Category: Corona Virus

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Persistent humoral immune response in youth throughout the … – Nature.com

November 27, 2023

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Persistent humoral immune response in youth throughout the ... - Nature.com

COVID-19 and migrants: lessons for pandemic preparedness from … – Globalization and Health

November 27, 2023

Thematic analysis was employed for data analysis following the six-step approach proposed by Braun and Clarke [55]. The initial step involved familiarizing with the data through repeated reading and note-taking, facilitating the creation of a timeline detailing events related to government policy actions directed towards migrant workers during the study period. Subsequently, in the second step, the content of each government policy and its implications for migrant workers were extracted and summarized, aligning with the research questions. Moving to the third step, open coding was used to generate codes deductively from the data, guided by the research questions focus on identifying the governments policy responses to migrants during the COVID-19 pandemic. Based on this, themes emerged and were reviewed in relation to the coded extracts and the entire dataset. Finally, the themes were defined and named to encapsulate the overarching narrative evident in the data, culminating in the composition of the analysis.

This review sought to identify the governments policy responses toward migrants with regard to COVID-19 and lessons that could be learned for future pandemic preparedness, especially in terms of migrant health policy. The governments policy and legislative responses directed toward migrant workers were categorized into the following three overarching themes:

Incoherence in migrant worker policy and gaps in inter-ministerial coordination: This theme revolves around the absence of a coherent policy framework and the lack of coordination among various ministries during COVID-19. These factors resulted in vulnerabilities and fear among migrant workers, uncertainty among their employers, and hindered the Ministry of Healths efforts to control the pandemic.

Normalization of cheap and disposable migrant labor in neoliberal economic regimes: This theme highlights the significance of cheap and disposable migrant labor within pre-existing neoliberal economic structures. It underscores how these labor practices, prevalent before COVID-19, became normalized during the humanitarian crisis of the pandemic.

Securitization of migration in the context of public health policies: This theme emphasizes the strengthening of migration securitization within the framework of public health policies designed to curb COVID-19 transmission. This approach led to the widespread arrest and detention of migrants, the States absence of action regarding xenophobic hate speech directed at migrants, and the emergence of avoidable COVID-19 clusters in detention centres.

As illustrated in Table 1 and this section, the examination of the governments policy responses toward migrant workers reveals an inconsistent and poorly coordinated approach marked by divergent policies across different ministries and agencies, each operating under distinct conceptual frameworks and objectives, in their efforts to address the pandemic.

Initially, Prime Minister Tan Sri Muhyiddin Yassin indicated that foreigners would be responsible for the costs of COVID-19 tests and treatment at government hospitals. However, aligning with a more equitable public health approach, the Ministry of Health later clarified that these services would be provided for free [56]. Regarding screening, the government agreed to subsidize employers for COVID-19 screening for documented foreign workers contributing to the Social Security Organisation (SOCSO) [57]. Nonetheless, starting in April 2020, when undocumented migrants hesitated to come forward for testing and treatment, the Ministry of Health reassured all migrant workers that they could access free COVID-19 care without fear of arrest. Contrary to this, the Immigration Department and the Ministry of Home Affairs initiated mass raids, arrests, and detention [58,59,60]. This reversal from their March 2020 stance not to arrest undocumented migrants resulted in avoidable COVID-19 clusters in overcrowded immigration detention centres [61].

A similar situation unfolded in 2021 when Health Minister Khairy Jamaluddin announced that undocumented migrants could freely get vaccinated. However, the Home Minister subsequently reversed this stance, citing the need to safeguard citizens and migrants from a new wave of the virus [59]. This flip-flopping contributed to fear of arrest and vaccine hesitancy among undocumented migrants [62].

Likewise, the Recalibration Programs [63, 64]which aimed at facilitating the return of undocumented individuals pre-COVID-19 (Repatriation Recalibration Plan) and regularizing those who became undocumented due to pandemic-related layoffs (Labor Recalibration Plan) also yielded mixed messages and proved ineffective. Initially, in 2020, the immigration department announced that details regarding the Repatriation Recalibration Plan and the Labor Recalibration Plan would be communicated from time to time [65], causing uncertainty about the program. Subsequently, in November 2021, the Home Minister announced that employers in the construction, manufacturing, plantation, and agriculture sectors could legally hire undocumented migrant workers under the Labor Recalibration Plan [66]. But, the Director-General of Immigration later clarified that this program was solely for undocumented workers held in immigration detention centers and that employers intending to hire them would be required to finance the repatriation of these detainees at a one-to-one ratio [67]. However, the Human Resources Minister specified that the policy was intended for foreign workers with valid documents who had lost their jobs due to their employers pandemic-related business closures, with no plans to legalize workers who had been undocumented prior to the pandemic [68]. Despite the governments initial intent to manage these programs directly, recruiting agents and intermediaries soon began offering their services to migrant workers for fees reaching up to RM3,000 (approximately USD 631) [69]. Ultimately, the government acknowledged the programs lack of success [70]. The government attributed this failure to the age limit requirement for workers to be below 45years old [70]. However, migrant activists argued that the high cost of hiring a worker (approximately RM 4,000 or USD 952) during an economic downturn, coupled with mixed messages about the arrest and detention of undocumented workers, deterred employers and workers from participating in the program [71].

This lack of policy coherence across various government initiatives left migrants vulnerable, subjected them to heightened security measures by the State, and exposed them to increased xenophobic and racist hate speech on social media. Furthermore, it created uncertainty for employers grappling with severe labor shortages and economic losses. Surveys by the National Chamber of Commerce and Industry of Malaysia (NCCIM) and other industry estimates revealed worker shortages in various sectors during the fourth quarter of 2021, including plantation (70,000), rubber glove manufacturing (25,000), furniture (30,000), construction (200,000), services (45,000), plastics (6,293) [72], cleaning services (68,000), and restaurants (30,000) [73]. While estimates varied among surveys, they all pointed to labor shortages, highlighting the adverse economic consequences of ad-hoc and fragmented policies for migrant workers. This predicament was exacerbated by the fact that small and medium enterprises (SMEs) constituted the majority of businesses in Malaysia, accounting for 98.5% of firms nationally [74]and contributing 38.3% to the countrys GDP and 48% of total employment in 2020 [75]. Markedly, the president of the SME Association of Malaysia noted that only 15% of migrant workers employed in this sector were documented, with the majority being undocumented, often hired without formal employment contracts or receiving only daily wages [76], highlighting the significant problems with the role of migration in the countrys development strategies.

