Category: Corona Virus

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The Threat of Coronavirus Is Looming Over Mexico’s Migrants – The New York Times

April 14, 2020

The city of Matamoros, Mexico, sits directly across the border from Brownsville, Tex. Over 2,500 people have gathered there since the Trump administration rolled out the Remain in Mexico policy, in a squalid encampment along the U.S.-Mexico border, while they wait for their asylum hearings. They live in cramped, unsanitary quarters some in tents, others in makeshift shelters without electricity or running water. They are increasingly susceptible to respiratory illness and malnutrition.

On April 1, the U.S. Department of Homeland Security and the Executive Office for Immigration Review announced that they would be postponing all hearings because of the coronavirus outbreak. They live in constant threat of the virus, all for exercising their human right to claim asylum.

Volunteers and nonprofit groups have all but vanished. UNICEF left. Doctors Without Borders still offers some services, but Global Response Management, an international nonprofit organization, is the only consistent presence. Its volunteer doctors, nurses and medics, in some cases asylum seekers, have been doing their best.

But the agencys best is limited to distributing vitamins, masks and moving tents apart. Under normal circumstances, if you can call any of this normal, doctors and nurses cant do much aside from tending to a wound that requires stitches, and diagnosing strep throat or the flu. They arent able to get tests to diagnose Covid-19.

The executive director of G.R.M., who is a nurse, reports that within the camp there were five patients with Covid-19 symptoms. The agency reported these to local authorities but were refused testing. It asked that these migrants be taken away from the camp to nearby hotels, but Mexican immigration authorities have not authorized the move.

Matamoros is the second largest city in the state of Tamaulipas, with a population of over 520,000. While there are no confirmed cases of Covid-19 in the camps, there are some eight confirmed cases in the city. People with mild or moderate cases could be quarantined in their tents and more severe cases sent to local hospitals. But, according to G.R.M., the citys five public hospitals have 10 ventilators and 40 intensive care unit beds between them. An outbreak would be catastrophic.

Mexico has been slow to react to the coronavirus threat. In mid-March, President Andres Manuel Lpez Obrador told reporters, I have faith that were going to move our dear Mexico forward, that these misfortunes, pandemics will not harm us. He has defiantly kissed and hugged supporters at recent events. Mexico has reported at least 4,219 cases of Covid-19 and 273 deaths. Medical workers have protested against the lack of protective gear.

Western news organizations are abuzz with worry over migrants on our southern border. They fret over what will happen if an outbreak were to erupt in the camp. But the plight of the migrants is nothing but a morbid concern. Were treated to images, taken from helicopters, of bodies lying on top of each other, swollen by the sun, and drowned children and their parents, embracing. Its the classic voyeuristic Jonestown footage. This is a mass killing of vulnerable people of color, preyed on because they dreamed of a better life. Despite the worry now about the asylum-seekers in Matamoros, no one is rushing to help them. People are just rushing to read about this impending mass grave.

As the mounting toll of the coronavirus comes into view, its clear that migrants around the world are among the most vulnerable. They often lack health insurance, struggle to make ends meet and are often in poor health. They dont have the luxury or the freedom to socially distance themselves from others. The undocumented men and women in our communities are on the front lines often with no protective equipment or safety net risking their lives to do the jobs most Americans wont. They are disinfecting hospitals and doctors offices, delivering your food and taking care of your elderly relatives.

President Trump believes the medical communitys insistence on quarantine is a conspiracy to destroy his presidency. My parents are among the aging, immunocompromised and undocumented in New York City. If they get sick, they will die. The Trump administration will not help us. We migrants, on the border, or here in New York, are left to fend for ourselves.

Do you know about crows? As an undocumented migrant, Ive always felt an affinity for them. Research has shown that they are as smart as a 7-year-old child. And yet, they are considered pests, undesirable birds, by most. People shoot them, or lay down barbed wire so they will not roost. If you hurt a crow, and it gets a good look at your face, generations of that crow flock could swoop and swerve and attack you. Crows never forget if you hurt them or one of their own.

As one of the fulfilled prophecies of the American dream, Ive earned the right to foretell one. If the American and Mexican governments let us die en masse, we will haunt your children, and your childrens children, and their children too. They will never sleep in peace, and they will come to know our names.

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The Threat of Coronavirus Is Looming Over Mexico's Migrants - The New York Times

Studies Show N.Y. Outbreak Originated in Europe – The New York Times

April 14, 2020

To not have any control over anything, to just be waiting and on the edge of your seat, its mind blowing at this point. Janettes fiance, Michael, is detained on Rikers Island. Hes serving time because he failed to check in with his officer, violating his parole for drug possession. Now Michael, and hundreds like him, are at the center of a public health crisis experts have been warning about for weeks. Two months owed to the city, its not worth somebodys life. Youre giving people a life sentence leaving them there. TV announcers: An inmate who tested positive for Covid-19 died yesterday at Bellevue Hospital. Rikers is one of the largest correctional facilities in the world, and right now, the infection rate there is seven times that of New York City. Is our prison system equipped to handle an outbreak? When the coronavirus seeped into the jails, public officials, public advocates all rushed to address the situation. We will continue to reduce our jail population. Were releasing people who are in jails because they violated parole. When the virus was first identified in New York, there were 5,400 inmates in city jails. To combat the spread of the virus, the Board of Correction recommended the release of 2,000 inmates. Parole violators, people over 50, those medically at risk and inmates serving short sentences. But two weeks later, government officials have released just half. Prisons, jails, are acting as incubators for the virus. Think about the jails as the worlds worst cruise ship. If we get a real situation here, and this thing starts to spread, its going to spread like wildfire, and New York is going to have a problem on their hands. Thousands of employees travel through the citys jails every day, forming a human lifeline to the city. Inmates also come and go. So its particularly urgent to get this under control because its not just about who is in the jails right now, its really about the city. This is Kenneth Albritton. He was being held on Rikers as Covid-19 spread through the city. Its scary in there, thats what I would tell you. When I was in there, you had guys making their own masks with their shirts. They didnt want to breathe in the air with the same people thats in the dorm with them. Kenneth was on parole after serving time for second-degree manslaughter when he was 18. I was brought to Rikers Island on Feb. 5 for a curfew violation. For me reading a paper and watching the news, and Im seeing that theyre saying no more than 10 to a group. But you have 50 guys thats in a sleeping area. Its impossible to tell us to practice social distancing there when theyre being stacked on top of each other. After someone in his dorm tested positive, Kenneth says he was quarantined. But less than 24 hours later, he was released. He was given a MetroCard, but no guidance about how to deal with the potential spread of Covid-19. If they would have tested me on my way out, then I would have felt like, OK, they took the proper steps. When I left the pen to come home, they told us nothing about how we should handle situation. Even though nobody told me nothing, I felt I should quarantine myself. Not much has been considered in terms of what happens to inmates after their release, and once theyre back in the communities and in their homes. When we asked about the pace of releases, the mayors office agreed it was slow, but said they dont have full control of the process. The states Department of Corrections said its working as quickly as possible. My fiance whos on Rikers, we had our son in September and about two weeks after that, he found out that he had a warrant for his arrest. Oh, you got those boogies. I told you that baby likes that camera Oh my goodness. This is a person with nonviolent charges. Its like a real health care disaster. The parolees is like the easiest thing they do. Right. Yeah, they said about 500 or 700 parolees. I just had read it last night. Yes, that he signed off on it. The outbreak at city jails doesnt just pose a threat to inmates. On March 27, Quinsey Simpson became the first New York City corrections officer to die from Covid-19. Correction officers every day, despite harm to themselves and their family, are rolling on this island to do this job. Officer Husamudeen criticizes the citys response, though hes arguing for improving jail conditions not releasing inmates. Thats not the answer to solving this problem. They havent served their time. If they served their time, they wouldnt be on parole. But his opposition is in the minority. While the overall population at Rikers has decreased, theres an unusual consensus from public defenders, prosecutors and corrections officials that the releases arent happening quickly enough. We need to reframe our thinking around public safety right now to accommodate the fact that public safety includes trying to prevent viral spread. My brother whos a New York City schoolteacher contracted the coronavirus. Are you OK? Oh, I love you. Oh, you scared? Whats the matter? Oh, God. Dont get into your head that its going to beat you. Youre going to beat this. OK? OK, I love you. OK, Ill call you in a little while. OK. As a teacher, he had a lot of precautions, and thought he was following everything he was supposed to be doing, and he contracted the coronavirus going into a school. This is why Im so adamant about fighting for Michael to get home. The person standing right next to you can have it and you wouldnt even know it. Across city jails, hundreds of inmates and corrections workers have tested positive, and half of all inmates are now under quarantine. Covid-19 and the pandemic has exposed pretty rapidly sort of all of the weakest places in our social safety nets. And it is no surprise that one of those is the ways that jails put people at risk. I know, love This is just ridiculously scary.

