Category: Corona Virus

Page 343«..1020..342343344345..350360..»

Summit County one of five in Utah with high coronavirus transmission risk – The Park Record

June 18, 2022

As coronavirus cases continue to rise in Utah and the rest of the country, Summit County is one of five places in the state with a high coronavirus transmission risk.

The county in May was the first to have its designation increased from low to medium as cases reached the double digits nearly every day. As of Friday, 15 of Utahs 29 counties were rated as having medium to high transmission risks, according to the Centers for Disease Control and Preventions COVID database. Salt Lake and Tooele counties were in the top risk category with Summit County on Thursday with Grand and San Juan counties also receiving a high designation on Friday.

There were 250 confirmed COVID cases in the county between May 16 and May 31, according to the Summit County Health Departments COVID dashboard. The data also shows 116 additional cases 103 of which were reported in the unvaccinated population between June 1 and June 7.

Phil Bondurant, the countys health director, speculated the higher number of unvaccinated cases may be because those who are sick are likely experiencing severe symptoms, which leads to more COVID tests being administered.

He said individuals who are vaccinated often report mild, allergy-like symptoms that some people dont associate with the virus. In certain cases, an individual may choose to self-isolate or take other precautions, but those who dont suspect theyre sick may continue the cycle of spread and contribute to the uptick, Bondurant said.

Cases have been increasing on the West Coast over the last few months and he compared it to the rise in cases the East Coast experienced in late April. However, Bondurant said, the case numbers locally may be skewed because at-home testing kits can be inaccurate and its hard for health officials to gauge who is using them. Summit County is also testing at higher rates than the rest of Utah following the closure of state testing sites at the end of March.

The good news is hospitalization rates, which are considered an important metric in the fight against COVID, appear to be stable and indicate the countys situation is still manageable, the health director said. There have been nine hospitalizations with one person in the intensive care unit in the last 30 days and one COVID-related death has been reported since March, according to the Health Department.

Approximately 47% of people living in Summit County who are eligible to receive the COVID-19 vaccine have received a booster shot as of Friday. Close to 88% of residents have completed their vaccination series and 100% have received at least one dose of a vaccine.

Bondurant said several factors play a role in why the county hasnt been able to reach the 50% mark. First, many people may be waiting to receive their booster in the fall when they anticipate theyll have the highest level of protection against COVID or they consider themselves at a lower risk during the summer. Others may expect theyre going to catch the virus either way and dont want to go through the inconvenience of the shot, according to the health director.

Bondurant admits hed like to see the booster number higher and said the Health Department is continuing messaging about the importance of the vaccine, while also recognizing its a personal choice.

Its likely a COVID vaccine similar to a seasonal flu shot, or one combining the two, will be offered sometime soon, he said. Until then, the CDC recommends a second booster for adults over 50 and people 12 and older who are moderately immunocompromised.

Everybody is aware and everyone knows what COVID is and how to protect yourself, the risks, those different things, Bondurant said. People know where [the booster and vaccine is] available so at this point we continue to take those appointments and help people make the decision thats best for them and their families.

With summer here and tourists likely on their way, Summit County health officials urge Parkites and visitors to follow precautions to limit their exposure to COVID. Individuals who are unsure if they have contracted the virus are also encouraged to get tested. Testing is available from 9 a.m. to 1 p.m. on Thursdays in Coalville and Tuesdays in Kamas as well as 9 a.m. to 4 p.m. on weekdays in Park City.

Here is the original post:

Summit County one of five in Utah with high coronavirus transmission risk - The Park Record

Justin Trudeau tests positive for coronavirus for a second time this year – CNN

June 18, 2022

Trudeau tweeted "I'll be following public health guidelines and isolating. I feel okay, but that's because I got my shots. So, if you haven't, get vaccinated -- and if you can, get boosted. Let's protect our healthcare system, each other, and ourselves."

Trudeau also tested positive in January, as did two of his children.

US President Joe Biden is not considered to have been in close contact with Trudeau, a White House official said, despite the fact the leaders had a bilateral meeting Thursday in Los Angeles. Neither wore masks, and they were sitting in close proximity.

CNN's Arlette Saenz contributed to this report.

More:

Justin Trudeau tests positive for coronavirus for a second time this year - CNN

Is Appendicitis a Side Effect of the COVID-19 Vaccine? – Healthline

June 18, 2022

You may have heard of several side effects of the COVID-19 vaccine. But appendicitis probably isnt one of them.

While appendicitis has been documented after the COVID-19 vaccine, its still unclear whether its an adverse vaccine effect. Research into this topic has returned mixed results.

Below, well cover more about appendicitis, its potential connection with the COVID-19 vaccine, and its known COVID-19 vaccine side effects. Keep reading to discover more.

Appendicitis happens when your appendix becomes inflamed. Your appendix is a hollow pouch attached to your large intestine. Its in the lower right-hand area of your abdomen.

When the opening of the appendix becomes blocked, it can lead to appendicitis. Some things that can cause blockages include:

Sometimes the exact cause of appendicitis is unknown. Regardless, blocking the opening of the appendix leads to a buildup of bacteria and inflammation. This causes symptoms like:

Appendicitis is a medical emergency. If its not treated promptly, the appendix can burst, causing severe and potentially life threatening complications like peritonitis and abscess formation.

