Category: Corona Virus

Page 422«..1020..421422423424..430440..»

How The mRNA Vaccines Were Made: Halting Progress and Happy Accidents – The New York Times

January 16, 2022

I said, I am an RNA scientist. I can do anything with RNA, Dr. Karik recalled telling Dr. Weissman. He asked her: Could you make an H.I.V. vaccine?

Oh yeah, oh yeah, I can do it, Dr. Karik said.

Up to that point, commercial vaccines had carried modified viruses or pieces of them into the body to train the immune system to attack invading microbes. An mRNA vaccine would instead carry instructions encoded in mRNA that would allow the bodys cells to pump out their own viral proteins. This approach, Dr. Weissman thought, would better mimic a real infection and prompt a more robust immune response than traditional vaccines did.

It was a fringe idea that few scientists thought would work. A molecule as fragile as mRNA seemed an unlikely vaccine candidate. Grant reviewers were not impressed, either. His lab had to run on seed money that the university gives new faculty members to get started.

By that time, it was easy to synthesize mRNA in the lab to encode any protein. Drs. Weissman and Karik inserted mRNA molecules into human cells growing in petri dishes and, as expected, the mRNA instructed the cells to make specific proteins. But when they injected mRNA into mice, the animals got sick.

Their fur got ruffled, they hunched up, they stopped eating, they stopped running, Dr. Weissman said. Nobody knew why.

For seven years, the pair studied the workings of mRNA. Countless experiments failed. They wandered down one blind alley after another. Their problem was that the immune system sees mRNA as a piece of an invading pathogen and attacks it, making the animals sick while destroying the mRNA.

Eventually, they solved the mystery. The researchers discovered that cells protect their own mRNA with a specific chemical modification. So the scientists tried making the same change to mRNA made in the lab before injecting it into cells. It worked: The mRNA was taken up by cells without provoking an immune response.

Read more from the original source:

How The mRNA Vaccines Were Made: Halting Progress and Happy Accidents - The New York Times

Brazil registers 48520 new cases of coronavirus and 175 deaths-health ministry – Reuters

January 16, 2022

A medical worker takes care of a patient at the intensive care unit (ICU) of Hospital das Clinicas amid the outbreak of the coronavirus disease (COVID-19), in Porto Alegre, Brazil January 14, 2022. REUTERS/Diego Vara

SAO PAULO, Jan 15 (Reuters) - Brazil had 48,520 new cases of the novel coronavirus reported in the past 24 hours and 175 deaths from COVID-19, the Health Ministry said on Saturday.

The South American country has now registered 22,975,723 cases since the pandemic began, while the official death toll has risen to 659,934, according to ministry data.

Register

Reporting by Carolina Mandl; editing by Jonathan Oatis

Our Standards: The Thomson Reuters Trust Principles.

See the original post here:

Brazil registers 48520 new cases of coronavirus and 175 deaths-health ministry - Reuters

3 big Covid misconceptions people still have, according to infectious disease experts – CNBC

January 16, 2022

As Covid's omicron variant continues to rip across the United States, causing record numbers of infections and hospitalizations, new coronavirus myths keep bubbling up.

The variant has been the subject of constant scientific scrutiny since it was first detected in South Africa in late November. Recent studies have unveiled its strengths and weaknesses: It's four times more transmissible than the delta variant, it causes less severe physical symptoms than previous variants, and Covid boosters significantly increase your protection against it.

In total, the World Health Organization has collected data from more than 5,800 studies surrounding Covid-19 from all over the world. But despite the data, pandemic falsehoods are still circulating and omicron seems to have given some of them new life.

CNBC Make It asked a trio of leading infectious disease experts for the biggest Covid misconceptions they're hearing right now. Here's what they said:

It's true that vaccinated people can catch omicron: A two-dose regimen of Pfizer's Covid vaccine only provides 22.5% protection against symptomatic infection from omicron, according to an early study from South Africa last month.

But crucially, the study observed, getting vaccinated helps keep your symptoms mild if you do get sick, reducing your chances of hospitalization or death. And if you add a booster shot, your protection against symptomatic infection rises significantly to 75%, according to real-world data from the U.K.

