn more

Vermonters are reminded that all state COVID testing sites were closed as of June 25, 2022. PCR and take-home tests are available through doctors' offices, pharmacies and via mail from the federal government. The federal government officially ended its pandemic response as of May 11, 2023. See more information BELOW or here: https://www.healthvermont.gov/covid-19/testing.

Starting May 11, 2023, the CDC and Vermont Department of Health will no longer use the COVID-19 Community Level to measure COVID-19 activity in the U.S. and Vermont. Instead, Vermont's statewide COVID-19 level will be measured by the rate of COVID-19 in people being admitted to the hospital, per 100,000 residents.

Focusing on hospitalization data is a better estimate of how COVID-19 is impacting the community now that reported COVID-19 cases represent a smaller proportion of actual infections. This also allows us to compare Vermonts hospitalization levels with other parts of the country.

The Delta variant caused a surge in COVID-related fatalities last fall and into the winter.

The highest concentration of deaths was from September 2021 through February 2022. Overall, December 2020 and January 2022 were the worst months with 72 fatalities each.

The US confirmed its first case of COVID-19 on January 20, 2020.

Vermonters ages 6 months and older are eligible for COVID-19 vaccines. Getting vaccinated against COVID-19 is the safer way to build protection from serious illnesseven for those who have already had COVID-19. Learn more about COVID-19 vaccines (CDC)

COVID-19 vaccines are free and widely available. Anyone can get vaccinated in Vermont, including those who live in another state, are non-U.S. citizens, or who have no insurance. See Vermont's current vaccine rates

Know your rights when getting free vaccines.

You are considered up-to-date if you are over the age of 6 years old and have received a bivalent (updated) COVID-19 vaccine.Learn more about kid vaccines

If you are unable or choose not to get a recommended bivalent mRNA vaccine, you will be up to date if you received the Novavax COVID-19 vaccine doses approved for your age group.

Find more on recommended doses from CDC

COVID Vaccine Information for Health Care Professionals

More on COVID-19 Vaccines (CDC)

Recommended COVID Vaccine Doses (CDC)

Find a COVID-19 vaccine near you.

Image

Use Vaccines.gov to find a location near you, then call or visit the location's website to make an appointment.

Vaccines.gov

Everyone 6 months of age and older is eligible to get a COVID-19 vaccination.Most children are also now eligible for a bivalent dose that offers increased protection against the original strain and omicron variants.

See more on recommended vaccine doses by age group (CDC)

Resources for parents and caregivers

Confident Care for Kids

Tips for Helping Kids Feel Ready for Any Vaccine (Vermont Family Network)

#factsheet

What Families with Children Should Know About COVID-19 Vaccines (translated)

https://www.youtube.com/watch?v=lWcqHOgQIVg&t=5s

Conversations About COVID-19 Vaccines for Children with Vermont Pediatricians (American Academy of Pediatrics)

If you cannot get vaccines through any of the options above, our local health offices

offer immunization clinics by appointment.

Need a ride? If you do not have transportation to get a free COVID-19 vaccine or booster, please contact your local public transportation provider or callVermont Public Transportation Association (VPTA)

at 833-387-7200.

English language learners, or immigrant or refugee community members, who would like to learn about more about vaccine clinics can contact theAssociation of Africans Living in Vermont

(AALV) at 802-985-3106.

If you lost your vaccine card or your information is wrong:

Recommendations for keeping your vaccination card and record up to date

Find more COVID-19 translations

COVID-19 resources for people who are deaf and hard of hearing

Report your COVID-19 test results

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VDH: COVID cases and deaths up, hospitalizations down - Vermont Biz

COVID-19 Nursing Home Resident and Staff Deaths – AARP

December 14, 2023

Most data are from analysis of data are from the Centers for Medicare & Medicaid Services (CMS) Nursing Home COVID-19 Public File (downloaded most recently on 12/8/2023). These data are self-reported by facilities to the Centers for Disease Control and Prevention (CDC) weekly.

Vaccine data for Q4 2023 are from the CDC Nursing Home COVID-19 Vaccination Data Dashboard (https://www.cdc.gov/nhsn/covid19/ltc-vaccination-dashboard.html; accessed 12/8/2023).

Several data points in the state fact sheets include general population state data (that is, not limited to nursing homes) as a denominator or stand-alone measure. These data are from CDC (downloaded most recently on 12/6/2023).

Data were analyzed by Scripps Gerontology Center at Miami University in Ohio, additional analysis and preparation of the dashboard by the AARP Public Policy Institute.

Key Definitions

CDC has issued detailed instructions to nursing homes for reporting these data:

Inclusion Criteria

For the four-week measures, nursing homes were included only if the facility reported to CDC for all four weeks (nationally, 98% of facilities for the most recent four-week period, for states ranging from 94% to 100%). If a nursing facility reported but had missing data for a specific measure, that facility is excluded from the calculation of that measure for the dashboard.

Most nursing facilities with missing data are only missing the most recent week (ending 11/19/2023). That is, most missing data are due to late responses, not skipped entirely. To have the most current data possible, we must exclude those facilities that were late in reporting the most recent week of data as well as those with one or more weeks of non-response in earlier weeks.

Vaccination data points are based on the most current week of data for each facility, as long as it is within the last four weeks. Facilities do not need to report for all four weeks to be included. The Dashboards use of multiple weeks of data and definition of booster rate and up to date rate as a percentage of all residents/staff means that rates may be systematically different than what is reported elsewhere.

Aggregate counts of deaths and cases may be an undercount if there are facilities that are not reporting. Percentages or rates might be slightly biased if the average of non-reporting facilities differs significantly from the average of reporting facilities.