Additionally, the lack of policy coherence hindered the Ministry of Healths ability to effectively implement an evidence-based public health strategy aimed at combating the pandemic through comprehensive measures such as universal testing, treatment, and vaccination for COVID-19.

The above complex and perplexing situation reveals the presence of competing and conflicting interests and spheres of influence among the State, employers, and intermediaries in the migration industry, all of which play a significant role in shaping the risk and vulnerability of migrant workers to COVID-19.

The salience of cheap and disposable migrant labor in neoliberal economic regimes which existed before COVID-19, became even more pronounced during the humanitarian crisis. As the economy faced challenges, migrant workers were among the first to be laid off [77]. Within a month of lockdowns, migrants were struggling to access food [29]. However, they were excluded from social protection and state-initiated financial assistance programs provided to citizens during the pandemic [5]without regard for their significant economic contributions to the economy [78]or their dire need during a humanitarian emergency.

Common complaints reported by migrant workers during the pandemic included unfair termination, unpaid wages, continuing nonessential work, and uncertainty about their employment status due to limited contact with employers, as noted by the International Labor Organization (ILO) and Malaysian Trades Union Congress (MTUC) [79]. Domestic workers faced additional challenges as work and education moved online, resulting in increased responsibilities, longer hours, uncompensated overtime, limited time off, and difficulties sending remittances back home [79].

Moreover, although the Workers Minimum Standards of Housing and Amenities (Amendment) Act 2019 (Act 446) initiated by the government aimed to improve access to safe housing, its enforcement was delayed, and migrant worker accommodations lacked robust monitoring during the pandemic. This resulted in over 90% of foreign workers in Malaysia residing in housing that did not comply with regulations [80]. Malaysian glove manufacturers who supplied 60% of the worlds gloves during the pandemic [81]and the construction sector faced scrutiny for their workers substandard living conditions. Top Glove, for example, became Malaysias largest COVID-19 cluster, with the majority of cases among its migrant workers. Workers reported overcrowded accommodations, limited sanitation facilities, and poor ventilation [82, 83]. Similar conditions were found on construction sites, with workers living in cramped containers under unsanitary conditions [84]. The national human rights institution of Malaysia, SUHAKAM, in monitoring the needs of vulnerable communities during COVID-19 reported that most migrant workers lived in overcrowded kongsi houses (makeshift housing for construction workers) with 4080 other occupants [27].

Workplace safety was also inadequately regulated, leading to preventable superspreader zones [28]. Despite Ministry of Health advisories to companies regarding Standard Operating Procedures (SOP) and preventive measures in the workplace [85], media reports exposed many companies that failed to implement recommended COVID-19 protocols such as sanitization, physical distancing, and mask-wearing [86]. Top Glove, for instance, faced criticism when a migrant worker revealed subpar safety measures and inconsistent enforcement of SOPs. Workers often felt compelled to continue working in these conditions due to debts owed to recruitment agents for their migration to Malaysia. Top Glove terminated the employment of the worker who raised concerns, further highlighting the challenges faced by these workers [82]. Investigations revealed the prevalence of forced labor and harsh working conditions in prominent factories during the pandemic [87, 88]. This issue gained international attention when the U.S. Customs and Border Protection (UCBP) banned the import of disposable rubber gloves from major companies like Top Glove, citing indicators of forced labor [88].

The work conditions in the glove-making industry before the pandemic were already a cause for concern. Investigative reports dating as far back to 2018 highlighted the prevalence of forced labor and deplorable working conditions within this sector. However, in July 2020, following an unscheduled visit, the Ministry of Human Resources cleared one of the companies implicated in the forced labor issue by the U.S. Customs and Border Protection (UCBP). Interestingly, despite the ministrys clearance, the company chose to compensate its workers who met certain criteria related to recruitment fees. This compensation amounted to a cumulative total of USD 40 million and was aimed at resolving the UCBP ban [89].This sequence of events suggests that the poor work conditions and inadequate enforcement of workplace safety policies that existed in the glove-making industry before the COVID-19 pandemic played a significant role in exacerbating the health risks faced by migrant workers during the pandemic.

While countries such as Canada, Turkey, and Denmark proactively disseminated COVID-related information in the languages spoken by migrants [90], Malaysia did not provide health information about COVID-19 in the languages understood by its migrant population.

From the examples provided above it emerges that the exceptional circumstances of the COVID-19 crisis entrenched the normalization of the pre-existing neglect of migrant rights and protection, often rooted in their exceptional status as non-citizens.

The securitization of migration was a pre-existing phenomenon in Malaysia, but the advent of the pandemic provided an opportunity to further reinforce this securitization, especially in the context of health and COVID-19. Presented as an unprecedented global health crisisand aligning with the WHO's concept of public health security [91], COVID-19 justified the necessity for states to undertake proactive and reactive measures in line with the norm of health security.

The diverse operational interpretations of security, however, exhibited inconsistencies across ministries, as exemplified in this case. In March 2020, despite the then Defense Minister and later Prime Minister, Datuk Seri Ismail Sabri Yaakob, initially reassuring undocumented migrants that they need not fear arrest due to the governments primary focus on pandemic response [92],this position was reversed within less than a month. Three buildings housing migrant workers in central Kuala Lumpur were placed under total lockdown or an enhanced movement control order (EMCO) as part of targeted cluster identification to stem disease transmission [58], and mass raids and arrests began. Moreover, to prevent the virus from entering the country, various enforcement agencies, including the police, army, Malaysian Maritime Enforcement Agency, Immigration Department, and the Peoples Volunteers Corps (RELA), tightened land, sea, and air borders to prevent the possibility of undocumented migrants entering through illegal routes, known as laluan tikus or rat lanes [93, 94]. Despite calls from rights groups and public health experts to cease the arrests, Datuk Seri Ismail Sabri Yaakob stated, We arrest them because its against the law [61]. On October 26, 2020, the Home Ministry revealed that 756 children were being held at immigration detention centers nationwide, of which 405 were held without their parents or guardians [95]. As arrests continued in 2020, the National Human Rights Commission, Suruhanjaya Hak Asasi Manusia Malaysias (SUHAKAM), estimated that immigration detention centers, which could only accommodate 12,530 detainees, had exceeded their capacity by 20 percent, with as many as 15,163 detainees being held [96].