"The vaccine does work, and that's been clearly shown by both death rates and hospitalization rates when comparing vaccinated people to unvaccinated people," says Dr. Mark Sawyer, an infectious disease specialist at Rady Children's Hospital who served on theU.S. Food and Drug Administration advisory committeethat approved Covid vaccines in 2020.

Not all states publicly track patients' vaccination status in hospitals, but the ones that do back up Sawyer's claims.

According to data compiled by Time, unvaccinated people account for a large percentage of hospitalized Covid patients in states like South Carolina, Montana and Mississippi. And recent data from New York State found that unvaccinated residents had a 13-times higher risk for hospitalization than vaccinated residents amid the state's omicron surge in late December.

That's because the vaccines prompt your body to produce an arsenal of Covid-fighting immune cells that work together to fend off the virus. Antibodies, which help prevent you from getting sick, are only the first line of defense: If you do get infected, your body's vaccine-induced T cells target and destroy virus-infected cells to make your symptoms less severe.

Dr.David Hirschwerk, an infectious disease specialist and medical director at Northwell Health's North Shore University Hospital, says he constantly reminds people that the "value of the vaccine" extends to reducing severe illness and hospitalizations.

"Hopefully, we can keep reminding ourselves about that fact," he says.

Dr. Shaun Truelove, an infectious disease epidemiologist at the Johns Hopkins Bloomberg School of Public Health, says he's seen lots of portrayals of omicron as "super mild" and "flu and cold-like."

While omicron's physical symptoms can sometimes resemble the flu or common cold, its rate of transmission is much higher. It's more transmissible and better at evading existing antibodies than previous Covid variants, too.

In other words, Truelove says, omicron is far more severe than the cold or influenza. And it's the reason hospitals across the country have gone into emergency mode in recent weeks, declaring they're at full capacity, he adds.

"Even if it's same severity [of symptoms], it produces in terms of numbers way more hospitalizations and deaths," he says. "I think people keep missing that point."

Additionally, omicron is still a form of Covid. If you catch it, even if your symptoms are mild, you're still enabling the virus to keep circulating and the more Covid spreads, especially in unvaccinated populations, the more chances it has to potentially mutate into another dangerous variant.

It's been more than a year since the first Covid vaccine was administered in the U.S. Since then, nearly 250 million people across the country have received at least one vaccine dose, according to the Centers for Disease Control and Prevention.

Yet Sawyer says much of the country's unvaccinated population is still concerned about "what we might not know about these vaccines," particularly in terms of long-term safety.

"We have given hundreds of millions of doses of these vaccines, including in young children, five to 11," Sawyer says. "So if there was some mysterious side effect that was going to emerge, we would see it by now and know about it."

Long-term vaccine side effects are extremely rare. For example, J&J's one-shot vaccine carries a very small risk of "thrombosis with thrombocytopenia syndrome," a severe blood clotting disorder. Pfizer and Moderna's mRNA vaccines can increase the risk of myocarditis, a heart inflammation condition, in men under age 29 but those cases are often mild, typically resolving on their own.

For Sawyer, the vaccine's benefits greatly outweigh its risks. As of Friday, roughly 63% of the U.S. population is fully vaccinated,accordingto the CDC. Of those fully vaccinated, approximately 38% have received a booster dose, which experts say is critical in protecting yourself against omicron.

Sign up now:Get smarter about your money and career with our weekly newsletter

Don't miss:

Omicron-specific vaccine is coming but may not mattereverybodys going to be infected, says expert

Why Covid vaccine booster shots are so important: Omicron will 'rip right through the population,' says expert

Omicron could burn through the U.S. and potentially hasten the Covid pandemic's end, says expert

Read the original post:

3 big Covid misconceptions people still have, according to infectious disease experts - CNBC

High demand for COVID testing calls Kauai War Memorial Convention Hall to action – KHON2

January 16, 2022

Posted: Jan 15, 2022 / 07:20 PM HST / Updated: Jan 15, 2022 / 07:20 PM HST

HONOLULU (KHON2) The Kauai War Memorial Convention Hall testing site will be open on Monday, Jan. 17 to accommodate the extremely high demand for coronavirus testing in Kauai.

Mahalo to all the staff and volunteers who are working tirelessly at the Convention Hall to help keep our community safe, said Mayor Derek S. K. Kawakami.

