Category: Corona Virus

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Coronavirus envelope protein is a drug target for new platform for the identification and optimization of peptides against … – EurekAlert

March 16, 2024

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Image Caption: Coauthors Masayuki Yazawa & Lauren Qiu wearing masks at their microscopy room used for this study.

Credit: Image Credit: Masayuki Yazawa (CC-BY 4.0, https://creativecommons.org/licenses/by/4.0/)

Coronavirus envelope protein is a drug target for new platform for the identification and optimization of peptides against SARS-CoV-2

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In your coverage, please use this URL to provide access to the freely available paper in PLOS Biology: http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002522

Article Title: Developing inhibitory peptides against SARS-CoV-2 envelope protein

Author Countries: United States

Funding: This work was supported by Columbia University Deans Office Fund and Columbia University Translational Therapeutics (TRx) Pilot Award (to M.Y.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Experimental study

Cells

Competing interests: I have read the journals policy and the authors of this manuscript have the following competing interests: M.Y., R.B., K.Y., D.D.H., M.S.N., and Y.H. (inventors) filed a patent (Attorney Docket No.: 01001/00889-US0; status: Filed, 04/13/2022) related to this manuscript. This patent is for using synthetic peptides targeting SARS-CoV-2 envelope protein for treating COVID-19 and related human coronaviruses. The rest of the authors declare no competing interests.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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Coronavirus envelope protein is a drug target for new platform for the identification and optimization of peptides against ... - EurekAlert

The Lasting Impacts of COVID-19 – WHYY

March 16, 2024

Its been four years since COVID-19 struck, transforming our modern world in ways wed never seen before and were still processing the aftershocks. The pandemic exposed fault lines lurking beneath the surface of our everyday lives friendships and bonds that werent as strong as we thought; political rifts that turned into chasms; shifts in our fundamental beliefs of who we should trust, and what rules we should follow. It showed us how fragile we are as human beings, and as a global community.

Now, we find ourselves trying to pick up the pieces to understand what happened, and what we can do better next time. On this episode, we explore the major changes caused by the pandemic, what we can learn from them, and how we can move forward. We hear stories about one mans dogged search for a treatment for his long COVID, how the pandemic both hurt and revived the field of public health, and how to repair relationships that became frayed or broken by the pressures of the pandemic.

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The Lasting Impacts of COVID-19 - WHYY

Lessons learned from the pandemic: Truth and risk-imposition – OCRegister

March 16, 2024

National Institute for Allergy and Infectious Diseases Director Dr. Anthony Fauci, left, accompanied by President Donald Trump, speaks about the coronavirus during a news conference in the press briefing room at the White House, Saturday, Feb. 29, 2020, in Washington. (AP Photo/Andrew Harnik)

Some time in the future, there will be another pandemic. Here are two very useful things to keep in mind when it happens again.

One might think that it was perhaps in the best interest of our country to slightly exaggerate the mortality rate of Covid or the effectiveness of the vaccine. If an infectious disease seems scarier than it is, we might be able to avoid many more deaths because individuals will be more willing to comply with safety restrictions and to take the vaccine. Anthony Fauci was guilty of a white lie when he initially recommended against masking to avoid a shortage of masks, which were needed by hospitals. The first thing to note about this is the objectionable level of paternalism involved.

But setting that aside, we can question whether this white lie strategy is actually in our best interest. Theres a strong case to be made that it isnt. When people start noticing inconsistencies in what officials are telling them, there is an inevitable erosion of confidence in the advice of the experts. For better or worse, once experts are thought of as liars, even their sensible and objectively accurate advice is brought into question.

Theres no doubt that at least part of the misinformation produced by experts was a result of the unprecedented nature of the pandemic. Sometimes, the experts just didnt have the answers and this caused them to guess. When they later contradicted themselves, it caused a loss in public trust. The right approach would have been to publicly acknowledge the uncertainty behind the recommendation and make it clear that they could change as more evidence was gathered.

The lesson here is that experts and the government should tell the truth. So much of our knowledge of the world comes from what the experts tell us. Its absolutely necessary that the public maintains a certain level of respect for the opinions of doctors, scientists, and economists. We cant pour through the data ourselves so we need to trust experts so that we can make reasonable decisions about our safety. Once the public becomes overly skeptical of expert opinion, they turn to dubious fringe theories, which can have disastrous consequences.

Another question many have asked is, does the government have the right to force us to use vaccines or to implement a lockdown? Well, strictly speaking the US never implemented compulsory vaccinations. But you could very easily argue that when you are restricted from participating in the goods of society by refusing the vaccine, it is just another form of coercion precisely because it imposes a costly penalty.

A substantial segment of the population argued that the lockdowns and vaccine requirements were unjustified because COVID deaths were exaggerated and mostly affected those of old age or with several comorbidities. Why should the rest of us have to lock down and take the vaccine?

