Category: Corona Virus Vaccine

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5 Ways Government Can Reimagine K-12 School Design in the … – Center For American Progress

November 2, 2023

Nearly four years since the COVID-19 pandemic first plunged Americas education system into turmoil, schools across the country are still fighting to recover from widespread disruptions to student learning and mental health. Many hope to focus their efforts not only on academic recovery and acceleration but also on comprehensive and transformative school redesign.

The term school redesign typically refers to restructuring at the system level meant to address longstanding inequities and facilitate stronger teaching and learning. Redesign is a community-based process that involves transforming not only the physical environment of schools but also the policies and procedures that drive classroom instruction and organize the school day.

School redesign is challengingand given constraints around time, finances, staff capacity, school schedules, credit systems, and a lack of data about what works, it is often also not easily scalable across districts and states. Consequently, a central question remains as state and federal governments look to reimagine education in the wake of the pandemic: How can policymakers promote and scale innovation in school design? The recommendations in this article outline actions that state and federal policymakers can take to foster thoughtful, transformative school redesign and pave the way for community-driven innovation.

Credit systems based solely on hours of instruction, such as the Carnegie unit, do little to address students individual needs. This traditional model holds seat time constant while making learning the variable. However, several states are leading the way in implementing innovative competency-based models that center content mastery as the basis for high school graduation. In Iowa, Kentucky, and Oregon, school districts have the option to offer proficiency-based credit to students who have successfully completed course requirements or otherwise demonstrated mastery of standards. Maine and New Hampshire require all their districts to base credit systems on mastery of course content or state standards. Research has shown that these systems are associated with increased intrinsic motivation and self-management skills among students, particularly in math courses.

Schools must recognize that learning can and does take place outside the classroom. Work-based learning opportunities, internships, apprenticeships, part-time jobs, after-school programs, service learning, at-home learning, and community-based projects all provide valuable opportunities for building knowledge and skills. Rhode Island and New Hampshire have embraced a credit for learning approach to personalize students individual graduation pathways and award credit for out-of-school experiences. Policies such as these improve student engagement and better prepare students for college and careers by recognizing and validating multiple forms of experience and community-based funds of knowledge.

The drawback of offering more flexibility in learning programs, however, is that some students, particularly those who are already marginalized, may fall through the cracks. Robust data collection and transparency are therefore essential to ensure that all students needs are being met in school. Statewide longitudinal data systems that collect students information from their entry into early childhood education to their entry into and participation in the workforceoften referred to as P-20W systemsare key for monitoring school redesign initiatives and making evidence-based decisions that meet student needs. Texas provides the Texas Public Education Information Resource website, which combines multiple sources of data on all the states public school students with reports on teacher certification and school district staffing. Similarly, California recently established its Cradle-to-Career Data System to gather a variety of data points, including students socioeconomic circumstances, in a centralized hub that families, educators, and policymakers can access in their pursuit of equitable educational outcomes. Strategies and systems such as these will help ensure that all students are seen and supported throughout their educational journeys.

To ensure that federal funding is available for states seeking to redesign their assessment systems, Congress should maintain and expand investments in the Competitive Grants for State Assessments (CGSA) program and the Innovative Assessment Demonstration Authority (IADA). Both can play a key role in promoting innovation in response to COVID-19. Funding should be prioritized toward states implementing personalized and competency-based learning approaches. Additionally, Congress should permanently eliminate the original seven-state cap on IADA participation to enable more states to take advantage of redesign opportunities in the future, as well as expand flexibility for states to establish their own timelines for innovative pilot programs. Most importantly, Congress should authorize the IADA to provide federal funding opportunities to support the startup costs associated with state pilot projects in order to incentivize equitable participation. These changes will help address the variety of challenges that participating states have experienced in implementing the authority.

The U.S. Department of Education should assemble and support peer-to-peer interstate learning networks to examine the effectiveness of innovative assessment models in improving student learning outcomes, as well as scale best practices from pilot programs and ongoing redesign efforts. The National Equity Projects District Redesign Network provides an excellent example of a local-level learning network in which participants come together for the purpose of transforming schools. Congress should consider appropriating the funds necessary to revive the Department of Educations State Support Network, a four-year initiative that, before ceasing operations in 2020, brought states together and offered technical assistance for school improvement efforts. As public schools continue to grapple with transforming schools while addressing the effects of the pandemic, state collaboration and federal support are more important than ever to taking advantage of this pivotal moment for the national education system. Finally, Congress should continue to invest in targeted professional development for educators and school leaders in order to expand educators capacity to implement school redesign initiatives from the ground up.

