Category: Corona Virus

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Trump’s case of coronavirus changed the conversation – CNN

October 23, 2020

All told, roughly 40% of respondents mentioned something related to coronavirus, which has raged throughout the US for nearly eight months, when asked what they had heard about the President recently. That was a decline compared with last week, but about on par with the share of mentions the topic received in the week Trump received his diagnosis, and well above most prior weeks in the project.

The results show the net sentiment associated with news about Trump shifted this week, rising into positive territory for the first time since July.

That shift appears to be mostly due to changes in how people talk about coronavirus when it comes to Trump. Since Trump's diagnosis, more people are using positive words to talk about Trump and coronavirus than did so before the news shifted to the President's health.

In the three weeks before Trump's diagnosis, Americans frequently used words like "lie," "downplay" and "vaccine" to talk about Trump and coronavirus, words which largely related to Trump's handling of the pandemic. Since his diagnosis, frequently used words around coronavirus and Trump have been more focused on his health: "Hospital," "recover," "sick" and "positive," for example.

At the same time, the change in topic within coronavirus mentions means more of the words used in responses related to coronavirus and Trump have a positive tone to them. That change accounts for much of the positive movement in Trump's net sentiment in this week's data.

For the final stretch in the campaign, it's possible this shift could benefit Trump if attention remains off of his handling of the pandemic. But as cases rise, Americans' focus may return to Trump's role in managing the US response more than his own health.

For Biden this week, his three most frequently mentioned topics were each mentioned by roughly one in 10 respondents. Two of those topics have landed near the top frequently for Biden: coronavirus and general references to his media appearances.

But the third is new for the Democratic nominee; there has been a sharp increase in words related to controversies around Biden. This week, those words primarily relate to recently published emails that purport to detail the business dealings of Biden's son in Ukraine and in China. The emails have been seized upon by President Donald Trump, Republican allies in Congress and conservative media in the closing weeks of the election to attack the Democratic nominee. CNN has not determined the authenticity of the emails. The FBI is investigating whether the emails are connected to an ongoing Russian disinformation effort targeting the former vice president's campaign, according to a US official and a congressional source briefed on the matter.

The top word for Biden in this week's data is "son," while "Ukraine" lands in the top 20.

The President and his staffers promoted articles about this information, even as Facebook and Twitter stopped users from freely sharing them.

Other words landing near the top for Biden this week are "good," "coronavirus," "town hall" and "campaign."

"Coronavirus" was the dominant word for Trump, with the rest of his frequently mentioned words trailing far behind. Other words for Trump mostly related to his return to the campaign trail, including mentions of rallies, the campaign and his town hall on NBC.

The word "debate" landed near the top for both candidates. It's the fourth word on Biden's list and the fifth for Trump. The two candidates will meet Thursday in Nashville for the final presidential debate before the election.

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Trump's case of coronavirus changed the conversation - CNN

America and the Coronavirus: A Colossal Failure of Leadership – The New York Times