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Studies Show N.Y. Outbreak Originated in Europe - The New York Times

The Red Dawn Emails: 8 Key Exchanges on the Faltering Response to the Coronavirus – The New York Times

April 14, 2020

WASHINGTON As the coronavirus emerged and headed toward the United States, an extraordinary conversation was hatched among an elite group of infectious disease doctors and medical experts in the federal government and academic institutions around the nation.

Red Dawn a nod to the 1984 film with Patrick Swayze and Charlie Sheen was the nickname for the email chain they built. Different threads in the chain were named Red Dawn Breaking, Red Dawn Rising, Red Dawn Breaking Bad and, as the situation grew more dire, Red Dawn Raging. It was hosted by the chief medical officer at the Department of Homeland Security, Dr. Duane C. Caneva, starting in January with a small core of medical experts and friends that gradually grew to dozens.

The Red Dawn String, Dr. Caneva said, was intended to provide thoughts, concerns, raise issues, share information across various colleagues responding to Covid-19, including medical experts and doctors from the Health and Human Services Department, the Centers for Disease Control and Prevention, the Homeland Security Department, the Veterans Affairs Department, the Pentagon and other federal agencies tracking the historic health emergency.

Here are key exchanges from the emails, with context and analysis, that show the experts rising sense of frustration and then anger as their advice seemingly failed to break through to the administration, raising the odds that more people would likely die.

One of the most active participants in the group was Dr. Carter E. Mecher, a senior medical adviser at the Veterans Affairs Department who helped write a key Bush-era pandemic plan. That document focused in particular on what to do if the government was unable to contain a contagious disease and there was no available vaccine, like with the coronavirus.

The next step is called mitigation, and it relies on unsophisticated steps such as closing schools, businesses, shutting down sporting events or large public gatherings, to try to slow the spread by keeping people away from one another. As of late January, Dr. Mecher was already discussing the likelihood that the United States would soon need to turn to mitigation efforts, including perhaps to close the colleges and universities.

Dr. James Lawler, an infectious disease doctor at the University of Nebraska who served in the White House under President George W. Bush and as an adviser to President Barack Obama, was also a regular participant in the email chain. He stayed in regular communication with federal officials as the United States attempted to figure out how to respond to the virus. From the beginning he predicted this would be a major public health event.

Convincing governors and mayors to intentionally cause economic harm by ordering or promoting mitigation efforts such as closing businesses is always a difficult task. That is why it is so important, these medical experts said, for the federal government to take the lead, providing cover for the local officials to kick off the so-called Nonpharmaceutical Interventions, such as school and business closures. Again, this group of doctors and medical experts recognized from early on that this step was all but inevitable, even if the administration was slow to recognize the need.

Strong evidence was emerging as of mid-February with the first cases of Covid-19 already in the United States that the nation was about to be hit hard. These doctors and medical experts researched how quickly the virus spread on the Diamond Princess cruise ship, which was quarantined in the port of Yokohama, Japan, on Feb. 3 before hundreds of United States citizens on the ship returned home.

Dr. Eva Lee, a researcher at Georgia Institute of Technology who has frequently worked with the federal government to create infectious disease projections, helped the Red Dawn group do modeling, based on the virus spread on the cruise ship. (Dr. Lee is facing sentencing on federal charges that she falsified the membership certificate behind a $40,000 National Science Foundation grant for unrelated research.)

The concern these medical experts had been raising in late January and early February turned to alarm by the third week in February. That was when they effectively concluded that the United States had already lost the fight to contain the virus, and that it needed to switch to mitigation. One critical element in that shift was the realization that many people in the country were likely already infected and capable of spreading the virus, but not showing any symptoms. Here Dr. Lee discusses this conclusion with Dr. Robert Kadlec, the head of the virus response effort at the Department of Health and Human Services and a key White House adviser.

Dr. Kadlec and other administration officials decided the next day to recommend to Mr. Trump that he publicly support the start of these mitigation efforts, such as school closings. But before they could discuss it with the president, who was returning from India, another official went public with a warning, sending the stock market down sharply and angering Mr. Trump. The meeting to brief him on the recommendation was canceled and it was three weeks before Mr. Trump would reluctantly come around to the need for mitigation.

This slow pace of action was confusing to the medical experts on the Red Dawn email chain, who were increasingly alarmed that cities and states that were getting hit hard by the virus needed to move faster to take aggressive steps.

When Mr. Trump gave a speech to the nation on March 11 in which he announced limits on flights from Europe to the United States but still no move to curb gatherings in cities where the virus had spread the experts on the email chain grew angry and fearful. Among those questioning Mr. Trumps decision was Tom Bossert, who had previously served as Mr. Trumps homeland security adviser.

The Red Dawn participants were even more upset when the Centers for Disease Control and Prevention, in mid-March, questioned the value of closing schools, at least for short periods of time. Soon enough, governors ignored this advice, and most schools in the United States were shut. But it happened largely without federal leadership.

The New York Times has collected more than 80 pages of these emails, from January through March, based in part on Freedom of Information Act requests to local government officials. Some of the emails were reported on last month by Kaiser Health News. Here is a fuller collection, arranged by The Times in chronological order. This file includes a list of many of the medical experts on the email chains. It also contains related emails from certain state government medical experts who were reaching out to the federal government during the same time period.

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The Red Dawn Emails: 8 Key Exchanges on the Faltering Response to the Coronavirus - The New York Times

US’s global reputation hits rock-bottom over Trump’s coronavirus response – The Guardian

April 14, 2020

Donald Trumps response to the coronavirus pandemic, which he once dismissed as a hoax, has been fiercely criticised at home as woefully inadequate to the point of irresponsibility.

Yet also thanks largely to Trump, a parallel disaster is unfolding across the world: the ruination of Americas reputation as a safe, trustworthy, competent international leader and partner.

Call it the Trump double-whammy. Diplomatically speaking, the US is on life support.

The Trump administrations self-centred, haphazard, and tone-deaf response [to Covid-19] will end up costing Americans trillions of dollars and thousands of otherwise preventable deaths, wrote Stephen Walt, professor of international relations at Harvard.

But thats not the only damage the United States will suffer. Far from making America great again, this epic policy failure will further tarnish [its] reputation as a country that knows how to do things effectively.

This adverse shift could be permanent, Walt warned. Since taking office in 2017, Trump has insulted Americas friends, undermined multilateral alliances and chosen confrontation over cooperation. Sanctions, embargoes and boycotts aimed at China, Iran and Europe have been globally divisive.

For the most part, oft-maligned foreign leaders such as Germanys Angela Merkel have listened politely, turning the other cheek in the interests of preserving the broader relationship.

But Trumps ineptitude and dishonesty in handling the pandemic, which has left foreign observers as well as Americans gasping in disbelief, is proving a bridge too far.

Erratic behaviour, tolerated in the past, is now seen as downright dangerous. Its long been plain, at least to many in Europe, that Trump could not be trusted. Now he is seen as a threat. It is not just about failed leadership. Its about openly hostile, reckless actions.

The furious reaction in Germany after 200,000 protective masks destined for Berlin mysteriously went missing in Thailand and were allegedly redirected to the US is a case in point. There is no solid proof Trump approved the heist. But its the sort of thing he would do or so people believe.

We consider this to be an act of modern piracy. This is no way to treat transatlantic partners. Even in times of global crisis, we shouldnt resort to the tactics of the wild west, said Andreas Geisel, a leading Berlin politician. Significantly, Merkel has refused to give Trump the benefit of the doubt.

Europeans were already outraged by Trumps reported efforts to acquire monopoly rights to a coronavirus vaccine under development in Germany. This latest example of nationalistic self-interest compounded anger across the EU over Trumps travel ban, imposed last month without consultation or scientific justification.

US reputational damage is not confined to Europe. There was dismay among the G7 countries that a joint statement on tackling the pandemic could not be agreed because Trump insisted on calling it the Wuhan virus his crude way of pinning sole blame on China.