For the measures of cases and deaths since 6/1/2020 and since January 2020, all nursing homes reporting at least one week of data are included. The national response rate is typically greater than 99% for both measures.

Comparability to Other Data Sources

The first reporting date for the CMS Nursing Home COVID-19 data was May 24, 2020, and includes all cases and deaths that were reported since the beginning of the year; however, retroactive reporting is not mandatory, and the accuracy of reporting at the state level is unknown. Vaccination data were first reported for the week ending May 30, 2021, and are mandated as of the week ending June 13, 2021.

Data points that go back prior to the first reporting date, including the since January 2020 counts of resident cases and deaths in the state fact sheets, may significantly undercount the total number of cases and deaths. At the national level, the CMS data source gives a significant undercount of the number of cases and deaths before June 2020, compared to other sources that were reporting in real-time.

Since June 2020, the CMS data are much more reliable and at the national level track well against data reported by the states (comparisons to individual states are difficult because each state categorizes and reports the data differently).

The state fact sheets include several measures of the percentage of total state deaths and cases that occurred among nursing home residents and nursing home staff. Because the denominator data is from a different source, the reported data may result in a percentage less than 0% or greater than 100%, which is impossible. The value of each such measure is capped at 100%, and values of less than 0% are marked as NA. These measures should not be used to compute the number of cases or deaths occurring outside of nursing homes.

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COVID-19 Nursing Home Resident and Staff Deaths - AARP

Hearing Wrap Up: The World Health Organization’s Flawed Framework Must Be Reformed – United States House … – House Committee on Oversight and Reform…

December 14, 2023

WASHINGTON The Select Subcommittee on the Coronavirus Pandemic held a hearing titled Reforming the WHO: Ensuring Global Health Security and Accountability to examine the effectiveness of the World Health Organization (WHO), assess its response to the COVID-19 pandemic, and explore areas for improvement. Three Biden Administration officials from the U.S. State Department, U.S. Agency for International Development, and U.S. Department of Health and Human Services were in agreeance that the Chinese Communist Party was not transparent in sharing COVID-19 information with the world and that the WHO must be reformed before the world faces another pandemic. Select Subcommittee members discussed the existing, severe flaws within the WHO framework, described the CCPs cover-up of COVID-19 which was aided by the WHO and demanded American interests be placed at the forefront of WHO reform discussions. Throughout the pandemic, the WHO shied away from placing any blame on China and must be held accountable. The Select Subcommittee remains committed to revealing any wrongdoing by China, the WHO, and other public health officials in order to prepare our country for the next health crisis.

Key Takeaways

The World Health Organization caved to political pressure from the Chinese Communist Party and placed CCP interests ahead of global public health. It is now time to hold China accountable for its intentional coverup of COVID-19.

Select Subcommittee on the Coronavirus Pandemic Chairman Brad Wenstrup opened todays hearing by detailing four major examples of the WHO bowing to political pressure from the CCP: We saw the WHO deny that COVID-19 was spread via human-to-human transmission, based entirely on the word of the Chinese government. The WHO delayed naming COVID-19 a Public Health Emergency of International Concern, a World Health Organization procedure that, amongst other things, would have allowed for the procurement and distribution of scarce supplies, all because the Chinese Communist Party told them the spread was under control. The WHO delayed serious measures to counter the global spread of COVID-19, because the CCP was only worried about their own bottom line. When the WHO produced a report evaluating the possible origins of COVID-19, it became unquestionably evident that the entire report was nothing but more Chinese propaganda.

Biden Administration officials from the U.S. State Department (State), U.S. Agency for International Development (USAID), and U.S. Department of Health and Human Services (HHS) all agree that the World Health Organization is in urgent need of reform.

Ms. Loyce Pace, Assistant Secretary for Global Affairs at HHS, admitted that the WHO is not sufficiently structured to serve the world and described the way HHS is working to reform the organization: If the WHO didnt exist, we would have to create it. That said, the COVID-19 pandemic also revealed major gaps in our global health security architecture, including and importantly, at WHO. Working with likeminded Member States, the U.S. is leveraging our seat at the table to drive dialogs and solutions required today, because unfortunately, weve learned the hard way that this is in our national interest.

Ambassador John Nkengasong, Senior Bureau Official for Global Health Security and Diplomacy at State, committed the Biden Administration to ensuring the WHO implements comprehensive reform: This administration is firmly committed to ensuring the WHO implements a comprehensive set of organizational reforms, particularly to strengthen its governance, budgetary and financial management processes and improve oversight to strengthen the organizations efficiency and effectiveness.

Dr. Atul Gawande, Assistant Administrator for Global Health at USAID, recognized the failures of the WHO during the COVID-19 pandemic and noted USAIDs role in reforming the WHO in preparation for a future health emergency: The COVID-19 pandemic exposed significant fractures in our global health security systems and structures, including at WHO. In lockstep with our interagency partners, USAID continues to push for critical reforms at WHO, applying lessons learned from recent disease outbreaks to increase effectiveness, transparency, agility, and accountability to better respond to future health emergencies and meet our other public health goals.

As the WHO drafts a new Pandemic Accord and amendments to the International Health Regulations, it is essential that American interests and sovereignty are protected.

Dr. Atul Gawande explained the importance of protecting American sovereignty when Member States meet to discuss WHO reforms: We want respect for our sovereignty, and so we also limit how much WHO can control or demand things of us. And that is one of the challenges here, that we are protective of our own sovereignty and therefore do not want to have those tools challenged or potentially challenge us or other Member StatesWere looking for a three-level set of tiers so that there is an earlier indication when countries have a health issue developing of concern, there are clearer standards about what transparency requires, and then clear requirements that WHO has to live up to for reporting, making public and indicating when countries are not adhering to those.