This was by far one of the most bizarre sorts of arguments that were seriously advanced during the pandemic. I take it that those who think that this is a good argument are being guided by some libertarian intuition. Something like what is known as the Non-Aggression Principle: it is wrong to force others to do something against their will. Its wrong to coerce people against their will and so its wrong to force others to quarantine or to take the vaccine.

The problem is that this principle is clearly false. Unless you just love dirt roads, we need to coerce people into paying taxes to fund infrastructure and the other goods of society. We also need to use coercion to enforce laws, particularly when it involves violent criminals. Of course, someone who refuses to take the vaccine or to obey safety restrictions is not quite like a violent criminal.

But the rationale is the same, that is, the government duty to protect public safety. This duty isnt unrestricted. For example, the government would not be justified in locking the country down in the name of public safety because some people die of food poisoning after eating at a restaurant.

This doesnt mean that all of the government responses to the pandemic were justified. Its likely that a subset of them were not. Im only arguing against the thought that restrictions went too far either because death projections were overly pessimistic or because young and healthy people were at a much lower risk of death. The government would be justified in jailing a drunk driver even if they were themselves relatively safe riding in a tank.

In future pandemics, whether a lock down or vaccine requirement is justified depends on whether failing to implement them would impose excessive risk to public safety and whether the economic costs outstrip the benefits, not on whether you yourself are at risk.

Rafael Perez is a doctoral candidate in philosophy at the University of Rochester. You can reach him at rafaelperezocregister@gmail.com.

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Lessons learned from the pandemic: Truth and risk-imposition - OCRegister

4 years of Covid pandemic: Our collective amnesia around Covid 19 – Moneycontrol

March 16, 2024

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On a clear April day in the summer of 2020, the peaks of the Dhauladhar mountains in Himachal Pradesh were visible from distant Jalandhar as the lockdown imposed on March 25 sent pollution levels plummeting, leaving the skies clear. Sadly, it would be the only bright spot for the next two years as the worst pandemic to hit humanity in a hundred years ravaged through the country. Its destructive trail left death and destruction all around with deliverance a distant dream.

But the nightmare did end with the promise that never again would we let such a man-made calamity hit us.Yet, four years later all that lingers of that period are piles of unused Covid test kits, masks and other useless paraphernalia like vegetable washing liquids that remind of how even in that darkest hour, companies thought only of profiting from our collective insecurities. How quickly we have forgotten the dark relentless hopelessness that bored into our collective souls!

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With another Lok Sabha election just weeks away, the pandemic should have been right up there, as an election issue. But it is off the map as far as political debates on television and in print are concerned. No one is questioning how we dealt with the pandemic and the horrors of its aftermath. Even the opposition is pretending that it never happened.

Conservatively, a million lives were lost.

The visual horror of dead bodies piled high waiting for a turn in the burning ghats or the half burnt bodies floating in rivers across the nation has been wiped out. Forgotten also is our passivity. Mute, helpless witnesses to this ravaging we couldn't help anyone.

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India wasn't the only country to flounder and flail in the wake of this scourge. Even in the worlds richest nation, the US, the hollowness of the healthcare system was shown up as it simply crumpled under the onslaught of the Covid virus. Who can forget the crazed hunt for just one oxygen cylinder for a parent on death bed or that one vial of Remdesivir and Ivermectin transported across the length and breadth of the country to save a life?

Of advice we had plenty: celebrity doctors issuing homilies on Covid-appropriate behaviour even as hospitals were dealing with triaging life support for patients in the face of an acute shortage of beds and oxygen. In March 2020, the health minister, himself a doctor, was assuring the nation that the virus had been contained and simple precautions" were all that was needed to keep the deadly virus at bay. Not surprisingly charlatans among us were on overdrive pushing herbal concoctions that had no scientific basis.

During those months we realized we could live clean. We started exercising, eating healthy, cutting back on useless, high-consumption activities like OTT weddings, parties, travel and shopping. Instead of single occupancy cars cruising on roads, we had work-from-home. But less than three years later, we have been sucked back in by jubilant saturnalia. Its party time again and to hell with the environment.

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Pandemic-era social networking was about helping, with a reel life villain like Sonu Sood becoming a real life Hercules by setting up an efficient organization to supply food, medicines and train tickets to the poor and the homeless. Individual and anonymous micro philanthropy from the most unlikely of people sprouted spontaneously and without waiting for any recognition or praise.

But we are back to a dog-eat-dog world. Social media is rife with lynch mobs targeting newer victims each day. Hospitals are back to charging huge sums. Forgotten is that resolve to beef up our creaking and grossly insufficient healthcare system.

There is a good reason the Germans built monuments to the Nazi horrors when they had stood back and watched millions of Jews murdered. They remember the Nazi past so that it may never happen again. Sure, we must forget our nightmares in order to live life and move past our own helplessness in order to avoid stasis. But constant reminders are another kind of civilizational moving on.