October 23, 2020

There is one graph that has to do with the coronavirus that blows my mind. It looks like this. This graph shows coronavirus cases in the United States versus the European Union. Do you see what happens here? Everyone has a surge around the same time, but while the European Union dramatically drops, the United States plateaus for a little bit and then skyrockets. This is shocking to me because the United States is perhaps the most prepared country on earth for a pandemic. The U.S. government has an actual playbook that tells us what we need to do in the case of a pandemic. Not to mention, its like the richest country in the world, with the best health institution on earth, the C.D.C., which literally fights pandemics in other countries and teaches even our peers how to do epidemiology. And yet, you look at this graph and you wonder, what happened? I want to piece together a timeline to find out how this happened. How does the country with the most money and experts and the C.D.C. and a literal pandemic playbook end up with so many deaths, and end up with a graph that looks like this? [MUSIC PLAYING] The countries best and worst prepared for an epidemic, were rated No. 1 at being prepared. Europe has largely contained the virus. Nearly 200,000 Americans dead from Covid. Were doing great. Our country is doing so great. [MUSIC PLAYING] As I piece together this timeline, Im going to need some help. And for that, I turned to Nick Kristof. Hes a Pulitzer Prize-winning journalist. He speaks Mandarin. Hes been all around the world, reporting on and explaining public health crises for decades. Ive always felt that I come from the country that helped invent public health. And now, my own country, arguably the most powerful country in the history of the world, has taken a challenge that we kind of knew what to do with, and just blowing it in ways that cost so many lives so needlessly. So if I want to understand how this all played out and how we got a graph that looks like this, where do we start? Lets go way back, before we were paying any attention to this. I figured our timeline would start somewhere in January of 2020, but Nick told me to go back even further, way back to 2005. That summer, President George Bush was on vacation at his ranch in Texas when he got ahold of this book. It was about the Spanish flu that killed tens of millions of people back in 1918. This book freaked George Bush out. He got back to Washington, and immediately got to work putting together a plan, a step-by-step guide of what the U.S. should do if a pandemic came to our country. He called it a playbook for pandemic response. President Obama developed a playbook of his own that had very specific plans in place on what the government should do in the case of a disease outbreak, including specifically citing coronaviruses. This pandemic playbook was then passed on to the Trump administration. We left them the detailed playbook, which specifically cited novel coronaviruses. Short of leaving a flashing neon sign in the Situation Room saying. Watch out for a pandemic, Im not sure what more we could have done. No one knew when the big pandemic would come, what it would look like. But even still, the previous two administrations were obsessed with making sure we were ready. But if we wait for a pandemic to appear, it will be too late to prepare. So now lets fast forward to when the big one did hit. And that part of the story happens on the last day of 2019. On Dec. 31, 2019, a report of 44 people with pneumonia comes in from a fish market in China. So at this point, it seems like this is a fairly small deal. Its 40 people with pneumonia in China. So who in the U.S. would even care or have this on their radar in the first place? `Epidemiologists were on top of this immediately in early January, about the risk this might be something serious. The World Health Organization was communicating with the C.D.C., the C.D.C. was communicating with the administration. And indeed, it appears to have entered the presidents daily brief in early January. Were going to begin here with the outbreak of a mystery virus in China that now has the World Health Organization on edge. I heard that China was concealing information. And didnt that stop American experts from getting a full picture on what was happening? Yes, absolutely. China behaved irresponsibly and was concealing information. But we had channels into China, into the World Health Organization. We were getting feedback about what was really happening. Its the middle of January, and coronavirus is potentially a thing of concern. Didnt President Trump get on a call with President Xi Jinping? Yeah, they did. They had an important phone conversation then. But what they talked about was trade. But it just doesnt get any bigger than this, not only in terms of a deal. Tell President Xi, I said, President, go out, have a round of golf. This was a huge, huge missed opportunity. OK, so we miss these first two opportunities of taking those early reports really seriously and that call with Xi Jinping, which potentially could have been a health collaboration to stop the virus. But it was still early on. The coronavirus hadnt even been detected in the United States yet. Gwen Stefani and Blake Shelton not quite yet engaged, right? Definitely not married. So while the United States was preparing for the Grammys and the Super Bowl, the coronavirus quietly came into our country. The first case is reported around Seattle on Jan. 21. At this point, Trump has been hearing more and more warnings from his intelligence briefings, as well as from the C.D.C. And as the news breaks of the first case in the U.S., Trump is on his way to Switzerland to speak at the World Economic Forum, where he talks a lot about China, but just not about the virus. Our relationship with China right now has probably never been better. Man, just like imagine what could have happened at this moment. End of January, the president reads his briefing. Hes like, oh, whoa, this is real. This is spreading globally. We need to get serious about this. He calls Xi Jinping back, and hes like, hey, Xi Jinping, I know weve been talking a lot about trade, but why dont we talk about this virus thats coming from your country to mine? What do we need to do to solve it? And Xi Jinping is like, yeah, youre right, lets do it. Trump gets up to tell the nation a pandemic is coming and that weve got to be ready for it, but dont worry because were super prepared. We have all the plans. We have a literal pandemic playbook. We have money. We have experts. We can squash this. Have you been briefed by the C.D.C.? I have. Are there words about a pandemic at this point? No, not at all, and we have it totally under control. Its one person coming in from China, and we have it under control. Its going to be just fine. There was some hope that we could have actually eliminated it in early January and avoided this catastrophe for the world. Instead, our leaders, and our citizens, were completely focused on other things. The Grammy Awards are finally here. CNN breaking news. Kobe Bryant Has been killed in a helicopter crash. Special coverage of the impeachment trial. Did nothing wrong. Did nothing wrong. [CHEERING AND APPLAUSE] So by the end of January, the virus has now arrived to the United States. There are reported cases here. We are now aware that it is a problem. I guess Im wondering, like, what is the response? What should the U.S. have done in that moment? The first step in response to a disease like this is to find out where it is, which means you develop a test. We have 12 cases 11 cases. And many of them are in good shape now, so. The United States and South Korea had their first reported case of Covid-19 on the same day. A month later, South Korea, who, by the way, has like a fifth the number of people that the United States has, had tested 13,000 people. Here in the U.S., we had tested 3,000. Im not afraid of the coronavirus, and no one else should be that afraid, either. A reminder that all of these steps, the testing was not a new idea. This was in the old playbooks. Testing and surveillance of where the virus is is like a fundamental step in responding to a pandemic. Its mind-blowing that because you cant get the federal government to improve the testing because they just want to say how great it is. And the testing is not going to be a problem at all. So this struggle to develop a test, wasnt this more of like an issue with the F.D.A. and the C.D.C. and H.H.S. sort of feuding with each other about who was going to do the test? At one level, the way we fumbled the development of testing in the United States was a result of bureaucratic infighting. But if President Trump had shown the same passion for getting a test that he showed for building a wall or for backing hydroxychloroquine to treat the coronavirus, we would have had a test all ready to go and all around the country by the end of January or beginning of February. Hydroxychloroquine, were just hearing really positive stories. I happen to be taking it. I think its good. Ive heard a lot of good stories. Sierra Leone in West Africa had an effective test before the United States did. And so as a result, we didnt know where the virus was. We were blind. Theyre working hard. Looks like, by April, you know, in theory, when it gets a little warmer, it miraculously goes away. Hope thats true. And then, Americans started to die. [MUSIC PLAYING] It started with just one in February. But soon one became 10 became 100, and soon it was 100 per day, and then 200 per day, and 500 per day. And now, were in the thousands. And then the month of April was here. And in one month, 57,000 Americans died from Covid-19. So was there a moment for you when you realized that this was spiraling out of control? I visited a couple of emergency rooms and I.C.U.s early in the crisis. And this was when people are still talking about how the coronavirus is like the flu. And meanwhile, these emergency rooms are just swamped. The doctors and nurses are traumatized. I need a vent. I need a vent. I need a ventilator. And the strength of those doctors contrasted with just the fecklessness of our political leadership. And again, I said last night, we did an interview on Fox last night You have to be calm. Itll go away. [BEEPING] Many of the places are really in great shape. They really have done a fantastic job. We have to open our country. We cannot let the cure be worse than the problem itself. Were not going to let the cure be worse than the problem. We have to be calm. Itll go away. Ive seen a lot of grim diseases, but the combination in Covid of such large numbers dying, all alone because their loved ones cant go with them, saddens me, but it also just enrages me because this was so unnecessary. OK, so lets realize where we are. Its April, and we really didnt get the early response down. We didnt get testing figured out. But now, were in the thick of a crisis. People are dying. There is a crisis in the United States. So the big question here is, what do you do once youre actually in the thick of this crisis? And in my conversations with Nick, and in all of these playbooks, theres this one theme that just keeps coming up, which is health communications. Which sort of just sounds like a boring P.S.A. from the government. Larry, you know this simple exercise can help you stay healthy. I didnt even know what that meant to begin with. But as I looked into it, I started to realize that there was something there. In fact, the Bush playbook says that the need for timely, accurate, credible and consistent information that is tailored to specific audiences cannot be overstated. So it turns out that, when a country is devolving into pandemic chaos, one of the most important things, if not the most important thing, a government can do is communicate to its citizens how important and risky this is. And the 15, within a couple of days, is going to be down to close to zero. Staying at home leads to death also. Are you telling the Americans not to change any of their behaviors? No, I think you have to always look, I do it a lot anyway, as you probably heard, wash your hands, stay clean. You dont have to necessarily grab every handrail, unless you have to. You know, you do certain things that you do when you have the flu. I mean, view this the same as the flu. The C.D.C. is recommending that Americans wear a basic cloth or fabric mask. This is voluntary. Its easy to focus just on the failures of President Trump, but look, there is plenty of failure to go around, and it involves blue states as well as red ones. New York was particularly hard hit, in part because New York leaders initially did not take this seriously enough. Mayor Bill de Blasio tweeted that people should get on with their lives and go out on the town. It would be difficult to think of any signal that a leader could possibly send that was more wrong and more lethal than that one. Tonight, FEMA is bringing in hundreds of ambulances to help with record-breaking 911 calls in New York. This morning, as an emergency field hospital is being built in iconic Central Park All of those beds, all 20,000, will have to be turned into intensive care beds to focus on Covid-19 patients who are really, really sick. We simply blew it. And the result was that Americans did not take the virus as seriously as they did in other countries. OK, so the U.S. blew it when it came to health communications, whereas Europe and many countries around the world got it right. I want to know what the actual proof is that thats the key to fixing it. Is it just because the playbook said it or because Nick said it? Well, I got my hands on some data that really helped me understand this. Google collected data from a bunch of peoples phones to track before the pandemic and during the pandemic how peoples movement changed. If you assemble that data onto a map, you see something really interesting. If you look over here, you can see these dark blue areas, which represent countries that shut down by up to 80 to 100 percent. This means they werent going out, they werent shopping, they werent going to cinemas. They were staying home like the government implored them to. Austria shut down by 64 percent, France by 80 percent, Ireland by 83 percent. All of this movement shut down in the name of beating the virus. Meanwhile, over here in the United States, were at about 39 percent on this same day in late April. We never really shut down. One of the basic things about this pandemic is that, if people really do take it seriously, and for four weeks or six weeks do adhere to stay-at-home orders in the way Europe did, with 90 percent of the travel shut down, then the virus is stopped in its tracks. Other countries did it, one after the other. The U.S. was never able to do that. We fought the virus, and the virus won. Again, I cant help but think of what could have happened if our president got up and said My fellow Americans This is going to be very difficult. We have to shut down our entire country. Not just the urban spots, the entire country. Its going to be painful, but it will help us reopen our economy quicker and it will help save American lives. But that didnt happen. I remember looking at the graphs in April and watching daily deaths climb so rapidly, just skyrocketing. The natural response wouldve been to say, whoa, slow down, we need to really tighten things up and learn from other countries that have done better. But instead, the very next day The president, remarkably, attacks stay-at-home orders in states around the country and encouraged supporters to liberate states like Michigan. This was an obliviousness to science and public health advice, a lack of empathy for those who were dying. I dont know what to call that failure except an example of extraordinary incompetence. I find that truly heartbreaking. This is where the graph starts to blow my mind, and really starts to get to the heart of my big question of why these lines look so different. Watch how the Covid cases sort of plateau in the U.S., but in Europe, cases start to look like this. Our peers buckled down and did the hard work to get ahead of the virus by following basic pandemic measures articulated in all of the plans, including our own playbooks. They saw the results of that. The U.S., on the other hand, plateaus for a bit, and by mid-June, starts to skyrocket again. In the nations three most populous states, things are going from bad to worse. California, Texas and Florida are in crisis. Today, reporting more than 5,000 Covid-related hospitalizations. And even though Europe is having an uptick now, you need to look at this gap. This gap represents a lot of unnecessary suffering, and the death of tens of thousands of Americans. I understand that were going to make mistakes. This is hard stuff. Lots of countries made mistakes. But what has troubled me is that we just didnt learn from them. We werent self-correcting. Instead, we doubled down on mistakes. And then, we just gave up. OK, so I now feel like I have a much better understanding of why our graph looks like this compared to other countries. It has a little bit to do with those early mistakes and whatever, but those are sort of forgivable. Instead, its what happened once the pandemic was here and raging and killing Americans. Instead of having leaders who told us what we needed to do to make it through this risky and uncertain time, we had leaders that denied that this was even a big deal, and then who eventually just gave up on the whole thing. The death certificates of more than 150,000 Americans will say something like Covid-19. In a larger sense, what should be written on those death certificates as the cause of death is incompetence.