International action has also been hampered at the UN security council by US objections over terminology.

Trump has ignored impassioned calls to create a Covid-19 global taskforce or coalition. He appears oblivious to the catastrophe bearing down on millions of people in the developing world.

Trumps battle against multilateralism has made it so that even formats like the G7 are no longer working, commented Christoph Schult in Der Spiegel. It appears the coronavirus is destroying the last vestiges of a world order.

Trumps surreal televised Covid-19 briefings are further undermining respect for US leadership. Trump regularly propagates false or misleading information, bets on hunches, argues with reporters and contradicts scientific and medical experts.

While publicly rejecting foreign help, Trump has privately asked European and Asian allies for aid even those, such as South Korea, that he previously berated. And he continues to smear the World Health Organization in a transparent quest for scapegoats.

To a watching world, the absence of a fair, affordable US healthcare system, the cut-throat contest between American states for scarce medical supplies, the disproportionate death toll among ethnic minorities, chaotic social distancing rules, and a lack of centralised coordination are reminiscent of a poor, developing country, not the most powerful, influential nation on earth.

Thats a title the US appears on course to lose a fall from grace that may prove irreversible. The domestic debacle unleashed by the pandemic, and global perceptions of American selfishness and incompetence, could change everything. According to Walt, Trump has presided over a failure of character unparalleled in US history.

Do Americans realise how far their countrys moral as well as financial stock has fallen? Perhaps at this time of extreme stress, it seems not to matter. But it will matter later on for them and for the future international balance of power.

Heiko Maas, Germanys foreign minister, said he hoped the crisis would force a fundamental US rethink about whether the America first model really works. The Trump administrations response had been too slow, he said. Hollowing out international connections comes at a high price, Maas warned.

Lasting resentment over how the US went missing in action in the coronavirus wars of 2020 may change the way the world works.

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US's global reputation hits rock-bottom over Trump's coronavirus response - The Guardian

Coronavirus Live Updates: Total Number of Confirmed Deaths in U.S. Surpasses Italy – The New York Times

April 12, 2020

U.S. surpasses Italy in the total number of confirmed deaths.

The United States on Saturday surpassed Italy in the total number of confirmed deaths from the coronavirus, reaching its deadliest day on Friday with 2,057 deaths. As of Saturday afternoon, the total stood at 20,229.

Already the pandemic has put more than 16 million out of work, forcing President Trump into the difficult choice of reopening the country as it reels economically from the pandemic.

Deaths in the United States per capita remained lower than in Italy, though some experts have warned that geography and population density have helped cushion the United States so far. To date, the virus has killed 19,468 in Italy, or 32 individuals per 100,000 people. In the United States, the number of deaths per 100,000 people was six.

The countrys death toll, which has more than doubled over the past week, is now increasing by nearly 2,000 most days.

As Mr. Trump grapples simultaneously with the most devastating public health and economic crises of a lifetime, he finds himself pulled in opposite directions. Bankers, corporate executives and industrialists are pleading with him to reopen the country as soon as possible, while medical experts beg for more time to curb the coronavirus.

Tens of thousands more people could die. Millions more could lose their jobs. And his handling of the crisis appears to be hurting his political support in the run-up to Novembers election.

In a Saturday night interview with Jeanine Pirro on Fox News, Mr. Trump said the decision on whether to reopen the country is the toughest he has ever faced, but he intends to make it fairly soon with input from political, business and medical leaders.

Its going to be based on a lot of facts and on instinct also, Mr. Trump said. Whether we like it or not, there is a certain instinct to it. But we have to get our country back. People want to get back. They want to get back to work.

But the decision on when and how to reopen is not entirely his. The stay-at-home edicts keeping most Americans indoors were issued by governors state by state.

The president did issue nonbinding guidelines urging a pause in daily life through the end of the month. And if he were to issue new guidance outlining a path toward reopening, many states would probably follow or feel pressure from businesses and constituents to ease restrictions.

But the central question is how long it will be until the country is fully back up and running.

The governors of Texas and Florida, both Republicans, have started talking about reopening businesses and schools in their states, echoing signals from Mr. Trump.

But the leaders of California and New York, both Democrats, are sounding more cautious notes about how quickly things can get back to normal.

Californias curve is flattening, Gov. Gavin Newsom said on Twitter on Friday. But that progress will only hold if we continue to STAY HOME and practice physical distancing. And Gov. Andrew M. Cuomo of New York said that widespread testing for coronavirus antibodies would be required before his state could consider reopening nonessential businesses.

Gov. Greg Abbott of Texas said on Friday that he wanted the states businesses to reopen sooner than later, insisting that the coronavirus had slowed its spread in some areas, and that it was not as prevalent in Texas as it was in New York, California and other hard-hit states.

Mr. Abbott said he would issue an executive order this week laying out the timetable and standards for reopening Texas businesses. We want to open up, but we want to open up safely, Mr. Abbott told reporters on Friday.

In Texas, the governors announcement came as the state has yet to hit its peak in coronavirus cases; more than 12,000 Texans have tested positive, with 253 deaths. And it came just 10 days after he issued what is effectively a statewide stay-at-home order on March 31, long after most other states had done so.

The governor of Florida, Ron DeSantis, said officials in his state were exploring reopening schools in May. But at the same time on Thursday, he made headlines by telling educators that he did not believe anyone under the age of 25 had died of the coronavirus. At least three children have.

A Times examination reveals the extent of President Trumps slow response as the virus spread.

Throughout January, as President Trump repeatedly played down the seriousness of the virus and focused on other issues, an array of figures inside his government including top White House advisers and experts deep in the cabinet departments and intelligence agencies identified the threat, sounded alarms and made clear the need for aggressive action.

Dozens of interviews and a review of emails and other records by The New York Times revealed many previously unreported details of the roots and extent of his halting response:

The National Security Council office responsible for tracking pandemics received intelligence reports in early January predicting the spread of the virus, and within weeks raised options like keeping Americans home from work and shutting down large cities.

Despite Mr. Trumps denial, he was told at the time about a Jan. 29 memo produced by his trade adviser, Peter Navarro, laying out in striking detail the potential risks of a coronavirus pandemic.

The health and human services secretary directly warned Mr. Trump of the possibility of a pandemic during a call on Jan. 30, the second warning he delivered to the president about the virus. The president said he was being alarmist.

The health secretary publicly announced in February that the government was establishing a surveillance system in five American cities to measure the spread of the virus. It was delayed for weeks, leaving administration officials with almost no insight into how rapidly the virus was spreading.

For the first time, all 50 states are now under a federal disaster declaration for the same event.

President Trump approved a major disaster declaration for Wyoming on Saturday, the last state to receive the designation in response to the coronavirus pandemic, according to the Federal Emergency Management Agency.

It is the first time the government has declared all 50 states a major disaster for the same event, an agency spokesman said. The District of Columbia, Puerto Rico, Guam, the Northern Mariana Islands and the Virgin Islands have also received the declaration, which provides access to billions in disaster relief funds.

FEMA has obligated more than $5.2 billion of the $60.5 billion allocated for major disasters in what is known as the Disaster Relief Fund, the spokesman said.

Wyoming, which has more than 250 reported cases of the coronavirus, will now have access to federal emergency aid to assist the states recovery efforts. The first coronavirus case in Wyoming was reported on March 11, but no deaths have been recorded.

There are two types of disaster declarations that fall under the Stafford Act, which authorizes federal disaster aid: emergency and major disaster. Requests for both types of declarations are made by state governors and approved by the president, but they offer access to separate buckets of money.

Abortion providers ask Supreme Court to let clinics continue to perform some procedures.

Abortion providers in Texas asked the Supreme Court on Saturday to let their clinics continue to perform some procedures after a federal appeals court upheld orders from state officials prohibiting most abortions.

In their Supreme Court filing, lawyers from Planned Parenthood and the Center for Reproductive Rights said the Texas health crisis did not justify severe restrictions on the constitutional right to abortion.

Three weeks ago, Gov. Greg Abbott, a Republican, ordered a halt to all surgeries and procedures that are not immediately medically necessary. That included abortions not medically necessary to preserve the life or health of the mother, Ken Paxton, the states attorney general, said in a news release. Other abortions, he said, must be postponed to preserve protective gear and other resources to fight the coronavirus pandemic.