Member Highlights

Select Subcommittee on the Coronavirus Pandemic Chairman Brad Wenstrup (R-Ohio), D.P.M, elicited agreement between all three executive branch witnesses that China was not sufficiently transparent or forthcoming throughout the COVID-19 pandemic.

Chairman Wenstrup: With your knowledge of what we have now and looking at COVID-19, I ask, was China, in your opinion, forthcoming and transparent regarding COVID-19?

Assistant Secretary Pace: With regards to your question, its an important one, especially because we have a lot of lessons to learn regarding COVID-19. Unfortunately, one of those lessons is the importance of transparency. We are quite disappointed and share your frustration with the government of China for not being as forthcoming as they should have been.

Ambassador Nkengasong: We fully agree with your opening remarks about the trust capital that is required to deal with global diseases. That comes with the ability to be fully transparent, to be accountable, to report in a timely fashion, and also to cooperate. All of these elements were lacking in Chinas ability to cooperate with WHO and the world.

Assistant Administrator Gawande: Im in complete agreement with my colleagues. China was not forthcoming early on about human-to-human transmission.

Committee on Oversight and Accountability Chairman James Comer (R-Ky.) shed light on HHS Global Affairs Assistant Secretarys effort to evade questions about Chinas culpability during COVID-19.

Oversight Chairman Comer: Do you believe that the Chinese government ought to be held accountable for the lack of cooperation in the early days of the pandemic? Ms. Pace.

Assistant Secretary Pace: Thank you, sir. We do think that the International Health Regulations, in improving those, will make all countries

Oversight Chairman Comer: But should China be held accountable?

Assistant Secretary Pace: We believe all countries should be held accountable.

Oversight Chairman Comer: Do you not think Chinas a little special in this situation since it came from China, and they completely lied and were not truthful with the world population about the outbreak of COVID 19. That they had veto power over who America put on boards and rejected, reports that we now know could have been helpful.

Assistant Secretary Pace: I share your frustration with Chinas lack of cooperation.

Oversight Chairman Comer: But shouldnt we hold China accountable?

Assistant Secretary Pace: Well, thats something that were trying to do by amending the International Health Regulations and ensuring that violations cant happen in the way that they did previously.

Rep. Nicole Malliotakis (R-N.Y.) laid out indisputable evidence that covering up the failures of the Chinese Communist Party was common practice at the World Health Organization throughout the pandemic.

Rep. Malliotakis: Im really concerned about what weve seen from the WHO throughout the COVID-19 pandemic. I mean, they deny human-to-human spread of COVID-19 based solely on CCP propaganda. It was not until January 23, 2020 that the WHO finally recognized that human-to-human spread was occurring. It was a month after the first warnings. The WHO delayed naming COVID-19 a public health emergency. It delayed serious measures like travel restrictions because the CCP told them the spread was under control. The WHO continued to praise the Communist Chinese Partys failed efforts to combat the pandemic despite a globally recognized cover up.

And then when we pushed for an investigation into the origins, the CCP was given full veto power over inclusion of American scientists. The Communist Chinese vetoed the three Americans put forward by our government to be in that investigative body, and the CCP was given full power to edit and alter the final reports.

Rep. Rich McCormick (R-Ga.), M.D., argued that American interests should always be at the forefront of global discussions on reforming the World Health Organization in order to ensure U.S. sovereignty is prioritized.

Rep. McCormick: Let me be clear, the United States should never ever allow international organizations, specifically the World Health Organization, to impede our sovereignty, which I know you just reaffirmed. With that said, I think that when you designed the World Health Organization, it was intended to be idea gathering, an observer, an informant to nations around the world with a goal of providing interchange of information from different health care organizations for emergencies.

However, the Biden administration must ensure the WHO authority is limited to setting public health standards and providing a forum for countries to exchange information, but not to be given greater authority to infringe on our nations sovereigntyCan you both commit to complete transparency during these processes?

Assistant Secretary Pace: Yes, sir.

Ambassador Nkengasong: Yes.

Rep. Michael Cloud (R-Texas) slammed the World Health Organization for caving to the political interests of the Chinese Communist Party instead of prioritizing global public health.

Rep. Marjorie Taylor Greene (R-Ga.) broke down major American concerns with the Biden Administrations proposed amendments to the International Health Regulations a legally binding agreement that requires all countries to conduct surveillance of potential international health threats.

Rep. Greene: The International Health Regulations, the IHR, is a treaty of the WHO, meant to usher in a new era of global public health that requires all member states to cooperate to make the world more secureIn an October 2023 meeting, the working group compiling the amendments for the 77th World Health Assembly in May 2024 was told that they do not have to produce their document before the meeting.

Some of the amendments include expanding the ability of the WHO Director-General to declare public health emergencies, to include regional declarations as well as intermediate threats, allowing Director-General to act on information in the public domain without verification from Member States, and creation of a compliance committee to enforce their rules. I can assure you the American people do not want the WHO enforcing any rules on their own personal decisions regarding their health.

If certain amendments are adopted next year, sovereign countries, including the United States, would be obligated to adhere to the treaty. The Biden administration led the charge for amendments to the IHR, including a new compliance committeeThe move toward a global health security state is reliant upon surveillance, which relies on data. Remember China? Thats what they did to their citizens and still do. The treaty and the IHR call for more sharing of personal health data in the name of safety and outbreak prevention. Thats an invasion of privacy for the American people.