Survival, wrote Simon Wiesenthal, the Nazi death camp survivor who dedicated his life to documenting the crimes of the Holocaust, is a privilege which entails obligations. Our obligation is to keep the memory of the millions of men, women and children who lost their lives to Covid, alive. It is also to ensure that the sufferings of millions of others who survived but suffered, are not forgotten or trivialized.

Sundeep Khanna is a senior journalist and the author of 'Cryptostorm: How India became ground zero of a financial revolution'. Views are personal, and do not represent the stand of this publication.

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4 years of Covid pandemic: Our collective amnesia around Covid 19 - Moneycontrol

COVID-19 Leaves Its Mark on the Brain. Significant Drops in IQ Scores Are Noted. – Scientific American

March 15, 2024

March 13, 2024

5 min read

COVID-19 Leaves Its Mark on the Brain. Significant Drops in IQ Scores Are Noted

Research shows that even mild COVID-19 can lead to the equivalent of seven years of brain aging

By Ziyad Al-Aly & The Conversation US

Eva Almqvist/Alamy Stock Vector

The following essay is reprinted with permission from The Conversation, an online publication covering the latest research.

From the very early days of the pandemic, brain fog emerged as a significant health condition that many experience after COVID-19.

Brain fog is a colloquial term that describes a state of mental sluggishness or lack of clarity and haziness that makes it difficult to concentrate, remember things and think clearly.

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Fast-forward four years and there is now abundant evidence that being infected with SARS-CoV-2 the virus that causes COVID-19 can affect brain health in many ways.

In addition to brain fog, COVID-19 can lead to an array of problems, including headaches, seizure disorders, strokes, sleep problems, and tingling and paralysis of the nerves, as well as several mental health disorders.

A large and growing body of evidence amassed throughout the pandemic details the many ways that COVID-19 leaves an indelible mark on the brain. But the specific pathways by which the virus does so are still being elucidated, and curative treatments are nonexistent.

Now, two new studies published in the New England Journal of Medicine shed further light on the profound toll of COVID-19 on cognitive health.

I am a physician scientist, and I have been devoted to studying long COVID since early patient reports about this condition even before the term long COVID was coined. I have testified before the U.S. Senate as an expert witness on long COVID and have published extensively on this topic.

Here are some of the most important studies to date documenting how COVID-19 affects brain health:

Large epidemiological analyses showed that people who had COVID-19 were at an increased risk of cognitive deficits, such as memory problems.

Imaging studies done in people before and after their COVID-19 infections show shrinkage of brain volume and altered brain structure after infection.

A study of people with mild to moderate COVID-19 showed significant prolonged inflammation of the brain and changes that are commensurate with seven years of brain aging.

Severe COVID-19 that requires hospitalization or intensive care may result in cognitive deficits and other brain damage that are equivalent to 20 years of aging.

Laboratory experiments in human and mouse brain organoids designed to emulate changes in the human brain showed that SARS-CoV-2 infection triggers the fusion of brain cells. This effectively short-circuits brain electrical activity and compromises function.

Autopsy studies of people who had severe COVID-19 but died months later from other causes showed that the virus was still present in brain tissue. This provides evidence that contrary to its name, SARS-CoV-2 is not only a respiratory virus, but it can also enter the brain in some individuals. But whether the persistence of the virus in brain tissue is driving some of the brain problems seen in people who have had COVID-19 is not yet clear.

Studies show that even when the virus is mild and exclusively confined to the lungs, it can still provoke inflammation in the brain and impair brain cells ability to regenerate.

COVID-19 can also disrupt the blood brain barrier, the shield that protects the nervous system which is the control and command center of our bodies making it leaky. Studies using imaging to assess the brains of people hospitalized with COVID-19 showed disrupted or leaky blood brain barriers in those who experienced brain fog.

A large preliminary analysis pooling together data from 11 studies encompassing almost one million people with COVID-19 and more than 6 million uninfected individuals showed that COVID-19 increased the risk of development of new-onset dementia in people older than 60 years of age.

Autopsies have revealed devastating damage in the brains of people who died with COVID-19.

Most recently, a new study published in the New England Journal of Medicine assessed cognitive abilities such as memory, planning and spatial reasoning in nearly 113,000 people who had previously had COVID-19. The researchers found that those who had been infected had significant deficits in memory and executive task performance.

This decline was evident among those infected in the early phase of the pandemic and those infected when the delta and omicron variants were dominant. These findings show that the risk of cognitive decline did not abate as the pandemic virus evolved from the ancestral strain to omicron.

