Category: Covid-19 Vaccine

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There Isn’t a COVID-19 Vaccine Yet. But Some Are Already Skeptical About It – TIME

May 19, 2020

Amid the American flags, Make America Great Again hats and freedom is essential posters appearing at recent protests against coronavirus lockdowns in Sacramento, Calif., another familiar slogan has materialized: We do not consent. Its long been a popular rallying cry among antivaccine activists, who claim without evidence that vaccines cause autism or other conditions. As the COVID-19 pandemic rages on, those activists have become intertwined with demonstrators who want businesses to reopen despite public health experts warnings.

Offline, the anti-vaxxers have done little beyond appear at sparsely-attended but widely-publicized rallies. But online, well-known antivaccine activists like Robert F. Kennedy Jr. and Del Bigtree have been hard at work sowing doubt about the COVID-19 vaccinea vaccine that does not yet exist, and likely will not exist for many months, if not longer. Yet their efforts seem to be working: approximately one in five Americans have already expressed unwillingness to get an eventual COVID-19 vaccine, according to an April 15 survey undertaken by Matt Motta, an assistant professor of political science at Oklahoma State University, and Kristin Lunz Trujillo, a University of Minnesota graduate student.

If we only saw it at the level of anti-vaxxers online, in very engaged and small communities, but it didnt translate to the public, I would feel a little bit better, says Motta. But the fact that we see approximately one in five Americans expressing a lack of willingness to get the [COVID-19] vaccinethat to me is whats alarming.

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So far, the digital misinformation campaign around COVID-19 has relied upon the techniques of the anti-vaccine movement, including discrediting public health officials, raising concerns about vaccine safety, and making claims that vaccination is primarily profit-driven. Some recent content spreads unsubstantiated claims about public health officials, like longtime National Institute of Allergy and Infectious Diseases head Dr. Anthony Fauci, and philanthropist and Microsoft co-founder Bill Gates. Other material celebrates those advocating for a reopening, or hails people challenging the truth of the virus origins. One notorious, widely-shared example: Plandemic, a slickly-produced pseudo-documentary alleging without evidence that the COVID-19 outbreak was orchestrated by global elites; a book written by a discredited scientist featured in the video now ranks among Amazons best-sellers.

There seems to have been the explicit intent to make it go viral on [digital] platforms, says David Broniatowski, an associate professor in the Department of Engineering Management and Systems Engineering at George Washington University. That both increases its reach, but also increases peoples perception that its somehow got some degree of legitimacy, because theyre hearing it from a lot of different sources.

Some U.S. officials are worried that foreign adversaries may be generating or amplifying COVID-19 misinformation, too. Russia, for instance, has been known to amplify local voices that push conspiracy theories, said Lea Gabrielle, special envoy and coordinator of the Global Engagement Center for the U.S. Department of State, during a press briefing on May 6. Theres a high probability that the Russian disinformation ecosystem will act to undermine faith in a COVID vaccine when it becomes available, she added. She has raised concerns about similar potential Chinese efforts as well.

Russia has denied spreading misinformation about COVID-19, according to Russian news agency TASS; China has also pushed back against misinformation accusations. It remains a possibility that foreign governments typically antagonistic towards Washington will decide that a vaccinated America is better for their own nations public health and economic growth.

The scientific community agrees that a vaccine is essential to resuming anything resembling normal life. But on a societal level, vaccines only work if theyre widely adopted. Experts say that 50% to 80% of the public will need immunity before COVID-19 is slowed enough to mostly resume our typical lives. Widespread vaccination can help communities reach that level without the suffering and death that would likely come with letting the virus run its course unabated. But public resistance to vaccination can result in clusters where a viral disease can rapidly spread, as the measles did in a handful of U.S. communities during a 2019 outbreak.

Even if people in certain areas of the country are highly vaccinated, if an infected individual goes to a population where there are more vaccine waivers, then they could easily start an outbreak, says Abram Wagner, a research assistant professor of epidemiology at the University of Michigan.

Researchers say that although the anti-vaxxer movement is small, it can have an outsize impact on social media discourse. A study published in Nature last week found that clusters of anti-vaccination tend to become more entwined with clusters of undecided clusters, while pro-vaccination clusters tend to be on the margins.