Abortion providers promptly challenged the orders as unconstitutional, and the case has twice reached the United States Court of Appeals for the Fifth Circuit, which both times overturned temporary restraining orders issued by Judge Lee Yeakel, who was appointed by President George W. Bush.

The latest ruling from the appeals court, on Friday, allowed almost all of the governors order to stay in place, quoting earlier decisions in saying that a state may implement emergency measures that curtail constitutional rights so long as the measures have at least some real or substantial relation to the public health crisis and are not beyond all question, a plain, palpable invasion of rights secured by the fundamental law.

Judge Yeakel had allowed exceptions to the governors order, which is scheduled to expire April 21 but may be renewed, for abortions performed using drugs and for women whose pregnancies were in their later stages.

A divided three-judge panel of the appeals court stayed Judge Yeakels latest temporary restraining order, making an exception only for any patient who, based on the treating physicians medical judgment, would be past the legal limit for an abortion in Texas, which is 22 weeks from the last menstrual period, on April 22.

The judges in the majority were Judge Stuart Kyle Duncan, appointed by President Trump, and Judge Jennifer Walker Elrod, appointed by Mr. Bush. Judge James L. Dennis, appointed by President Bill Clinton, dissented, saying he would have upheld Judge Yeakels order.

Several other states, including Alabama, Ohio and Oklahoma, have also sought to limit abortions as part of their response to the pandemic, and those efforts have been challenged in court. The Texas case is the first to reach the Supreme Court.

The Pentagon said it would use special powers to ramp up production of millions of N95 masks.

The Defense Department announced on Saturday that it would use a Korean War-era law in an attempt to increase American production of badly needed N95 masks by 39 million over the next three months.

The law, the Defense Production Act, allows the government to take extraordinary measures to procure supplies and materials deemed necessary for the nations defense and security.

President Trump invoked the law last month, but its use so far has been limited, even as states and medical facilities sound alarms about the shortage of personal protective equipment, including masks, in the face of the coronavirus outbreak.

Pentagon officials said they had received signoff from the White House late Friday to use the authorities under the law to award $133 million in contracts for the masks, which they anticipate would be delivered in the next 90 days. It was the first time the department had used the authorities related to the virus, though the White House has already taken other steps allowed under the law to try to increase American mask supplies.

The increased production will ensure the U.S. government gets dedicated long term industrial capacity to meet the needs of the nation, Lt. Col. Mike Andrews, a Pentagon, spokesman, said in a statement on Saturday.

The department did not announce which companies had received the contracts. Defense Production Act authorities include the ability for the government to issue loans to expand production capacity for a given company, to compel companies to prioritize its orders over other clients and to control the distribution of a companys products.

A Trump ally, who the president said had the coronavirus, died from complications.

Stanley Chera, the New York real-estate developer and friend of President Trump whom the president described during a White House briefing as suffering from the coronavirus, has died from complications related to the disease, three people familiar with his death said on Saturday.

Mr. Chera, 78, who was being treated at NewYork-Presbyterian/Weill Cornell Medical Center, died there, according to the people familiar with what took place.

Mr. Chera had left New York City for Deal, N.J., in early March, as a number of wealthier city residents fled the city, one of the centers of the outbreak, to avoid the virus. It was unclear where Mr. Chera contracted it.

The president repeatedly referred to Mr. Cheras illness while speaking to reporters at the White House. He did not name him, but people close to the president said it was Mr. Chera he had been describing.

At the end of March, as Mr. Trump extended the social-distancing guidelines through April 30, he told reporters of a friend who had suddenly found himself ill.

Hes sort of a tough guy, Mr. Trump said. A little older, a little heavier than hed like to be, frankly. And you call up the next day: Hows he doing? And hes in a coma.

Federal prison chief defends response as infection and unrest spread behind bars.

Jails, prisons and detention centers have emerged as major spreaders of the coronavirus in the United States. At the Cook County Jail in Chicago, at least 492 inmates and employees had tested positive by Saturday, making it the top-known source of U.S. infections. A state prison in Michigan had 194 confirmed cases. And New York Citys jails have been hard hit, with hundreds of inmates and corrections staff contracting the virus.

In the federal system, which holds about 174,000 people across the country, at least 481 inmates and prison workers have tested positive for the virus, according to New York Times tracking data, and at least nine federal inmates have died, mainly in Louisiana. The Times has spoken with dozens of workers and inmates who say the federal Bureau of Prisons was ill-prepared for the outbreak.

On Friday, the director of the federal prison system defended his agencys response in an interview on CNN, saying the pandemic was an overwhelming challenge that no one expected. I dont think anybody was ready for this Covid, so were dealing with it just as well as anybody else, and Id be proud to say were doing pretty good, said Michael Carvajal, who took over as the head of the Bureau of Prisons less than two months ago.

Six of the federal prisoners who died were being held in Oakdale, La., where nearly 1,000 people are incarcerated, and where there have been reports of a revolt among inmates.

Attorney General William P. Barr last week ordered the Bureau of Prisons to release more people from federal custody and to focus on three prisons that have been hardest hit by the coronavirus, including the Federal Correctional Institution Oakdale.

State prisons and jails, which hold the vast majority of the people incarcerated in the United States, have also faced unrest in recent days. More than 100 men at a Washington State prison demonstrated in response to positive tests at the facility. Police officers fired pepper spray and sting balls, which eject rubber pellets, to quell the demonstration. In Kansas, inmates at the Lansing Correctional Facility, where at least 28 people have tested positive, set small fires and broke windows in a demonstration that lasted for nearly 12 hours. Two inmates suffered injuries. In Pennsylvania, families of inmates at the Franklin County jail told The PA Post, a local news website, that the inmates were staging a hunger strike.

And in Texas, the state prison system will no longer take new inmates from county jails starting on Monday, according to the states Department of Criminal Justice. In a letter sent to county sheriffs on Saturday, Bryan Collier, the departments executive director, said the decision put additional strain on counties but was necessary to fight the spread of the virus.

Immigrants held at the Otay Mesa detention center in San Diego, Calif., said in phone calls recorded by their lawyers that guards had pepper-sprayed them on Friday after they demanded masks and began to make their own out of clothing and plastic bags. They also said they were asked to sign liability waivers absolving CoreCivic, the private prison company that operates the facility, from responsibility for any coronavirus-related illnesses.

Amanda Gilchrist, a spokeswoman for CoreCivic, described the document that detainees were asked to sign as an educational document explaining that masks were not entirely protective against the virus. She said the company dropped the requirement after the protest and denied that pepper spray was used. At least 16 detainees at the facility have tested positive, according to local news reports.

New York City schools will be closed through the end of the academic year, the mayor says. Not so fast, Cuomo responds.

New York Citys public schools would remain closed through the end of the academic year, Mayor Bill de Blasio announced Saturday, confirming that more than three months of regular schooling for 1.1 million children will be lost because of the spread of the coronavirus.

But soon after the mayor ended his news conference on Saturday, Gov. Andrew M. Cuomo at his own news briefing said there had been no decision on closing schools in the state or city. He described the mayors announcement as Mr. de Blasios opinion. The governor and mayor have been political rivals for years.

It makes no sense for one locality to take an action thats not coordinated with the others, Mr. Cuomo said.

Though New York City is the center of the nations coronavirus outbreak, more than a dozen states and many more local school districts have already announced that their public schools would remain closed through the end of the school year, including California, Pennsylvania and Washington.

But in California, there is one lonely exception: In a rural San Joaquin Valley community where many adults work in citrus and walnut groves, students can still attend kindergarten through eighth grade at Outside Creek Elementary.

Derrick Bravo, the schools principal, superintendent and eighth-grade teacher, said he had leaned on advice from the Centers for Disease Control and Prevention, which suggested that some small schools outside dangerous areas could remain open.

Last week, 21 students about a quarter the schools normal attendance showed up for classes.

Coronavirus is ravaging nursing homes around New York, as Washington State grapples with its losses.

At Crown Heights Center for Nursing and Rehabilitation in Brooklyn, workers said they had to convert a room into a makeshift morgue after more than 15 residents died of the coronavirus, and funeral homes could not handle all the bodies.

At Elizabeth Nursing and Rehabilitation Center in New Jersey, 19 deaths have been linked to the virus; of the 54 residents who remain, 44 are sick.

The coronavirus has snatched lives in every part of society, but has perhaps been cruelest at nursing homes and other facilities for older people, where an aging or frail population, chronic understaffing, shortages of protective gear and constant physical contact has hastened its spread.