Top-down mandates alone cannot drive the reimagining of public education. Equally necessary is locally driven transformation from the inside outtransformation based on the unique strengths and needs of individual communities. However, state governments still hold an important role in school transformation, including expanding flexibility in scheduling and graduation requirements while holding schools accountable for student outcomes. Further, both state and federal governments can and should fund equitable pilot and seed projects targeted toward schools that have the least capacity and greatest need to restructure their learning environments. This will empower schools to redesign teaching and learning for the generations to come.

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5 Ways Government Can Reimagine K-12 School Design in the ... - Center For American Progress

High school state testing scores are incrementally increasing after … – WPSD Local 6

November 2, 2023

PADUCAH Educators state-wide are trying to close the gap for students who retained less knowledge from hybrid learning during the COVID-19 pandemic.

The Kentucky Department of Education released the state's test results on Tuesday for the 2022-2023 Kentucky Summative Assessment, a benchmark exam given in grades 3 through 8, 10, and 11.

The results showed most schools had a yearly incremental increase since 2020, but it is clear that growth needs to continue.

While most high schools in western Kentucky exceeded the state average, some fell below.

The Kentucky Summative Assessment grades the assessments using Novice, Apprentice, Proficient, and Distinguished.

Schools strive for students to receive Proficient and Distinguished grades. Apprentice is considered below average, and Novice is considered far below standard.

State-wide, the average percentage of high school students that earned a Proficient or Distinguished in reading was 44%. The state-wide average in math was 33%.

Paducah Tilghman High School and Marshall County High School were the only schools to perform below the state average.

The graph below shows how students in western Kentucky performed on the state assessments last year and the year after COVID.

With a few exceptions, schools are seeing improvement in student performance since switching back to in-person classes, and educators are motivated to do what it takes to close the gap.

Ballard Memorial High School tested 12% above the reading average and 33% above the math average.

Ballard Memorial High School tested 12% above the reading average and 33% above the math average.

Principal Tim Adams said the school has programs to maximize student learning.

"We utilize two things here at school. We utilize mastery prep for the ACT, and we utilize i-Ready, which is for our sophomores and freshmen in math and reading," Adams explained.

The i-Ready software allows the administration to assess areas where students need more help.

Principal Tim Adams said the school has programs to maximize student learning.

"Incrementally, we assess those students three times a year, and that allows us to get feedback on their learning...and make adjustments in their instruction," Adams said.

Adams said by preparing students for college and integrating them into career pathways at the Career Technical Center, they receive a quality education.

"When you combine those together, we challenge our students academically in math, science, English, and social studies, but we also provide them the career areas as well," Adams said.

McCracken County High School tested 7% above the state average in reading and 7% above the average in math.

McCracken County Superintendent Josh Hunt said the schools in the district conduct benchmark assessments.

"What we do is take the data from the benchmarks and look at it just like we would state testing data. We look for the gaps. We look at where our weaknesses are," Hunt said.

By adjusting the curriculum throughout the year, students' weaknesses are addressed.

"A lot of our professional learning committees, our communities, and our meetings with our staff are about finding out as we go to more of an individualized approach," Hunt said. "Let's know where each student is and if their individual needs are being met."

Ballard County Schools and McCracken County say ARPA funding during COVID has been a big help to teachers and staff over the past three years.

They've used it to help with tutoring and other student services, but next September, that money will run out.

School officials with Ballard say they hope it won't impact test scores, but they say it is a possibility.

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High school state testing scores are incrementally increasing after ... - WPSD Local 6

Changes in self-reported cannabis use during the COVID-19 … – BMC Public Health

November 2, 2023

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Changes in self-reported cannabis use during the COVID-19 ... - BMC Public Health

Lessons learned from the rapid rollout of nirmatrelvir/ritonavir for … – PLOS

November 2, 2023

Authors: Shanti Narayanasamy, Mwaba Mulenga, Prudence Haimbe, Hilda Shakwelele, Lloyd Mulenga, Jessica Joseph, and Nellie Bristol on behalf of the COVID Treatment QuickStart Consortium

Although nirmatrelvir/ritonavir was strongly recommended more than a year ago by the World Health Organization for rapid treatment of COVID-19, the medication and the technical assistance needed to administer it are still only available in a handful of low- and middle-income countries (LMICs). As COVID-19 continues to circulate globally, ensuring equitable access to the drug and other oral antivirals has been a challenge.