The contradictory statements and policy reversals regarding the arrest and detention of undocumented migrants during the peak of the pandemic gave rise to various public health issues. First, following mass arrests in April and May 2020, new clusters of coronavirus infections were detected at three immigration detention centers [97], with similar clusters continuing to emerge in other detention centers. The Bukit Jalil Immigration Detention Center cluster was the first to be detected primarily comprising migrant detainees who had come into contact with a COVID-19-positive case In one detention center, almost 40 percent of the detainees tested positive for COVID-19 [98]. The Ministry of Health identified immigration detention centers as high-risk areas [38, 99], and targeted screening and sampling of detainees and staff commenced, as the rapid transmission of the disease was attributed to the overcrowded and confined conditions within these centers [100, 101]. These arrests also contributed to vaccine hesitancy among undocumented migrants [62]This hesitancy emerged as the Ministry of Health aimed to maximize vaccination coverage as a strategy to attain herd immunity, a crucial step in transitioning the nation toward endemicity.

COVID-19 also exposed and exacerbated overt xenophobia, racial discrimination, and ethnic biases in Malaysia undermining the effort to fight the pandemic in the country. Notably, the arrival of a boat carrying Rohingya asylum seekers in Malaysian waters in mid-April 2020, subsequently being turned away and escorted by two Navy vessels after providing sustenance to those on board [102], with the emergence of COVID-19 cases within detention centers, triggered a surge in hate speech targeting migrants, refugees [103]and human rights advocates advocating for their welfare [104]. Remarkably, despite this backdrop, the government remained conspicuously silent on the issue of hate speech and violent threats directed at migrants and refugees [105]. Furthermore, Reuters reported the existence of over 36 pages and groups, some linked to current and former Malaysian security officials, which contained discriminatory content directed towards Rohingya refugees and undocumented migrants [106]. In response to this concerning development on hate speech against migrants, the Director-General of Health, cautioned against healthcare discrimination targeting migrants [107].

Based on the identified key issues related to policies concerning migrant workers during the COVID-19 pandemic in Malaysia, two important lessons emerge:

The necessity for a paradigm shift in migration governance discourse.

The importance of the Health in all Policies (HiAP) approach.

This imperative arises from the pre-existing disparities in the social determinants of health of migrants before the onset of the COVID-19 pandemic, leading to unequal exposure to SARS-CoV-2. The problem originates from unquestioned neoliberal norms that underlie both migration and development. These norms idealize a good migrant, regardless of their status or conditions, as someone who is law-abiding, adaptable to market demands, and eager to contribute to the development of their country of origin[108](p.434). Furthermore, the neoliberal norms of autonomy and individual responsibility that underlie both migration and development normalize the compelling of migrants to maintain their status and functioning even in situations characterized by weak labor and social protection policies or lax enforcement of policies and laws. This compels migrants to persevere under adverse conditions, often without adequate safeguards or recourse.

A recent International Organization for Migration (IOM) published study[109]that investigates the process of migrants becoming undocumented in Malaysia sheds light on the pivotal role played by exploitative employment conditions. These conditions encompass various issues, including inadequate wages and compensation, substandard living conditions, the absence of health and safety regulations and practices, both prior to and during the pandemic, and excessively long working hours. Additionally, deceptive practices carried out by recruitment agencies and employers further compound the problem. When migrants opt to leave such exploitative working conditions, they inadvertently transition into undocumented status because their residency and work permits are intricately tied to their employers under existing laws. Viewed from this perspective, the problem of undocumented or irregular migration is not primarily a security issue, but an administrative issue that can be solved with appropriate policies and mechanisms, although there are security dimensions to irregular migration. Effectively addressing these systemic disparities necessitates a fundamental shift towards the principles of structural justice in migration governance.

In light of the circumstances, it is imperative to reconsider the tagline of safe, orderly, regular migration, which was initially promoted by the International Organization for Migration (IOM), used in discourses on the Sustainable Development Goals (SDGs), and more recently adopted by the World Health Organization (WHO) as a comprehensive and inclusive response to COVID-19[90](p.34). Instead, the appropriate policy approach should be safe, just, and regular migration, as the absence of justice and respect for human rights jeopardizes human security and health everywhere. Without an internationally agreed-upon definition of safe and orderly migration[110], state-centric discourses surrounding these terms presume and reinforce subjectivities that prioritize regular migration as a prerequisite for safety and well-being in the context of migration. While regular migration is undoubtedly important, assuming safety in regular migration, viewed as orderly, can be disputed due to the fluidity of migration statuses, such as regular/irregular or documented/undocumented, during the migration process. Regular and orderly migration does not inherently guarantee the safety or health of migrants, particularly considering the framing and implementation of current migrant policies that create precariousness and risks, even for documented migrants, as this case study has demonstrated. When state policies disregard human rights, eschew inclusive approaches, and perpetuate inequalities, both the safety and health of migrant populations are compromised, even if their status is regular. COVID-19 has accentuated this reality most poignantly.

Thus, the establishment of sustainable pathways for migrants to pursue safe, just, and regular migration is crucial for safeguarding the health and well-being of both migrants and host populations. In the Malaysian context, this entails the development of a comprehensive and coherent migration policy that harmonizes and integrates diverse forms of mobility and administrative mechanisms tailored to different migrant categories. This approach also necessitates the reinforcement of workplace safety regulations and the protection of workers rights, including mechanisms for addressing wage theft and unjust termination. Additionally, it involves rigorous monitoring and oversight of migrant workers housing conditions, as well as ensuring access to healthcare and social protection, both in ordinary circumstances and during pandemics.

In addition to the aforementioned considerations, the implementation of more suitable migrant health policies can also mitigate the transmission of the pathogen to the general population and hold a broader societal impact, extending beyond migrant communities. The beneficial outcomes include the potential to reduce disease transmission, expedite herd immunity, prevent future disease resurgences, bolster economic productivity, enhance public health system resilience, and promote social cohesion, underscoring the importance of equitable and comprehensive migrant policies in safeguarding the health and well-being of both migrants and the host populations.