The testing center will be offering free rapid PCR COVID-19 testing with same-day results between Monday through Friday from 8 a.m. to 3:30 p.m.

There will be 500 tickets handed out each day that include an appointment time for that same day.

Alden Alayvilla, Kauai countys Public Information Officer, said that tickets are available on a first-come, first-served basis so they are often gone by 9 a.m.

This ticketing system is meant to prevent extended lines and crowds due to the current high demand for testing, said Alayvilla. Testing at this site is not for those who are experiencing symptoms. If you are sick with COVID symptoms, please seek testing at a drive-thru or clinical site.

Find more COVID-19 news: cases, vaccinations on our Coronavirus News page

The testing center is located at 4191 Hardy St. in Lhue. Kauai also has a list of other available testing options as well.

See the article here:

High demand for COVID testing calls Kauai War Memorial Convention Hall to action - KHON2

The Covid Race to Watch: Vaccines vs. Variants – The Wall Street Journal

January 16, 2022

As the Covid-19 pandemic enters its third year, the world is settling in for the moment the disease becomes endemicand less disruptiveat least in the U.S. Against that is the race to vaccinate while anticipating new variants.

The coronavirus that causes Covid-19 has continued to turn up winning numbers in the evolutionary lottery, alighting on mutations that can help it survive and thrive. With uneven Covid-19 vaccine uptake in the developed world and slow rollout in poorer nations, virologists say the virus has ample avenues to generate more variants that could challenge immune defenses developed through vaccination, infection or both.

Originally posted here:

The Covid Race to Watch: Vaccines vs. Variants - The Wall Street Journal

Hacking a home COVID test by adding a throat swab is a hot topic on Twitter : Goats and Soda – NPR

January 13, 2022

A COVID-19 home test in the U.S. comes with a swab to swirl in the nostrils. But some users say they're swabbing the throat too even though that's not what the instructions say to do. "They may stab themselves," cautions Dr. Janet Woodcock, acting head of the Food and Drug Administration. Angus Mordant/Bloomberg via Getty Images hide caption

A COVID-19 home test in the U.S. comes with a swab to swirl in the nostrils. But some users say they're swabbing the throat too even though that's not what the instructions say to do. "They may stab themselves," cautions Dr. Janet Woodcock, acting head of the Food and Drug Administration.

Lots of folks on Twitter say that swabbing your throat in addition to your nose may be a better way of using your COVID-19 testing kit to detect the omicron variant. Is this true?

If you've used a do-it-yourself COVID-19 home test in the U.S. the "antigen" rapid tests that promise results in 15 minutes or so you know the drill. You typically swirl a cotton swab around in your nostrils, mix it with some liquid and then drop it on a test strip to await the results: positive or negative for the coronavirus.

But in recent weeks, there has been an online debate about where to stick that cotton swab. Although the directions specify a nasal swab on U.S. products, some medical professionals believe the test is more effective at detecting the coronavirus, and specifically the omicron variant, if the kit's swab is used in the throat and/or cheek in addition to the nose.

Why did this hack emerge and is there any medical science to back it up?

The idea of a throat swab is not in and of itself a radical step. Even though antigen test kits in the U.S. are designed for a nasal swab, home tests are designed for a throat swab in other countries in Canada and the U.K., for example.

The idea of improvising with a throat swab is connected to the omicron variant, which was identified in late November and has swept the world. Researchers increasingly believe omicron may replicate in the throat before the nose.

That was one of the findings of a study conducted at the University of Cape Town in South Africa. Researchers examined the ability of PCR tests to detect the variant by comparing diagnostic tests for 382 symptomatic COVID-19 patients who weren't hospitalized. In patients with the delta variant of the coronavirus, saliva swabs detected the virus 71% of the time, while nasal swabs found it 100% of the time. But in patients with omicron, researchers found the reverse: Saliva swabs detected the virus 100% of the time, while nasal swabs caught it 86% of the time.

The research has not been peer reviewed. And the tests used in the study were PCR tests, not antigen tests. (PCR tests are the gold standard and are administered typically in a health care facility; antigen tests are less precise and can be done at home. See this story for details on the differences.)