In all, around 2,000 residents of nursing homes have died in the outbreak in the New York region, and thousands of other residents are sick. But the crisis in nursing homes is also occurring in virus hot spots elsewhere in the country, with infections growing in places like Rhode Island, Pennsylvania and North Carolina.

In Washington State, the daughter of a woman who died at a Seattle-area nursing home linked to dozens of deaths has filed what appears to be the first coronavirus-related lawsuit against the facility, accusing the company that runs it of fraud.

Debbie de los Angeles said in her lawsuit that Life Care Center in Kirkland, Wash., concealed information to hide the ongoing danger and threat at the facility, which is linked to 43 deaths. Her mother, Twilla Morin, died there on March 4. The facility had started noticing an outbreak of respiratory illness in the weeks before Ms. Morins death, but the company has said workers did not realize it was the coronavirus until later.

Guam is the center of the Navys coronavirus outbreak.

Strapped by the same problems facing health care workers around the world, including a limited supply of personal protective equipment, hospital beds and ventilators, Guams government is contending with how it can protect its own people and simultaneously help the crew of infected sailors on the Theodore Roosevelt carrier, which arrived in Guam on March 27. The outbreak on the ship ended up creating a moral crisis for the military.

As an American territory roughly 7,200 miles from the continental United States, Guam in many ways represents the edge of the United States empire, one that happens to be on the front lines of the American deterrence strategy against China.

The island, at 212 square miles, is home to Joint Region Marianas, a military command made up of Andersen Air Force Base on the northern part of the island that supports stealth-bomber rotations, and Naval Base Guam to the south, where four attack submarines are stationed to counter Chinese military expansion in the South China Sea.

Theyre the ones that are out there, protecting our waters, said Lourdes Leon Guerrero, the islands governor, of the Navy. With about two dozen Guam residents serving aboard the carrier, finding space was the least we could do.

In interviews with The New York Times, local residents, and Theodore Roosevelt sailors and their loved ones, described a complicated situation in which the island is providing logistical support to the Navy while also trying to protect the local population from the coronavirus, which could quickly overwhelm Guams fragile health care system.

The first Americans to recover from the virus have emerged.

Elizabeth Schneider hated to appear to be violating rules that were meant to protect others, and that she knew relied on collective determination to enforce.

But the state health department said people who had tested positive for the coronavirus were allowed to leave self-isolation seven days after their first symptom and three days after their last fever. By those metrics, she was free to fly to Tucson, Ariz., to visit her parents.

She would be more useful there, she had reasoned, as her familys designated grocery shopper. Especially since her mother has asthma.

But re-entry to a society that is largely shut down can also come with a new sense of isolation, Ms. Schneider found.

I thought to myself, Should I mention to them that I had it? she said of her fellow passengers on her mostly empty flight. Ultimately I chickened out.

As recently as mid-March, fewer than 5,000 people in the United States had tested positive for the new coronavirus. Some are still coughing, or tethered to oxygen tanks. Many have died. But the first large wave of Covid-19 survivors, likely to be endowed with a power known to infectious disease specialists as adaptive immunity, is emerging.

Republicans press for $250 billion to replenish small-business program as governors push for more aid.

Top Republican congressional leaders said on Saturday that they would continue to push for a stand-alone infusion of $250 billion to replenish a fast-depleting loan program for distressed small businesses, rebuffing their Democratic counterparts who demanded conditions on the new money and additional funds for hospitals, state and local governments and food aid.

Senator Mitch McConnell of Kentucky, the majority leader, and Representative Kevin McCarthy of California, the minority leader, said in a joint statement on Saturday that their lawmakers reject Democrats reckless threat to continue blocking job-saving funding unless we renegotiate unrelated programs which are not in similar peril.

The administration requested quick action to approve the money to bolster a loan program created last month by the $2 trillion stimulus law for small businesses, . But Democrats blocked an effort by Republicans to push it through the Senate on Thursday with their demand to place conditions on the new funds.

The National Governors Association on Saturday called on lawmakers to allocate at least an additional $500 billion for states and territories to address budgetary shortfalls that have resulted from this unprecedented public health crisis.

That amount is more than double what Democrats had proposed adding to the package, which was to be an interim step as lawmakers look toward a far larger package expected to top $1 trillion to build on the stimulus law.

See original here:

Coronavirus Live Updates: Total Number of Confirmed Deaths in U.S. Surpasses Italy - The New York Times

Loss of sense of smell may be among the symptoms of coronavirus – CNN

April 12, 2020

The novel coronavirus outbreak

Children wave to a person dressed as the Easter Bunny during a neighborhood parade in Haverford, Pennsylvania, on April 10. The neighborhood parades were organized by a local photography studio and have traveled throughout Delaware County.

The novel coronavirus outbreak

Health workers cry during a memorial for their co-worker who died of the coronavirus in Leganes, Spain, on April 10.

The novel coronavirus outbreak

Members of a volunteer organization spray disinfectant in an alley at the Santa Marta favela in Rio de Janeiro on April 10.

The novel coronavirus outbreak

A drone photo taken on April 9 shows bodies being buried on New York's Hart Island, where the city's Department of Correction is dealing with burials amid the coronavirus outbreak.

The novel coronavirus outbreak

A healthcare staff member holds the hand of a coronavirus patient as he is being moved at the Hospital Universitari de Bellvitge near Barcelona, Spain, on April 9.

The novel coronavirus outbreak

Emergency service boats spray water to show support for healthcare workers near the Houses of Parliament in London, England, on April 9.

The novel coronavirus outbreak

Employees of Hyundai Card, a credit card company, sit behind protective screens as they eat in a cafeteria at their offices in Seoul, South Korea, on April 9.

The novel coronavirus outbreak

People wait in their cars for the San Antonio Food Bank to begin food distribution at Traders Village on April 9, in San Antonio, Texas.

The novel coronavirus outbreak

A worker disinfects a carved cross at the Salt Cathedral in Zipaquira, Colombia, on Wednesday, April 8.

The novel coronavirus outbreak

A cake shop employee in Athens, Greece, prepares chocolate Easter bunnies with face masks on April 8.

The novel coronavirus outbreak

Californians Sarah and Aaron Sanders, along with their children, use video conferencing to celebrate a Passover Seder with other family members on April 8.

The novel coronavirus outbreak

The novel coronavirus outbreak

Cars in Wuhan line up to leave at a highway toll station.

The novel coronavirus outbreak

Rabbi Yaakov Kotlarsky places Passover Seder to-go packages into a car trunk in Arlington Heights, Illinois, on Tuesday, April 7.

The novel coronavirus outbreak

The novel coronavirus outbreak

The novel coronavirus outbreak

A man is sprayed with disinfectant prior to going to a market in Tirana, Albania, on Monday, April 6.

The novel coronavirus outbreak

Izzie, left, and Tippi wear ventilated dog masks in Philadelphia on April 6.

The novel coronavirus outbreak

The novel coronavirus outbreak

Police detain a doctor in Quetta, Pakistan, who was among dozens of health-care workers protesting a lack of personal protective equipment on April 6.

The novel coronavirus outbreak

A Catholic priest sprinkles holy water on devotees during Palm Sunday celebrations in Quezon City, Philippines, on Sunday, April 5.

The novel coronavirus outbreak

The novel coronavirus outbreak

The novel coronavirus outbreak

Paramilitary members unload provisions in Kampala, Uganda, on Saturday, April 4. It was the first day of government food distribution for people affected by the nation's lockdown.

The novel coronavirus outbreak

A police officer wearing a coronavirus-themed outfit walks in a market in Chennai, India, to raise awareness about social distancing.

The novel coronavirus outbreak

A woman in Moscow cooks while watching Russian President Vladimir Putin address the nation over the coronavirus pandemic.

The novel coronavirus outbreak

The hashtag "stayhome" is projected onto the Matterhorn mountain that straddles Switzerland and Italy on April 1. The mountain was illuminated by Swiss artist Gerry Hofstetter, who is transforming buildings, monuments and landscapes all over the world to raise awareness during the pandemic.

The novel coronavirus outbreak

Volunteers load food bags on a truck to deliver them to low-income families in Panama City, Panama, on April 1.

The novel coronavirus outbreak

Designer Friederike Jorzig adjusts a mannequin wearing a wedding dress and a face mask at her store in Berlin on March 31.