Appendicitis has been reported after COVID-19 vaccination. One possible mechanism for this could be enlarged or swollen lymph nodes in the body following vaccination.

Research on this topic is conflicting. Some data indicate appendicitis may be a potential adverse effect of vaccination, while others note that the risk of appendicitis after vaccination is no higher than in the general population.

Appendicitis was noted in the large-scale clinical trial of the Pfizer-BioNTech mRNA COVID-19 vaccine. Out of 43,448 trial participants, 8 in the vaccine group and 4 in the placebo group experienced appendicitis.

These cases were considered unrelated to vaccination. This is because they didnt happen more frequently than is expected within the general population.

A 2021 study looked into the adverse effects of the Pfizer-BioNTech vaccine in over 1.7 million people in Israel. Researchers used a matched group of vaccinated and unvaccinated individuals for each adverse effect.

The adverse effect with the strongest association with vaccination was myocarditis. But researchers also found an increased risk of swollen lymph nodes and appendicitis.

Another 2021 study looked into appendicitis after COVID-19 vaccination using a World Health Organization (WHO) database. At the time of the study, researchers estimated that 1.82 billion vaccine doses had been given worldwide.

From the database, researchers were able to find 334 unique reports of appendicitis after vaccination. Most of these were associated with mRNA vaccines and occurred 0 to 4 days after vaccination.

The researchers found that the number of appendicitis cases after vaccination was slightly higher than expected. They concluded that appendicitis was a possible adverse effect of COVID-19 vaccination but that more research was needed.

A 2021 study disagreed with the findings above. In this study, researchers in the United States evaluated vaccine safety data from the Vaccine Safety Datalink for 23 adverse effects.

A total of 11,845,128 mRNA vaccine doses given to 6.2 million people were included in the study. Researchers found that the incidence of appendicitis in people getting an mRNA vaccine was not significantly higher than expected.

A 2022 study looked into appendicitis and COVID-19 vaccination in a large cohort of people in Denmark. Researchers compared over 4 million people vaccinated with an mRNA vaccine to an unvaccinated reference group.

It was found that appendicitis occurred at about 8 cases per 100,000 vaccinated people. When this rate was compared with the rate of appendicitis in the unvaccinated reference group, no significant difference was found.

According to the Centers for Disease Control and Prevention (CDC), the most common side effects of the COVID-19 vaccine are:

These side effects are a sign that your immune system is building a response to the vaccine. Vaccine side effects typically go away on their own within a few days. In the meantime, you can help to ease them by:

If your side effects dont go away within a few days or begin to get worse, contact a doctor.

COVID-19 vaccines are safe and effective at preventing severe illness, hospitalization, and death due to COVID-19. As such, the CDC currently recommends COVID-19 vaccines and boosters for everyone ages 5 and older.

Vaccination is particularly essential for people at an increased risk of severe COVID-19 illness. This includes, but isnt limited to, individuals who are immunocompromised and those with medical conditions like:

Getting immunity through vaccination is also safer than getting immunity by having COVID-19. Contracting SARS-CoV-2, the virus that causes COVID-19, can cause severe illness in some people and lead to long-term health issues, including long COVID.

While any treatment, medication, or vaccine comes with risks, the risks of serious complications due to COVID-19 are extremely low. This includes appendicitis.

For example, according to the CDC, anaphylaxis occurs in only 5 out of every 1 million vaccine doses. Further, out of over 55 million vaccine doses given to people under age 18, only 647 cases of myocarditis have been confirmed.

While appendicitis has been reported following the COVID-19 vaccine, its not entirely clear whether its an actual adverse effect of vaccination. Research results have been mixed on this topic, and more research is needed overall.

Regardless, appendicitis after vaccination has happened very rarely.

Overall, the benefits of receiving a COVID-19 vaccine outweigh the potential risks. If you have concerns about the COVID-19 vaccine, discuss them with a doctor.

Visit link:

Is Appendicitis a Side Effect of the COVID-19 Vaccine? - Healthline

COVID cases are upending cycling, and the Tour de France starts in 2 weeks – NPR

June 18, 2022

Cyclist Aleksandr Vlasov was leading the Tour de Suisse before a positive coronavirus test forced him to abandon the race a fate shared by many other riders. Vlasov is seen here in March, at the Paris-Nice race. Francois Mori/AP hide caption

Cyclist Aleksandr Vlasov was leading the Tour de Suisse before a positive coronavirus test forced him to abandon the race a fate shared by many other riders. Vlasov is seen here in March, at the Paris-Nice race.

Two races that are supposed to be tune-up events for the Tour de France are instead raising worries about COVID-19's impact on cycling's biggest event, with dozens of riders forced to withdraw because of positive tests.

"It's just crazy," Welsh cyclist Geraint Thomas said at the Tour de Suisse on Friday. "Kind of thought all of this was behind us now."

Around 30 riders abandoned the Tour de Suisse on Friday alone, including race leader Aleksandr Vlasov of the Bora-Hansgrohe team who was coming off of winning Thursday's stage. Several teams withdrew their entire squads.