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America and the Coronavirus: A Colossal Failure of Leadership - The New York Times

Pa. Health Dept. Announces 2,063 More Coronavirus Cases, One Of The Highest Days Of The Pandemic – CBS Pittsburgh

October 23, 2020

By: KDKA-TV News Staff

HARRISBURG (KDKA) The Pennsylvania Department of Health is reporting 2,063 new cases of Coronavirus and 30 additional deaths.

The number of cases today is one of the highest numbers since the beginning of the pandemic, but there was a faulty data file which prevented some lab results from being properly reported. Some of the cases should have been part of Oct. 21s report.

The statewide total number of cases has risen to 188,360 since Wednesdays report, according to the states data.

The number of tests administered within the last seven days, between Oct. 15-21, is 231,482 with 10,375 positive cases, the Health Department says. There were 37,114 test results reported to the department through 10 p.m.

The Health Department says all 67 counties in Pennsylvania have had cases of COVID-19. Current patients are either in isolation at home or being treated at the hospital.

The statewide death toll has risen to 8,592.

There are 2,185,079 patients across the state who have tested negative for the virus to date.

The state Health Department numbers show there are 24,990 resident cases of COVID-19 in nursing and personal care homes across Pennsylvania. Among employees, there are 5,436 diagnosed cases. That brings the entire total to 30,426 cases. Out of the total deaths across Pennsylvania, state officials say 5,670 have occurred in residents from nursing or personal care facilities.

Approximately 11,846 of the states total cases are in healthcare workers.

Currently, all 67 counties are in the green phase of reopening. However, restrictions are in place for bars, restaurants and large gatherings.

If you have concerns about the virus, you can check out the states COVID-19 Early Warning Monitoring System Dashboard.

More information on the Coronavirus pandemic:

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Pa. Health Dept. Announces 2,063 More Coronavirus Cases, One Of The Highest Days Of The Pandemic - CBS Pittsburgh

Can Mouthwash Protect You Against Covid-19 Coronavirus? What This Study Really Said – Forbes

October 23, 2020

A study suggested that mouthwashes can inactivate coronaviruses in a laboratory. But what does this ... [+] mean for the Covid-19 coronavirus. (Photo by Igor Golovniov/SOPA Images/LightRocket via Getty Images)

Theres a difference between a laboratory and your mouth. One of them is a controlled environment. The other is your mouth.