The novel coronavirus outbreak

People pray next to the grave of musician Robson de Souza Lopes after his burial in Manaus, Brazil, on March 31. According to authorities at the Amazonas Health Secretary, the 43-year-old died after being diagnosed with the novel coronavirus.

The novel coronavirus outbreak

Chris Lyndberg hands out a free lunch to a truck driver at a rest area along Interstate 10 in Sacaton, Arizona, on March 31. The Arizona Trucking Association was giving away 500 Dilly's Deli lunches to show its appreciation for truck drivers who have been delivering medical supplies, food and other necessities during the coronavirus pandemic.

The novel coronavirus outbreak

The novel coronavirus outbreak

The novel coronavirus outbreak

Farmers deliver vegetables to a customer in Saint-Georges-sur-Cher, France, on March 29.

The novel coronavirus outbreak

People listen from their homes as priests conduct Sunday mass from a church roof in Rome on March 29.

The novel coronavirus outbreak

The novel coronavirus outbreak

A worker fixes partitions at a quarantine center in Guwahati, India, on March 28.

The novel coronavirus outbreak

Devices used in diagnosing the coronavirus are inspected in Cheongju, South Korea, on March 27. The devices were being prepared for testing kits at the bio-diagnostic company SD Biosensor.

The novel coronavirus outbreak

A student does homework in Bratislava, Slovakia, on March 27. Schools have been shut down across the world, and many children have been receiving their lessons online.

The novel coronavirus outbreak

A National Guard truck sprays disinfectant in Caracas, Venezuela, on March 27.

The novel coronavirus outbreak

The novel coronavirus outbreak

Pope Francis prays in an empty St. Peter's Square on March 27.

The novel coronavirus outbreak

Coffins carrying coronavirus victims are stored in a warehouse in Ponte San Pietro, Italy, on March 26. They would be transported to another area for cremation.

The novel coronavirus outbreak

Members of Iran's Revolutionary Guard prepare to take part in disinfecting the city of Tehran on March 25.

The novel coronavirus outbreak

Lydia Hassebroek attends a ballet class from her home in New York on March 25.

The novel coronavirus outbreak

People visit the Beijing Zoo on March 25 after it reopened its outdoor exhibits to the public.

The novel coronavirus outbreak

The novel coronavirus outbreak

A woman suspected of having coronavirus is helped from her home by emergency medical technicians Robert Sabia, left, and Mike Pareja, in Paterson, New Jersey, on March 24.

The novel coronavirus outbreak

People practice social distancing as they wait for takeout food at a shopping mall in Bangkok, Thailand, on March 24.

The novel coronavirus outbreak

The novel coronavirus outbreak

The novel coronavirus outbreak

People arrive at the South Municipal Cemetery in Madrid to attend the burial of a man who died from the coronavirus.

The novel coronavirus outbreak

Passengers arrive at Hong Kong International Airport on March 23.

The novel coronavirus outbreak

Giuseppe Corbari holds Sunday Mass in front of photographs sent in by his congregation members in Giussano, Italy, on March 22. Many religious services are being streamed online so that people can worship while still maintaining their distance from others.

The novel coronavirus outbreak

People clap from balconies to show their appreciation for health care workers in Mumbai, India.

The novel coronavirus outbreak

A woman attends a Sunday service at the Nairobi Baptist Church in Nairobi, Kenya, on March 22. The service was streamed live on the internet.

The novel coronavirus outbreak

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Loss of sense of smell may be among the symptoms of coronavirus - CNN

Coronavirus – Wikipedia

April 12, 2020

Subfamily of viruses in the family Coronaviridae

Coronaviruses are a group of related viruses that cause diseases in mammals and birds. In humans, coronaviruses cause respiratory tract infections that can range from mild to lethal. Mild illnesses include some cases of the common cold (which has other possible causes, predominantly rhinoviruses), while more lethal varieties can cause SARS, MERS, and COVID-19. Symptoms in other species vary: in chickens, they cause an upper respiratory tract disease, while in cows and pigs they cause diarrhea. There are yet to be vaccines or antiviral drugs to prevent or treat human coronavirus infections.

Coronaviruses constitute the subfamily Orthocoronavirinae, in the family Coronaviridae, order Nidovirales, and realm Riboviria.[5][6] They are enveloped viruses with a positive-sense single-stranded RNA genome and a nucleocapsid of helical symmetry. The genome size of coronaviruses ranges from approximately 26 to 32 kilobases, one of the largest among RNA viruses.[7] They have characteristic club-shaped spikes that project from their surface, which in electron micrographs create an image reminiscent of the solar corona from which their name derives.[8]

Coronaviruses were first discovered in the 1930s when an acute respiratory infection of domesticated chickens was shown to be caused by infectious bronchitis virus (IBV). In the 1940s, two more animal coronaviruses, mouse hepatitis virus (MHV) and transmissible gastroenteritis virus (TGEV), were isolated.[9]

Human coronaviruses were discovered in the 1960s.[10] The earliest ones studied were from human patients with the common cold, which were later named human coronavirus 229E and human coronavirus OC43.[11] Other human coronaviruses have since been identified, including SARS-CoV in 2003, HCoV NL63 in 2004, HKU1 in 2005, MERS-CoV in 2012, and SARS-CoV-2 in 2019. Most of these have involved serious respiratory tract infections.

The name "coronavirus" is derived from Latin corona, meaning "crown" or "wreath", itself a borrowing from Greek korn, "garland, wreath". The name refers to the characteristic appearance of virions (the infective form of the virus) by electron microscopy, which have a fringe of large, bulbous surface projections creating an image reminiscent of a crown or of a solar corona. This morphology is created by the viral spike peplomers, which are proteins on the surface of the virus.[8][12]

Coronaviruses are large pleomorphic spherical particles with bulbous surface projections.[13] The average diameter of the virus particles is around 120nm (.12 m). The diameter of the envelope is ~80 nm (.08 m) and the spikes are ~20 nm (.02 m) long. The envelope of the virus in electron micrographs appears as a distinct pair of electron dense shells.[14][15]

The viral envelope consists of a lipid bilayer where the membrane (M), envelope (E) and spike (S) structural proteins are anchored.[16] A subset of coronaviruses (specifically the members of betacoronavirus subgroup A) also have a shorter spike-like surface protein called hemagglutinin esterase (HE).[5]

Inside the envelope, there is the nucleocapsid, which is formed from multiple copies of the nucleocapsid (N) protein, which are bound to the positive-sense single-stranded RNA genome in a continuous beads-on-a-string type conformation.[15][17] The lipid bilayer envelope, membrane proteins, and nucleocapsid protect the virus when it is outside the host cell.[18]

Coronaviruses contain a positive-sense, single-stranded RNA genome. The genome size for coronaviruses ranges from 26.4 to 31.7 kilobases.[7] The genome size is one of the largest among RNA viruses. The genome has a 5 methylated cap and a 3 polyadenylated tail.[15]

The genome organization for a coronavirus is 5-leader-UTR-replicase/transcriptase-spike (S)-envelope (E)-membrane (M)-nucleocapsid (N)-3UTR-poly (A) tail. The open reading frames 1a and 1b, which occupy the first two-thirds of the genome, encode the replicase/transcriptase polyprotein. The replicase/transcriptase polyprotein self cleaves to form nonstructural proteins.[15]

The later reading frames encode the four major structural proteins: spike, envelope, membrane, and nucleocapsid.[19] Interspersed between these reading frames are the reading frames for the accessory proteins. The number of accessory proteins and their function is unique depending on the specific coronavirus.[15]

Infection begins when the viral spike (S) glycoprotein attaches to its complementary host cell receptor. After attachment, a protease of the host cell cleaves and activates the receptor-attached spike protein. Depending on the host cell protease available, cleavage and activation allows the virus to enter the host cell by endocytosis or direct fusion of the viral envelop with the host membrane.[20]

On entry into the host cell, the virus particle is uncoated, and its genome enters the cell cytoplasm.[15] The coronavirus RNA genome has a 5 methylated cap and a 3 polyadenylated tail, which allows the RNA to attach to the host cell's ribosome for translation.[15] The host ribosome translates the initial overlapping open reading frame of the virus genome and forms a long polyprotein. The polyprotein has its own proteases which cleave the polyprotein into multiple nonstructural proteins.[15]