Wagner is also concerned that people may grow even less willing to get a COVID-19 vaccine in the time it takes for one to become available. During the 2009 H1N1 outbreak, he says, people grew more reluctant to get vaccinated over time, possibly because their sense of danger from the outbreak decreased. Im worried that as we progress through this, people might get more and more fatigued, and acceptance [of a vaccine] will decrease, he says. And beyond that, I am also concerned that vaccine hesitancy in general will increase.

Of course, many Americans are anxiously awaiting a vaccine and will line up for one the second its available. President Trump and his administration have so far been working to assure the public that a vaccine will be available quickly (Trumps timeline is more generous than those of public health officials.) But counterintuitively, some experts are worried that the Administrations emphasis on speedy production including dubbing an effort to find vaccines Operation Warp Speed could have the perverse effect of making people more skeptical about the end result for fear the process was rushed, says Peter Hotez, the dean of the National School of Tropical Medicine at Baylor College of Medicine and co-director of the Texas Childrens Hospital Center for Vaccine Development.

The key part is to emphasize that theyre not sacrificing safety, things are not being rushed, that no shortcuts are being taken, and that even though things are accelerated, they built in elements to ensure the safety of the vaccines, says Hotez, whos working on two COVID-19 vaccines. The coronavirus task forces publicizing of unproven treatments, like hydroxychloroquine, may be making people more skeptical about their public health recommendations as well, Hotez adds.

If and when a COVID-19 vaccine is available, health officials will have to overcome whatever public skepticism is generated between now and then, says Brendan Nyhan, professor in the department of government at Dartmouth College. He suggests getting all corners of civil societyfrom religious leaders to politicians and beyondto speak up in support of vaccines. Its a strategy thats worked well in the past: Elvis famously had his picture taken for the papers while getting the polio shot in 1956, for example, and was credited with encouraging teenagers to vaccinate.

I think theres going to be a massive mobilization to encourage people to go get those vaccines, says Nyhan. And when those messages are coming from trusted sources in peoples community, or from groups that people trust or identify with, its going to be more powerful than what the media, or even the President or other public officials, can do alone.

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There Isn't a COVID-19 Vaccine Yet. But Some Are Already Skeptical About It - TIME

Who Is Winning the COVID-19 Vaccine Race? – Investopedia

May 19, 2020

Experts including the U.S. Federal Reserve Chair Jerome Powell believe that a complete economic recovery is only possible once a vaccine against the mysterious and deadly novel coronavirus is discovered. Shares in Moderna (MRNA) are over 20% higher today after the biotech company announced positive data from a Phase 1 study of its COVID-19 vaccine. Two weeks after receiving two doses of 25 microgramsor 100 micrograms each, all participants had levels of binding antibodies at or exceeding that of convalescent sera (blood samples from people who have recovered from the disease).

Moderna's mRNA-1273 is one of six vaccine candidates that have both a reasonable likelihood of clinical success and can be manufactured at scale to be relevant, according to a new report from Morgan Stanley. Analysts looked closely at the 110 candidates that currently exist and decided that the following six organizations/collaborators have the best chance of winning the vaccine race :

Morgan Stanley also predicted timelines and production capacities for each candidate. Novavax (NVAX) is not on the brokerage's list but shares in the company have also been surging since it announced last week that Bill Gates' Coalition for Epidemic Preparedness Innovations(CEPI) is investing a total of $388 million to advance the clinical development of its vaccine candidate.

There are 7.7 billion people in the world and experts are hoping more than a single effective vaccine emerges so that demand can be met. "Based on current company commentary, we believe millions of doses of the vaccine could be available in the fall, 10-30M/month by YE20 and 100s of millions per month by mid-2021," said the note. However, bottlenecks, like shortages of medical glass, could slow delivery. AstraZeneca yesterday claimed it will manufacture 100 million doses of coronavirus vaccine developed by Oxford Uni. for the U.K. this year and 30 million of those by September.

Analysts believe the market for COVID-19 vaccines would be between $10-30 billion during the pandemic and $2-25 billion annually during the endemic phase when mutations, unvaccinated populations or new child birth will drive demand. For this calculation they assumed that 1.8 billion people would be served by Western companies, with India, China and Russia developing their own, and U.S. pricing at $10- 20/treatment, Western Europe at $5-15 and the remaining countries at $5-10.

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Who Is Winning the COVID-19 Vaccine Race? - Investopedia

Israel says COVID-19 vaccine is only weeks away – SFGate

May 19, 2020

Tourists from Korea wearing protective masks walk with their belongings while waiting for a flight back to South Korea at the Ben Gurion airport near Tel Aviv, Israel, Monday, Feb. 24, 2020. On Thursday, Israel Science and Technology Minister Ofir Akunis said researchers were developing a vaccine for COVID-19 that could be ready in 90 days.