A study published in Journal of Medical Virology showed that in a laboratory, different types of nasal rinses and mouthwashes seemed to inactivate human coronaviruses. For example, a 1% baby shampoo nasal rinse solution appeared to inactivate 99.9% of human coronaviruses after about two minutes. Listerine and Listerinelike products apparently could inactivate similar amounts of virus even faster, after just 30 seconds.

This revelation prompted some reactions on social media such as:

And some additional speculation:

However, before you turn your mouth into a mouthwash jacuzzi with the hopes of ridding your body of the Covid-19 coronavirus, keep in mind several things about the study. First of all, the study tested the solutions on more common types of coronavirus and not the severe acute respiratory syndrome coronavirus 2 (SARSCoV2). They may have similar structures but are not necessarily exactly the same in all regards. In some ways, comparing the SARS-CoV2 with other coronaviruses can be like comparing a cheese rolling team with a football team. Sure they are both sports teams. Sure they both involve people. But having a wheel of Double Gloucester cheese roll over you is not the same as a 250-plus pound middle linebacker.

Nonetheless, solutions that disrupt the membrane surrounding one type of coronavirus may do so with the membranes around other types. In fact, this isnt the first study to suggest that mouthwashes can affect the SARS-CoV2 membrane. A study published in a June issue of theJournal of Infectious Diseases found that different oral rinses inactivated SARS-CoV-2 in a laboratory, findings that Dr. Judy Stone covered previously for Forbes

Speaking of laboratory, for the Journal of Medical Virology study, the researchers from the Pennsylvania State College of Medicine (Craig Meyers PhD, Janice Milici, Samina Alam, PhD, David Quillen, MD, David Goldenberg, MD, FACS, and Rena Kass, MD) and Brigham Young University (Richard Robison PhD) applied the various nasal rinse and mouthwash solutions to the human coronaviruses in what were basically culture dishes in a laboratory. Now people may have told you that your mouth is a culture dish. But thats because your mouth has lots of different microbes in it. Your mouth isnt actually a glass or plastic culture dish. At least, it shouldnt be. If it is, then see a doctor as soon as possible.

What works in a culture dish in a laboratory may not necessarily apply to your mouth. Your mouth isnt smooth like a real culture dish. Its more like the Grand Canyon with various places for microbes to hide away.

Plus your mouth is not the only place the Covid-19 coronavirus may be. The SARS-CoV2 is considered a respiratory virus and will typically infect cells in your respiratory tract. So unless you are snorting Listerine (which you shouldnt do), it is not going to reach your respiratory tract. By the way, be careful about putting anything besides baked lasagna vapors up your nose. For example, using Neti pots with tap water is a bad idea as I have covered previously for Forbes. So it is highly unlikely that mouthwash or a nasal rinse will be able to rid your body of the Covid-19 coronavirus.

Actress Stacy Keibler gargles with mouthwash during an attempt to set a new Guinness World Record ... [+] for the most people using mouthwash simultaneously at Times Square on June 25, 2013 in New York City. (Photo by Slaven Vlasic/Getty Images)

Mouthwash is not going to allow you to freely kiss someone either. Well, not from a Covid-19 coronavirus standpoint at least. It may not prevent the SARS-CoV2 coming out out of one persons nose and mouth from getting into the other persons nose and mouth. Gargling with mouth wash while kissing is highly impractical, will make very strange motorboat noises, and isnt going to be failsafe either.

Similarly, dont treat mouthwash or nasal rinses as a way to forego social distancing and face mask wearing. If someone tries to get within one Denzel of you (which is within six feet since Denzel Washington is around six feet tall) and tells you, dont worry I used mouthwash, say WTH and back away quickly. You can replace WTH with oh, no you dont too.

Of course, it probably wont hurt to use mouthwash, assuming that you do it properly. For example, dont bathe in it or pour it into your ear. One way mouthwash, baby shampoo, and nasal rinse solutions could be helpful against coronaviruses and maybe the Covid-19 coronavirus is to clean things when using a disinfectant or another cleaning methods is not safe or practical. Examples include your toothbrush, a mouth guard, a set of vampire teeth, or anything that you may put into your mouth, nose, or other opening in your body. Keeping such things virus free can ultimately protect you against the Covid-19 coronavirus.

So the results from this study do have some practical applications. Nonetheless, unless you happen to be a gigantic toothbrush, do not expect mouthwash, baby shampoo, or nasal wash solutions to rid 99.9% of the Covid-19 coronavirus from you. Remember just because something happens in a lab doesnt mean that it will work in all aspects real life. Lots of things can inactivate or kill viruses and other pathogens in the lab but either dont work or are impractical on or in human beings. Take disinfectants such as Lysol for example. They may kill the Covid-19 coronavirus on a table or a Justin Bieber shrine for example. But no one in his or her right mind should recommend that Lysol be ingested or injected into the body, right?

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Can Mouthwash Protect You Against Covid-19 Coronavirus? What This Study Really Said - Forbes

To Test Coronavirus Vaccines, UK Study Will Intentionally Infect Volunteers – The New York Times

October 23, 2020

LONDON Scientists at Imperial College London plan to deliberately infect volunteers with the coronavirus early next year, launching the worlds first effort to study how vaccinated people respond to being intentionally exposed to the virus and opening up a new, uncertain path to identifying an effective vaccine.

The hotly contested strategy, known as a human challenge trial, could potentially shave crucial time in the race to winnow a number of vaccine candidates. Rather than conducting the sort of trials now underway around the world, in which scientists wait for vaccinated people to encounter the virus in their homes and communities, researchers would purposely infect them in a hospital isolation unit.

Scientists have used this method for decades to test vaccines for typhoid, cholera and other diseases, even asking volunteers in the case of malaria to expose their arms to boxes full of mosquitoes to be bitten and infected. But whereas the infected could be cured of those diseases, Covid-19 has few widely used treatments and no known cure, putting the scientists in charge of Britains study in largely uncharted ethical territory.