The COVID Treatment QuickStart Consortium is in partnership with ten countries in Africa and Asia to address this inequity. Launched in September 2022, QuickStart brings together Duke University, Americares, the Clinton Health Access Initiative (CHAI), and the COVID Collaborative as implementing partners, with support from the Open Society Foundations, Pfizer, and the Conrad N. Hilton Foundation. QuickStart is supporting governments to introduce and scale up access to COVID-19 testing and treatment for high-risk populationsolder individuals and those with underlying health conditionsreducing their risk of hospitalization and death. In addition to protecting those most vulnerable to severe disease, QuickStart lowers the burden of COVID-19 management on health personnel and services while building capacity within primary care to respond to future emerging infections.

Zambia was the first country to receive a 1,000-course donation of nirmatrelvir/ritonavir in December 2022, coinciding with its 5th wave of COVID-19 infections. Over the next six weeks, health officials successfully integrated the drug into national treatment guidelines, trained healthcare personnel on appropriate use and side effects, and distributed nirmatrelvir/ritonavir across the country. The arrival of effective treatment spurred greater testing and 8,758 cases were reported in January and February compared to 693 recorded in the last quarter of 2022. The Zambia Ministry of Healths (MoH) swift launch of test-and-treat programs resulted in treatment initiation for 434 cases during that two-month period.

Zambias experience is a clear example of how health officials can quickly and effectively deploy new medical countermeasures if they have the necessary tools and partners in place to provide technical assistance. Several characteristics of the response provide key lessons for other LMICs as they launch their own test-and-treat programs.

1. Every program needs a champion

Prior to Zambias fifth COVID-19 wave in December 2022, cases had declined markedly and there was a growing perception globally that COVID was over. In this climate, and faced with other pressing health priorities, advocating for resources to integrate nirmatrelvir/ritonavir into standard-of-care treatment for high-risk patients with mild to moderate COVID-19 was daunting. Dr. Nyuma Mbewe, National COVID-19 Case Management Specialist in the Ministry of Health, drove awareness of the continued threat and its long-term impacts and emphasized the importance of test-and-treat as a fundamental tool in containing spread of the virus. Working closely with health care professionals, policymakers, and community leaders she led development of the program and integration into existing public health services. She also played a crucial role in communicating the significance of testing to the public, building trust in the new treatment, and encouraging widespread participation in the program. Dr. Mbewes actions epitomized the high-level political will and program ownership driven by MoH leadership and government officials. Having a well-placed, locally trusted champion willing to advocate for program implementation was crucial to creating a receptive climate and integral to the successful test-and-treat rollout.

2. Leveraging established organizational structures to integrate COVID-19 disease management into existing programs and management

The test-and-treat program in Zambia was launched through existing patient pathways and points of contact within the national public health system. COVID-19 testing was offered at all hospital clinical entry points for any patients showing symptoms. Patients testing positive had a specific record created and were referred to the COVID-19 center within the hospital. COVID-19 centers have been integrated into existing tuberculosis (TB) programs in Zambia, a crucial part of their success and sustainability. Recognizing the overlapping symptoms and transmission routes of the diseases, this allowed health systems to use well-established TB infrastructure, resources, and expertise to diagnose and manage both diseases simultaneously. The approach has also prevented siloing of COVID-19 testing and treatment and ensured the ongoing viability of the program.

3. A whole-of-team approach to programmatic training

Introducing nirmatrelvir/ritonavir in Zambia during a COVID-19 wave required rapid training of clinical providers. To expedite the process, different cadres of providers were all trained together rather than in individual groups, previously the norm. This was both a more efficient training model and facilitated conversation among providers on potential challenges during the roll-out of a new therapeutic product.

4. Taking a holistic approach to patient care

People at highest risk of severe COVID-19 disease are those with other medical comorbidities. Some high-risk factors, such as diabetes, cardiovascular disease, chronic respiratory diseases, and hypertensionconditions known as non-communicable diseases (NCDs)are not as well known or diagnosed in LMICs despite being a leading cause of death. In Zambia, screening for COVID-19 and NCDs has now become bi-directional, meaning that people testing positive for COVID-19 are now also being assessed for NCDs, while COVID-19 testing is also now occurring at NCD clinics. This new process has been a direct result of the QuickStart program.

COVID-19 is here to stay. Integrating effective test and treat programs into existing health services is critical to containing outbreaks, protecting health resources, and building capacities for primary care and future emergencies. The QuickStart Consortium is dedicated to addressing therapeutics inequities as well as collecting and disseminating implementation lessons to aid other countries in improving test-and-treat programs.