In the same study, those who had mild and resolved COVID-19 showed cognitive decline equivalent to a three-point loss of IQ. In comparison, those with unresolved persistent symptoms, such as people with persistent shortness of breath or fatigue, had a six-point loss in IQ. Those who had been admitted to the intensive care unit for COVID-19 had a nine-point loss in IQ. Reinfection with the virus contributed an additional two-point loss in IQ, as compared with no reinfection.

Generally the average IQ is about 100. An IQ above 130 indicates a highly gifted individual, while an IQ below 70 generally indicates a level of intellectual disability that may require significant societal support.

To put the finding of the New England Journal of Medicine study into perspective, I estimate that a three-point downward shift in IQ would increase the number of U.S. adults with an IQ less than 70 from 4.7 million to 7.5 million an increase of 2.8 million adults with a level of cognitive impairment that requires significant societal support.

Another study in the same issue of the New England Journal of Medicine involved more than 100,000 Norwegians between March 2020 and April 2023. It documented worse memory function at several time points up to 36 months following a positive SARS-CoV-2 test.

Taken together, these studies show that COVID-19 poses a serious risk to brain health, even in mild cases, and the effects are now being revealed at the population level.

A recent analysis of the U.S. Current Population Survey showed that after the start of the COVID-19 pandemic, an additional one million working-age Americans reported having serious difficulty remembering, concentrating or making decisions than at any time in the preceding 15 years. Most disconcertingly, this was mostly driven by younger adults between the ages of 18 to 44.

Data from the European Union shows a similar trend in 2022, 15 percent of people in the EU reported memory and concentration issues.

Looking ahead, it will be critical to identify who is most at risk. A better understanding is also needed of how these trends might affect the educational attainment of children and young adults and the economic productivity of working-age adults. And the extent to which these shifts will influence the epidemiology of dementia and Alzheimers disease is also not clear.

The growing body of research now confirms that COVID-19 should be considered a virus with a significant impact on the brain. The implications are far-reaching, from individuals experiencing cognitive struggles to the potential impact on populations and the economy.

Lifting the fog on the true causes behind these cognitive impairments, including brain fog, will require years if not decades of concerted efforts by researchers across the globe. And unfortunately, nearly everyone is a test case in this unprecedented global undertaking.

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COVID-19 Leaves Its Mark on the Brain. Significant Drops in IQ Scores Are Noted. - Scientific American

COVID Wastewater Monitoring: Experts Share Tips To Assess Risk – TODAY

March 15, 2024

Should you still wear a mask in public? Is it safe to attend concerts or travel right now? Experts are increasingly recommending that we consult COVID-19 wastewater data to make decisions like these. And, they say, the pandemic revealed the true potential of monitoring what's in our poop.

Wastewater monitoring isn't entirely new. Epidemiologists have been using it to keep track of polio outbreaks for decades, Amy Kirby, Ph.D., microbiologist and program lead for the National Wastewater Surveillance System at the Centers for Disease Control and Prevention, tells TODAY.com.

Before the pandemic, researchers knew they could find evidence of enteric viruses, which infect the gut, in wastewater samples, Yinyin Ye, Ph.D., assistant professor of civil, structural and environmental engineering at the University of Buffalo, tells TODAY.com.

It "makes sense" that we'd find viruses like those in feces and sewage, Ye says. But, before the pandemic, "people never thought wastewater could be used to track respiratory viruses," she says. It wasn't until COVID-19 came along that experts realized how helpful wastewater monitoring could be in tracking other types of viruses as well, she explains, including respiratory viruses.

As other COVID monitoring tools we once relied on have become less useful, wastewater is an increasingly valuable tool to make safer choices. Heres what experts want you to know about COVID-19 wastewater monitoring and what those numbers mean for you.

Early in the pandemic, individual groups of researchers proved they could detect the coronavirus in wastewater, particularly on college campuses.

For instance, experts at the University of Arizona even used it to help contain an outbreak on campus as early as August 2020. In 2021, a group at Emory University used wastewater to spot a rise in COVID-19 on campus when students returned from spring break.

From there, the CDC began monitoring wastewater for COVID-19 in 2020 (the first widespread sewage monitoring program in the U.S., Kirby says), and ramped up the program in 2022.

Today, wastewater monitoring is also helping researchers keep tabs on other illnesses, such as Mpox, norovirus and hepatitis A.

When people are infected with SARS-CoV-2, the virus that causes COVID-19, they shed bits of the virus in their feces whether or not they have noticeable symptoms. That's why the CDC started looking into wastewater monitoring for COVID in the first place, Kirby says.

"We were really focused on, how can we get a better idea of those people that are infected but may not have any symptoms or may have very mild symptoms?" she says. "We know they're still going to shed virus in their feces, and so we can detect those cases (through wastewater monitoring) and look at how they impact the overall trends in a community."

Ye and Kirby both noted that researchers still aren't entirely sure why we shed this virus, a respiratory virus, in our stool. It could be a result of swallowing viral particles in respiratory secretions orof the virusreplicating in the gut the same way foodborne illnesses do, Kirby says.