Starting with tiny doses, the scientists will first administer the virus to small groups of volunteers who have not been vaccinated at all, in order to determine the lowest dose of the virus that will reliably infect them. That process, scheduled to begin in January at a hospital in north London, will be followed by tests in which volunteers are given a vaccine and then intentionally exposed to this carefully calibrated dose of the virus.

The study will be led by scientists with Imperial College London and hVivo, a company specializing in human challenge trials. It still requires approval from Britains drug regulation agency, but the government said on Tuesday that it would allot 34 million pounds, or $44 million, in public funding.

The first round of volunteers, up to 90 healthy adults aged 18 to 30, will have the virus dripped into their noses without having been vaccinated. If not enough participants become infected, the scientists will try to expose these early-stage volunteers to a higher dose, repeating the process until they have identified the necessary exposure level of the virus.

Only once the scientists decide on a dose, which they intend to do by late spring, will they begin the process of comparing vaccine candidates by immunizing the next group of volunteers and then exposing them to the virus.

Some vaccine candidates now undergoing trials may already have received approval by then, but researchers hope a challenge trial will add direct evidence of efficacy and help them compare the performance of different vaccines.

Deliberately infecting volunteers with a known human pathogen is never undertaken lightly, said Professor Peter Openshaw, an immunologist and co-investigator on the study. However, such studies are enormously informative about a disease, even one so well studied as Covid-19.

Many important questions about the study remain unanswered. The British governments vaccine task force, which will select the first vaccine candidates to include in the human challenge trial, has not yet announced its plans.

The idea of human challenge trials has already been met with a lukewarm reception by several leading vaccine makers, including Johnson & Johnson and Moderna, leaving analysts uncertain as to which companies vaccines will end up being included.

And it is not yet clear how regulators in Europe or the United States will evaluate results from human challenge trials, or whether such studies will accelerate the vaccine approval process.

For proponents of the strategy, saving lives by potentially speeding the development of a vaccine and advancing the understanding of the virus is a moral imperative. Those scientists and bioethicists say that the risk of the coronavirus seriously sickening or killing young, healthy volunteers the sort of people who would be infected is low enough as to be outweighed by the possibility of saving tens of thousands of lives.

Im surprised they havent been used earlier, Professor Julian Savulescu, the director of the Oxford Uehiro Center for Practical Ethics, said of human challenge trials on coronavirus vaccines. Every day that you delay developing a vaccine and effective treatment, another 5,000 people die. Itd be useful for screening out less effective vaccines and for understanding the immune response.

Skeptics have urged scientists to wait, or to forgo the approach entirely. There have been unexpected and unexplained cases of severe illness in young patients, and the long-term consequences of an infection are unknown, with the pandemic having started only months ago. It is also difficult to extrapolate widely from a human challenge trial. It is unclear, for example, whether studies in healthy young adults could reliably predict the efficacy of a vaccine in older adults or people with pre-existing conditions.

Scientists have also warned about the challenges of mimicking real-world transmission in a laboratory. That could make it difficult for the researchers to know whether a vaccine that may protect volunteers from deliberate exposure in a hospital would do the same for people encountering the virus at work or at home.

Is it breathed out, sneezed out, do you sniff it all in one fell chunk of virus coming at you? said John Moore, a professor of microbiology and immunology at Weill Cornell Medical College. No one really knows. Its so hard to model. Squirting a bolus of virus into the nose is an imperfect model of natural transmission.

The debate has split an advisory panel to the World Health Organization, which published guidelines about the safest way to conduct challenge trials in June. In the United States, the National Institutes of Health said that it was not planning to support such trials and that randomized clinical trials were sufficient.

But Britain took a different view.

Prime Minister Boris Johnson, facing a barrage of criticism for his handling of a pandemic that has left Britain with the highest death toll in Europe, has tried to cast the country as being at the forefront of scientific progress on the coronavirus. Researchers at the University of Oxford have developed one of the leading vaccine candidates, as well as one of the most promising treatments, the steroid called dexamethasone.

Some scientists questioned whether the fierce competition to be the first to develop an effective vaccine had unduly influenced plans for a human challenge trial.

Theres unquestionably vaccine nationalism involved, Prof. Moore said. Its a race for money and glory. Thats the reality of it.

The scientists overseeing the trial said they would use the antiviral medicine remdesivir to treat volunteers as soon as they began detecting viral infection, even before the onset of symptoms. But that drug has been found to have only modest benefit. And some analysts said the treatment, while necessary, would limit researchers ability to determine whether the vaccine candidates being evaluated reduced the severity of illness.

The volunteers in London will be paid roughly Britains minimum wage, which is about 9, or $11, per hour, for their time in taking part in the trial and their two to three weeks in mandatory quarantine. The researchers said they were wary of offering additional incentives that could cloud the judgment of volunteers.

Thousands of people in Britain have already expressed interest in taking part in challenge trials for the coronavirus through an American group, 1Day Sooner, that advocates for such studies.

But with the virus now surging again across Europe and parts of the United States, some scientists have argued there is no shortage of people enrolled in ordinary vaccine trials being exposed to the virus under natural conditions.

This is not a rare disease, said Dr. Paul Offit, a professor at the University of Pennsylvania and a member of the Food and Drug Administrations vaccine advisory panel. You can probably find a hot spot to do a vaccine trial.

Original post:

To Test Coronavirus Vaccines, UK Study Will Intentionally Infect Volunteers - The New York Times

Rural South Dakota Doctor On His Town’s Struggle With Coronavirus Surge – Here And Now

October 23, 2020

In the last 24 hours, close to 600 cases of the coronavirus have been diagnosed in South Dakota, an increase of nearly 40% from two weeks ago. The small state has had 333 deaths since the pandemic began.

In North Dakota, the numbers are so high that a Financial Times analysis shows that if the tiny state was a country, it would have the world's most severe COVID-19 outbreak, surpassing that of the Czech Republic.

Those infection rates are overwhelming rural community hospitals, where medical resources are limited. Dr. Thomas Dean practices at the Jerauld Community Health Center in rural Wessington Springs, South Dakota. It's one of 32 rural clinics operated by Horizon Healthcare. He joins host Robin Young to talk about the dire situation.