The sudden exits were the talk of the bus ride to the start of Friday's stage, Thomas said: "This rider out; that rider out; this team; whole team; another whole team."

"Despite all precautions, corona has crept into the team again," Dutch team Jumbo-Visma, which withdrew Thursday, said via Twitter.

In addition to Vlasov, the departures include some of cycling's most well-known names, such as Adam Yates, Rui Costa, Marc Hirschi, Rigoberto Urn and Tom Pidcock.

"It's a bloodbath!" the French news outlet Ouest France declared, as news of the positive tests spread.

"Everyone has the jitters," sports director Philippe Mauduit of the team Groupama-FDJ told Ouest France. His team is crossing its fingers, he said, adding that he's now seeing more people wear masks.

Thomas said he'll keep riding in the Tour de Suisse, but it's not a certainty that the race will finish as planned: Organizers said they are "monitoring further developments and will assess the situation together again on Saturday morning."

The abrupt exits are another reminder that the pandemic isn't over and similar scenes are playing out on a smaller scale at the Tour of Slovenia, where defending Tour de France champion Tadej Pogaar won Friday's stage despite losing two teammates to positive coronavirus tests.

The 2022 Tour de France is slated to begin in Copenhagen on July 1, further expanding the footprint of a race that sprawls from the north to the south of France in this year's route.

At least one team official has called for the organizers of the French race to reimpose a tight bubble and other COVID-19 protocols, according to Cycling Weekly.

France has reported the most COVID-19 cases in Europe, with more than 30 million. This month, transmission rates have been rising across Europe, according to the European Centre for Disease Prevention and Control, although the agency notes that death rates have continued to fall.

Read more:

COVID cases are upending cycling, and the Tour de France starts in 2 weeks - NPR

Covid Updates: Fauci Has His First Positive Test for the Coronavirus – The New York Times

June 16, 2022

Dr. Anthony Fauci has not recently been in close contact with President Biden or other senior government officials, the institute he leads said in a statement.Credit...Stefani Reynolds for The New York Times

WASHINGTON Maybe it was only a matter of time.

Dr. Anthony S. Fauci, President Bidens top medical adviser for the coronavirus pandemic, has tested positive for the virus and is experiencing mild symptoms, the National Institute of Allergy and Infectious Diseases said on Wednesday.

Dr. Fauci, the institutes director, was positive on a rapid antigen test, the agency said in a statement. It added that he was fully vaccinated against the virus and had been boosted twice. He is taking Paxlovid, the Pfizer antiviral therapy authorized by the Food and Drug Administration for treatment of Covid-19, an agency spokeswoman said.

News that Dr. Fauci, one of the worlds foremost infectious disease specialists and a household name thanks to the pandemic, had fallen victim to the coronavirus reverberated across Washington and the country. The positive test was the first for Dr. Fauci, who is 81.

But with the Centers for Disease Control and Prevention estimating that more than half of Americans have contracted Covid-19, he is hardly the only big-name sufferer. Xavier Becerra, the secretary of health and human services, tested positive on Monday for the second time in less than a month. Representative Maxine Waters, Democrat of California, who is 83, announced on Tuesday that she had tested positive; she had also done so in April.

Dr. Fauci has not been in close contact with Mr. Biden or other senior government officials recently and will isolate and continue to work from his home, the statement from his institute said. He will return to his office once he tests negative.

But he had been making public appearances. The AIDS Clinical Trials Group a network of hundreds of researchers conducting studies to improve treatment of H.I.V. and related infections is meeting in Washington this week, and Dr. Fauci, whose laboratory work has been focused on H.I.V./AIDS, addressed the group in person on Tuesday.

Along with other top federal health officials, Dr. Fauci was expected to testify on Thursday before the Senate health committee on the state of the pandemic. An official said that Dr. Faucis institute was working with committee staff members to arrange for a remote appearance.

While much of the nation appears to be trying to move on, the coronavirus remains a pervasive threat. According to a New York Times database, more than 100,000 new cases are still being identified each day in the United States a figure that has stayed roughly flat during June. Many experts believe the number is an undercount because so many people are taking at-home tests whose results are not recorded with public health authorities.

While cases are declining in the Northeast and the Midwest, cases and hospitalizations are surging in the West and the South. Reports of deaths, however, remain low. Fewer than 350 deaths are being reported each day, The Timess database shows, down from more than 2,600 a day at the height of the Omicron surge.

Dr. Fauci has spent half a century in government and has advised seven presidents, beginning with Ronald Reagan, on epidemic and pandemic threats.

But the coronavirus pandemic turned him into a political lightning rod. His public urging of health precautions like mask-wearing and social distancing made him a frequent target of critics who questioned or opposed such measures.

Perhaps more than anyone, he knows how infectious the coronavirus is. This spring, he decided against attending the White House Correspondents Dinner a gathering of prominent political and news media figures that featured an appearance by the president because of my individual assessment of my personal risk, he said then. At the time, Dr. Fauci was preparing for other public engagements, including commencement speeches at Princeton and the University of Michigan.