Nonetheless, the South African study has led some epidemiologists and immunologists in the U.S. to experiment with antigen tests by swabbing their throats or cheeks in addition to the nose when administering a self-test.

That's not an authorized use of the kits, reminds the Food and Drug Administration, which regulates the kits: "FACT: When it comes to at-home rapid antigen #COVID19 tests, those swabs are for your nose and not your throat," it said in a tweet issued on Jan. 7.

And even proponents of the throat swab stop short of endorsing the practice for the public without a green light from the FDA.

One of the most often quoted voices in favor of throat swabbing is Dr. Michael Mina, formerly an epidemiologist and immunologist at the Harvard T.H. Chan School of Public Health and now the chief science officer at the testing company eMed. He has tweeted: "We should be rigorously looking into throat swabs to add some level of sensitivity" and "Throat swab + nasal may improve chances a swab picks up virus."

But Mina has gone on to tweet that the FDA was right to warn the public not to go against manufacturer's directions: "Telling US public not to go against directions is the *right* thing to do."

"The tests haven't been designed to do [throat swabs], so we don't know whether there are false positives or negatives," agrees Dr. Jill Weatherhead, assistant professor of adult and pediatric infectious diseases at Baylor College of Medicine. "It logically makes sense that you'd want to do it, but that's not how [the tests have] been developed or tested."

One potential problem could be the thicker viscosity of throat saliva, says Dr. Yuka Manabe, associate director of global health research and innovation and a professor of medicine at the Johns Hopkins Bloomberg School of Public Health. It's possible the sample would need to be filtered first, she says, to produce an accurate result.

That's not necessarily a critical concern, says Michael Daignault, an emergency physician who serves as chief medical adviser to Reliant Health Services, a medical testing company. He says that the nature of throat saliva could simply cause the test to display a message that the result is invalid rather than a false positive.

Another obvious potential problem, Manabe points out, is the length of the swab in some of the kits: "The swab that you use doesn't have a very long stick because it's just meant to be used in the front of your nose. So for you to get that into the back of your throat would not be very easy, truthfully, for some of the kits, depending on the length of the swab."

The public debate about the best way to swab has prompted a growing chorus of voices to call for new studies and a revamping of the kits and/or the instructions.

That kind of change is what Michal Tal is hoping for. Tal, an instructor at Stanford University's Institute for Stem Cell Biology and Regenerative Medicine and a visiting scientist at the Massachusetts Institute of Technology, is a proponent of throat swabs. Before seeing anyone in person, she asks that they take a coronavirus test and swab not only their nose but their cheeks, the roof of their mouth, under their tongue and if they don't gag easily their throat near the tonsils.

"I'm feeling very frustrated that the FDA and CDC didn't jump on this and try to make more rapid changes," says Tal. "The virus is always two steps ahead and we don't adapt."

At a congressional hearing Monday, the acting head of the FDA, Dr. Janet Woodcock, noted that the National Institutes of Health has helped accelerate the authorization of new home tests so that they can get the FDA's signoff in just one or two days. But she said it may take a while for companies to change their test configurations to include larger swabs for the throat.

In the meantime, she warned people not to swab their throats with the current devices, which are designed as nasal swabs. "They may stab themselves," she said. "That would not be good."

Sheila Mulrooney Eldred is a freelance health journalist in Minneapolis. She has written about COVID-19 for many publications, including The New York Times, Kaiser Health News, Medscape and The Washington Post. More at sheilaeldred.pressfolios.com. On Twitter: @milepostmedia.

Excerpt from:

Hacking a home COVID test by adding a throat swab is a hot topic on Twitter : Goats and Soda - NPR

Coronavirus Data for January 11, 2022 | mayormb – Executive Office of the Mayor

January 13, 2022

(Washington, DC) - The Districts reported data for January 11, 2022 includes 1,216 new confirmed positive coronavirus (COVID-19) cases, bringing the Districts overall confirmed positive case total to 118,802. The District also reports 159 new probable cases, bringing the overall positive probable cases since October 15, 2021 to 7,687.

The District reported that three additional residents lost their lives due to COVID-19.

Tragically, 1,240 District residents have lost their lives due to COVID-19.