Read more:

Rural South Dakota Doctor On His Town's Struggle With Coronavirus Surge - Here And Now

Coronavirus patients at hospitals in Grand Rapids area surge – MLive.com

October 23, 2020

GRAND RAPIDS, MI -- As Kent Countys coronavirus cases surge to new highs, hospitals also are seeing peak or near-peak levels of coronavirus patients.

Spectrum Health data shows 111 inpatients at its health care facilities on Wednesday, Oct. 21. That a few more patients than the previous high, in the low 100s, who occupied hospital beds in early May.

But its drastically higher than in June, when Spectrum inpatient COVID-19 cases were in the 30s.

The higher patient loads are coming as Kent County appears to be a hot zone for new cases, although the entire state is trending upward.

The county now has 12,094 cases, up from about 9,400 cases on Oct. 1. The county currently has a seven-day average of 165 cases per day, thats up from 80 cases per day on Oct. 1.

Spectrum Health administrators, in a written statement, said they are watching the inpatient numbers.

We are seeing a large number of COVID patients right now, more than we had seen during our peak last spring. We are watching our capacity closely to be sure we have the team members and rooms for COVID-19 patients as well as other patients who need care, according to the statement.

RELATED: Despite new records, Michigan almost certainly had more coronavirus cases in spring

At the moment, concern is low about hospital capacity issues.

We have planned for this and are ready with testing supplies, PPE and staffing and operational plans. We ask the community to please get your flu shots and continue the COVID-19 prevention practices, including wearing masks, social distancing of at least 6 feet and washing hands often. We know these behaviors work and we need the community to help us by staying the course! It will save lives and keep people out of the hospital, according to the statement.

Other Kent County hospitals also have seen increases in inpatient numbers.

At Mercy Health St. Marys Hospital, there are now 26 inpatients with COVID-19. Thats slightly below the 29 patients recorded in early May but significantly higher than the coronavirus patient load in early September. Then, there were just four COVID-19 patients.

At Metro Health, there are now 13 inpatients with confirmed or suspected COVID-19. Thats more than early May, when the hospital had nine patients. In early September, there was just one coronavirus inpatient.

Kent County Health Director Adam London said now is a critical time for both Kent County and Michigan to keep coronavirus spread in check. With the weather colder, more people are indoors and the conditions for transmission will be greater.

When we look back at the first wave we had (in April), we had the benefit of the weather improving, London said.

London said hes concerned because the new cases are cutting across all demographics and ages. One of the most vulnerable groups is people 80 and older.

In September, there was 21 cases. So far in October, there are 97 cases involving people 80 or older.

Until a vaccine is widely available, London said the best way to prevent coronavirus spread is by the usual health recommendations -- wearing masks, social distancing and frequent hand washing.

I think the majority of the people are following the recommendations, but they are not fool proof, he said.

We need everyone to follow them, London said of the guidelines designed to limit the spread of coronavirus.

He cautioned people against having large Halloween parties or election day parties, warning that coronavirus cases could grow even more from them.

More from MLive

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Link:

Coronavirus patients at hospitals in Grand Rapids area surge - MLive.com

The Worst Virus Outbreaks in the U.S. Are Now in Rural Areas – The New York Times

October 23, 2020

New reported cases by day in the United States, 7-day average

New reported cases by day in the United States, 7-day average

New reported cases by day in the United States, 7-day average

New reported cases by day in the United States,

7-day average

Note: Rural areas are those counties located outside of metropolitan areas, as defined by the United States Department of Agricultures Economic Research Service. They may include small cities and towns.

The coronavirus was slow to come to Foster County, N.D., a community of just over 3,000 people in the eastern part of the state. When virus cases surged in the Northeast in the spring, the county recorded just one positive case. When national case counts peaked in mid-July, it had recorded just two more.

But by Tuesday, about one in every 20 residents had tested positive for the virus. More than half of those cases were reported in the past two weeks.

Most of the worst outbreaks in the United States right now are in rural places like Foster County. Where earlier peaks saw virus cases concentrated mainly in cities and suburbs, the current surge is the most geographically dispersed yet, and it is hitting hard remote counties that often lack a hospital or other critical health care resources.

Since late summer, per capita case and death rates in rural areas have outpaced those in metropolitan areas.

New reported deaths by day in the United States, 7-day average

New reported deaths by day in the United States, 7-day average

New reported deaths by day in the United States, 7-day average

New reported deaths by day in the United States,

7-day average

Note: Rural areas are those counties located outside of metropolitan areas, as defined by the United States Department of Agricultures Economic Research Service. They may include small cities and towns.

The total number of coronavirus cases and deaths in rural places remains smaller than those in cities because of the comparatively low population in rural areas. But the rural share of the virus burden has grown over time.

Now, about one in four deaths from the virus is recorded in a rural county. That stands in contrast to March and April, when almost every death was in a metropolitan area, as the virus tore through the Northeast, after early clusters in the Seattle area and populous parts of California.

These maps show the case rates in rural areas at different points of the national outbreak:

Avg. daily cases per million in the past week

Metro areas

are not shown

Cases in rural areas when cases peaked over the summer

The summer surge spread

to many rural counties

in the South.

Cases in rural areas when cases first peaked

Clusters at

meatpacking plants

in Iowa

Counties outside

Albany, Ga.

Avg. daily cases per million in the past week

Metro areas

are not shown

Cases in rural areas when cases peaked over the summer

The summer surge spread

to many rural counties

in the South.

Cases in rural areas when cases first peaked

Clusters at

meatpacking plants

in Iowa

Counties outside

Albany, Ga.

Avg. daily cases per million in the past week

Metro areas

are not shown

Cases in rural areas when cases peaked over the summer

The summer surge spread

to many rural counties

in the South.

Cases in rural areas when cases first peaked

Clusters at

meatpacking plants

in Iowa

Counties outside

Albany, Ga.

Avg. daily cases per million in the past week

Metro areas

are not shown

Cases in rural areas when cases peaked

over the summer

Cases in rural areas when cases first peaked

Avg. daily cases per million in the past week

Metro areas

are not shown

Cases in rural areas when cases peaked over the summer

The summer surge spread

to many rural counties

in the South.

Cases in rural areas when cases first peaked

Clusters at

meatpacking plants

in Iowa

Counties outside

Albany, Ga.

During the summer surge, rural outbreaks occurred more often than they had in the spring, but reported cases per million remained higher in cities and their suburbs than in rural counties.