The correspondents dinner, which drew more than 2,000 guests to a packed hotel ballroom, ended up spreading the virus among many journalists and other attendees.

Its a matter of time before we all get infected, honestly; this virus has become so transmissible, Dr. Carlos del Rio, an infectious disease specialist at Emory University, said on Wednesday. What I tell people is that at some point in time you will encounter this virus, because we are doing more things and getting together. And if you are going to encounter the virus, youd better be vaccinated and boosted.

View post:

Covid Updates: Fauci Has His First Positive Test for the Coronavirus - The New York Times

Can I Breastfeed If I Have COVID-19? Safety Recommendations – Healthline

June 16, 2022

Getting sick with a newborn in the house can be stressful, especially if youre worried about passing the illness to your baby through close contact or even breast milk.

It might be a relief to know that the virus that causes COVID-19 doesnt pass to your baby through breast milk. However, its still possible to infect your baby if you are sick and providing care to an infant.

This article will discuss the risks and benefits of breastfeeding if youre infected with COVID-19, and how to protect an infant if you are sick with COVID-19.

Breast milk and the act of breastfeeding itself have many benefits for your baby even if you are sick with COVID-19. Numerous studies have analyzed the milk of mothers infected with COVID-19 and found that the virus is not passed through breast milk but antibodies that protect them from infection can be.

As with other viral illnesses, your body begins making antibodies shortly after infection. These antibodies are similar to vaccines in the way they include information to help your body fight the infection.

However, when you breastfeed with a COVID-19 infection, your baby can be infected if other precautions such as washing your hands and wearing a mask are not taken. This is due to face-to-face and hand-to-body contact while breastfeeding, not the breast milk itself.

Although the virus isnt passed through breast milk, its important to remember that you can still infect your baby through regular transmission methods like saliva and respiratory particles.

While your breast milk itself is safe, there are still precautions you should take to avoid transmitting the virus to your baby in other ways. These include:

Pregnant and breastfeeding women are at an increased risk of becoming severely ill with COVID-19, but vaccination is considered safe and is strongly recommended.

The Centers for Disease Control and Prevention (CDC) currently recommends vaccination against COVID-19 for pregnant and nursing mothers, as well as other close caregivers.

In general, CDC recommends pregnant and nursing mothers stay up to date on all vaccinations not just the COVID vaccine except vaccines that contain live virus particles like:

Aside from protecting mothers from becoming severely ill, there is evidence that vaccination can help protect babies, too. Antibodies that offer protection from the virus can be passed through breast milk, whether those antibodies came from a COVID-19 infection itself or from vaccination.

If you are sick with COVID-19, its best to isolate yourself from other members of the household who are not infected including your baby. This means having other members of the household who are well, and ideally vaccinated, take care of the baby while you recover.

When this isnt an option either because you live alone or other household members are also infected, you or other caregivers should wear a mask and practice careful hand hygiene when caring for your baby.

Even household members who are well should wear masks when caring for your infant as long as you are in isolation or ill.

If you or other members of the household are feeling better after having COVID-19, you should continue to wear a mask when caring for your baby until at least the 10th day after you tested positive for COVID-19 or began experiencing symptoms.

One report that tracked mothers infected with COVID-19 who breastfed their babies found that between 2 and 5 percent of infants ended up infected also, but they were either asymptomatic or only mildly sick.

If you suspect your baby has become infected with COVID-19, call your pediatrician for guidance.

No. No particles of virus that cause active infection have been found in breast milk.

Breast milk has been found to contain antibodies to the COVID-19 virus that can help protect your baby from severe infection. This includes antibodies you develop during an active COVID-19 infection or from vaccination.

At this time babies cannot be vaccinated. Children must be at least 5 years old to receive the COVID vaccine.

If you have COVID-19 and have an infant you are breastfeeding, consider expressing milk and allowing someone else who is not infected to feed the baby while you isolate.

If you or someone else who is infected must feed and care for your baby while you have COVID-19, wear a mask and be sure to wash hands for at least 20 seconds before handling the baby or breast milk.

Breast milk is a nutritional and readily available food source for your baby, and it can even provide protective antibodies that can prevent severe infection should COVID be passed to your child.

The virus that causes COVID-19 is not passed through breast milk, but anyone handling a baby still has to be careful to avoid infecting the baby through respiratory particles or close contact.

More here:

Can I Breastfeed If I Have COVID-19? Safety Recommendations - Healthline

The Books Swallowed by the Black Hole of the Coronavirus – The Atlantic

June 16, 2022

There are moments when one can dive into the sustained dream of a book and stay there for hours. The spring of 2020 was not one of those times. If you werent actively battling COVID-19 or grieving a loved one, your life was likely all of a sudden relentlessly logistical: the sudden evaporation of childcare, the Tetris of fitting multiple working adults inside one tiny apartment, the paranoid wiping down of groceries. Reading often felt impossible, even for those of us who love to read. How could anyone focus long enough, amid all the chaos and grief, to absorb complex ideas? Instead, I found myself flicking through the latest headlines and my multiple email inboxes, or obsessively checking COVID-19 case statistics in my area. The world was on fire, and it was hard to tear my eyes away.