The divergent approaches to migrant policies in relation to COVID-19 are rooted in contrasting perspectives that juxtapose universal approaches to testing, treatment, and care with the securitization of migration and health. As an unparalleled global health emergency, COVID-19 reinforced the need for states to undertake extraordinary measures in line with the norm of health security, to minimize vulnerability to acute public health events that endanger the collective health of populations living across geographical regions and international boundaries[91](p.ix).

Explaining the mechanism of norm diffusion through the case of health securitization from a global to local context, Kaunert, Leonard, and Wertman [111]provide a valuable framework for understanding how global norms can undergo modifications in content and normative foundations when implemented locally. They argue that the adaptation of global norms at the local level is influenced by pre-existing domestic norms, which serve as interpretative lenses for the core global norm. This adaptation is also shaped by the contextual factors from which the norm originates and the agent and strategies of the norms promoter. They further emphasize that primary norms encounter profoundly contested normative terrains when applied at the local level. In the context of COVID-19, where the securitization of health encompasses the primary norm of disease containment to mitigate harm and vulnerability among populations, the initiation of this norm was led by international entities such as the World Health Organization (WHO). However, the specific manifestations of this primary norm in addressing COVID-19 for migrant populations varied across different countries, contingent upon local circumstances and the actors responsible for translating these norms. For example, across 53 jurisdictions, governments aimed to mitigate overcrowding and minimize COVID-19 transmission in incarcerated settings by reducing prison populations via the release of both prisoners and pre-trial detainees, restricting new admissions into correctional systems, and implementing temporary releases, where prisoners were allowed to leave confinement for a specified duration, with an obligation to return to prison afterward[112]. Similarly, other good practice policies included considering undocumented migrants pending regularization as regular migrants (Peru), providing limited amnesty (Kuwait, Bahrain), waiving of sanctions and financial penalties (South Africa), and suspension of forced return (Canada, Chile, Czechia, Finland, Ireland, Latvia, Lithuania, Luxembourg, Malta, the Russian Federation, Slovakia, and Spain) [90]. On the other hand, in Malaysia, despite the international community discouraging a punitive approach toward migrant populations [113], the alignment of health securitization and the response to COVID-19 with the securitization of migration yielded a series of stringent measures including the mass apprehension and incarceration of migrant workers, and the repatriation of undocumented migrants to reduce COVID-19 transmission. Scholars note that discourses framing migration as a security concern are frequently accompanied by acts of violence, threats, and xenophobic rhetoric directed at migrant communities [114], the phenomenon of hate speech being observed in Malaysia.

The above critique of the securitization of migration and migrant health during COVID-19 does not undermine the importance of the states role in safeguarding and upholding the territorial integrity and sovereignty of the nation or in addressing irregular or undocumented migration, as these are legitimate responsibilities of the state. However, it prompts the question of the extent to which undocumented or irregular migration should be perceived as a security issue as opposed to an administrative one? Could a change in framing lead to a resolution of a longstanding issue? Would the development of a coherent migration policy, accompanied by effective administrative mechanisms targeting the underlying causes of documented workers transitioning to undocumented status, offer a solution to the problem of undocumented migrants in the country? Given the pivotal role that migration has played in the countrys development for decades, it raises concerns that only 15% of migrant workers employed in the SME sector, which comprises over 95% of the countrys businesses, contributes to more than a third of the GDP and nearly half of the total employment, possess proper documentation. This issue becomes particularly significant when considering that approximately 17 ministries are involved in the SME sector development [115]. While these questions prompt contemplation on how irregular migration after arrival in the country can be curtailed, with regards to border enforcement, could a proactive approach to securing the borders, rather than accepting porous borders as an inevitability, help in stemming irregular entry into the country? Should migrants be held responsible for porous borders? These inquiries hold significance due to the fragile ethical basis upon which the argument for the securitization of migration rests, especially when all the evidence and arguments pertaining to the development of undocumented migration and the ramifications of securitization of migration on their human security is taken into account.

Returning to the discussion on COVID-19 and migrants in Malaysia, the emergence of clusters in detention centers, coupled with the disregard for workplace safety, overcrowded living conditions, and inadequate sanitation and water supply, underscores the profound impact that policies in non-health sectors can exert on health outcomes through intricate and multifaceted pathways. This underscores the critical significance of the Health in All Policies (HiAP) approach. In fact, closer home, the Singaporean context serves to reinforce this idea. Migrant laborers residing in dormitories at the lower end of the wage spectrum in Singapore experienced a disproportionate impact from the COVID-2019. This disparity was linked to their communal living in high density and unsanitary dormitory facilities, as well as the absence of comprehensive protection mechanisms [116].

HiAP is an approach to public policies across sectors that systematically takes into account considers the health implications of decisions, seeks synergies, and avoids harmful health impacts to improve population health and health equity [117]. Via a whole-of-government approach, HiAP seeks to bring about a collaborative and coordinated response, particularly crucial for facilitating intersectoral coordination during crises. Equally, the migrant experience of the pandemic also emphasizes the critical importance of a whole-of-society approach to pandemic preparedness [118]so that greater efficiency and effectiveness can be achieved through the coordinated response of governments, businesses, and civil society. Such an approach is guided by robust governmental leadership and complemented by the involvement of civil society organizations that possess the capacity to transform scientific and government data into actionable strategies, largely due to the trust they have established with various constituencies. Employers also play a pivotal role in promoting workplace safety, disseminating accurate and timely information, and safeguarding employee health. However, in the case of migrant populations, the requisite inclusivity in a whole-of-society approach is frequently compromised because migrants, as non-citizens, are often perceived as the other and subjected to moral judgments regarding their entitlement to healthcare and other protections, which are otherwise considered universal entitlements for citizens [119]. This case study reinforces the global lesson that equity and inclusivity are fundamental components of effective pandemic control [120]and the journey toward achieving equity must commence before a pandemic emerges. Only through the establishment of such structural prerequisites can migrants experience reduced vulnerability to pathogen exposure, gain access to health information and services, and enjoy occupational health safeguards and worker protection.

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COVID-19 and migrants: lessons for pandemic preparedness from ... - Globalization and Health

California vs. Florida: Surprising which handled COVID better – Los Angeles Times

November 27, 2023

When California Gov. Gavin Newsom and Florida Gov. Ron DeSantis take the stage Thursday for their much-hyped televised debate, it will be perhaps the starkest visual representation of the divide between the two states.