It was not until August, when the outbreak was receding from Sun Belt cities like Houston, Miami and Phoenix that per capita rates of cases and deaths in rural areas surpassed those in metropolitan areas.

Now, with the national case count and hospitalization rates approaching a third peak, none of the countrys biggest hotspots are in a large city. Almost all the counties with the largest outbreaks have populations under 50,000, and most have populations under 10,000. Nearly all are in the Midwest or the Mountain West.

Though the outbreaks geographic spread is expanding, many of the same kinds of places remain at risk for clusters of infections. In Norton County, Kan., the hardest-hit county in the country relative to its population, all 62 residents of one nursing home have been infected with the virus, and 10 have died. A state prison in the county also has an outbreak.

Hospitals across the Upper Midwest and the Mountain West are also feeling the surge. Facilities are struggling with capacity, and in some cases residents are finding that the nearest hospital with available beds is hours away, or in another state.

Earlier this month, hospitals in North Dakota had to turn patients away. Bismarck, the states capital, had one staffed I.C.U. bed available as of Monday.

Overwhelmed by the record case numbers, North Dakota suspended its contact tracing program this week. New Mexicos governor, also seeing hospital beds fill up in her state, plans to put in effect new restrictions on restaurants, bars and retail stores.

And Alaska, which is experiencing record numbers, provides a cautionary tale: Even with extensive testing and robust contact tracing, the virus is poised to thrive as temperatures drop and people move activities indoors.

Most of the counties with the worst per capita outbreaks now have fewer than 10,000 people

Read the original here:

The Worst Virus Outbreaks in the U.S. Are Now in Rural Areas - The New York Times

Doctors say this will be the worst surge yet. From treatments to testing to PPE, is the US better at handling Covid-19 now? – CNN

October 23, 2020

"It's not that I don't want to. But the patients keep on coming," said Varon, a critical care doctor and chief of staff at United Memorial Medical Center in Houston.

It used to be worse. After Covid-19 crushed the hospital earlier this year, his team juggled as many as 88 patients at once with the disease. But in the last few weeks, as few as 10 coronavirus patients needed their care.

"Then the last five days have been hell. We're getting a lot of patients. And the patients are coming in very, very ill."

For example, ventilators -- once widely used early in the pandemic -- are now used less frequently, as doctors have learned how they may injure Covid-19 lungs.

But in some places, nurses still don't have enough protective equipment. People keep flouting masks and social distancing. And rapid, at-home testing remains a pipe dream.

Here's where experts say the US stands as it enters the next phase of the Covid-19 pandemic.

What doctors have learned about treatments

Many Covid-19 patients who entered hospitals earlier this year did not make it out alive.

Since then, "the death rate per case ... has definitely dropped. And that's a tribute to modern medicine," epidemiologist Dr. Larry Brilliant said.

But as more patients survive, many are also stuck at the hospital with long-term complications.

"Before, people would come in when they were just dying. Now, we keep them alive. But many of them have very bad lung disease, and they will require long-term care," Varon said.

These days, Varon said he's again seeing patients come in with more advanced Covid-19.

"Part of that is based on what I call Covid fatigue syndrome. People are tired ... they are looking the other way. If they have symptoms, (they think) it's no big deal. And then by the time they come to us, they are very sick."

It's critical to seek medical care immediately because "at the early start of the illness when you have Covid, the virus is multiplying like there is no tomorrow," Varon said.

"The evidence on convalescent plasma as a treatment for severe cases of COVID-19 is promising but incomplete," Dr. Francis Collins, director of the National Institutes of Health, said in a written statement last month.

For now, the NIH treatment guidelines don't recommend for or against using convalescent plasma to treat Covid-19.

But this month, the World Health Organization said remdesivir has "little or no effect on mortality" for patients hospitalized with Covid-19 and it doesn't seem to help patients recover any faster, either.

Despite the ever-evolving research, "we have learned a lot," Varon said. "What I do today is not what I was doing three, four months ago."

Why ventilators might be bad for Covid-19

With many patients, "we learned that putting somebody on a ventilator is basically signing their death sentence," Varon said.

"We learned the hard way that putting pressure into your lungs in somebody that has damaged lungs, like Covid patients, was creating more injury than benefit."

Brilliant said it's "good news" that hospitals aren't using ventilators as much on Covid-19 patients.

"Doctors are not shoving ventilators down people's throats quite as quickly. That's a wonderful thing," he said.

"You know how everybody thinks that an oxygen (level) of more than 90% is good, and that's where you need to stay? We learned that because we were causing so much damage (with ventilators), maybe we should tolerate a little lower oxygen. So if it came down to 85%, we probably would be OK."

That's different from his previous methods with non-coronavirus patients, in which those with "85% (oxygen) gets a (breathing) tube. 89% gets a tube. So we learned that we can actually allow lower oxygen concentrations."

Doctors have also learned that laying patients facedown on their stomachs can help increase the amount of oxygen that's getting to their lungs.

"We're saving lives with this," Dr. Mangala Narasimhan, regional director for critical care at Northwell Health in New York, said in April.

"It's such a simple thing to do, and we've seen remarkable improvement. We can see it for every single patient."

When patients lie on their backs, the weight of the body effectively squishes some parts of the lungs.

But "by putting them on their stomachs, we're opening up parts of the lung that weren't open before," said Dr. Kathryn Hibbert, director of the medical ICU at Massachusetts General Hospital.

How hospital capacity has improved -- or not

Across the country, many hospitals are already starting to max out due to soaring Covid-19 cases, said emergency medicine physician Dr. Megan Ranney, who directs the Brown-Lifespan Center for Digital Health in Rhode Island.

"My colleagues across the country are sharing stories of their ERs getting overwhelmed, their ICUs being full, running out of nursing staff because their nurses are getting sick," Ranney said.

"We are facing the same situation that we were in in April and May in the Northeast and in July in the South. And the trouble now is that we're seeing it literally across the country," she said.

"We're hearing similar stories from my colleagues literally across the country, including here in the Northeast. We're starting to see hospitalizations tick up. We are seeing people who are much sicker than they have been since that first wave in the Northeast in the spring."

Infectious disease specialist Dr. Aileen Marty, a professor at Florida International University, said Covid-19 hospital admissions are going up in her state.