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Hearing Wrap Up: The World Health Organization's Flawed Framework Must Be Reformed - United States House ... - House Committee on Oversight and Reform...

IFN identified as crucial for reducing pulmonary viral loads in COVID-19, new research shows – News-Medical.Net

December 14, 2023

In a cohort study published in Nature Communications, researchers from the United States of America investigated the role of type-2 interferon (IFN) in antiviral immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in murine models.

They found that an IFN response pre-established within the lungs may protect against SARS-CoV-2 infection, indicating the potential use of IFN as a prophylactic agent in managing coronavirus disease 2019 (COVID-19).

Study:Bacterial-induced or passively administered interferon gamma conditions the lung for early control of SARS-CoV-2. Image Credit:PrinceJoy/Shutterstock.com

COVID-19, caused by SARS-CoV-2, primarily infects lung epithelial cells expressing angiotensin-converting enzyme 2 (ACE2). While interferons (IFNs) of types 1 and 3 are known for their role in antiviral response, the role of type-2 IFN (IFN), especially in SARS-CoV-2 infection, is poorly understood. IFN is a cytokine immune cells produce in response to bacterial infection to combat intracellular pathogens.

Although IFN is not typically required for pulmonary viral resistance, studies in mice and immunocompromised patients indicate that recombinant IFN treatment may be useful against viral infections, including that of SARS-CoV-2.

Evidence on therapies acting through IFNs has highlighted that timing of treatment relative to viral exposure is critical, often requiring pre- or early post-exposure administration.

Interestingly, an ongoing IFN response to existing or recent infection, such as lung infection with Mycobacterium bovis BCG (short for Bacillus Calmette-Gurin), has shown protection against SARS-CoV-2 in animal models.

Therefore, researchers in the present study explored the mechanisms underlying the protection offered by a concurrent bacterial infection against SARS-CoV-2 while shedding light on the potential role of IFN in the process.

In the present study, wild-type (WT) B6 mice were inoculated intravenously (iv) with BCG or phosphate-buffered saline (PBS, control) 4045 days before they were intranasally challenged with SARS-CoV-2 strain B.1.351. On day 3, lungs were isolated, and viral titer was measured in the homogenate using TCID50(short for 50% tissue culture infectious dose) assay.

Additionally, single-cell RNA sequencing (scRNAseq) was performed on the isolated lung cells. Cell clusters were analyzed using Seurat clustering and flow cytometry.

After 28 days of BCG vaccination, cytokine staining was performed on lung cell suspensions. Similar experiments were performed in Ifngr1/mice to understand the effect of IFN signaling on protection.

Additionally, to understand whether IFN signaling in the non-hematopoietic compartment is enough forBCG-driven protection, Ifngr1/mice were irradiated, and their bone marrow was reconstituted with WT cells.

Actively infected cells were identified by staining lung tissue for the SARS-COV-2 nucleocapsid and using in situ hybridization (ISH). Recombinant IFN was administered intranasally to WT orIfngr1/animals two days before and one day after the SARS-CoV-2 challenge, and their lungs were analyzed on day 3.

Statistical analysis involved the determination of p-values using Studentst-test, Mann-Whitney test, one-way analysis of variance (ANOVA) with Tukeys post-test, or Kruskal-Wallis test with Dunns post-test.

Three days after the SARS-CoV-2 challenge, the lungs of WTBCG animals showed a significantly reduced viral load compared to controls. While the lungs of BCG-treated animals were enriched in T-cells, those of control PBS-treated animals were enriched in fibroblasts.

scRNAseq datashowed that the lungs of BCG-treated animals had more differentially expressed genes (related to inflammation, antiviral immunity, and IFN signaling) in macrophages and dendritic cells compared to controls.

While levels of other IFNs did not vary between the two groups, IFN and IFN were significantly higher in BCG-treated animal samples than controls. T-cells and natural killer cells were the major sources of IFN.

No reduction in viral load was observed inIfngr1/mice (without IFN receptor), suggesting that IFN signaling is required for BCG-induced protection against SARS-CoV-2. Also, BCG was found to protect severe-disease mice models from the virus, but animals treated with anti-IFN did not receive significant protection, confirming the role of IFN.

BCG-treated WT mice also showed a reduced inflammatory cytokine response irrespective of the presence of IFN. The study shows BCG-induced IFN present during the viral challenge controls viral load rather than SARS-CoV-2-related inflammation.

Studies conducted on irradiated and reconstituted Ifngr1/mice showed that IFN signaling in non-hematopoietic cells is sufficient forBCG-induced protection against SARS-CoV-2.

Bronchiolar epithelial cells, macrophages, and pneumocytes were most immunoreactive to the SARS-CoV-2 nucleocapsid. Findings suggest that BCG-induced IFN controls SARS-CoV-2 infectivity and/or replication within the epithelial cells. Data showed that IFN induced the expression of IFN-regulated proteins by pulmonary epithelial cells, including a viral restriction factor.

Notably, WT mice administered with recombinant IFN showed reduced or no viral load, suggesting that pre-existing IFN responses can control SARS-CoV-2 infection and/or replication across epithelial cells, thereby protecting the host from related tissue damage and immunopathology.

The present study's findings suggest that bacterial infections, particularly intravenous administration of BCG, which specifically elicit IFN responses in the lung, could limit SARS-CoV-2 infection.

They highlight the prophylactic potential of intranasally administered recombinant IFN in offering protection against SARS-CoV-2 infection for improved outcomes in COVID-19 management and encourage further research.