"We don't know. But, for our purposes, it doesn't really matter," Kirby explains. "We know that it's there and (that it's a) great signal to understand what's going on in the community."

As it turned out, not only does wastewater reflect general trends in the spread of COVID-19 within a community, but it also does so relatively quickly. Throughout the pandemic, Kirby says, experts noted wastewater trends changing four to six days before case numbers or test positivity showed the same change.

"It really is the first sign that cases are starting to pick up in a community," she says. "It's also the first sign that cases are starting to go down," which is a major advantage over other metrics.

Experts use a familiar test polymerase chain reaction technology (PCR) to look for viral RNA in untreated wastewater, explains Ye, whose team is involved with COVID wastewater monitoring for much of western New York. Depending on the type of PCR test the researchers use, they can also look for changes in the viral genetics, giving them a heads-up about possible shifts in coronavirus variants.

Different labs may have different protocols for detecting the viral particles, analyzing the data and making sure their results are accurate, Hoerger says. For example, if heavy rain dilutes rainwater, it can be challenging to account for that in interpretations, he says.

Ye stresses that public health officials are only looking at this data at the community level. They're not monitoring wastewater at the individual or household level. (No one is keeping track of what you, as an individual, are pooping out.)

And, for the record, researchers believe the viral particles in feces to be inactive, Ye says. To date, no one has contracted COVID-19 via exposure to wastewater, the CDC says.

In previous years, we may have relied on case numbers or test positivity to assess how much and how quickly COVID-19 was spreading in our area.

But those metrics "aren't very useful anymore," Hoerger says, for two major reasons: First, a lot of people aren't getting tested at all anymore for COVID-19, he says. And, second, if they do get tested, that's likely happening at home with a rapid test, which isn't reported to any public health agency.

On the other hand, one major benefit of wastewater monitoring is that "it doesn't require any individual to do any testing," he explains. "It's just tracking what's going on in a community."

Wastewater data also has the advantage of being highly local and, therefore, relevant to what's going on in your area, Ye says.

To find COVID-19 wastewater monitoring data in your area, take a look at your local public health department website. The CDC also keeps track of local sewage numbers and national numbers.

"We have about 1,500 sites that are doing testing, and that covers over 40% of the US population," Kirby says. "So we're covering a big chunk of the population."

That said, if you don't have local wastewater monitoring in your community, Hoerger recommends keeping an eye on the national or state-level numbers. "When things are getting bad nationally, there's a good chance that things could be bad locally, or they're about to be bad," he says.

But local information is always going to be the most helpful, Ye says, noting that trends can be different from county to county. And rural areas, which often aren't connected to larger sewage systems, may not be counted in those estimates, she explains. Researchers are working on ways to reach those areas right now, she says.

Also, keep in mind that the numbers you're seeing on the dashboard may be a week or two behind what's actually happening in the community, Hoerger says. For example, Ye says the samples for her lab are typically collected once or twice per week, and those numbers are included in health department updates the following Monday or Friday.

It's not entirely clear how wastewater numbers may translate to actual case numbers in the community. But spikes in wastewater monitoring generally do mirror spikes in actual COVID-19 cases.

"There's not a direct correlation," Kirby explains, "(but) we know that when you see so wastewater concentrations increase twofold, cases in the community have also increased twofold."

Additionally, when traveling, Ye checks wastewater trends for her destination to plan out what precautions she may need to take.

When looking at the data, you don't need to get deep into what the specific numbers might mean, Kirby says. "Focus on the trends and not so much the levels," she says. "That's the best way (for the general public) to interpret that data." The CDC wastewater trends dashboards are designed to be intuitive and used for this exact purpose, she adds.

Both Kirby and Ye recommend thinking of wastewater monitoring data like a weather report for health. In the future, Ye hopes "we can use wastewater data as a kind of forecast to tell us if theres a higher possibility youll get COVID tomorrow."

For now, Kirby hopes people check the data to decide if they should wear a mask on public transit or scale back on indoor events, for instance. Incorporating that kind of decision-making into your day-to-day, Kirby says, will go a long way to keeping communities healthy."

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COVID Wastewater Monitoring: Experts Share Tips To Assess Risk - TODAY

Long COVID doesnt exist as we know it, according to new research – Sydney Morning Herald

March 15, 2024

The research, led by Queenslands chief health officer Dr John Gerrard, followed about 2400 people who caught COVID-19 and about 2700 people with other respiratory infections, including influenza.

COVID-19 testing at St Vincents Hospital, Sydney, during the pandemic, 2020. Louise Kennerley

A year after infection, 3 per cent of people who were COVID positive reported moderate to severe impairment (i.e. long COVID). Among the people who had caught the flu or another respiratory illness, it was 4.1 per cent.