It wasnt just bad for readers. Early 2020 was simply a very bad time to publishand publicizea book. First-time author and Atlantic staff writer Olga Khazan, whose book Weird: The Power of Being an Outsider in an Insider World came out on April 7, reflected on the experience of releasing a book into a giant dumpster fire on Twitter a year later: I realized I felt guilty for feeling so robbed, and honestly just acknowledging the guilt and frustration was a good step forward. The publishing industry mostly moved online, and suddenly publicists couldnt easily send out physical review copies, whether because of supply-chain issues or because the books were trapped in offices that were now inaccessible. Libraries and physical bookstores closed, launch events were canceled, and publishers hadnt quite figured out Zoom yet.

Still, once I was finally able to focus, sometime in the fall, I found that among the galleys and not-so-new releases I had packed into boxes were titles that I immediately longed to talk to someone about. The nine works below, a selection of excellent books released between March and June 2020, include some of those gems. Each illuminates some underappreciated aspect of contemporary life or allows us to see the greater context beyond our own circumstancesperspective that the early days of the pandemic swept away.

Fiebre Tropical, by Julin Delgado Lopera (March 4, 2020)

What makes this novel is the swaggering, vulnerable, bilingual voice of Francisca, the 15-year-old narrator newly arrived in Miami, much to her chagrin. This wasnt a Choose Your Own Migration multiple-choice adventure with (a), (b), and (c) laid out at the end of each page and you could simply choose (b) Stay in Bogot, you idiot. Cachaco, please, she thinks. Shed rather wear all black and listen to the Cure than get involved in the youth group at the evangelical church that forms her relatives social and emotional world. That is, until she catches the interest of Carmen, the pastors charismatic daughter. As the two become more intimate, Francisca cant tell whether shes feeling Jesus or falling desperately, confusedly in love. There are gorgeous interludes depicting her mother and grandmother at around Franciscas age, in 1970s Bogot and 1950s Cartagena, filled with the same yearning and stubbornness. Its a coming-of-age story in triplicate, where dreams dont quite pan out in messy realityincluding the glamorous vision of the U.S. that draws the family there in the first place. But the longing that suffuses the writing has its own beauty.

Some Assembly Required: Decoding Four Billion Years of Life, from Ancient Fossils to DNA, by Neil Shubin (March 17, 2020)

Evolutionary biologist Neil Shubin wants us to know that feathers didnt in fact develop specifically to help animals fly, nor did lungs or legs appear to help animals walk on land. This absorbing book traces how monumental evolutionary changes actually happen, and Shubins answers are illuminating even to people who think they know how evolution works. Life as we know it, the reader learns, was actually formed by a grand process of bricolage, where body parts like feathers and lungs appeared, then eventually conferred advantages on their owners to serve different purposes than what they initially arose to do. (Evolution, in other words, is kind of like MacGyver.) Our own genomes are littered with randomly duplicate genes and the viruses that once infected our ancestors; we now use that DNA to make proteins crucial for pregnancy and the formation of memories. Through the stories of scientists like Susumu Ohno, who used cardboard cutouts to theorize about gene duplication, and Barbara McClintock, who won a Nobel Prize for discovering that certain genes move around within a genome, one gets a sense of how quickly our understanding of genetics has progressedand how human the scientific endeavor is.

The Everlasting, by Katy Simpson Smith (March 24, 2020)

This time-skipping novel tells the stories of four characters living in Rome at vastly different historical moments: an aquatic biologist named Tom in 2015; Giulia de Medici, self-conscious of her African heritage, in 1559; Felix, a closeted monk in 896; and Prisca, a 12-year-old girl who becomes a Christian martyr in 165. All come to Rome from elsewhere, all are haunted by unattainable love, and all are desperately lonely. A metal fishhook performs a decisive role in each arc. And Satan himself interjects throughout, responding to the characters rhetorical questions with snark and affectionhe can relate to their romantic anguish; he's never gotten over his breakup with God. The Everlasting meditates on faith, contingency, and human longing through a wealth of period detail in each setting: Who knew that spending time in a putridarium, a room beneath monasteries where the corpses of monks were seated on toilets to rot, could be so riveting? From seeing what changes and what stays the same in these glimpses of the Eternal City, an intimate sense of history arises.

Read: The exquisite pain of reading in quarantine

Afterlife, by Julia Alvarez (April 7, 2020)

Alvarezs first book for adults in 14 years is a quiet, philosophical novel, fraught with questions of what we owe to others and to ourselves. It also happens to be a page-turner. Antonia is a recently retired English professor whose beloved husband died nine months ago, and all of her instincts are to practice self-care and hold herself apart from otherswhich, throughout the story, can seem necessary, selfish, or both. That slippage is the central point of the novel. Antonia is always piously lecturing her three sisters about personal responsibility: Take care of yourself so you dont become a burden on others, she says, and they set their phones to play the sound of church bells when she calls. But then her erratic sister Izzy goes missing and a pregnant 17-year-old undocumented Mexican immigrant named Estela takes shelter in Antonias garage, and Antonia is caught between her own inclinations and the memory of her husband, Sam, who would likely help others in need even at a cost to himself. A bleak world of self-protections, she thinks close to the end. Did she really want to live in it? Antonias constant self-questioning anchors this deft work, showing readers the thoughts of a woman who decides to do the right thing despite herself.