Tourists from Korea wearing protective masks walk with their belongings while waiting for a flight back to South Korea at the Ben Gurion airport near Tel Aviv, Israel, Monday, Feb. 24, 2020. On Thursday,

Tourists from Korea wearing protective masks walk with their belongings while waiting for a flight back to South Korea at the Ben Gurion airport near Tel Aviv, Israel, Monday, Feb. 24, 2020. On Thursday, Israel Science and Technology Minister Ofir Akunis said researchers were developing a vaccine for COVID-19 that could be ready in 90 days.

Tourists from Korea wearing protective masks walk with their belongings while waiting for a flight back to South Korea at the Ben Gurion airport near Tel Aviv, Israel, Monday, Feb. 24, 2020. On Thursday,

Israel says COVID-19 vaccine is only weeks away

Israel is only weeks away from developing a vaccine against the novel coronavirus, according to its science and technology minister.

The Jerusalem Post reported Thursday that Minister Ofir Akunis said in a press release that the vaccine could be available to patients within 90 days. Akunis credited MIGAL (the Galilee Research Institute) for the breakthrough.

"I am confident there will be further rapid progress, enabling us to provide a needed response to the grave global COVID-19 threat," he said.

Israel got a jump on the coronavirus crisis because researchers had already created a vaccine against avian coronavirus Infectious Bronchitis Virus (IBV), which affects poultry, according to the Jewish Press. The IBV vaccine has already passed clinical trials at Israel's Veterinary Institute.

By "pure luck," the MIGAL team selected a poultry coronavirus to test their new vaccine technology, which doesn't target any specific virus, according to Dr. Chen Katz, biotechnology group leader at MIGAL. Katz told the Press and Post that after the current COVID-19 virus broke out in China, the researchers studied the new virus and realized it was genetically similar to IBV and that the infection mechanism was the same. They now are confident they can adjust the system to combat COVID-19.

"In a few weeks, if it all works, we would have a vaccine to prevent coronavirus," Katz said.

The new vaccine, which would be orally administered, faces pre-clinical trials and clinical trials before mass production begins. But MIGAL thinks development could be fast-tracked to receive safety approval in 90 days. Akunis reportedly has ordered his ministrys director-general to accelerate the process.

ALSO: UC Davis student shows signs of coronavirus, 2 others isolated

The World Health Organization reported 11 days ago that the earliest that a COVID-19 vaccine could be expected was in 18 months. If the Israeli researchers are successful in developing their vaccine, they would shave more than a year off that estimate.

For more coverage, visit our completecoronavirus section here.

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Mike Moffitt is an SFGATE Digital Reporter. Email: moffitt@sfgate.com. Twitter: @Mike_at_SFGate

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Israel says COVID-19 vaccine is only weeks away - SFGate

Markets surge amid Covid-19 vaccine hopes and Fed’s …

May 19, 2020

Many traders had a nice weekend as some normalcy crept back into their lives. The return of German soccer, Nascar, and golf provided many households with some fresh entertainment. The start of the trading week was supposed to have some optimism with the global economic recovery, but no one anticipated this Mondays start.

Risk appetite is running wild after Modernas experimental vaccine showed promising early signs to create an immune-system response might be able to fight off COVID-19. Global equities are roaring higher on vaccine hopes combined with continued major economies reopening, and as the Fed continues to promise more stimulus is coming when it is needed.

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Moderna’s COVID-19 vaccine shows positive results, moves …

May 19, 2020

A COVID-19 vaccine candidate has shown it can prompt an immune response in the human body, and was also found to be safe and well-tolerated in a small group of patients.

Moderna, a Cambridge, Massachusetts-based company that manufactured the vaccine, announced the encouraging early results from its phase 1 clinical trial Monday morning. The drug is now being tested in larger studies.

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The phase 1 trial involved 45 people. Results on eight of those participants revealed they developed neutralizing antibodies which are believed to be key in providing protection from the virus at levels seen in patients who've recovered from COVID-19.

"We could not be happier about this interim data," Moderna CEO Stphane Bancel said during a conference call with investors Monday. He said the results indicate the vaccine has a "high probability to provide protection from COVID-19 disease in humans."