After controlling for factors including age, sex and whether participants were Indigenous, the researchers concluded there was no evidence that COVID-19 infection made impairment more likely.

Gerrard said long COVID appeared to be a severe and distinct disease simply because of the huge number of infections during the pandemic.

We believe it is time to stop using terms like long COVID, Gerrard said. They wrongly imply there is something unique and exceptional about longer-term symptoms associated with this virus.

Queensland Chief Health Officer John Gerrard. Getty

This terminology can cause unnecessary fear, and in some cases, hypervigilance to longer symptoms that can impede recovery.

The research will be presented at the European Congress of Clinical Microbiology and Infectious Diseases in April, but it hasnt been published in a peer-reviewed journal.

An earlier iteration of the study, in which the researchers reported the status of participants 12 weeks after infection, was published in last year, however.

In the BMJ study, Gerrard and his research colleagues found similar rates of ongoing symptoms and long-term impairment between those infected with COVID and the flu.

A virologist from the Kirby Institute analyses antibody reaction with the COVID-19 Omicron variant in 2021. Kate Geraghty

They concluded in the BMJ study that long COVID may manifest as a post-viral syndrome of no greater severity than seasonal influenza.

The study was limited by the fact participants with pre-existing illnesses werent identified, and it focused on a highly vaccinated population contending with Omicron, a variant than the ancestral strain.

Long COVID has forced Sydney resident Stephenie Watts to hospital twice and fundamentally rearranged her life. Watts was outraged by the suggestion long COVID should be folded in to other post-viral illnesses.

I felt really frustrated by the fact theyre saying [the phrase] causes unnecessary fear and is probably harmful, because it really undermines the seriousness of the long COVID, Watts said.

Stephenie Watts has suffered cognitive impairment since acquiring COVID-19. Kate Geraghty

Long COVID really does describe what happens to oneself. It was triggered by COVID and you have this long tail of ensuing illness.

Watts has suffered through more than three years of brain inflammation, chronic pain and vascular impacts from long COVID.

I cant walk more than 30 metres without stopping. I can no longer go to the shops because I cant walk the distance in the shops. I cant work because of the migraines and I cant drive, she said.

My whole identity has really been washed away from this.

Watts also cited that found COVID increased the risk of 64 diseases and other negative health impacts 18 months after infection. The seasonal flu was associated only with six.

Jeremy Nicholson, professor of medicine at Murdoch University, said the question at hand was whether long COVID was truly a unique condition worthy of its own name, or just another syndrome caused by a range of viruses.

Unfortunately, this question cannot be simply answered in this work, Nicholson said. The study is observational, based on reported symptoms with no physiological or detailed functional follow-up data.

Without lab analysis of the patients, and without knowing for sure that long COVID isnt physiologically different to other post-viral syndromes, the evidence to dismiss it isnt there, he argued.

This terminology can cause unnecessary fear, and in some cases, hypervigilance to longer symptoms that can impede recovery.

Until this is resolved, we should still use the long COVID term because it pinpoints exactly the underlying viral cause for a given individual, which may be relevant to future treatments, Nicholson said.

Professor Paul Fisher from La Trobe University is working to find signatures in the gut, immune system or blood cells that could help diagnose long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and to tell us if there are any biological differences between long COVID and ME/CFS.

Weve done some work on blood cells, and weve looked at thousands of differences between ME/CFS and healthy controls. And weve done the same with a small number of long COVID patients, Fisher said. They are really similar, if not identical.

The government announced $50 million in research funding into long COVID last year after an inquiry into the illness. Fisher said some ME/CFS researchers have applied for that funding in the hope of finding the link between general post-viral syndromes and long COVID.

Researchers will travel to Canberra later this month with Emerge Australia, the lead organisation for people with ME/CFS, to discuss recommendation 8 of the inquiry, which pushed for more ME/CFS research funding.

The Examine newsletter explains and analyses science with a rigorous focus on the evidence. .

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Long COVID doesnt exist as we know it, according to new research - Sydney Morning Herald

New bioengineered protein design shows promise in fighting COVID-19 – Phys.org

March 15, 2024

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In the wake of the COVID-19 pandemic, scientists have been racing to develop effective treatments and preventatives against the virus. A recent scientific breakthrough has emerged from the work of researchers aiming to combat SARS-CoV-2, the virus responsible for COVID-19.

Led by Jin Kim Montclare and her team, the study, published in the Biochemical Engineering Journal, focuses on the design and development of a novel protein capable of binding to the spike proteins found on the surface of the coronavirus. The goal behind this innovative approach is twofold: first, to identify and recognize the virus for diagnostic purposes, and second, to hinder its ability to infect human cells.

The engineered protein, resembling a structure with five arms, exhibits a unique featurea hydrophobic pore within its coiled-coil configuration. This feature enables the protein not only to bind to the virus but also to capture small molecules, such as the antiviral drug Ritonavir.