The Address Book: What Street Addresses Reveal About Identity, Race, Wealth, and Power, by Deirdre Mask (April 14, 2020)

Addresses are sort of like flush toilets, I concluded after reading this wide-ranging exploration of the subject: an assumed part of modern life you only really see once you go somewhere without them. Mask traces the origins of addressing systems beginning in Enlightenment-era Europe, when burgeoning nation-states were eager to collect more detailed information about its citizens in order to provide them with services, but also to tax, conscript, and surveil them. Today, simply giving someone an addressa resident of a Kolkatan slum, or a homeless person in the U.S.could help lift them out of poverty by allowing them to open bank accounts and apply for jobs. Charming historical facts abound, including a chapter describing the way ancient Romans likely navigated a city largely without street names. But the books most striking point is how passionately people throughout history have felt about the names of their streets, from reunified Berlin to Tehran, South Africa, and Hollywood, Florida. They invite such heated debate, Mask writes, because they are about powerthe power to name, the power to shape history, the power to decide who counts, who doesnt, and why.

Synthesizing Gravity: Selected Prose, by Kay Ryan (April 14, 2020)

In 1976, when she was 30, Kay Ryan bicycled across the United States in order to decide, once and for all, whether to become a poet. Today shes about as decorated as a poet can bea Pulitzer Prize winner, two-term U.S. poet laureate, and a MacArthur fellow. Synthesizing Gravity is the first collection of her prose, written over three decades; it includes an essay that tells the story of that cross-country bike ride, as well as ones that dissect her favorite poets: Philip Larkin, Emily Dickinson, Robert Frost, Marianne Moore, Stevie Smith. Its a little ironic that I have so many quotes from this book dutifully recorded, considering that one essay elaborates on the danger of notebooks. (Almost everything is supposed to get away from us, she argues.) Even her criticism inspires envy and an urge to jot down everything she writes: Nobel Prizewinning poet Joseph Brodsky was born to be posthumous, she tells us, and Annie Dillard could get high C out of a potato. What she advocates for is a life of simplicity, repetition, and solitude, and her insights are so bracing that the collection feels like a palate cleanser for everything thats overwhelming about our world.

Read: You wont remember the pandemic the way you think you will

Sansei and Sensibility, by Karen Tei Yamashita (May 5, 2020)

In this collection, Yamashitas characters are all growing up as sansei, the relatively pampered children of a generation of Japanese Americans who had been sent to internment camps during World War II. Theyre grappling with the weight of a history their parents never talk about. One protagonist considers what it means to apply the KonMari method to artifacts from the camps; a woman locked in her dead aunts apartment becomes interested in the Japanese antiques and old groceries she left behind. Throughout, theres a pleasingly casual sense of intimacy. One of the stories is, in fact, a timeline of important events in Los Angeless Japanese American community, while another incorporates recipes from Yamashitas friends and family, with directions like Toss, and serve with sake and beer. Play cards. Oh, and the books latter half consists of extremely witty sendups of all of Jane Austens completed novelsyes, even Lady Susanset in the Southern California of Yamashitas childhood. Eligible teens attend prom instead of fancy balls and Emma is now Emi, afire with plans to start the Japanese American revolution. The transplanted stories are fun (who doesnt love an Austen adaptation?) and also revealing, as this particular milieu is rife with unspoken expectations about what station in life the young protagonists are meant to attain.

One Mighty and Irresistible Tide: The Epic Struggle Over American Immigration, 1924-1965, by Jia Lynn Yang (May 19, 2020)

For most of this countrys past, Yang points out, it had been firmly established that being an American was inextricably tied to European ancestry. Her book charts the long, agonizing fight to recast the U.S. as a nation of immigrants, in which lawmakers and activists created a story about the countrys core values that became popular more recently than one might expect. This history is bookended by two laws: the Immigration Act of 1924, which barred nearly all new Asian immigrants and established national quotas based on eugenics and white nationalism, and the Immigration and Nationality Act of 1965, which eliminated these quotas and banned discrimination against immigrants based on race or ethnicity. Its a fascinating and often sobering picture of how immigration in America has been shaped by a host of factorsforeign affairs, political expediency, anti-Communist hysteria, and principled, determined lawmakersand valuable context for the still-roiling battles over what it means to be an American. In the end, Yang argues, those of us who believe in multiculturalism as one of our countrys fundamental values have unfinished work if were to create a vision that recognizes and actively embraces our country's unprecedented diversity.