Visit coronavirus.dc.gov/data for interactive data dashboards or to download COVID-19 data.Below is the Districts current Key Metrics Summary Table.

Below is the Districts aggregated total of confirmed positive COVID-19 cases, sorted by age and gender.

Patient Gender

Total Confirmed Positive Cases

%

Female

%

Male

%

Unknown

%

All

118,802*

100

63,068

100

54,383

100

1,351

100

Unknown

245

<1

89

<1

127

<1

29

2

0-18

22,558

19

11,245

18

10,976

20

337

25

19-30

33,223

28

18,979

30

13,889

26

355

26

31-40

24,325

21

12,802

20

11,221

21

302

23

41-50

14,293

12

7,351

12

6,770

12

172

13

51-60

11,294

10

5,621

9

5,585

10

88

6

61-70

7,389

6

3,801

6

3,552

7

36

2

71-80

3,461

3

1,892

3

1,549

3

20

2

81+

See the original post here:

Coronavirus Data for January 11, 2022 | mayormb - Executive Office of the Mayor

Shawnee County Covid Indicator shows cases of coronavirus rising by more than 25% – KSNT News

January 13, 2022

TOPEKA (KSNT) - Shawnee County is considering a new program for non-emegency medical calls to 911. It's called the "Nurse Navigation Line" and would give emergency dispatchers another option for medical calls other than sending AMR.

Shawnee County Emergency Management and AMR Topeka/Shawnee County presented the possible program to the Shawnee County Commission Thursday. The new program is expected to cost around $60,000 a year and would be ran by Kansas licensed nurses.

Follow this link:

Shawnee County Covid Indicator shows cases of coronavirus rising by more than 25% - KSNT News

Coronavirus in Ohio Thursday update: More than 19,000 new cases reported – NBC4 WCMH-TV

January 13, 2022

COLUMBUS, Ohio (WCMH) The Ohio Department of Health has released the latest number of COVID-19 cases in the state.

Numbers as of Thursday, Jan. 13 follow:

The 21-day case average is above17,600.

The department reported9,677people started the vaccination process, bringing the total to7,084,804, which is 60.61% of the states population. And24,987received booster shots.

The Ohio Hospital Association reported the following numbers related to COVID-19 patients:

Franklin County Public Health Commissioner Joe Mazzola said he thinks we should all be very concerned about the rate at which COVID-19 is spreading in the community. With vaccination rates steadying in the state, the ripple effect is being felt among young children in central Ohio. As the six-month mark for those who got a COVID-19 booster shot in early fall approaches, an Ohio State doctor said it is likely another booster will be needed soon.

Read the original here:

Coronavirus in Ohio Thursday update: More than 19,000 new cases reported - NBC4 WCMH-TV

England cuts coronavirus isolation to 5 days – POLITICO Europe

January 13, 2022

England has become the latest country to cut its isolation requirement for people infected with coronavirus to five days, as industries including the health sector face vast staff absences due to the highly transmissible Omicron variant.

Health Secretary Sajid Javid said Thursday that the decision was based on U.K. Health Security Agency (UKHSA) data that showed "around two-thirds of positive cases are no longer infectious by the end of day five."

Therefore, from next Monday, anyone who tests positive for coronavirus will no longer need to isolate for seven days, but five. They can leave isolation at the start of day six if they produce two negativelateral flowtest resultson days five and six.

England follows the U.S., Greece and France in cutting its isolation to five days, on condition of negative tests and no symptoms. While based on data on how infectious people are, the head of the U.S. Centers for Disease Control and Prevention, Rochelle Walensky, later admitted the period really had a lot to do with what we thought people would be able to tolerate.

The NHS Confederation has been calling for this move if it could be backed by appropriate evidence. We are glad the government has acted quickly, said Matthew Taylor, chief executive of the confederation.

He pointed out that the number of people in hospital is still high, with admissions still rising in some areas, adding that we are certainly not out of the woods yet.

Javid said there were encouraging signs that infections are falling in London and the East of England, but acknowledged rates were still rising in other parts of the country. He pointed out that there were already early signs that the rate of hospitalization is also starting to slow.

Excerpt from:

England cuts coronavirus isolation to 5 days - POLITICO Europe

Page 422«..1020..421422423424..430440..»