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IFN identified as crucial for reducing pulmonary viral loads in COVID-19, new research shows - News-Medical.Net

Newsroom – Newsroom – City of Burbank

December 14, 2023

The purpose of this notification is to inform you that based on the Los Angeles County definition of close contact, you may have been exposed to COVID-19 if you were in attendance at the City of Burbank, cake cutting ceremony at the City Hall Rotunda, and the Council Meeting in City Hall Council Chambers on Tuesday, December 12, 2023. Close contact means sharing the same indoor airspace with someone with COVID-19 for a total of 15 minutes or more in a 24-hour period during the contagious period.

Published on: December 14, 2023

10:24 AM

Originally posted here:

Newsroom - Newsroom - City of Burbank

Wastewater survey results show high prevalence of COVID-19, health officials say | CTV News – CTV News London

December 10, 2023

Not enough people are getting vaccinated for COVID-19.

Thats according to a Western University professor involved in the Ontario COVID-19 Waste Water Survey Program.

What we have is a lot of people that harbour the virus for periods of time, then transmit it to someone else, said Canada Research Chair in HIV Pathogenesis and Viral Control, Eric Arts.

He said that while there is some immunity in the population from previous infections and previous vaccine doses, it can only last for so long.

Just not enough people are getting vaccinated, and that means that we will just have wave after wave after wave, he explained. And so it really wont end. Thats the problem. Its endemic now in the population.

The warning comes as the latest Ontario Public Health wastewater survey results indicate the prevalence of COVID-19 in Ontario is more than twice what it was one year ago.

The wastewater signal now stands at 2.1, up from 0.98 at this time last year. Southwestern Ontario, which stretches from Grey-Bruce down to Windsor, is at 3.2 thats more than six times higher than it was one year ago when the signal was 0.5.

Arts said were very much into a COVID-19 wave.

Now the southwest has quite exploded in terms of what we see in wastewater, reflecting the number of cases there are in the southwest. And you can see that as well in London, Ontario, where theres a huge increase, said Arts.

Doctors said transmission of both COVID-19 and influenza will peak over the holiday season. Thats why they said the next week will be critical for people to get vaccinated, who havent already, as it takes about two weeks to develop immunity.

Dr. Ninh Tran, medical officer of health for Southwestern Public Health, said both COVID-19 and influenza are on the uptick.

Our flu activity went from low to high in the last week or so. Weve got seven cases. And flu season, once it starts it keeps going up for about four to six weeks, she explained. So were expecting peak transmission of these two viruses around the holiday season.

Tran said vaccination clinics can be found on the Southwestern Public Health website, while vaccination information for London and Middlesex can be on its website.

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Wastewater survey results show high prevalence of COVID-19, health officials say | CTV News - CTV News London

Many Vermont mutual aid efforts born during Covid-19 continue their work – VTDigger

December 10, 2023

Residents of the South Meadows neighborhood in Burlington gather free produce from the Peoples Farmstand on June 30. Photo by Glenn Russell/VTDigger

Toward the beginning of the Covid-19 pandemic, one thing was made quickly and strikingly clear: To survive a crisis, people need each other. For the thousands of Vermonters who helped galvanize a swell of grassroots mutual aid efforts that year, that was a reality worth acting upon.

Since then, roughly one third of those groups have continued operating in Vermont, responding to crises that have continued beyond the flashpoint of the early pandemic, according to research conducted by VTDigger.

The term Mutual aid refers to local networks through which people crowdsource and redistribute food, supplies, skills, money and other resources on a grassroots level.

With origins in Black and Indigenous liberation movements and anarchist theory, mutual aid networks often arise explicitly in response to the failures of established systems to support people, according to Linus Owens, a professor of sociology at Middlebury College.

While organizers and participants vary in their personal political perspectives on the practice, mutual aid traditionally involves non-hierarchical and reciprocal forms of organizing aimed explicitly at disrupting the unequal power dynamics that mainstream forms of charity often reinforce.

Almost always in the immediate aftermath of a disaster, rather than people turning against each other, we see a kind of flowering or proliferation of neighbors taking care of neighbors, strangers taking care of strangers, Owens said. But it doesnt necessarily last super long.

Before 2020, only a handful of mutual aid networks existed in Vermont. Yet as Vermonters sought more ways to meet each others needs during the Covid-19 pandemic lockdowns, 50 new groups burgeoned across the state, mirroring a national surge in the radical practices mainstream popularity.

By the middle of 2020, at least 53 distinct networks were operating across all 14 counties, according to a survey conducted by VTDigger.

Since then, 21 of the networks VTDigger identified have closed. Another 13 showed signs of having shut down, like a lack of active internet presence. Others have become less consistently active, rekindling energy during new crises, such as this summers historic flooding.

Five additional mutual aid networks began operating between 2021 and 2023. All of those, plus nearly one-third of the networks that were founded in 2020, have operated steadily since then, continuing or shifting their focus toward ongoing crises, such as poverty, homelessness and racism, which acute crises intensify.

At the Marketplace Garage one summer afternoon in Burlington, dozens of people gathered around containers of salad and homemade mac and cheese. As people talked and ate, someone began playing music. Burlington resident Alex Olsen requested the song The Greatest by Sia and started dancing.

Just weeks before, Olsen was among the 800 Vermonters who were evicted from the states pandemic-era hotel and motel programs. Amid the tumult, Olsen said, Food Not Cops was a constant source of caloric and social nourishment.

Food Not Cops, a grassroots mutual aid group that ignited in 2020 as a Burlington offshoot of Food Not Bombs, began when a swell of volunteers many of whom experienced food insecurity themselves began cooking meals to distribute outside daily. Food Not Cops continues to host free lunches daily, making it one of several mutual aid groups in Vermont whose work has not ended.