Read: How I came to love my epic quarantine reading project

The Dragons, the Giant, the Women, by Waytu Moore (June 2, 2020)

It feels nearly impossible to write about ones experiences as a 5-year-old with the clarity and narrative surety of a novelist, and yet thats exactly what Moore does in this memoir, which chronicles her familys escape from Liberia to the United States after civil war breaks out in 1989. The hardship itself commands attentionthe family, including three children, walks for weeks, passing through checkpoints surrounded by volatile soldiers and dead bodies. But Moores storytelling abilities and structural ingenuity are what made this one of my favorite books of 2020; after reading it I felt, despite everything that was going on, mildly outraged that people werent gushing about it on every platform. As Moores family flees, we feel her fathers and grandmothers terror and, simultaneously, the confusion of a child who weaves her own mythology of princes and dragons to make sense of the chaos. And, at a crucial juncture in their escape, the memoir leaps in time to Moore as a young woman in America, adjusting to racism and her identity as a West African immigrant, not to mention the buried trauma of her childhood. Her search for the female soldier who helped smuggle them out of the country brings her back to Liberia and a conclusion that moved me to tears.

When you buy a book using a link on this page, we receive a commission. Thank you for supporting The Atlantic.

More here:

The Books Swallowed by the Black Hole of the Coronavirus - The Atlantic

More than One Thousand Genes Linked to Development of Severe COVID-19 – Genetic Engineering & Biotechnology News

June 16, 2022

Researchers from the University of Sheffield and Stanford University say they have discovered that there are specific genetic signals in people who develop severe coronavirus infection.

It is known that age, body mass index, and pre-existing health problems account for some of the disparities, but genetics also plays a significant role. The current study Multiomic analysis reveals cell-type-specific molecular determinants of COVID-19 severity, published in Cell Systems, aimed to address why some people with COVID-19 become seriously ill or die, while others have few, if any, symptoms.

The scientists used a machine learning tool named RefMap, which can find patterns in vast amounts of data, to help identify the genetic basis for complex and poorly understood diseases. The identified more than 1,000 genes linked to the development of severe COVID-19 cases that required breathing support, or were fatal. They were also able to identify specific types of cells in which those genes act up.

The study is one of the first to link coronavirus-associated genes to specific biological functions.

Researchers used several large data sets to unpack the genetics behind severe COVID-19. [Peterschreiber.media/Getty Images]The determinants of severe COVID-19 in healthy adults are poorly understood, which limits the opportunity for early intervention. We present a multiomic analysis using machine learning to characterize the genomic basis of COVID-19 severity. We use single-cell multiome profiling of human lungs to link genetic signals to cell-type-specific functions, write the investigators.

We discover >1,000 risk genes across 19 cell types, which account for 77% of the SNP-based heritability for severe disease. Genetic risk is particularly focused within natural killer (NK) cells and Tcells, placing the dysfunction of these cells upstream of severe disease. Mendelian randomization and single-cell profiling of human NK cells support the role of NK cells and further localize genetic risk to CD56brightNK cells, which are key cytokine producers during the innate immune response. Rare variant analysis confirms the enrichment of severe-disease-associated genetic variation within NK-cell risk genes.

Our study provides insights into the pathogenesis of severe COVID-19 with potential therapeutic targets.

During the research we discovered the genetic architecture underlying coronavirus infection, and found that these 1,000 genes account for three quarters of the genetic drivers for severe COVID-19, said Johnathan Cooper-Knock, PhD, National Institute for Health and Care Research (NIHR) clinical lecturer in the department of neuroscience at the University of Sheffield and co-author of the study. This is significant in understanding why some people have had more severe symptoms of COVID-19 than others.

Michael P. Snyder, PhD, principal investigator in the department of genetics at Stanford, led the study in collaboration Stanford genetics instructor Sai Zhang, PhD, and Cooper-Knock, who is currently a Stanford visiting scholar.

The research team used several large data sets to unpack the genetics behind severe COVID-19. The first data set contained genetic information from healthy human lung tissue. The data helped identify gene expression in 19 different types of lung cells, including epithelial cells that line the respiratory tract and are the first defense against infection.

Other data came from the COVID-19 Host Genetics Initiative, one of the largest genetic studies of critically ill coronavirus patients. The researchers looked for genetic clues in the datasingle nucleotide polymorphismsthat might indicate if someone is at a higher risk for severe COVID-19. They tracked whether some mutations occurred more or less often in COVID-19 patients with severe disease.

Mutations that continued to appear, or were notably absent, in the patients who developed severe COVID-19 suggested those variations might be behind the infections severity.

But genetic mutations on their own can be difficult to interpret. To better understand their findings the team used other data describing which regions of the genome are important for different cell types within lung tissue. By overlapping the mutations onto the cell-specific genomes the researchers could pinpoint which genes were dysfunctioning and within which cell-types.

The researchers also wanted to know which types of cells harbored faulty gene expression. Through their machine learning tool, they determined that severe COVID-19 is largely associated with a weakened response from two well-known immune cells, i.e., natural killer (NK) cells and T cells. NK cells and a subtype called CD56 bright are considered the most important.

NK cells, which humans are born with and are the bodys first line of defense against infection, are known for their ability to destroy viruses and cancer cells, noted Cooper-Knock. NK cells also help produce a range of immune system proteins called cytokines. One cytokine, interferon gamma, is a key activator of immune cells. Acting in concert with interferon gamma, NK cells mount an immediate and coordinated defense against viral infections.