The goal of phase 1 trials is to evaluate the safety of a new drug in a small group of participants, not effectiveness. Phase 2 trials study whether a drug works.

In total, 45 study participants each received two doses of the vaccine, about a month apart. Participants were given one of three dosage levels: 25 micrograms, 100 micrograms and 250 micrograms.

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Moderna said those who received the two lower doses developed COVID-19 antibodies about two weeks after the second dose. Final information on the 250 microgram dosing was not available.

The only side effect, the company reported, was redness around the area where people got the shot.

Physicians not involved with the trials expressed optimism based on the study results, even though it's still relatively early in the clinical trial process.

"It's great news to see what appears to be a potentially effective vaccine has been created and appears safe," Dr. Iahn Gonsenhauser, chief quality and patient safety officer at the Ohio State University Wexner Medical Center, said. What's more, it's promising the antibodies the patients developed were "shown to be effective at limiting the virus's replication in the lab," he added.

Still, many questions remain about the level of protection those antibodies might offer, Dr. Michael Ison, a professor in the division of infectious disease and organ transplantation at Northwestern University Feinberg School of Medicine in Chicago, said.

It will be important to continue to monitor patients in the study because Moderna is using a kind of vaccine approach, called messenger RNA, that's never been marketed in the United States, he said.

"Overall this looks pretty good," Ison said. "That being said, this is a new kind of vaccine platform, and some of the safety signals may take time to be recognized."

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In earlier mouse studies, the vaccine prevented the virus from reproducing in the animals' lungs.

Moderna, which has partnered with the National Institute of Allergy and Infectious Diseases in the trials, is pushing forward with a larger phase 2 study. That phase will also look at the effectiveness of a 50 microgram dose.

The company expects to begin a phase 3 clinical trial as early as July. Phase 3 trials involve a much larger group of participants to confirm results of phases 1 and 2.

Other COVID-19 vaccine candidates are being studied at Oxford University in the United Kingdom and at a company called Inovio, headquartered in Pennsylvania.

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Erika Edwards is a health and medical news writer and reporter for NBC News and "TODAY."

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Moderna's COVID-19 vaccine shows positive results, moves ...

The COVID-19 Pandemic: US Death Toll Exceeds 90,000; Vaccine Trial Shows Promising Early Results; and More – DocWire News

May 19, 2020

World News:

Were more than half way through the month of May, and COVID-19 has now infected almost 5 million people worldwide and caused over 317,000 deaths. The SARS-CoV-2 virus has a foothold on 213 countries and territories and is present in all but one continent.

Outside of the US, the countries with the most confirmed cases are:

About 100 countries are backing a resolution at the upcoming World Health Assembly (WHA), calling for an independent evaluation into Chinas handling of the COVID-19 pandemic, CNN reported. The European Union-backed resolution has met with an angry response from China, and was called a move that could disrupt international cooperation in fighting the pandemic and goes against peoples shared aspiration.

As Italy begins to reopen after months of being under lockdown, Italian Prime Minister Giuseppe Conte said that the next few months will be very hard. As of Monday, Italy reopened region bars, restaurants, retail stores, hairdressers, and museums after nearly 10 weeks of lockdown.

Conte commented that: We are facing the toughest test since the post-war period. The government is fully aware of this. We are doing everything we can to meet everyones needs even faster, Conte added, referring to the economic stimulus package on which the government is working on to support workers and companies affected by the coronavirus crisis.

Monday, May 18, 2020

There are now over 1.5 million confirmed cases of COVID-19 in the United States and over 91,000 deaths to report. Despite the numbers and the fact that only 18 states show a downward trend of cases, virtually all US states have began phased reopenings of their economy. New York, the hardest hit state in the nation, reports 359,847 confirmed cases and 28,326 deaths. New York Governor Andrew Cuomo announced on Monday that Western New York is expected to enter the first phase of the states reopening plan on Tuesday. During phase one, regions can reopen construction, retail (for curbside or in-store pickup or drop off), manufacturing, wholesale trade, and agriculture, forestry, fishing and hunting.

Gov. Cuomo added that New York sports teams should plan to reopen without fans. New York state will help thosemajor sports franchises to dojust that.Hockey, basketball, baseball,football, whoever can reopen.Were a ready, willing and ablepartner, the governor said.