A number of the nonstructural proteins coalesce to form a multi-protein replicase-transcriptase complex (RTC). The main replicase-transcriptase protein is the RNA-dependent RNA polymerase (RdRp). It is directly involved in the replication and transcription of RNA from an RNA strand. The other nonstructural proteins in the complex assist in the replication and transcription process. The exoribonuclease nonstructural protein, for instance, provides extra fidelity to replication by providing a proofreading function which the RNA-dependent RNA polymerase lacks.[21]

One of the main functions of the complex is to replicate the viral genome. RdRp directly mediates the synthesis of negative-sense genomic RNA from the positive-sense genomic RNA. This is followed by the replication of positive-sense genomic RNA from the negative-sense genomic RNA.[15] The other important function of the complex is to transcribe the viral genome. RdRp directly mediates the synthesis of negative-sense subgenomic RNA molecules from the positive-sense genomic RNA. This is followed by the transcription of these negative-sense subgenomic RNA molecules to their corresponding positive-sense mRNAs.[15]

The replicated positive-sense genomic RNA becomes the genome of the progeny viruses. The mRNAs are gene transcripts of the last third of the virus genome after the initial overlapping reading frame. These mRNAs are translated by the host's ribosomes into the structural proteins and a number of accessory proteins.[15] RNA translation occurs inside the endoplasmic reticulum. The viral structural proteins S, E, and M move along the secretory pathway into the Golgi intermediate compartment. There, the M proteins direct most protein-protein interactions required for assembly of viruses following its binding to the nucleocapsid.[22] Progeny viruses are then released from the host cell by exocytosis through secretory vesicles.[22]

The interaction of the coronavirus spike protein with its complement host cell receptor is central in determining the tissue tropism, infectivity, and species range of the virus.[23][24] The SARS coronavirus, for example, infects human cells by attaching to the angiotensin-converting enzyme 2 (ACE2) receptor.[25]

The scientific name for coronavirus is Orthocoronavirinae or Coronavirinae.[2][3][4] Coronaviruses belong to the family of Coronaviridae, order Nidovirales, and realm Riboviria.[5][6] They are divided into alphacoronaviruses and betacoronaviruses which infect mammals, and gammacoronaviruses and deltacoronaviruses which primarily infect birds.[26]

The most recent common ancestor (MRCA) of all coronaviruses is estimated to have existed as recently as 8000 BCE, although some models place the common ancestor as far back as 55 million years or more, implying long term coevolution with bat and avian species.[27] The MRCAs of the alphacoronavirus line has been placed at about 2400 BCE, the betacoronavirus line at 3300 BCE, the gammacoronavirus line at 2800 BCE, and the deltacoronavirus line at about 3000 BCE. Bats and birds, as warm-blooded flying vertebrates, are ideal hosts for the coronavirus gene pool (bats the reservoir for alphacoronavirus and betacoronavirus and birds the natural reservoir for gammacoronavirus and deltacoronavirus). The large number of host bat and avian species, and their global range, has enabled extensive coronavirus evolution and dissemination.[28]

Many human coronavirus have their origin in bats.[29] MERS-CoV, although related to several bat coronavirus species, appears to have diverged from these several centuries ago.[30] The human coronavirus NL63 and a bat coronavirus shared an MRCA 563822 years ago.[31] The most closely related bat coronavirus and SARS-CoV diverged in 1986.[32] A path of evolution of the SARS virus and keen relationship with bats have been proposed. The authors suggest that the coronaviruses have been coevolved with bats for a long time and the ancestors of SARS-CoV first infected the species of the genus Hipposideridae, subsequently spread to species of the Rhinolophidae and then to civets, and finally to humans.[33][34]

Bovine coronavirus is thought to have originated in rodents, unlike most other betacoronaviruses which originated in bats.[29] In the 1790s, equine coronavirus diverged from the bovine coronavirus after a cross-species jump.[35] Later in the 1890s, human coronavirus OC43 evolved from bovine coronavirus after another cross-species spillover event.[36][35] It is speculated that the flu pandemic of 1890 may have been caused by this spillover event, and not by the influenza virus, because of the timing, neurological symptoms, and unknown causative agent of the pandemic.[37] In the 1950s, the human coronavirus OC43 began to split into its present genotypes.[38]

Alpaca coronavirus and human coronavirus 229E diverged before 1960.[39]

Coronaviruses vary significantly in risk factor. Some can kill more than 30% of those infected (such as MERS-CoV), and some are relatively harmless, such as the common cold.[15] Coronaviruses cause colds with major symptoms, such as fever, and a sore throat from swollen adenoids, occurring primarily in the winter and early spring seasons.[40] Coronaviruses can cause pneumonia (either direct viral pneumonia or secondary bacterial pneumonia) and bronchitis (either direct viral bronchitis or secondary bacterial bronchitis).[41] The human coronavirus discovered in 2003, SARS-CoV, which causes severe acute respiratory syndrome (SARS), has a unique pathogenesis because it causes both upper and lower respiratory tract infections.[41]

Six species of human coronaviruses are known, with one species subdivided into two different strains, making seven strains of human coronaviruses altogether. Four of these strains produce the generally mild symptoms of the common cold:

Three strains (two species) produce symptoms that are potentially severe; all three of these are -CoV strains:

The coronaviruses HCoV-229E, -NL63, -OC43, and -HKU1 continually circulate in the human population and cause respiratory infections in adults and children worldwide.[43]

In 2003, following the outbreak of severe acute respiratory syndrome (SARS) which had begun the prior year in Asia, and secondary cases elsewhere in the world, the World Health Organization (WHO) issued a press release stating that a novel coronavirus identified by a number of laboratories was the causative agent for SARS. The virus was officially named the SARS coronavirus (SARS-CoV). More than 8,000 people were infected, about ten percent of whom died.[25]

In September 2012, a new type of coronavirus was identified, initially called Novel Coronavirus 2012, and now officially named Middle East respiratory syndrome coronavirus (MERS-CoV).[53][54] The World Health Organization issued a global alert soon after.[55] The WHO update on 28 September 2012 said the virus did not seem to pass easily from person to person.[56] However, on 12 May 2013, a case of human-to-human transmission in France was confirmed by the French Ministry of Social Affairs and Health.[57] In addition, cases of human-to-human transmission were reported by the Ministry of Health in Tunisia. Two confirmed cases involved people who seemed to have caught the disease from their late father, who became ill after a visit to Qatar and Saudi Arabia. Despite this, it appears the virus had trouble spreading from human to human, as most individuals who are infected do not transmit the virus.[58] By 30 October 2013, there were 124 cases and 52 deaths in Saudi Arabia.[59]

After the Dutch Erasmus Medical Centre sequenced the virus, the virus was given a new name, Human CoronavirusErasmus Medical Centre (HCoV-EMC). The final name for the virus is Middle East respiratory syndrome coronavirus (MERS-CoV). The only U.S. cases (both survived) were recorded in May 2014.[60]

In May 2015, an outbreak of MERS-CoV occurred in the Republic of Korea, when a man who had traveled to the Middle East, visited four hospitals in the Seoul area to treat his illness. This caused one of the largest outbreaks of MERS-CoV outside the Middle East.[61] As of December 2019, 2,468 cases of MERS-CoV infection had been confirmed by laboratory tests, 851 of which were fatal, a mortality rate of approximately 34.5%.[62]

In December 2019, a pneumonia outbreak was reported in Wuhan, China.[63] On 31 December 2019, the outbreak was traced to a novel strain of coronavirus,[64] which was given the interim name 2019-nCoV by the World Health Organization (WHO),[65][66][67] later renamed SARS-CoV-2 by the International Committee on Taxonomy of Viruses. Some researchers have suggested the Huanan Seafood Wholesale Market may not be the original source of viral transmission to humans.[68][69]

As of 12 April 2020, there have been at least 108,862[49] confirmed deaths and more than 1,777,515[49] confirmed cases in the coronavirus pneumonia pandemic. The Wuhan strain has been identified as a new strain of Betacoronavirus from group 2B with approximately 70% genetic similarity to the SARS-CoV.[70] The virus has a 96% similarity to a bat coronavirus, so it is widely suspected to originate from bats as well.[68][71] The pandemic has resulted in travel restrictions and nationwide lockdowns in several countries.