"We're balancing those by being able to get people out of the hospital sooner than we were because we've learned a lot," she said. "But it's still happening."

Some health care workers still don't have enough PPE

Fast-forward to October, and PPE shortages are still a concern, according to National Nurses United, the largest union of registered nurses in the US.

"We must currently rely on firsthand accounts from our members because hospitals are only required to report PPE stock levels to the US Department of Health and Human Services, which does not publicly release the data," the union said in a written statement.

"The lack of transparency on PPE stock and supply is outrageous."

Without sufficient PPE, health care workers treating coronavirus patients are at high risk because "the viral load -- the amount of virus -- does determine the severity of your illness," said emergency medicine physician Dr. Leana Wen, a former Baltimore health commissioner.

"So that could happen in the case of health care workers who are exposed to a lot more Covid-19 as a result of their work -- that they get more severely ill."

"Let's be clear that this pandemic is not over. Cases are rising again in many areas of the country," the union said this week.

"We are still demanding that President Trump activate the Defense Production Act to mass produce PPE, and that federal OSHA promulgate an emergency temporary standard on infectious diseases to mandate that our employers give nurses optimal PPE."

Insufficient testing is holding the US back

"We have more people infected. We have more states, we have our rural areas affected. Once again, we have hospitals filling up -- this time, not just in our major metropolitan areas, but in more rural areas. The death rates are going up," he said.

Americans should have quick, easy access to testing, Haseltine said. But that's still not the case in many places.

"One of my grandchildren had a cold. And we had to get tested. It was murderous. In New York City, there were two places that could do the rapid tests," he said. "Two places in Manhattan. That is unbelievable. And we had to wait hours -- six hours just to get tested."

Since the beginning of the pandemic, "we are a little bit better at testing, (but) not much," Haseltine said.

Haseltine said tests have gotten more accurate in recent months, and some are more affordable -- as cheap as 50 cents.

"My recommendation is make (tests) universally available to every household, and if somebody in the household is positive ... we make it economically possible by paying them to stay home -- the whole family -- for 14 days," Haseltine said.

"That could end this epidemic within three to four months."

Haseltine said he has calculated the estimated costs for "a program to get everybody three or four months' worth of free tests -- they can test everybody in their family -- and pay everybody $500 to stay home for two weeks, for their entire family" if someone tests positive.

This plan is "comparatively inexpensive, compared to what we are putting up with," Haseltine said. "If we decided to push the button now, go full-speed ahead, we could probably have this epidemic over and done with by March."

So why don't we all have Covid-19 tests in our medicine cabinets yet?

"From the President on down, most of the official leadership has been deeply misguided," Haseltine said. "They have focused first on treatment and not on prevention."

Adm. Brett Giroir, the White House testing czar, said Covid-19 testing has improved dramatically in the US.

But Giroir has repeatedly said, "We can't test our way out of this" pandemic.

"He's right in a limited way," Haseltine said. "He's right that testing isn't enough. Testing plus isolation is the way to drive this down to zero ... voluntary testing followed by paid isolation."

As for the theory that Covid-19 cases are surging just because of increased testing, "that is absolutely not the case," Haseltine said.

"That is not why hospitalizations are going up. That's not why deaths are going up."

'A war against stupidity'

Doctors are "better prepared. We're better studied. But patients are coming in. And people are being stupid," said Varon, the critical care doctor who's worked every day for seven months.

"I am fighting two wars. I am fighting a war against Covid, and I'm fighting a war against stupidity. It is unbelievable."

After spending 16 to 20 hours a day at work, Varon said he's disgusted by images of people socializing without face masks.

"I just had one of the worst weekends (at work) I've had for a very long period of time," he said. "This is not a hoax. This is real. And anybody who doesn't believe me, they can come and spend a day with me."

As for young people, "if you think nothing bad is going to happen to you, you are wrong," he said. "And I would hate to see you on long-term oxygen or being crippled, having to be on a wheelchair or a walker for the rest of your life."

That's not hyperbole.

He vividly recalls a 32-year-old man with no pre-existing conditions and was "healthy as a horse" -- until he came down with coronavirus.

"He ended up here with us in the hospital. He was a very sad story," Varon said. "He spent with us close to 70 days and eventually went home on oxygen -- probably for the rest of his life."

But there are ways to get out of this pandemic, Haseltine said.

"The first thing that we have to do right away is for everybody to take what you hear every public health official say, which is wear a mask and socially distance," he said.

"The second thing is we have to have a federal policy that we are going to do everything we can to get rapid tests in everybody's hands immediately. And we are going to pay people to stay home so they don't infect other people when they are potentially infectious."

If we take those steps, he said, "we could put this close to zero in four months."

CNN's Jen Christensen and Elizabeth Cohen contributed to this report.

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Doctors say this will be the worst surge yet. From treatments to testing to PPE, is the US better at handling Covid-19 now? - CNN

Coronavirus cases surge in the U.S. – CBS News

October 23, 2020

New York has added several states and territories to its travel restriction list as coronavirus cases continue to surge across the country, Governor Andrew Cuomo announced Tuesday. People who are traveling to New York from the restricted areas are required to quarantine for 14 days.

"We are now in a situation where 43 states meet the criteria for our travel advisory. This is really a bizarre outcome, considering New York once had the highest infection rate," Cuomo said in a statement.

"There is no practical way to quarantine New York from Pennsylvania, New Jersey and Connecticut. There are just too many interchanges, interconnections, and people who live in one place and work in the other. It would have a disastrous effect on the economy, and remember while we're fighting this public health pandemic we're also fighting to open up the economy. However, to the extent travel between the states is not essential, it should be avoided."

Here's the updated list of restricted states and territories:

Alaska, Alabama, Arkansas, Arizona, Colorado, Delaware, Florida, Georgia, Guam, Iowa, Idaho, Illinois, Indiana, Kansas, Kentucky, Louisiana, Maryland, Michigan, Minnesota, Missouri, Mississippi, Montana, North Carolina, North Dakota, Nebraska, New Mexico, Nevada, Ohio, Oklahoma, Puerto Rico, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, Utah, Virginia, Wisconsin, West Virginia, Wyoming

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Coronavirus cases surge in the U.S. - CBS News

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