Outside of New York, the US states with the most confirmed COVID-19 cases are:

The first COVID-19 vaccine tested in humans, developed by the company Moderna, is showing early safety and efficacy stimulating an immune response against the respiratory virus, the New York Times reports. The first eight people enrolled in the trial back in March, all healthy volunteers, produced antibodies that were tested on human cells in a lab, and were subsequently able to stop the virus from replicating. Moderna said that it working on an accelerated timetable, with phase two of testing to be begin soon. Phase two will comprise 600 people, while a third phase will be begin in July, and involve 1,000 healthy volunteers.

Apple will that both staff members and patrons wear masks when they reopen the more than 500 stores they closed in response to the coronavirus pandemic. They will also require temperature checks at the door, and more frequent deep cleanings. We look at every available piece of data, including local cases, near and long-term trends, and guidance from national and local health officials, said Deirdre OBrien, Apples senior vice president of retail and people, in a statement. These are not decisions we rush into? and a store opening in no way means that we wont take the preventative step of closing it again should local conditions warrant.

Uber will cut another 3,000 jobs, the company said in an email to staffers. The ride-hailing giant initially cut around 3,700 full-time roles on May 2, or roughly 14% of its staff on its customer support and recruiting teams. The lay offs are the result of a reduced volume of ride requests due to the coronavirus pandemic. Uber CEO Dara Khosrowshahi also said the company is closing or consolidating around 45 office locations globally.

New York City has identified Almost 150 Children Possibly Suffering from multi-system inflammatory syndrome (MIS-C), Mayor Bill de Blasio announced on Monday. Given the new federal definition of the syndrome the city expects to update those numbers later this week. Of the 145 affected children, one has died, and 67 have tested positive for COVID-19 or its antibodies.

Friday, May 15, 2020

Thursday, May 14, 2020

Wednesday, May 13, 2020

A new model frequently used by the White House is now predicting 147,000 people in the US will die from COVID-19 by August. The prediction comes from the University of Washingtons Institute for Health Metrics and Evaluation (IMHE).

Tuesday, May 12, 2020

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Monday, May 4, 2020

Friday, May 1, 2020

The COVID-19 Pandemic: April Round-up

Heres a full wrap-up of COVID-19 happenings from the month of March.

The COVID-19 Pandemic March Round-up: Coronavirus Declared a Pandemic; People, Businesses and Economies Devastated

DocWire News will provide breaking updates on the COVID-19 pandemic as they become available.

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The COVID-19 Pandemic: US Death Toll Exceeds 90,000; Vaccine Trial Shows Promising Early Results; and More - DocWire News

COVID-19 Questions: What Is The Status Of A COVID-19 Vaccine? – WCCO | CBS Minnesota

May 19, 2020

Firefighters Battle Blaze At St. Paul Senior Hi-RiseThe St. Paul Fire Department says two units were on fire Monday night at a senior living high-rise senior in St. Paul, reports Frank Vascellaro (0:43).WCCO 4 News At 10 May 18, 2020

Celebrating 2020 Grads On WCCO 4 News At 10: May 18, 2020Every day, we're taking some time out to pay tribute to the 2020 graduates (0:40). WCCO 4 News At 10 May 18, 2020

Twins Vet Corey Koskie Talks Baseball's FutureMike Max talks to former Twin Corey Koskie, who is now an active youth coach, about where the game is headed in the midst of the pandemic (2:21).WCCO 4 News At 10 May 18, 2020

10 P.M. Weather ReportThe winds will settle down a bit Tuesday, reports Chris Shaffer (1:48). WCCO 4 News At 10 May 18, 2020

8-Year-Old Celebrates Birthday With Dunk TankWhen they couldn't throw a party, a Minneapolis family found a way to make a splash for their son's birthday, reports Frank Vascellaro ().WCCO 4 News At 10 May 18, 2020

Good Question: Can A/C Help Spread COVID-19?As the weather heats up, homes and offices will start running air conditioners - circulating what we breathe, reports Heather Brown (2:34).WCCO 4 News At 10 May 18, 2020

Sweden's Controversial Approach To COVID-19A country that shares many of the same traditions as Minnesota is handling COVID-19 quite differently, reports Susan-Elizabeth Littlefield (3:08).WCCO 4 News At 10 May 18, 2020

No Memorial Day Public Services At Fort SnellingCOVID-19 is forcing Fort Snelling National Cemetery to make some historic changes, reports John Lauritsen (1:58).WCCO 4 News At 10 May 18, 2020