While many social, political and economic factors contribute to that gulf, perhaps no topic better encapsulates the bicoastal conflict than the states respective responses to the COVID-19 crisis the ramifications of which are still resonating and being debated half a year after the end of the pandemics emergency phase.

On one side was California, which trusted in science and data, as Newsom has put it, and was the first state to issue a stay-at-home order, which helped us avoid the early spikes in cases. It was part of a strategy the Democratic governor reasoned was worth the sacrifice: People are alive today because of the public health decisions we made.

And on the other was Florida, whose approach DeSantis touted as mindful of economic health attacking temporary business closures and vaccine mandates.

We refused to let our state descend into some type of Faucian dystopia, where peoples rights were curtailed and their livelihoods were destroyed, the Republican governor said during a March speech at the Ronald Reagan Presidential Library in Simi Valley, referencing Dr. Anthony Fauci, one of the architects of the nationwide COVID-19 response, who has since retired.

Though the controversy over stay-at-home orders and mask mandates preoccupied the minds of many early in the pandemic, the deeper, more lasting debate surrounding COVID vaccines may be the most notable distinction between the states.

By the first winter wave of the pandemic, COVID-19 rampaged through swaths of California, sending patients to the hospital in droves, overwhelming Los Angeles morgues with bodies and prompting officials to issue new stay-at-home orders.

Florida, with its more laissez-faire approach, seemingly saw a less severe winter, prompting supporters to take something of a victory lap.

But over the next year, as Florida officials adopted a more critical view of COVID-19 vaccines, the Sunshine States fortunes waned. The following summers surge, fueled by the Delta variant, was particularly deadly despite vaccines being widely available.

Given how different California and Florida are in terms of the age of their populations, overcrowded housing and the like its hard to establish a definitive scorecard of who handled COVID-19 better in terms of policy. Structural factors may have provided one state an advantage at any point in time.

But in raw terms, significantly more Floridians died on a per capita basis during the COVID-19 emergency than Californians. Of the four most-populous states, California had the lowest cumulative COVID death rate: 2,560 for every 1 million residents. Floridas rate was 60% worse, with 4,044 COVID fatalities for every 1 million residents, according to a Times analysis of Johns Hopkins University data through early March, when the university ended its data tracking.

In other words, Floridas raw death tally 86,850 in early March came close to Californias total, 101,159, despite California having roughly 18 million more residents.

The overall death toll, however, may not tell the whole story.

When factoring in demographics, another estimate has Florida with an age-adjusted COVID mortality rate thats only slightly higher than Californias. And when adjusting for how Floridas population is relatively unhealthier than Californias, another estimate actually ranks Florida better.

Such caveats cut both ways, though. The pandemic revealed just how rapidly COVID can carve through overcrowded settings. That proved to be a big vulnerability in California, particularly in Los Angeles County, where more homes are overcrowded than in any other large U.S. county, according to a Times analysis of census data published last year.

And Floridas status as a state with one of the oldest populations in the country might have, counterintuitively, prevented the coronavirus from spreading as quickly in the pre-vaccine era. Many of Floridas seniors may have strictly avoided gatherings during that first winter while younger, restriction-weary Californians could have been more apt to travel, socialize and potentially pass the virus to more vulnerable family members.

DeSantis message on COVID shots evolved from boasting about his states high vaccination rate among seniors in early 2021 to this year accusing federal agencies of using healthy Floridians as guinea pigs. He asserted that the latest inoculations have not been proven to be safe or effective, despite strong evidence cited by the U.S. Centers for Disease Control and Prevention and U.S. Food and Drug Administration that they are.

Some health experts say Florida couldve curbed its deadly 2021 summer surge had more younger adults gotten vaccinated and different mitigation policies been implemented.

By mid-June 2021, about 3 in 4 seniors in both Florida and California had completed their primary vaccination series. But just 43% of Floridas younger adults had completed theirs, compared with 54% in California.

Earlier in the pandemic, only 20% of COVID-19 deaths in Florida were people younger than 65. But that share climbed to 40% during the peak of the Delta wave, according to Jason Salemi, associate professor of epidemiology at the University of South Florida.

That was an astonishing number, he said.

The lower vaccine uptake in younger adults probably played a role.

It didnt need to be as bad as it was because I felt like if we would have all kind of read the tea leaves and seen what was happening and started to ... do [more] mitigation efforts ... I think it would have resulted in a much lower morbidity and mortality rate during the Delta wave, he said.

As documented by Florida journalists, DeSantis changed his tone on COVID vaccines by spring 2021 and since has elevated voices skeptical of them.

Florida had an enviable early-vaccination rate among its seniors. But when it came to boosters which first became available in fall 2021 the state had one of the nations worst coverage rates for older adults by the end of the pandemic emergency in spring 2023.

By early 2022, as the highly infectious Omicron variant spawned what eventually would prove the second-deadliest surge of the pandemic nationally, 69% of Californias seniors had received their first booster, compared with 59% of Floridas seniors, according to data from the CDC.

As of early May, 48% of Californias seniors had received an updated booster formulated specifically to combat Omicron, compared with 31% of Floridas seniors.

Since DeSantis shift on vaccines, Floridas cumulative COVID death rate began climbing at a faster pace than Californias a pattern that continued through the end of the pandemic emergency in May.

That shift accelerated after DeSantis appointed a new health secretary and surgeon general, Dr. Joseph Ladapo, who has issued a number of recommendations and statements that have been roundly criticized by other medical officials and experts.

The CDC and FDA went so far as to write an extraordinary public letter rebuking some of Ladapos claims such as his recommendation that young men not receive mRNA vaccines because of an increased risk of cardiac complications. The CDC and FDA said the assertion was incorrect, misleading and could be harmful to the American public and said the risk of stroke and heart attack are actually lower in vaccinated people, not higher.

Ladapo reiterated his critical stance on the latest COVID-19 vaccine formulation in September, and recommended against the shots for those younger than 65. That defied official federal recommendations, which called for virtually everyone 6 months and older to get an updated vaccination this autumn.

COVID-19 continues to pose a risk at all age groups, CDC Director Dr. Mandy Cohen said in an interview with the In the Bubble with Andy Slavitt podcast when asked about Floridas recommendations. We also see a very safe vaccine.

California health officials have defended their approach to the pandemic as appropriately rooted in science, and ultimately effective.