Photo credit: Training/information session with QuickStart data collectors at the TB Clinic at University Teaching Hospital in Lusaka.

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Investigating resiliency and vulnerability of global supply chains during the COVID-19 pandemic – Phys.org

November 2, 2023

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It's no secret that the COVID-19 pandemic disrupted supply chains across the globe. In the United States, it often seemed like stores couldn't keep certain items in stock. Now, new research is diving more deeply into the resiliency and vulnerability of global supply chains during the COVID-19 pandemic.

The research team investigated the U.S.-China supply chain during each of its economic shutdowns in the COVID-19 pandemic and focused on measuring credit risk through one of its most liquid variables called credit default swaps, which essentially is insurance against default. The paper, "The impact of COVID-19 on supply chain credit risk," was published in the journal Production and Operations Management.

Researchers found that when China experienced its economic shutdown first and the rest of the world was not yet impacted, U.S. firms with Chinese suppliers and customers were vulnerable to the economic downturns happening in China.

Conversely, when China's economy reopened and the United States went into an economic shutdown, U.S. firms with Chinese suppliers and customers remained more resilient to the local shocks of the U.S. economy. Essentially, firms with global supply chains remain resilient to local shocks, but it exposes firms to global shocks.

Additionally, the researchers find that factors like firm size, investment grade rating, cash holdings, inventory, number of business segments, network centrality, and capital redeployability make a firm more resilient to global risks. On the other hands, factors like high financial leverage, operational leverage, and strong market competition make a firm more vulnerable to global economic shocks.

Senay Agca, study author and a professor of finance at the George Washington University, says this study demonstrates how markets adjust to global supply chain risks. She said it'll be important for companies moving forward to weigh these pros and cons as they re-evaluate their supply chain strategies.

More information: enay Aca et al, The impact of COVID19 on supply chain credit risk, Production and Operations Management (2023). DOI: 10.1111/poms.14079

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United States Attorney Freedman Announces First-Ever Settlement … – Department of Justice

November 2, 2023

ALBANY, NEW YORK Feast American Diners LLC and Dawood David Beshay, the corporate owner and managing member of multiple Dennys restaurants throughout Arizona and New York, including locations in Syracuse, Auburn, Camillus, Cicero, and Watertown, will pay $2 million to resolve allegations that Beshay falsely certified that Feast American Diners was eligible for a Restaurant Revitalization Fund (RRF) grant when he knew or should have known that his company owned and operated too many locations to qualify for the funding, announced United States Attorney Carla B. Freedman.

United States Attorney Freedman stated: The Restaurant Revitalization Fund was meant to provide a financial lifeline to restaurants and other eligible entities that were struggling to stay afloat during the COVID-19 pandemic. Feast American Diners and Dawood Beshay are paying a steep price for falsely certifying their eligibility for these funds.

Congress enacted the American Rescue Plan Act, in March 2021, as a continuation of the federal governments efforts to provide relief to American individuals and businesses suffering the economic and public health effects of the pandemic. The Act allocated $28.6 billion toward an RRF, to be administered by the United States Small Business Administration (SBA), that could grant qualifying restaurants and other eligible entities monetary awards equal to revenue losses caused by the pandemic. Any restaurant that owned or operated more than 20 locations as of March 13, 2020 was not eligible for an RRF grant.

In April 2021, SBA released guidelines for completing RRF applications. The guidance reiterated that an entity was not an eligible entity if it owned or operated more than 20 locations as of March 13, 2020. At various points throughout the guidance, SBA explained that a restaurant was in operation if it was making sales.

In the settlement agreement, Feast American Diners and Beshay admit, acknowledge, and accept responsibility for the following facts: In May 2021, Beshay applied for an RRF grant on behalf of Feast American Diners, in the amount of $928,554. One of the questions on the application asked whether Feast American Diners owned or operated more than 20 locations as of March 13, 2020, to which Feast American Diners responded no. That same question indicated that an applicant who responded yes would not be eligible for the grant. Later in the application, Beshay affixed his initials next to the following statement: The Applicant, together with its affiliates, does not own or operate more than 20 locations. In fact, Feast American Diners owned 21 Dennys locations as of March 13, 2020 and each of those locations made sales that day, facts that Beshay acknowledges that he should have known.