Coronaviruses have been recognized as causing pathological conditions in veterinary medicine since the 1930s.[9] Except for avian infectious bronchitis, the major related diseases have mainly an intestinal location.[72]

Coronaviruses primarily infect the upper respiratory and gastrointestinal tract of mammals and birds. They also cause a range of diseases in farm animals and domesticated pets, some of which can be serious and are a threat to the farming industry. In chickens, the infectious bronchitis virus (IBV), a coronavirus, targets not only the respiratory tract but also the urogenital tract. The virus can spread to different organs throughout the chicken.[73] Economically significant coronaviruses of farm animals include porcine coronavirus (transmissible gastroenteritis coronavirus, TGE) and bovine coronavirus, which both result in diarrhea in young animals. Feline coronavirus: two forms, feline enteric coronavirus is a pathogen of minor clinical significance, but spontaneous mutation of this virus can result in feline infectious peritonitis (FIP), a disease associated with high mortality. Similarly, there are two types of coronavirus that infect ferrets: Ferret enteric coronavirus causes a gastrointestinal syndrome known as epizootic catarrhal enteritis (ECE), and a more lethal systemic version of the virus (like FIP in cats) known as ferret systemic coronavirus (FSC).[74] There are two types of canine coronavirus (CCoV), one that causes mild gastrointestinal disease and one that has been found to cause respiratory disease. Mouse hepatitis virus (MHV) is a coronavirus that causes an epidemic murine illness with high mortality, especially among colonies of laboratory mice.[75] Sialodacryoadenitis virus (SDAV) is highly infectious coronavirus of laboratory rats, which can be transmitted between individuals by direct contact and indirectly by aerosol. Acute infections have high morbidity and tropism for the salivary, lachrymal and harderian glands.[76]

A HKU2-related bat coronavirus called swine acute diarrhea syndrome coronavirus (SADS-CoV) causes diarrhea in pigs.[77]

Prior to the discovery of SARS-CoV, MHV had been the best-studied coronavirus both in vivo and in vitro as well as at the molecular level. Some strains of MHV cause a progressive demyelinating encephalitis in mice which has been used as a murine model for multiple sclerosis. Significant research efforts have been focused on elucidating the viral pathogenesis of these animal coronaviruses, especially by virologists interested in veterinary and zoonotic diseases.[78]

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Coronavirus - Wikipedia

Coronavirus Update (Live): 1,423,379 Cases and 81,848 …

April 12, 2020

How dangerous is the virus?

There are three parameters to understand in order to assess the magnitude of the risk posed by this novel coronavirus:

The attack rate or transmissibility (how rapidly the disease spreads) of a virus is indicated by its reproductive number (Ro, pronounced R-nought or r-zero), which represents the average number of people to which a single infected person will transmit the virus.

WHO's estimated (on Jan. 23) Ro to be between 1.4 and 2.5. [13]

Other studies have estimated a Ro between 3.6 and 4.0, and between 2.24 to 3.58. [23].

Preliminary studies had estimated Ro to be between 1.5 and 3.5. [5][6][7]

An outbreak with a reproductive number of below 1 will gradually disappear.

For comparison, the Ro for the common flu is 1.3 and for SARS it was 2.0.

See full details: Coronavirus Fatality Rate

The novel coronavirus' case fatality rate has been estimated at around 2%, in the WHO press conference held on January 29, 2020 [16] . However, it noted that, without knowing how many were infected, it was too early to be able to put a percentage on the mortality rate figure.

A prior estimate [9] had put that number at 3%.

Fatality rate can change as a virus can mutate, according to epidemiologists.

For comparison, the case fatality rate for SARS was 10%, and for MERS 34%.

See full details: COVID-19 Coronavirus Incubation Period

Symptoms of COVID-19 may appear in as few as 2 days or as long as 14 (estimated ranges vary from 2-10 days, 2-14 days, and 10-14 days, see details), during which the virus is contagious but the patient does not display any symptom (asymptomatic transmission).

See latest findings: Age, Sex, Demographics of COVID-19 Cases and Deaths

According to early estimates by China's National Health Commission (NHC), about 80% of those who died were over the age of 60 and 75% of them hadpre-existing health conditions such as cardiovascular diseases anddiabetes.[24]

According to the WHO Situation Report no. 7 issued on Jan. 27:

A study of 138 hospitalized patients with NCIP found that the median age was 56 years (interquartile range, 42-68; range, 22-92 years) and 75 (54.3%) were men.[25]

The WHO, in its Myth busters FAQs, addresses the question: "Does the new coronavirus affect older people, or are younger people also susceptible?" by answering that:

As of Jan. 29, according to French authorities, the conditions of the two earliest Paris cases had worsened and the patients were being treated in intensive care, according to French authorities. The patients have been described as a young couple aged 30 and 31 years old, both Chinese citizens from Wuhan who were asymptomatic when they arrived in Paris on January 18 [19].

The NHC reported the details of the first 17 deaths up to 24 pm on January 22, 2020. The deaths included 13 males and 4 females. The median age of the deaths was 75 (range 48-89) years.[21]

See full details: WHO coronavirus updates

On January 30, the World Health Organization declared the coronavirus outbreak a Global Public Health Emergency.

For more information from the WHO regarding novel coronavirus: WHO page on Novel Coronavirus (2019-nCoV)

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Coronavirus Update (Live): 1,423,379 Cases and 81,848 ...

NPR’s Weekly Roundup on the Coronavirus Crisis – NPR

April 12, 2020

Special Report: Coronavirus The Week's Best from NPR News

A sign of the times, reminding joggers and dog walkers on Boston's Charles River Esplanade to stay six feet apart to avoid transmitting the coronavirus. Steven Senne/AP hide caption

A sign of the times, reminding joggers and dog walkers on Boston's Charles River Esplanade to stay six feet apart to avoid transmitting the coronavirus.

It's been nearly 12 weeks since the first case of the novel coronavirus was confirmed in Washington state, and it's unclear when the wave of infections may subside.

One of the biggest questions for officials who are managing the government response is whether the country has reached the peak. In this Special Report, NPR's Lulu Garcia-Navarro wraps up the week's best reporting on all of these angles and more. Click "Listen" at the top of the page.

The Trump administration is looking at a variety of scientific modeling to try to figure that out. Projections of the death toll vary by the tens of thousands.

"We're nearing the peak of the outbreak," Centers for Disease Control and Prevention Director Robert Redfield told NPR this week. He added that he expects "to see the curve begin to go down."

But some governors say their states are still struggling to get needed supplies. And critics like retired Army Lt. Gen. Russel Honore, who helped coordinate military relief in response to Hurricane Katrina, say the federal government can still be more aggressive in centralizing the distribution of resources.

Meantime, as Americans settle into wearing masks in public to avoid transmitting the coronavirus, they also need to look after their emotional well-being. A Kaiser Family Foundation Health tracking poll found that an increasing share of Americans about half now, up from a third say their mental health has been affected by the coronavirus crisis.

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NPR's Weekly Roundup on the Coronavirus Crisis - NPR

Coronavirus Survivors: Test Driving Immunity After Recovering in the U.S. – The New York Times

April 12, 2020

People have understood for a long time that surviving an acute infection provides immunity, said Michael Oldstone, an emeritus professor of virology and immunology at Scripps Research Institute, and author of the book Viruses, Plagues and History.

That history, though, does not quell all the questions now in the heads of those convalescing from the new coronavirus. On Facebook groups like Survivor Corps, on their doctors voice mail, in messages to reporters, they ask questions that have no easy answers.

When is it safe to go out? What does it mean that the fever is gone but taste and smell have not returned? Is it OK to hug ones grandmother? Does a positive antibody test guarantee immunity?

Some of the confusion has been exacerbated by a continued shortage of testing. And some of the urgency is fueled by the stigma now associated with being out and about. Walter Lamkin, 69, general counsel for a company in St. Louis, Mo., tested positive in March and was cleared by the St. Louis County public health department in early April.

I cant infect anyone and I cant be infected, he said.

But as the designated grocery shopper for his extended family, people are judging me, Mr. Lamkin said, and wondering whether he should be out. Unless I get a negative test, I cant answer that question.

But he has been told that he cannot get retested to confirm that he no longer has the virus because tests are reserved for people with symptoms.

OK, but if no one will test you, what are you supposed to do? he asked.

The thing to do, the thing that throngs of Covid-19 survivors are uniformly eager to do, it seems, is participate in antibody studies.

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Coronavirus Survivors: Test Driving Immunity After Recovering in the U.S. - The New York Times

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