NK cells are like the generals directing the war. They mobilize other immune cells, telling them where to go and what to do. We found that in people with severe coronavirus infection, critical genes in NK cells are expressed less, so theres a less robust immune response. The cell isnt doing what its supposed to do.

Stanfords Snyder likened COVID-19 risk genes to harmful variants of the BRCA genes that predispose some people to breast and ovarian cancer.

Our findings lay the foundation for a genetic test that can predict who is born with an increased risk for severe COVID-19, he said. Imagine there are 1,000 changes in DNA linked to severe COVID-19. If you have 585 of these changes, that might make you pretty susceptible, and youd want to take all the necessary precautions.

Cooper-Knock pointed out that drugs that kickstart sluggish NK cells are already proposed to treat some types of cancer. The drugs bind to receptors on the NK cells and trigger them to have a more robust response, he explained, noting that trials of NK cell infusions for severe COVID-19 are underway.

Follow this link:

More than One Thousand Genes Linked to Development of Severe COVID-19 - Genetic Engineering & Biotechnology News

Hawaii Department of Health reports 7,199 new infections, 9 coronavirus-related deaths – Honolulu Star-Advertiser

June 16, 2022

JAMM AQUINO / JAN. 20

Angelica Bagaoisan, medical assistant with Project Vision Hawaii, secures a COVID-19 antigen test sample during a vaccination and testing clinic put on by Honolulu Community Action Program, Project Vision Hawaii, and Kaiser Permanente at Palama Settlement.

The Hawaii Department of Health today reported 7,199 new COVID-19 infections over the past week, bringing the total since the start of the pandemic to 297,851 cases.

State health officials also reported nine coronavirus-related deaths, bringing the states coronavirus-related death toll to 1,474.

The states seven-day average of new cases today was reported at 976 compared to 1,085 on June 8, representing a decrease for the second week in a row after more than two months of increases. The seven-day average reflects new cases per day from June 4 to 10.

The states average positivity rate, meanwhile, decreased to 18.9% from 19.2% reported last week. It is the first decrease in the positivity rate reported after two-and-a-half months of consecutive increases.

The average positivity rate reflects a different set of seven days tests performed between June 7 and 13.

By island, there were 5,276 new infections reported on Oahu, 803 on Hawaii island, 602 on Maui, 377 on Kauai, 10 on Molokai and 10 on Lanai. Another 121 infections were reported out of state.

The Hawaii Emergency Management Agencys dashboard reported 218 patients with COVID-19 in hospitals today, up from 190 reported on June 8. Of the 218, 10 are in the intensive care unit and five are on ventilators.

View post:

Hawaii Department of Health reports 7,199 new infections, 9 coronavirus-related deaths - Honolulu Star-Advertiser

WATCH LIVE: Ohio Department of Health gives update on COVID-19 in Ohio Thursday – News 5 Cleveland WEWS

June 16, 2022

COLUMBUS, Ohio The Ohio Department of Health (ODH) will host a briefing to update Ohioans on the status of COVID-19 in the state, the department announced in a news release.

The briefing is scheduled to begin at 11 a.m. Watch it live in the media player below:

News 5 livestream event

ODH Medical Director Dr. Bruce Vanderhoff will be joined by Dr. Michael Forbes of Akron Childrens Hospital and Dr. Grant Paulsen of Cincinnati Childrens Hospital.

This briefing comes after a government advisory panel has endorsed a second brand of COVID-19 vaccine for school-age children and teens.

The expert panel agreed Tuesday that the vaccine made by Moderna is safe and effective enough to give to U.S. kids ages 6 to 17.

Download the News 5 app for free to easily access local coronavirus coverage, and to receive timely and limited news alerts on major COVID-19 developments. Download now on your Apple device here, and your Android device here.

See complete coverage on our Coronavirus Continuing Coverage page.

Vaccinating Ohio - Find the latest news on the COVID-19 vaccines, Ohio's phased vaccination process, a map of vaccination clinics around the state, and links to sign up for a vaccination appointment through Ohio's online portal.

See data visualizations showing the impact of coronavirus in Ohio, including county-by-county maps, charts showing the spread of the disease, and more.

Rebound Northeast Ohio News 5's initiative to help people through the financial impact of the coronavirus by offering one place to go for information on everything available to help and how to access it. We're providing resources on:

Getting Back to Work - Learn about the latest job openings, how to file for benefits and succeed in the job market.

Making Ends Meet - Find help on topics from rent to food to new belt-tightening techniques.

Managing the Stress - Feeling isolated or frustrated? Learn ways to connect with people virtually, get counseling or manage your stress.

Doing What's Right - Keep track of the way people are spending your tax dollars and treating your community.

We're Open! Northeast Ohio is place created by News 5 to open us up to new ways of thinking, new ways of gathering and new ways of supporting each other.

View a map of COVID-19 testing locations here.

Visit Ohio's Coronavirus website for the latest updates from the Ohio Department of Health.

View a global coronavirus tracker with data from Johns Hopkins University.

See the original post here:

WATCH LIVE: Ohio Department of Health gives update on COVID-19 in Ohio Thursday - News 5 Cleveland WEWS

Page 343«..1020..342343344345..350360..»