Those who provide false information for the purpose of receiving and retaining SBA program funds meant for eligible small businesses will be held accountable, said SBA Office of Inspector General (OIG) Eastern Region Special Agent in Charge Amaleka McCall-Brathwaite. Todays settlement sends a strong message that those responsible will be brought to justice. I want to thank the U.S. Department of Justice and our law enforcement partners for their dedication and pursuit of justice.

The investigation began in December 2022, when a whistleblower filed a qui tam complaint under seal in the United States District Court for the Northern District of New York. When a whistleblower, or relator, files a qui tam complaint, the False Claims Act requires the United States to investigate the allegations and elect whether to intervene and take over the action or to decline to intervene and allow the relator to go forward with the litigation on behalf of the United States. The relator is generally able to then share in any recovery. Pursuant to the settlement agreement, the relator will receive $200,000 of the settlement.

The investigation and settlement were the result of a coordinated effort between the United States Attorneys Office for the Northern District of New York, SBA-OIG, and SBAs Office of General Counsel. The United States was represented by Assistant United States Attorney Adam J. Katz.

On May 17, 2021, the Attorney General established the COVID-19 Fraud Enforcement Task Force to marshal the resources of the Department of Justice in partnership with agencies across the federal government to enhance efforts to combat and prevent pandemic-related fraud. The Task Force bolsters efforts to investigate and prosecute the most culpable domestic and international criminal actors and assists agencies tasked with administering relief programs to prevent fraud by, among other methods, augmenting and incorporating existing coordination mechanisms, identifying resources and techniques to uncover fraudulent actors and their schemes, and sharing and harnessing information and insights gained from prior enforcement efforts. For more information on the Departments response to the pandemic, please visit https://www.justice.gov/coronavirus.

Anyone with information about allegations of attempted fraud involving COVID-19 can report it by calling the Department of Justices National Center for Disaster Fraud (NCDF) Hotline at 866-720-5721 or via the NCDF Web Complaint Form at: https://www.justice.gov/disaster-fraud/ncdf-disaster-complaint-form.

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United States Attorney Freedman Announces First-Ever Settlement ... - Department of Justice

Boulder County collaborates on interactive art pieces in response to COVID-19 pandemic – Boulder Daily Camera

November 2, 2023

A 1990s phone booth, part of the Boulder County Public Health sponsored Story Collective art installation, is seen on North Public Road near East Geneseo Street in Lafayette on Wednesday. Other locations are at the Firehouse Art Center in Longmont and at Barker Reservoir in Nederland. (Matthew Jonas/Staff Photographer)

Boulder County Public Health is working with community partners to create a series of interactive art installations across the county that reflect community members experiences of the COVID-19 pandemic.

According to a project website, the exhibits feature oral histories of hope and loss from the pandemic. They were developed with guidance from residents and leaders in each municipality in the county.

All of the installations together form the Story Collective project, which is intended to capture the communitys journey through this time by expressing the fears of the unknown woven with poignant memories, disconnects between the actions we take for ourselves and how they affect the community, and the not-so-subtle push and pull of constant, crucial, conflicting information leaving us feeling disjointed, pulled apart by violent ambivalence, the website stated.

The campaign centers around real voices from our communities and is the result of focus groups with residents from across Boulder County, Indira Gujral, deputy director of Boulder County Public Health, stated in a release. This led to the creation of a design team that included local government representatives and a diverse mix of residents consisting of, among others, a University of Colorado Boulder professor, a bluegrass musician, an opera singer and an immigration activist who worked collaboratively to shape the project.

There will be a total of six art installations, with several already installed at the Firehouse Art Center at 667 Fourth Ave. in Longmont, the Fairy Garden between the intersection of East Street and East Second Street and the western shore of Barker Reservoir in Nederland, and at 186-189 N. Public Road in Lafayette. Others are slated to be added in Lyons and Boulder in the coming months.

More information about the project is available at storycollective.co.

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Boulder County collaborates on interactive art pieces in response to COVID-19 pandemic - Boulder Daily Camera

New COVID vaccines are here: Now’s the time to get one, officials say – Los Angeles Times

October 29, 2023

With Halloween just days away, and the wider autumn and winter holiday season fast approaching, now is the time for most everyone to get their updated COVID-19 vaccine, officials say especially since initial supply shortages have eased.

There are some indications the winter respiratory virus season is just beginning, exacerbating the threat not only of another potential coronavirus wave, but a resurgence of flu and respiratory syncytial virus, or RSV. Last year, all three viruses surged roughly simultaneously, leaving hospitals straining under the weight of a so-called tripledemic.