Sam Bliss, an organizer at Food Not Cops, said the pandemic and coinciding Black Lives Matter protests that summer were examples of how acute crises can illuminate how, on an everyday basis, the state fails to meet peoples needs.

Food Not Cops is prefigurative, which means were creating the world that we want to live in, right here as best we can, Bliss said.

In the world that Food Not Cops imagines, receiving free food is not shameful but liberating. While organizers encourage people experiencing food insecurity to join meals, they also hope those with more resources will as well.

(There are) benefits of food being a gift in terms of the sorts of relationships that it creates and the community resilience that come from those relationships, Bliss said.

While participation in Food Not Cops has decreased since a surge in 2020, Bliss said, specifically among members of the white middle and upper classes, its daily meals are part of a growing grassroots effort to provide free food, especially as pandemic-era programs like Everyone Eats and extra SNAP benefits have ended.

Once the pandemic started, the need for food and meals just went way up, said FaRied Munarsyah, a member of the Peoples Kitchen, another mutual aid group that has distributed weekly free meals in Burlington since 2012. The world was ending, but we were thriving. I dont know what that means for the world were living in.

Food Not Cops isnt the only group that has struggled with consistent community participation since pandemic restrictions were lifted and many people with the resources to do so returned to their previous lives and schedules.

Stacy Raphael, a Vergennes resident who organized with Addison County Mutual Aid, and Kim Souza, who worked with The Upper Valley Response Team, described the increasing lack of volunteers free time that foreshadowed the end of their networks activity. Members of Winooski Mutual Aid announced their decision to dissolve in April 2022, citing similar reasons.

But for Raphael, the spirit of mutual aid is still present in Addison County, even though its formal structure has fallen away.

I would argue that in a million different ways, it was like creating an underground root system. Everywhere we look, manifestations of mutual aid pop up, Raphael said.

Part of the legacy of mutual aid in Vermont might be connected to how it has resurfaced when new crises strike, Raphael said. When floods devastated Vermont in July, Vermonters mobilized mutual aid responses by the first night of the storm. Similarly, when Vermonters were evicted from the states motel program this summer, people turned to mutual aid.

However, activist Brenda Siegel said Vermonters neighborly desires to help one another dont always transcend their conscious or unconscious social bigotry.

What we often see is that Vermonters are like, we love to come together and help our neighbors, and actually, in this (eviction) crisis, that is not whats happening, Siegel said over the summer. Towns themselves are rejecting people and telling them they dont even deserve to sleep somewhere, even in a tent. Thats making mutual aid a lot harder.

At Food Not Cops, things have also felt harder and more thankless, Bliss said last month, describing how a shrinking volunteer base, colder weather, increased homelessness and other factors have strained peoples capacity to show up to one another.

To keep going, he said, mutual aid requires sustained commitment beyond moments of extreme crisis, from people with capacity and time. Otherwise, networks can be crushed by the same systemic struggles they work to resist.

Theres always edible food thats not sellable, (but) if it turns out that crucial resource of (peoples) time is no longer available eventually (Food Not Cops) will be one more thing that started during Covid that no longer exists, Bliss said.

Maeve McCurdy, a coordinator with Old North End Mutual Aid, said many of her groups challenges reflect needs that have only intensified along class lines as state-run responses to the pandemic have expired.

Old North End Mutual Aid began in spring 2020, initially as a disaster-response group, McCurdy said. The group circulates an online request form, summarizes peoples requests, and then invites responses from community members via email and Instagram.

Early in the pandemic, McCurdy said it was common for Old North End Mutual Aid to receive smaller requests from people across the economic board. But now, she said, the requests have gotten bigger, increasing from asks for $50 to requests for thousands.

The number of requests has also increased over time, which caused the group to temporarily close their form in late October to catch up on responding to inquiries. The network received a total of 197 requests in 2020, 432 in 2021 and 567 in 2022. McCurdy said the group has responded to 215 requests and redistributed thousands of dollars so far this year.

I think, in an ideal world, people wouldnt have to go to mutual aid for housing or food but could go there for help with a gardening project, McCurdy said. Anecdotally, I would say a lot of the requests were getting right now are for housing.

As Owens, the Middlebury professor, put it, everyone wanted to get back to normal (after Covid-19), but for a lot of people, normal wasnt great.

For Owens, McCurdy and other members of active mutual aid groups in Vermont, the social, political and environmental crises that Covid-19 helped illuminate did not end when the pandemic purportedly did. Instead, they said, these crises are ongoing and deeply connected to the normal reality that the pandemic itself disrupted.

For these organizers, mutual aid belongs both in a utopian world and also along the road to get there.

I think it both over-inflates the success of the current system and under-inflates the value of mutual aid to write it off as something that (only) works in (acute) crisis, Owens said. Mutual aid asks the question of (whether) we can be more or less autonomous, more or less free.

In Vermont, examples of mutual aid have flourished long before the terms recent surge in popularity from the labor radicalism of Barres granite workers in the 1920s to volunteers formation of a fund for abortion access in 2002 to Migrant Justices formation of a solidarity collective in 2009.

Historically, mutual aid has most often developed in communities neglected or criminalized by the state, according to Zion Wilcox, an activist who organized at the 2020 Battery Park encampment in Burlington.

Despite mutual aid often being viewed as an Anarchist concept with communist origin, Black and brown communities across the globe have practiced it in the past, Wilcox wrote in an Instagram message to VTDigger.