Do I think California did better than Florida? I think your crude numbers show that we did, said Dr. Mark Ghaly, Californias health and human services secretary.

But, he added, Do I think if you really got small and granular, whether its age adjustment, or other adjustments, and add layers of comorbidity ... can you split this even further? Absolutely.

I guess the question for me is: What does it tell you? he said. And in California, I think the data does speak for itself.

California and Florida had similar cumulative COVID-19 death rates in the first few months of the pandemic. But Floridas rate accelerated faster starting in summer 2020 as the state more quickly loosened restrictions.

California saw its own cumulative death rate rise at a faster pace than Floridas during the first pandemic winter, and the gap between the two states narrowed. Still, for virtually the entire pandemic, Californias cumulative death rate has remained below Floridas.

A Times analysis of the unadjusted COVID mortality rate, based on the Johns Hopkins University tally, shows that Florida had the highest rate of the four most populous states and the 12th-worst of the 50 states. Californias rate was 11th lowest of all states.

A separate calculation, which adjusts for age in a database run by the CDC, had Florida with a slightly worse ranking than California the 34th highest age-adjusted COVID mortality rate versus the 38th highest.

A third analysis, published in the medical journal the Lancet earlier this year, looked at COVID-19 death rates through the end of July 2022 and calculated Florida as having a 43% worse unadjusted death rate than California. But when adjusted for differences in age, the gap was narrower with a 12% worse death rate in Florida. When also factoring in how Floridas population as a whole is unhealthier than California, in addition to the age adjustment, the roles reversed and California had a 34% worse adjusted death rate.

But California and Florida may be outliers. A broader look at data from the Lancet report show that states in the South, Southwest and Rocky Mountains had a worse COVID death rate, even when adjusted for age and health conditions, compared with the Northeast and Pacific Northwest.

Our results suggest that vaccine coverage is linked to fewer COVID-19 deaths, and protective mandates and behaviors were associated with fewer infections, the Lancet analysis said. The states that implemented and maintained more mandates were statistically associated, on average, with higher mask use and greater vaccine coverage rates, which in turn were associated with fewer infections.

Generally, the Lancet analysis found that poverty, lower educational attainment, higher rates of chronic health conditions, limited access to quality healthcare services and lower rates of interpersonal trust trust that people have in one another were statistically associated with worse COVID-19 mortality rates.

Some experts are wary about comparing death rates, given how vastly different states can be. Any state-level analysis may also paper over regional differences L.A. Countys death rate, for instance, was much higher than the San Francisco Bay Areas.

The University of South Floridas Salemi called such comparisons apples and oranges.

Theres so many factors at play that help a county or state navigate a pandemic. ... Its not just about these policies, its not just about vaccination uptake although all of those things certainly matter. Its just such a challenging thing to isolate the independent effect of each, Salemi said.

In terms of overall judgment of policymakers in how they tried to tackle the COVID crisis, Dr. Robert Wachter, chair of the Department of Medicine at UC San Francisco, said he thought California was following the scientific evidence better than many other states, including Florida.

When you looked at the early curves of death rates, it was substantially lower in California than in many other states. I think a lot of lives were saved at that stage, he said.

Theres lately been a lot of hindsight history, with some questioning whether the tough measures early in the pandemic were an overreaction, Wachter said. But generally, he said, I dont know how you say that when you have well over a million Americans that have died.

Had Florida been in a vaccine-skeptical mood earlier, there would be many, many, many more deaths in Florida, Wachter said. So Im grateful that in part because my mother lives there, and shes older that the early message at least was in keeping with what the science tells us to do.

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California vs. Florida: Surprising which handled COVID better - Los Angeles Times

Long COVID Now Common in U.S. Nursing Homes – HealthDay

November 27, 2023

MONDAY, Nov. 27, 2023 (HealthDay News) Repeated COVID-19 outbreaks in nursing homes have had a stark and lasting impact on vulnerable older residents, a new study reports.

Long COVID has left many residents of these facilities relying more and more on staff to help them months later with basic, everyday activities such as bathing and using the toilet.

Many also experience a drop-off in their brain function, according to the study by researchers from Michigan Medicine, the University of Michigan's academic medical center.

"Nursing home residents who had COVID-19 experienced new decline in their function and needed substantially more help with daily activities after their acute infection period, lasting for months," said study co-author Dr. Lona Mody, interim chief of geriatrics and palliative medicine at Michigan's medical school and a staff physician at VA Ann Arbor Health Care System. "This places an even greater burden on nursing home staff, who are already stretched thin."

Her team looked at physical and mental functioning in two groups: one made up of nursing home residents who had had COVID and a similar group who had not. They were followed for up to a year.

COVID survivors had continuing effects for about nine months, on average. And 30% of those with a confirmed case of COVID died during the follow up, more than double the percentage of deaths in the comparison group.

For the study, researchers looked at residents who lived in two Michigan nursing homes. They had full data on 90 who tested positive on a PCR test for COVID between March 2020 and October 2021, and 81 residents who lived there during that time but did not have a positive test.

Most were white women over 80 years of age. All had several chronic health conditions and half had dementia. Nearly all were unvaccinated when they got infected.

Researchers compared patients' scores from before the pandemic and over the next year on two scales that nursing homes use to gauge physical and mental functioning. Each had at least four quarterly reports of how much help they needed for activities such as getting dressed, going to the toilet and bathing. The team also looked at residents' scores on mental tasks such as repeating and recalling words and knowing the current date.

"Before the pandemic, the two groups scored about the same on both their need for help with activities of daily living, or ADL, and their cognitive status," said co-author Dr. Sophie Clark, a former geriatrics fellow at Michigan who is now at the University of Colorado. "But the patients who tested positive for COVID showed a sudden decline in both measurements that lasted long after their infection."

Those with dementia continued to decline faster than their peers who had not been infected.

Researchers noted that infection-fighting steps such as reducing social activity and visiting options in 2020 and 2021 may have played a role in the decline.

The study did have a bright spot: Little by little, COVID survivors without dementia regained their ability to do daily activities. A year after infection, they were nearly on par with their uninfected peers.

Researchers noted that the experience of patients in this study may not match what is happening today in vaccinated nursing home patients because those studied mostly got sick before vaccines were available.