Rick Huggins Survives COVID-19 After 2 Months In ICUJeff Wagner gives an inside look at surviving the virus (2:12).WCCO 4 News At 10 May 18, 2020

RV Rentals Surge Across The CountryAs families try to stay safe, there's been a surge in a unique type of travel. RV rentals are up by record numbers across the country, Kate Raddatz reports (2:17). WCCO 4 News at 6 May 18, 2020

6 P.M. Weather ReportPrepare for the heat this week, Wednesday will be about five degrees above average with temps in the high 70s throughout the state, Chris Shaffer reports (3:27).WCCO 4 News at 6 May 18, 2020

Celebrating 2020 Grads On WCCO 4 News at 6: May 18, 2020Every day, we're taking some time out to pay tribute to the 2020 graduates (0:41). WCCO 4 News at 6 - May 18, 2020

Rosedale Mall Opened Today With Half Capacity Allowed InsideAs part of the governor's effort to turn the dial on the economy, retail shops were given the green-light to open today, Susan-Elizabeth Littlefield reports (2:47).WCCO 4 News at 6 May 18, 2020

COVID-19 Questions: What Is The Status Of A COVID-19 Vaccine?YOUR COVID-19 QUESTIONS: What Is The Status Of A COVID-19 Vaccine? Were here to provide answers for your most pressing coronavirus-related questions (0:49).WCCO 4 News at 5 May 18, 2020

5 P.M. Weather ReportAs Chris Shaffer reports, the metro are can expect a warmer day Tuesday, with highs reaching into the 70s ().WCCO 4 News at 5 May 18, 2020

Celebrating 2020 Grads On WCCO 4 News at 5: May 18, 2020Every day, were taking some time to pay tribute to the 2020 graduates (0:38).WCCO 4 News at 5 May 18, 2020

European Capitals Work To Salvage Tourism Season As Restrictions LiftCountries around the world are working to reopen, especially those that rely on tourism. Much of Europe remains on lockdown, with borders closed and travel restricted. But as Gwen Baumbardner reports, cities are in a race to save summer vacations (1:37).WCCO 4 News at 5 May 18, 2020

Hundreds Of MN National Guard Soldiers To Deploy OverseasHundreds of soldiers with the Minnesota National Guard are preparing to deploy overseas, Frank Vascellaro reports (0:22).WCCO 4 News at 5 May 18, 2020

MN Legislative Session Ends, Special Session Set For JuneMinnesotas legislative session ended with no deal on a billion dollar bonding bill. That issue and other unfinished business will get a second chance in a special session on June 12, Esme Murphy reports ().WCCO 4 News at 5 May 18, 2020

New Safety Protocols Across The Country Amid COVID-19Nearly every state has now loosened restrictions or started reopening businesses. Elise Preston shows us the new safety protocols (2:02).WCCO 4 News at 5 May 18, 2020

Outbreak Of COVID-19 Reported At River Falls, Wis. Apartment ComplexHealth officials in Wisconsin say they've identified a COVID-19 Outbreak at an apartment complex in River Falls, Frank Vascellaro reports (0:21).WCCO 4 News at 5 May 18, 2020

Albany Bar Owner Backs Down On Reopening In Defiance Of Governors OrderSome businesses were allowed to reopen, but not bars and restaurants. And that isn't going over well with a chain of restaurants in Stearns County, Bill Hudson reports (2:10).WCCO 4 News at 5 May 18, 2020

Canterbury Park Owners Looking To Get Creative To Stay AfloatCurbside pre-race betting is one option, but hardly an answer, Mike Max reports (1:38). WCCO 4 News - May 18, 2020

WCCO Evening Digital Update: May 18, 2020Amelia Santaniello has your WCCO Evening Digital Update for May 18, 2020 (1:19).

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COVID-19 Questions: What Is The Status Of A COVID-19 Vaccine? - WCCO | CBS Minnesota

How supercomputers are getting us closer to a COVID-19 vaccine | TheHill – The Hill

May 19, 2020

The global scientific community has joined forces in an unprecedented effort to understand, track, forecast, test for, and find a cure for the current coronavirus pandemic. But in a crisis where every second lost means more loss of lives, solidarity alone isnt enough. Supercomputers are enabling a vastly accelerated pace by which scientists can conduct research and collect and analyze data. Never have they proven their value to society more than during this COVID-19 pandemic.

Supercomputers provide scientists who are studying COVID-19 with unique capabilities: they can explore the structure and behavior of the virus at the molecular level while designing drugs and forecasting the spread of the disease much faster than would otherwise be possible.