We have a good supply of COVID-19 and flu vaccines in Los Angeles County and there are options for everyone 6 months and older, county Public Health Director Barbara Ferrer said in a statement. I hope that if many people take advantage of the updated vaccines, L.A. County can avoid a big surge in respiratory virus cases this winter that strains our healthcare system and leads to more deaths.

So far, though, uptake of the updated shots has not been up to snuff for public health officials.

Only 5% of Californians, or 1.8 million people, have received the updated COVID-19 vaccine since it became available last month. Among seniors, the rate is 14%.

Thats not good enough. We should really be seeing much higher rates, especially amongst the old, Dr. Toms Aragn, director of the California Department of Public Health, said at a briefing Thursday. Winter is coming.

Getting the updated shot now, health officials say, will help protect people against the expected wave of COVID-19 thats historically arrived in November and December.

Federal survey data suggest that 7% of U.S. adults got the new COVID-19 vaccine in the first month of the rollout. In a survey in August, 43% of U.S. adults said they planned to get the latest COVID-19 vaccine, according to findings shared by the U.S. Centers for Disease Control and Prevention.

Such uptake would be more in line with that of the annual flu shot. Survey results suggest 47% of U.S. adults got vaccinated during the 202223 flu season. By contrast, only 21% of adults nationwide received the previously updated COVID-19 shot after it was introduced a year ago.

Separately, a survey of more than 1,000 L.A. County adults by the USC Pandemic Research Center suggested that 64% planned on getting the updated COVID-19 vaccine. That would be significantly higher than the 20% of county residents 5 and older and 41% of seniors countywide who received last years reformulated COVID-19 vaccine.

While state officials are pushing for more residents to get vaccinated, the L.A. City Council on Wednesday introduced a motion to sunset that requirement for city employees. If enacted, it would align with similar outside policies, including in L.A. County and the federal government. The state of California ended coronavirus test requirements for unvaccinated state employees in 2022.

There remain demographic disparities among those who are getting vaccinated. Nearly 9% of those living in Californias wealthiest communities have received the new COVID vaccine, compared with fewer than 2% of those living in the lowest-income areas.

Roughly 7% of white Californians have gotten the vaccine, as have 6% of Asian Americans, 4% of Native Hawaiian/Pacific Islanders, 3% of Black, Native American and multiracial Californians and 1.5% of Latino residents.

If youre 6 months or older, you should be getting vaccinated against COVID-19, regardless of previous immunizations, Aragn said. Its no longer a booster. This is now just one shot. And if its been at least two months since the last time you may have received the old bivalent ... booster, or at least three months since youve recovered from an infection, all you need is one shot.

There are a couple of exceptions. The youngest children and those who are immunocompromised may need more than one dose. That is also the case for previously unvaccinated people choosing to get the Novavax vaccine for their first COVID inoculation.

Vaccine supply shortages have eased in recent weeks. But Kaiser Permanente members in Southern California in particular have reported major problems, including being unable for weeks to find appointments close to their homes.

In a statement Thursday, Kaiser said it has a stable supply of the Pfizer-BioNTech vaccine for all age groups.

All healthcare providers nationwide have experienced supply and shipment challenges during the initial launch of the updated COVID-19 vaccine. The majority of those issues have been resolved, the statement said.

Kaiser said some of its locations do not require appointments and that appointments are being added as needed.

The L.A. County Department of Public Health has said anyone including Kaiser members can get the COVID-19 vaccine at no cost at their vaccine sites, including Ted Watkins Memorial Park in Florence-Firestone and Eugene A. Obregon Park in East L.A., which are open from 11 a.m. to 6 p.m. Wednesday through Sunday.

The county also offers vaccinations at eight public health centers in downtown L.A., Hollywood, Willowbrook, Monrovia, Pacoima, Pomona, Whittier and Lancaster.

The county Department of Public Health is considered in-network for all insurers, and can bill Kaiser for the vaccinations.

Uninsured children can get COVID vaccines for free through the Vaccines for Children program. Uninsured adults can get access to free vaccines through Bridge Access Program sites, which include federally qualified health centers and CVS and Walgreens.

No-cost COVID-19 vaccines are also available at the Orange County Health Care AgencysFamily Health Clinic in Santa Ana.

For now, coronavirus levels in wastewater continue to trend downward in Los Angeles County. For the week that ended Oct. 14, the most recent available, the coronavirus level in sewage was 12% of last winters peak, down from 14% the previous week.