"This is especially true for those who have gotten the updated vaccine that became available in September," Mody said. "We encourage all nursing home residents and staff, and the family members who visit these homes, to get vaccinated and help prevent more cases of acute and long COVID in this especially vulnerable population."

The findings were recently published in the Journal of the American Geriatrics Society.

More information

The U.S. Centers for Disease Control and Prevention has more about long COVID.

SOURCE: Michigan Medicine-University of Michigan, news release, Nov. 21, 2023

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Long COVID Now Common in U.S. Nursing Homes - HealthDay

Scientists analyze antibody responses to SARS-CoV-1 and SARS-CoV-2 infections – Medical Xpress

November 27, 2023

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After the outbreak of the novel coronavirus in 2020, vaccines, antibodies (Abs), small molecule drugs, and other interventions needed to be researched, and such a rapid development is partly due to the accumulation of scientific research on severe acute respiratory syndrome virus (SARS virus, SARS-CoV-1), MERS-CoV, and other coronaviruses that cause human disease.

SARS-CoV-1 and SARS-CoV-2 are members of the beta coronavirus and share similarities in the structure and function of the surface membrane protein Spike, and both enter cells through the interaction between the viral spike (S) glycoprotein and the angiotensin-converting enzyme 2 (ACE2) receptor on the host cell surface. However, due to the limitations of technology and methodology, there exist many questions in the characteristics of SARS-CoV-1 antibody response and the relationship with to SARS-CoV-2 antibody response.

Researchers led by Prof. Yang Yuhe from the National Center for Nanoscience and Technology of the Chinese Academy of Sciences, Prof. Zhang Linqi from Tsinghua University, and Prof. Li Taisheng from Peking Union Medical College Hospital have analyzed the antibody response of SARS-CoV-1 convalescents from the aspects of polyclonal antibodies (pAbs) and monoclonal antibodies (mAbs), and they compared the duration, classification and properties of receptor-binding domain (RBD) Abs.

The results were published in Immunity.

Using blood samples from SARS convalescents during their recovery period that had been stored for 20 years, the researchers systematically analyzed the antibody responses of SARS-CoV-1 patients, and made a comprehensive comparison with the antibody responses of SARS-CoV-2 patients.

According to the researchers, the plasma neutralization titer of SARS-CoV-1 convalescents was higher than that of SARS-CoV-2 severe convalescents, and the duration was longer. One reason may be the higher proportion of antibodies targeting SARS-CoV-1 RBD. In addition, cross-binding of plasma from SARS-CoV-1 convalescents is high, but the cross-neutralization is low, suggesting differences in spike gene sequence, protein structure, and immunogenicity between the two viruses.

They isolated 77 mAbs from SARS-CoV-1 convalescents, 60 of which targeted the RBD and most of which showed strong neutralization with SARS-CoV-1, while the other 17 non-RBD Abs showed little or no neutralization. In addition, the neutralization proportion of these RBD Abs was significantly higher than that isolated from SARS-CoV-2 convalescents, consistent with the result of the plasma antibodies response.

The antibodies induced by two coronaviruses have a similar high frequency of mutation after infection, indicating that the mutation and maturation rate of antibody genes follow the internal rhythm of the human body and are independent of the type of virus or the infection severity.

They then analyzed the structure and function of 60 RBD-targeting antibodies. These 60 RBD-targeting antibodies were classified into seven groups by competitive SPR analysis with ACE2 or typical antibodies with known epitopes, named RBD-1 to 7. RBD 1-3 are RBM antibodies that strongly compete with ACE2 and 80R, and have different competitiveness with S230, m396 and S309, respectively.

Subsequently, the binding modes and specificities of 21 selected Abs from the seven groups to the spike of SARS-CoV-1 were further characterized by single-particle, negative-stain electron microscope (ns-EM).

RBD-1 Abs bound to the "peak" of the RBD, RBD-2 Abs bound to the "mesa" and inner ridge of the RBM, RBD-3 Abs targeted to the outer ridge of RBM, RBD 1-3 Abs showed high neutralization to SARS-CoV-1 and weak cross activity. However, RDB-5 and RDB-6 Abs do not compete strongly with ACE2, and the binding sites mainly include the outer face (RDB-5) or the inner face (RDB-6) of RBD.

RBD-6 Abs has weak neutralization but strong cross-reactivity, the IgG and Spike trimer complexes all form the dimers-of-trimers or trimers-of-trimers conformation.

RBD-7 Abs target a specific region on the "up" RBD that interfaced with the N-terminal domain (NTD) of the adjacent spike protomer (NTD proximal). Abs targeting this epitope are extremely rare in reported human COVID-19 convalescents, but account for a large proportion (13/60) of SARS-CoV-1 convalescents and share the same V region gene, which is one of the characteristics of antibody response in SARS-CoV-1 convalescents.

Finally, the team evaluated the cross-neutralization of eight Abs against several novel coronavirus mutants and other ACE2 receptor coronaviruses, and analyzed the structure of the spike protein complex of two cross-antibodies (W328-6A1 and W328-6E10) by cryo-electron microscopy (cryo-EM). It provides structural information for further understanding of the broad neutralization mechanism.

"This work explores the SARS-CoV-1 antibody field, and in parallel explores the antibody response to COVID-19, so we believe that this research perspective will be very valuable. The antibody response caused by SARS-CoV-1 and SARS-CoV-2 infection has many similarities, such as their antibodies can cross each other, and the RBD antibodies mainly contribute to the neutralization," said Prof. Zhang Linqi.

"This study firstly classifies RBD-targeting antibodies of SARS, provides important basis and guidance for the development of new-generation broad coronavirus antibody drugs and vaccines," said Prof. Yang Yuhe.

More information: Ruoke Wang et al, Dissecting the intricacies of human antibody responses to SARS-CoV-1 and SARS-CoV-2 infection, Immunity (2023). DOI: 10.1016/j.immuni.2023.10.007

Journal information: Immunity

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Scientists analyze antibody responses to SARS-CoV-1 and SARS-CoV-2 infections - Medical Xpress

Why people aged over 60 are not getting the Covid-19 vaccine in … – Surinenglish.com

November 27, 2023

Monday, 27 November 2023, 13:36

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The number of people aged above 60 who have received the Covid-19 vaccination this autumn in Malaga province has dropped compared to last year, new data shows.