The Texas Advanced Computing Center (TACC) began fielding requests for computing time to assist in the fight against COVID-19 in February 2020. In March, the White House enlisted some of the world's most powerful supercomputers through the COVID-19 High Performance Computing (HPC) Consortium, a public-private partnership providing researchers worldwide with massive computing resources.

As part of this effort, we are working closely with teams to provide priority access to supercomputing resources here and across the world. In the U.S. alone, there are more than 100 projects, involving thousands of researchers, using HPC systems to predict the effects of interventions like stay-at-home orders and school closings; to simulate the molecular behavior of the proteins that make the virus virulent; to understand the genetics of the virus and its mutability; to screen potential drugs and vaccines for efficacy, and to visualize and interactively share data with decision-makers.

At TACC, nearly a third of all computing time has been dedicated to accelerating these efforts the equivalent of 40,000 desktop computers churning non-stop. None of this would be possible without federal funding for high-performance computing by the National Science Foundation (NSF) and Department of Energy (DOE), who have made open access to supercomputers part of their mission for more than four decades.

Beyond big machines, supercomputing centers employ some of the brightest minds in computational science, and these individuals are collaborating with teams across the nation to fast-track research.

Among these partnerships is the University of Texas at Austin COVID-19 Modeling Consortium, led by Dr. Lauren Ancel Meyers, which developed one of the leading epidemiological models of how the disease spreads based on virus transmission and real-time cell phone data. The White House and CDC, as well as the national media and public, have used the model to inform their understanding and decision-making.

A team from DOEs Argonne and Brookhaven National Laboratories applied several of the most powerful supercomputers in the world to accelerate an AI-based approach to drug docking. Their effort narrowed 6 billion possible small molecules to the 30 with the best chance of binding to one of the virus proteins and disrupting its function. These are now being tested in labs at the University of Chicago.

The TACC-powered COVID-19 Drug Discovery Consortium is collaborating with Enamine, the worlds largest provider of screening compounds, and Boston University, Texas A&M, and the University of Texas Medical Branch, to identify the 600 most promising, readily available, drug-like molecules (out of 2.6 million) and test them in high-containment laboratories in order to find potential drugs in months rather than years.

New projects are launching daily.

In many of these cases, long-term research collaborations helped speed the projects out of the gate. The UT Austin Modeling Consortiums projections built on a decade of federally-funded R&D on flu pandemic modeling by Meyers team. The DOE researchers adapted AI-based cancer drug discovery methods for SARS-CoV-2. The Drug Discovery Consortium leveraged tools and methods developed over many years to fight bioterrorism. Our ongoing relationships with these teams has made it possible for them to shift their research focus, expand their scope, and reduce limitations as they work towards a common good.

Academic research is frequently the first step in a long process that requires efforts by government agencies, philanthropic organizations, and industry. Basic science helps decision-makers protect the populace, and informs the creation of vaccines and treatments.

Under normal circumstances, this process takes years or decades. However, time is a luxury we simply do not have. The urgency of the challenge we face makes the application of research accelerators like supercomputers even more critical to help flatten the curve and ultimately solve the greatest crisis we as a society have ever faced.

Dr. Dan Stanzione is the associate vice president for Research at The University of Texas at Austin and executive director of the Texas Advanced Computing Center (TACC).

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How supercomputers are getting us closer to a COVID-19 vaccine | TheHill - The Hill

Controlling coronavirus spread could take 4-5 years, can’t depend on a COVID-19 vaccine alone, says WHO scientist – Times of India

May 17, 2020

However, scientists from World Health Organisation are now saying that pinning our hopes on a vaccine alone won't solve the crisis at large, adding that it could take anywhere between 4-5 years to actually contain the virus at large.

The predictions were made by a WHO expert, Soumya Vishwanathan, who in an interview said that it could take a long while before we are reading to bid goodbye to the virus.

"I would say in a four to the five-year timeframe we could be looking at controlling this."

She also added that even while vaccines and treatment plans are being explored, there are lots of things to be considered, including production, the safety of the trials, any side-effects, pricing or transportation.

The statement comes after WHO chief, Mike Ryan said that the chances seem high that coronavirus might "never really go away" and we learn to adapt to the virus in the long run.

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Controlling coronavirus spread could take 4-5 years, can't depend on a COVID-19 vaccine alone, says WHO scientist - Times of India

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