Ritonavir, already utilized in the treatment of SARS-CoV-2 infections, serves as a logical choice for integration into this protein-based therapeutic. By incorporating Ritonavir into the protein, the researchers aim to enhance the treatment's efficacy while simultaneously targeting the virus directly.

The study marks a significant advancement in the fight against COVID-19, showcasing a multifaceted approach to combating the virus. Through a combination of protein engineering and computational design, the team has devised a promising strategy that may revolutionize current treatment modalities.

Although the research is still in its early stages, with no human or animal trials conducted as yet, the findings offer a proof of principle for the therapeutic potential of the designed protein. The team has demonstrated its ability to enhance the protein's binding affinity to the virus spike protein, laying the groundwork for future investigations.

The potential applications of this protein-based therapeutic extend beyond COVID-19. Its versatility opens doors to combating a range of viral infections, offering a dual mode of actionpreventing viral entry into human cells and neutralizing virus particles.

Furthermore, the success of this study underscores the importance of computational approaches in protein design. By leveraging computational tools such as Rosetta, the researchers have accelerated the process of protein engineering, enabling rapid iterations and optimization.

The development of this novel protein represents a significant step forward in the ongoing battle against COVID-19. As research progresses, the integration of computational design and protein engineering holds promise for the development of innovative therapeutics with broad-spectrum antiviral capabilities. While challenges remain, this study offers hope for a future where effective treatments against emerging viral threats are within reach.

More information: Dustin Britton et al, Dual coiled-coil protein domain mimic and drug delivery vehicle for SARS-CoV-2, Biochemical Engineering Journal (2024). DOI: 10.1016/j.bej.2024.109261

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New bioengineered protein design shows promise in fighting COVID-19 - Phys.org

Queensland’s Chief Health Officer says it’s time to stop using the term ‘long COVID’ – ABC News

March 15, 2024

The term "long COVID" should be scrapped,according to Queensland's Chief Health Officer, because it creates unnecessary fear and is "probably harmful".

John Gerrard said the description wrongly implied long-term post-COVID viral symptoms were "somehow unique and exceptional" to other viral infections, but new research suggested they were indistinguishable.

The infectious disease physician said a Queensland study of more than 5,000 people found similar rates of functional limitations in the daily lives of people a year after a COVID-19 infection, compared to seasonal flu and other respiratory illnesses.

Dr Gerrard will present the results of the study next month at the European Congress of Clinical Microbiology and Infectious Diseases in Barcelona.

"We believe it's time to stop using the term long COVID," he said.

"[It] causes unnecessary fear. It implies that there is something particularly sinister and ominous about COVID-19.

"Our evidence suggests that there isn't, that it is not dissimilar to other viruses. That does not mean that you can't get these persistent symptoms following COVID-19, but you're no more likely to get it after COVID than with other respiratory viruses."

Queensland researchers compared 2,399 adults who tested positive for COVID-19 with 995 influenza patients, and 1,718 others who reported respiratory symptoms in mid-2022 but were negative for COVID-19 and the flu.

They surveyed the participants a year later, asking about ongoing symptoms and functional impairments using a questionnaire delivered by text message.

Dr Gerrard said after controlling for influential factors such as age, sex and First Nations status the researchers found no evidence the COVID-19 patients were more likely to have ongoing symptoms or moderate to severe functional limitations, a year after their diagnosis, than the other participants.

After 12 months, 16 per cent of respondents reported ongoing symptoms, regardless of whether they had COVID-19, the flu, or another respiratory infection.

The survey also found three per cent of the COVID-19 patients said they had moderate to severe functional impairment compared with 4.1 per cent of the non-COVID participants.

Dr Gerrard said 94 per cent of participants who reported themoderate to severe level of functional limitations experienced fatigue, post-exertion symptom exacerbation, brain fog and changes to taste and smell a year after their infection.

The rates were similar regardless of whether the person had tested positive to COVID-19 or not.

Given the study results, Dr Gerrard described long COVID as "probably a harmful term", given its potential to make some people hypervigilant to symptoms in the months after their infection, which could be detrimental to recovery.

However, he stressed he was not questioning the validity of long COVID.

"Post-viral syndromes do occur. We're absolutely saying that it does exist," Dr Gerrard said.

"We see it with Ross River virus. Clearly, we see it with influenza as well.

"A severe viral infection can be quite a significant inflammatory insult and, in some people, that clearly can cause persistent symptoms. But in the vast majority of people, recovery is the norm."

The latest study builds on Queensland Health research, published in the British Medical Journal last year, that found no difference between COVID-19 and influenza symptoms three months on from infection.

Dr Gerrard said limitations of the Queensland research included that participants who had pre-existing illnesses were unable to be identified in the study.