This late-year respiratory virus season is the first since the official end of the COVID-19 emergency. And as many return to pre-pandemic norms such as large indoor family gatherings, Aragn urged residents to get vaccinated not only against COVID-19, but the flu and, for those who are recommended, RSV.

As with COVID, officials recommend everyone 6 months and older get vaccinated against the flu via either a shot or a nasal spray. October is an ideal time to get the flu vaccine, but getting it later in the season can still be helpful. Older people also are eligible for a high-potency version of the flu vaccine.

One new development for the flu vaccine this year is that people with a history of allergy to eggs no longer need to take additional safety precautions, according to the CDC.

Most flu vaccines contain a small amount of egg proteins, such as ovalbumin. However, studies that have examined the use of both the nasal spray vaccine and flu shots in egg-allergic and non-egg-allergic patients indicate that severe allergic reactions in people with egg allergies are unlikely, the CDC said.

People who have allergies to other ingredients in the flu vaccine should still avoid getting vaccinated, the CDC said.

Though flu and COVID-19 are not yet spreading widely, circulation of RSV is starting to pick up, Aragn said. RSV can be dangerous, especially for infants and older adults. Immunizations are available at least for certain people.

Those who are at least 60 should talk with their doctor about getting an RSV vaccine, officials say. There are two brands of RSV vaccines available for this age group, one made by GSK, known as Arexvy;and Abrysvo, made by Pfizer.

Those that have chronic medical conditions are the ones that are at highest risk, Aragn said. However, if youre otherwise a very, very healthy 60-year-old, 65-year-old, in consultation with your doctor, you may decide that youre not going to get the vaccine for RSV.

Those who are pregnant can also get a RSV vaccine. They should get it during September through January, only when they are weeks 32 and 36 of their term, to reduce the risk of severe disease in their infants, as the baby will receive protection that will last for months after birth.

Another option to protect newborns is to give them, after birth, an immunization that has preventive antibodies that helps fight RSV infections and protects them from getting very sick.

The immunization is suggested for infants 8 months and younger, as well as those age 8 to 19 months who are at higher risk of severe illness. These antibodies known by the generic name nirsevimab and the trademarked name Beyfortus, which was developed by AstraZeneca and Sanofi are recommended between September and January to help protect babies during RSV season.

There is a shortage of the nirsevimab immunization, the CDC said this week, particularly for prefilled syringe doses intended for babies weighing 11 or more pounds. The CDC recommended that for babies in that weight range, only those at highest risk for severe RSV disease get the immunization.

Masking up continues to be an important tool to help prevent the transmission of infectious diseases, Aragn added, as well as opening the windows, choosing to eat outdoors, being in spaces that are well ventilated, making sure that you wash your hands, and of course, staying home when youre sick, and making sure that you get tested.

Free coronavirus tests remain available at libraries run by the city and the county of Los Angeles, vaccination sites run by the county Department of Public Health, and many food banks and senior centers. Households are also eligible to order four free at-home tests through covid.gov/tests.

In California, most private insurance plans regulated by the state must reimburse their members for eight at-home COVID test kits a month through Nov. 11. After that date, free COVID tests must still be provided through most insurance plans, but covered people must go through an in-network provider to get them at no cost.

For a number of Medicare patients in California, free COVID-19 at-home tests ended on May 11, but COVID-19 testing remains free if ordered by a doctor. For people with a Medicare Advantage plan, the cost of at-home test kits varies and might remain free in some plans, according to the California Department of Public Health.

The L.A. County Department of Public Health suggested that people test for the coronavirus ahead of indoor Halloween and other holiday activities if the guest list includes people at higher risk, such as grandparents, infants and those who are pregnant.

People who get COVID-19 or flu should ask their healthcare provider about treatment options, such as Paxlovid for COVID or a number of anti-flu drugs.

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New COVID vaccines are here: Now's the time to get one, officials say - Los Angeles Times

Could a New Vaccine Head Off the Next Pandemic? – Yale School of Medicine

October 29, 2023

A new experimental vaccine that could provide protection against multiple varieties of dangerous coronaviruses just passed a major hurdle in its development that may bring it closer to being tested in clinical trials, according to David Martinez, PhD, assistant professor of immunobiology at Yale School of Medicine and a member of the Yale Center for Infection and Immunity.

Coronaviruses are behind some of the deadliest outbreaks of the past few decades. These viruses tend to jump from animal hosts to humans. This has occurred at least three times with different coronaviruses during this century. These viruses then produce deadly respiratory illnesses.