Not even one in four citizens over 60 has been inoculated - for coronavirus and influenza - according to figures from Andalusian Health Service, seen by SUR. A total of 37% of this age group went to their health centre for the flu vaccination, a figure that drops slightly in the case of Covid-19. According to the head of vaccination in Andaluca, David Moreno, the figure for coronavirus was already lower than that for influenza in 2022, and has has fallen by around five and a half points less than last year.

"In Andaluca, more than 1.2 million people have already been vaccinated. It is not that there is little vaccination, but it is true that if we compare it with last year, it is a noticeable drop," Moreno said. While pointing out that there is less fear of Covid-19 and "less interest" in being vaccinated, Moreno insisted people get their shots as cases start to rise ahead of winter.

"When it gets colder it will be worse, because we start to spend more time indoors with more people and that's how it spreads," he said. "They [the elderly] are people who are more at risk because of their age. They are the ones who are admitted to hospital for flu every year; and the older they are, the greater the risk of complications during admission."

Moreno said peak Covid-19 and flu cases emerge in late December and early January and urged people to get inoculated before then. To get vaccinated appointments can be booked through the Salud Responde app or at the health centre counter.

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Why people aged over 60 are not getting the Covid-19 vaccine in ... - Surinenglish.com

Reversal sought in Tyson COVID death suit dismissals – WCF Courier

November 27, 2023

WATERLOO Attorneys for the estates of Tyson workers who died of COVID-19 related complications during the 2020 pandemic are asking the court to reconsider a ruling that dismissed their lawsuits.

In October 2023, Judge John Sullivan ruled that suits brought by representatives of Kabeya Axel Mukendi and Felicie Joseph lacked jurisdiction in civil court because workplace injuries are covered under workers compensation system, not the courts.

The ruling mirrored a January 2023 decision in suits brought by the representatives of Isidro Fernandez, Sedika Buljic, Reberiano Leno Garcia and Jose Luis Ayala Jr. that failed to find claims of wanton neglect needed to give the court jurisdiction.

While the court recognizes the tragic circumstances that arose from the situation, the law requires that plaintiffs claims proceed under the Iowa Division of Workers Compensation pursuant to the IWCA. This Court lacks the subject matter jurisdiction to consider the plaintiffs claims, Sullivan wrote in his ruling.

The court does not find that the plaintiffs have pled sufficient facts as to each individual defendant that rise to the level of gross negligence amounting to wanton neglect that would remove these matters from the jurisdiction of the Iowa Division of Workers Compensation, the opinion reads.

Workers compensation claims, which have lesser opportunity for damages, have been filed, according to court records.

Attorneys John Rausch, Thomas Frerichs and Mel Orchard III who are handling the Mukendi and Joseph cases asked the district to reconsider the ruling in papers filed earlier this month.

An earlier challenge brought by attorneys in the others suits was defeated in district court.

The lawsuits alleged Tyson officials misled employees at Tyson Fresh Meats in the spring of 2020 about the dangers of the coronavirus and the presence of the virus at the hog-processing facility.

Tyson workers in Waterloo got the COVID-19 vaccine Thursday.

Tyson workers in Waterloo got the COVID-19 vaccine March 4.

Tyson workers in Waterloo got the COVID-19 vaccine March 4.

Tyson workers in Waterloo line up for the COVID-19 vaccine in 2021.

Tyson workers in Waterloo got the COVID-19 vaccine March 4.

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Reversal sought in Tyson COVID death suit dismissals - WCF Courier

Impact of COVID-19-Related Social Distancing on the Incidence of … – Cureus

November 27, 2023

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Impact of COVID-19-Related Social Distancing on the Incidence of ... - Cureus

It’s not over until it’s over. Keep up with the latest COVID research in … – Newswise

November 27, 2023

Since its debut two years ago, the Omicron variant of the COVID-19 virus has demonstrated its remarkable adaptability and transmissibility, defying many virological preconceptions held prior to the pandemic. Its lineage has expanded to include a formidable array of descendants, exhibiting an enhanced ability to evade immune defenses and seek out new hosts.The possibility exists that Omicron could become an enduring presence in our lives, evolving much like the seasonal influenza virus. However, researchers caution that the virus harbors the potential to catch us off guard, particularly if we slacken our vigilance.

Stay informed! Keep up with the latest research on the COVID-19 virus in the Coronavirus channel on Newswise.

Computer simulation suggests mutant strains of COVID-19 emerged in response to human behavior

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The COVID-19 pandemic imposed new burdens on already disadvantaged groups and left pre-existing social inequalities in place

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The Next Phase in Monitoring Wild Animals for COVID-19

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Survey finds many Americans are letting their guard down during respiratory illness season

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WHO updates its guidance on treatments for COVID-19

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U.S. to offer another round of free at-home Covid tests starting Monday – CNBC

November 21, 2023

COVID-19 home test kits are pictured in a store window during the coronavirus disease (COVID-19) pandemic in the Manhattan borough of New York City, New York, U.S., January 19, 2022.

Carlo Allegri | Reuters

The Biden administration on Monday said it is offering another round of free at-home Covid tests to U.S. households ahead of the holiday season, when more people gather indoors and the virus typically spreads at higher levels.

Starting Monday, Americans can useCOVIDtests.govto request four free tests per household. Those who have not ordered any tests this fall can now place two orders for a total of eight tests, according to the website.

The administration in September allowed people to request an initial round of four free tests through the site, resuming a federal program that temporarily shut down during a political fight over Covid funding.

At-home tests are a critical tool to protect against the virus, especially now that lab PCR tests the traditional method of detecting Covid have become more expensive and less accessible since the government ended the public health emergency in May.

But demand for tests, along with Covid vaccines and treatments, has plummeted over the last year as cases and public concern about the virus dwindled from earlier in the pandemic.

Only a small share of Americans appear to be worried about Covid disrupting their holiday plans this fall and winter.

About 3 in 10 Americans said they are concerned they will get seriously sick from Covid or will spread the virus to people close to them over the holidays, according to a poll released Friday by health policy research organization KFF.

Less than half were concerned about the potential for another Covid surge during the winter, which has occurred in previous years of the pandemic, the poll said.

Still, signs of a winter Covid wave are emerging.

More than 16,200 Americans were hospitalized in the week ending Nov. 11, according to the latest data from the Centers for Disease Control and Prevention.That marks an 8.6% increase from the previous week.

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