The Black Panthers and other unions of color were (and still are) criminalized and targeted for practicing mutual aid, which often is not included in this conversation of mutual aid history, Wilcox said. The legacy of mutual aid as a form of resistance cultivated in communities of color continues in Vermont, where many organizers see it as essential to justice movements.

On Nov. 4, at a rally in Battery Park in support of a cease-fire in Gaza, Burlington resident Nour El-Naboulsi, of the Peoples Farmstand, spoke about his relationship to mutual aid as a Palestinian American.

(At the Peoples Farmstand,) we want to show our refugee neighbors, our neighbors of color, our houseless neighbors, our queer neighbors, that you are welcome here and you are loved, El-Naboulsi said, standing on a stage before about 1,200 protesters, to the left of a Peoples Kitchen pop-up.

As a Palestinian, Ive felt alone and out of place my whole life, El-Naboulsi said. To see my community come out in support like this helps me get out of bed in the morning.

Lydia Diamond, another longtime organizer with the Peoples Kitchen, was one of the children who received breakfast from the Black Panthers free breakfast program one of the most famous and large-scale examples of mutual aid as a kid growing up in Brooklyn.

Now, Diamond carries on that legacy each week while distributing food at South Meadow and Baird Street in Burlington.

Food insecurity was one of the things that people struggled with immensely during the pandemic, and it hasnt changed, Diamond said in June. I love to invite folks to come and hang out with us and see what we do. Its a mutual aid of love as well.

For organizers who explicitly choose to describe their work using the term mutual aid, the question of what distinguishes the practice from charity is often important. For some, the practice cannot be separated from its radical political roots.

Theres no activism without mutual aid, said Mohamed Shariff, who organized mutual aid efforts at the 2020 Battery Park protests. You cannot be a person who is fighting for anything righteous without mutual aid.

Yet, even as organizers navigate theoretical positions, many of them agree that the line between charity and mutual aid is often, in practice, blurry. This distinction can be a matter of language, according to Bethany Dunbar, an organizer with Hardwick Area Neighbor to Neighbor.

Some folks would call something charity that someone else might call mutual aid, Dunbar said, I like the notion of mutual aid as a way to (organize). It does seem more egalitarian.

Helen Beattie, who organizes alongside Dunbar, said that the Hardwick network takes particular care to minimize hierarchy in their group. Yet, to her, mutual aid is apolitical and fundamental to life, especially in a rural community.

For others, practicing mutual aid involves resisting the way that charity and nonprofits can reinforce power dynamics and offer an excuse for (governments) to do less, as McCurdy of Old North End Mutual Aid said.

Charity, in (radical leftist) mutual aid circles is like a bad word because a lot of elements of charity are really condescending (and) just recreate systems of need, said Rachel Siegel, a co-founder of Old North End Mutual Aid. But when peoples needs are unmet, she said, sometimes charity is better than no charity.

Middlebury resident Andrs Oyaga spoke about mutual aid efforts run through Conscious Homestead. In 2020, the homestead began distributing CSA-style Community Care Shares among Vermonters who are Black, Indigenous and people of color whose experience of the pandemic was compounded by systemic oppression. According to Oyaga, the homestead doesnt resemble a charity at all its a community.

Its a really special place where people in the diaspora connect and support one another on an emotional (and) spiritual level, but also in a very material way, Oyaga said.

According to Meghan Wayland and Michael Reddy, of Northeast Kingdom Organizing who both identify as anarchists, mutual aid is always political, but it doesnt always need to be spoken about that way.

Its refreshing when its perceived as apolitical because, for me, strategically, it will always be political, Wayland said.

Traditions of mutual aid such as barn-raising, communal haying and responding to snowstorms have existed in rural Vermont for a long time, according to Reddy. Practices of mutual aid (have the potential to) transcend political divisions, which are themselves fomented and utilized by (structures of) power to undermine the power of the grassroots, Reddy said.

As Reddy, Wayland and several other organizers put it, the outpouring of mutual aid that the pandemic catalyzed in Vermont tended to peoples visceral and immediate needs for food, housing and connection.

Simultaneously, they said, it did and continues to do something that is far less easy to quantify by compelling thousands of Vermonters to imagine and act upon the idea that our social ecosystems can and should be different.

(Our) economic system tries to commodify everything, whether its the relationships you have, the content you make (online), or the carbon in the air, Reddy said. Mutual aid (posits) a different way of doing things that isnt based on commodification. I think well need it more as natural disasters or man-made disasters or capitalist-made disasters continue to proliferate.

Correction: An earlier version of a photo caption misspelled Nour El-Naboulsis name.

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Many Vermont mutual aid efforts born during Covid-19 continue their work - VTDigger

APS counselor weighs in on children’s mental health after COVID-19 – KOB 4

December 10, 2023

In the latest data from the U.S. Department of Health, more than a quarter of children in America are depressed, and more than 20% deal with anxiety.

ALBUQUERQUE, N.M. In the latest data from the U.S. Department of Health, more than a quarter of children in America are depressed, and more than 20% deal with anxiety.

Albuquerque Public Schools counselor Leia Viscarra says the pandemic caused more children to be on social media.

Theyre going through a lot, coming back from the pandemic. The trauma that our kids deal with, a lot of issues that social media has brought about, said Viscarra.

The latest data from our states health department revealstwo out of five New Mexico high school students reported feeling sad or hopeless, and one out of every six experienced severe depression.

And, with New Mexico having the fourth-highest rate of suicide in 2020, more resources are coming into schools to remove the stigma of mental health, and to make talking about it normal.