For these reasons, developing vaccines that can provide broad coverage against lethal coronaviruses is essential. In a study published in Cell Reports, Martinez and colleagues at the Duke Human Vaccine Institutewhere Martinez worked before coming to Yale in May 2023tested a newly developed vaccine intended to protect against three deadly coronaviruses, including SARS-CoV-2, the virus that led to the COVID-19 pandemic. Martinez, the studys first and lead corresponding author, led the research team along with co-corresponding authors Ralph Baric, PhD, of the University of North Carolina; and Barton Haynes, MD, and Kevin Saunders, PhD, of Duke University.

The study found that vaccinated mice infected with lethal SARS-CoV 2003 and MERS-CoV survived their infections, while unvaccinated mice did not. The vaccine also provided protection against rising SARS-CoV-2 variants, like XBB1.5. This finding could help move the vaccine into phase-1 clinical trials, says Martinez, andeventuallyinto peoples arms.

While the year 2020 is inextricably linked with the coronavirus dubbed SARS-CoV-2, that virus is just one of many that can cause illness and death. This massive group of viruseswhich can be found in animals all over the worldhad shown itself to be a potential danger to people nearly two decades earlier.

In 2003, a coronavirus called SARS-CoV-1, commonly known as SARS (for severe acute respiratory syndrome), started infecting people in Asia. Presumed to have jumped to people from bats, it infected around 8,000 people, nearly 800 of whom diedmaking SARS-CoV-1 the first new, highly-infectious disease of the 21 st century, according to the World Health Organization. Ten years later, anothertotally distinctcoronavirus called Middle East Respiratory Syndrome (or MERS) also emerged, this time spilling over into people from camels.

Despite their being genetically distinct from one another, the viruses had a few commonalities: each one came from animal hosts, mortality rates were relatively high, and the diseases manifested as respiratory illnesses.

It became very clear that coronaviruses are a public threat to humanity, says Martinez. And then came a virus that needs no introductionSARS-CoV-2.

Martinez started working on a universal coronavirus vaccine during his postdoctoral training at the height of the COVID-19 pandemic. After first focusing his research on the development of a vaccine for SARS-CoV-2 he got caught up in the idea of developing a vaccine that could provide broader coverage for other animal-origin coronaviruses.

The concept has precedent. Other scientists have tried to develop universal vaccines for HIV and viruses that cause influenzawith mixed success. To do this, Martinez and his colleagues searched for an Achilles heelan element that the viruses needed to survive, and that the immune system could be reliably expected to spot. The team chose the RBD receptor, a binding domain found both on MERS and SARS that the viruses need to infect host cells.

To make their vaccine, the researchers engineered a scaffold to attach all three versions of the RBD receptor. They then mixed up the vaccine and injected it into their mice, before introducing their subjects to the three deadly viruses.

Vaccinated mice all survived. But some of the unvaccinated succumbed to their infectionshinting that the vaccine was key to helping mice fend off the worst of the illness.

Previous studiesincluding in labs where Martinez has workedhave tested universal vaccines before. But this study is the first to show that a SARS and MERS vaccine can provide protection against three lethal respiratory illnesses in animals, says Martinez.

The vaccine is a triple threat to the viruses, he says.

The vaccine may work because it reduces viral load in the respiratory and nasal passages. One of the reasons that SARS-CoV-2 and other coronaviruses are thought to be so deadly is that the virus accumulates in cells in the lungs.

The researchers found that vaccinated mice had lower viral load in their upper airway in the respiratory system than unvaccinated micehinting that the vaccine was helping to keep down the viral count and potentially reduce transmission.

And the vaccine wasnt just broadly protective of original variants of SARS-CoV-2. Vaccinated mice also had greater immunity to new COVID variants like XBB1.5, which are being included in the updated versions of the fall COVID booster shots.

The universal coronavirus vaccine wont be available anytime soon. And even if it were, it wouldnt entirely eliminate the need for boosters, says Martinez, who is continuing his work on universal vaccines at Yale. But if it passes clinical trials, it might lengthen the time needed between boosters, he says, as newer variants would have less of an edge than they do now.

The vaccine may be good news for more just than tackling coronaviruses. If a universal coronavirus vaccine is approved, it could open the door for developing other universal vaccines to tackle tricky or deadly illnesses, including influenza, Martinez says.

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Could a New Vaccine Head Off the Next Pandemic? - Yale School of Medicine

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