He also said the risk of so-called long COVID in Queensland was lower during the Omicron waves, compared with other variants as 90 per cent of the state's population was vaccinated when Omicron emerged.

"We may well have found a different result in an un-immunised population, prior to the arrival of the Omicron variant," Dr Gerrard said.

"What they described in the UK with long COVID in the early days, we know their experience of COVID was completely different to our experience.

"It's quite possible their experience of long COVID is different to ours here in Queensland."

Dr Gerrard said the researchers sent text messages to more than 30,000 Queenslanders last year as part of the study, about 6,400 people responded and some of those were deemed ineligible because they didn't have respiratory symptoms at the time of the initial test.

He said Queensland Health planned to do more research into other complications following COVID-19 infection compared to other viruses including strokes, heart attacks and myocarditis an inflammation of the heart muscle.

"Somewhere between four and five million Queenslanders have caught COVID-19 over the last couple of years, so even a very small complication rate translates to a significant number of people when you have so many people infected," Dr Gerrard said.

Mater infectious diseases director Paul Griffin, who was not involved in the study, cautiously welcomed the findings but said much more research was needed to better understand long COVID.

"We should be looking at much larger samples and collaborating with people in other locations," Dr Griffin said.

He said the sheer volume of Queenslanders who had been infected with COVID-19 supported the need for public long COVID clinics.

"I do think long COVID clinics would be worthwhile," he said.

"I think investing in some guidelines for how practitioners can help long COVID patients, and then bringing together appropriate expertise into long COVID clinics for those that require it would be really helpful for those people that are suffering the worst.

"We need to be able to identify who's at highest risk and ideally, work out ways to prevent it and treat it if people do get it. All of those areas are sadly lacking."

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Queensland's Chief Health Officer says it's time to stop using the term 'long COVID' - ABC News

How Did the Covid-19 Pandemic Affect You, Your Family and Your Community? – The New York Times

March 15, 2024

It has been four years since the World Health Organization declared Covid-19 a global pandemic on March 11, 2020. The New York Times writes of the anniversary:

Four years ago today, society began to shut down.

Shortly after noon Eastern on March 11, 2020, the World Health Organization declared Covid or the coronavirus, then the more popular term to be a global pandemic. Stocks plummeted in the afternoon. In the span of a single hour that night, President Donald Trump delivered an Oval Office address about Covid, Tom Hanks posted on Instagram that he had the virus and the N.B.A. announced it had canceled the rest of its season.

It was a Wednesday, and thousands of schools would shut by the end of the week. Workplaces closed, too. People washed their hands frequently and touched elbows instead of shaking hands (although the C.D.C. continued to discourage widespread mask wearing for several more weeks).

The worst pandemic in a century had begun.

For some people, the earliest days of the pandemic may feel like a lifetime ago; for others, it may feel like just yesterday. But for all of us Covid has indelibly changed our lives and the world. What do you remember about the earliest days of the pandemic? When did it first hit home for you? How did it affect you, your family and your community? What lessons did you learn about yourself and the world?

In Four Years On, Covid Has Reshaped Life for Many Americans, Julie Bosman writes that while the threat of severe illness and death has faded for many people, the pandemics effects still linger:

Jessie Thompson, a 36-year-old mother of two in Chicago, is reminded of the Covid-19 pandemic every day.

Sometimes it happens when she picks up her children from day care and then lets them romp around at a neighborhood park on the way home. Other times, its when she gets out the shower at 7 a.m. after a weekday workout.

I always think: In my past life, Id have to be on the train in 15 minutes, said Ms. Thompson, a manager at United Airlines.

A hybrid work schedule has replaced her daily commute to the company headquarters in downtown Chicago, giving Ms. Thompson more time with her children and a deeper connection to her neighbors. The pandemic is such a negative memory, she said. But I have this bright spot of goodness from it.

For much of the United States, the pandemic is now firmly in the past, four years to the day that the Trump administration declared a national emergency as the virus spread uncontrollably. But for many Americans, the pandemics effects are still a prominent part of their daily lives.

In interviews, some people said that the changes are subtle but unmistakable: Their world feels a little smaller, with less socializing and fewer crowds. Parents who began to home-school their children never stopped. Many people are continuing to mourn relatives and spouses who died of Covid or of complications from the coronavirus.

The World Health Organization dropped its global health emergency designation in May 2023, but millions of people who survived the virus are suffering from long Covid, a mysterious and frequently debilitating condition that causes fatigue, muscle pain and cognitive decline.

One common sentiment has emerged. The changes brought on by the pandemic now feel lasting, a shift that may have permanently reshaped American life.

As part of our coverage of the pandemics anniversary, The Times asked readers how Covid has changed their attitudes toward life. Here is what they said:

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How Did the Covid-19 Pandemic Affect You, Your Family and Your Community? - The New York Times

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