Recently, Ive done our suicide prevention lessons. Ive done lessons on bullying. And so, and then, offering just resources, Vicarra said.

Help is as easy as dialing 988 a mental health hotline that will connect a child with a peer or a fellow student whos trained to provide support in any way necessary.

A lot of times what we know is our kids will talk to peers before theyll talk to an adult. And so peer helpers are trained in a way that itll get students to talk to them, said Viscarra.

One of the greatest forms of trauma among teens is from gun violence. 6% of high school students reported carrying a gun to school in the past year, and 44% of students report living in a home with a gun.

Thats why Albuquerque Mayor Tim Keller wants to expand a program to get a handle on the number of teens falling victim to gun violence called the VIP into every metro high school.

I think we should have it in every high school in our city, said Keller.

That will be discussed in the upcoming legislative session in January.

Originally posted here:

APS counselor weighs in on children's mental health after COVID-19 - KOB 4

Experimental drug that alters gut microbiome shows promise for long-COVID relief – University of Minnesota Twin Cities

December 10, 2023

A randomized controlled trial in Hong Kong finds that the synbiotic drug SIM01 relieves multiple symptoms of long COVID, or post-acute COVID-19 syndrome (PACS).

SIM01 contains strains of anaerobic Bifidobacterium bacteria (which are probiotics) and soluble fibers (prebiotics) to alter the gut microbiome and possibly modify immune response.

From June 2021 to August 2022, researchers from the Chinese University of Hong Kong randomly assigned 463 adult long-COVID patients at a single hospital in a 1:1 ratio to receive SIM01 or a vitamin C placebo by mouth twice daily for 6 months. The median interval between infection and random assignment was 4 months.

The investigators clinically assessed participants at baseline for symptoms, quality of life, and physical activity level. At 6 months, interviewers administered a 14-item symptom questionnaire to participants and collected blood and fecal samples to assess changes in the gut microbiome and blood cytokines (small proteins that trigger the immune response).

"Decreased abundance of short-chain fatty acid-producing bacteria in the gut of patients with COVID-19 might represent one of the crucial mechanisms contributing to the gutlung interaction and thereby disease severity in COVID-19," the researchers wrote.

The study was published yesterday in The Lancet Infectious Diseases.

Nearly one third of patients (31%) had been hospitalized during their infections. At 6 months, significantly higher proportions of the SIM01 group reported an improvement in fatigue (odds ratio [OR], 2.27), memory loss (OR, 1.97), difficulty concentrating (OR, 2.64), gastrointestinal upset (OR, 2.00), and general unwellness (OR, 2.36) than the placebo group.

Decreased abundance of short-chain fatty acid-producing bacteria in the gut of patients with COVID-19 might represent one of the crucial mechanisms contributing to the gutlung interaction and thereby disease severity in COVID-19.

Increases in relative benefit after SIM01 therapy were 47% for fatigue, 56% for memory loss, 62% for difficulty concentrating, 30% for gastrointestinal upset, and 31% for general unwellness.

Rates of adverse events were similar between the two groups (SIM01, 10% vsplacebo, 11%), and none were considered related to treatment. Receipt of SIM01, infection with Omicron subvariants, vaccination before COVID-19 infection, and mild COVID-19 infection were predictors of symptom improvement.

Average visual analog quality-of-life scores (on a scale of 0 to 100) at 6 months weren't significantly different (76.0 for SIM01 recipients vs 74.5 for the placebo group). Nor was there a significant difference in physical activity at 6 months, per total metabolic equivalent of task-minutes per week (SIM01 median, 1,646.3 vs placebo, 1,902.0).

Fecal metagenomic analyses showed that the gut microbiome was more diverse, including more short-chain acid-producing bacteria and fewer genes related to antibiotic resistance, at 6 months than at baseline in SIM01 recipients but not the placebo group.

Correlation of microbial changes with symptoms showed that relief of specific symptoms was tied to distinct compositional and functional changes in the microbiome.

"For instance,Bifidobacterium adolescentisshowed positive correlations with alleviation in fatigue, gastrointestinal upset, and memory loss," the researchers wrote. "We also found that alleviation in fatigue and general unwellness correlated with an elevated relative abundance ofBifidobacterium bifidum, whereas alleviation in difficulty in concentration correlated with a positive shift inBifidobacterium longum."

Cytokine analyses yielded no significant results.

"Treatment with SIM01 alleviates multiple symptoms of PACS," they wrote. "Our findings have implications on the management of PACS through gut microbiome modulation. Further studies are warranted to explore the beneficial effects of SIM01 in other chronic or post-infection conditions."

In a related commentary, Betty Raman, DPhil, and Maheshi Ramasamy, DPhil, both of the University of Oxford, said that emerging evidence points to the importance of the gut microbiome in the development of long COVID, with a disruption in microbial balance, or gut dysbiosis, in some patients.

"There are now several studies showing that probiotics, consisting of beneficial bacteria such asLactobacillusandBifidobacteriumspecies, might enhance gut health, modulate inflammation, and improve immune function," they wrote.

The real benefits of the treatment on general health perception and functional capacity might be low.

But study limitations such as the lack of a universally accepted long-COVID symptom assessment tool and a reliance on subjective symptom reports complicates interpretation of the findings.

"Although alleviation of some symptoms of PACS was observed, this alleviation did not correspond with measurable improvements in quality of life or physical activity after 6 months, suggesting that the real benefits of the treatment on general health perception and functional capacity might be low," Raman and Ramasamy wrote.

See the article here:

Experimental drug that alters gut microbiome shows promise for long-COVID relief - University of Minnesota Twin Cities

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