Category: Corona Virus Vaccine

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Virus that causes COVID-19 can damage heart even if heart tissue not directly affected – Healio

March 21, 2024

March 20, 2024

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Among patients who died of acute respiratory distress syndrome associated with SARS-CoV-2, the virus that causes COVID-19, heart tissues were damaged even when they were not directly affected by the virus, researchers reported.

For the NHLBI-funded study, the researchers investigated whether COVID-19-related heart damage was caused by direct action on the heart from SARS-CoV-2 or resulted from systemic inflammation caused by the immune systems response to SARS-CoV-2 infection among patients who died of acute respiratory distress syndrome (ARDS) as a result of COVID-19.

What this study shows is that after a COVID infection, the immune system can inflict remote damage on other organs by triggering serious inflammation throughout the body and this is in addition to damage the virus itself has directly inflicted on the lung tissue, Matthias Nahrendorf, MD, PhD, professor of radiology at Harvard Medical School, said in a press release. These findings can also be applied more generally, as our results suggest that any severe infection can send shockwaves through the whole body.

Nahrendorf and colleagues compared autopsy results, focusing on cardiac macrophages, of 21 people who died of ARDS as a result of COVID-19 and 33 people who died of other causes. They also conducted a study in mice determine what happens to cardiac macrophages after SARS-CoV-2 infection or lung injury not related to SARS-CoV-2.

Compared with people who died of other causes, in people who died of ARDS as a result of COVID-19, there were higher counts of total cardiac macrophages and a greater proportion of CCR2+ macrophages, which promote inflammation, Nahrendorf and colleagues found.

In mice, both infection with SARS-CoV-2 and lung injury not related to SARS-CoV-2 were associated with remodeling of cardiac resident macrophages and expansion of CCR2+ macrophages. In mice with lung injury not related to SARS-CoV-2, treatment with a tumor necrosis factor-alpha-inhibiting antibody reduced cardiac monocytes and CCR2+ macrophages and preserved cardiac function, and among those mice, those with preexisting HF were more likely to die, according to the researchers.

Our data suggest that viral ARDS promotes cardiac inflammation by expanding the CCR2+ macrophage subset and that the associated cardiac phenotypes ... can be elicited by activating the host immune system even without viral presence in the heart, the researchers wrote.

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Disclosures: Nahendorf reports receiving funds or material research support from Alnylam, Biotronik, CSL Behring, GlycoMimetics, GlaxoSmithKline, Medtronic, Novartis and Pfizer and consultant fees from Biogen, Eli Lilly, Gimv, IFM Therapeutics, Molecular Imaging, Sigilon and Verseau Therapeutics. The other authors report no relevant financial disclosures.

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Virus that causes COVID-19 can damage heart even if heart tissue not directly affected - Healio

COVID-19 changed everything in Ventura County four years ago today – VC Star

March 21, 2024

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COVID-19 changed everything in Ventura County four years ago today - VC Star

Severe Lung Infection During COVID-19 Can Cause Damage to the Heart – Diagnostic and Interventional Cardiology

March 21, 2024

March 20, 2024 SARS-CoV-2, the virus that causesCOVID-19, can damage the heart even without directly infecting the heart tissue, a National Institutes of Health-supported study has found. The research, published in the journalCirculation, specifically looked at damage to the hearts of people with SARS-CoV2-associatedacute respiratory distress syndrome(ARDS), a serious lung condition that can be fatal. But researchers said the findings could have relevance to organs beyond the heart and also to viruses other than SARS-CoV-2.

Scientists have long known that COVID-19 increases the risk of heart attack, stroke, and Long COVID, andprior imaging research has shownthat over 50% of people who get COVID-19 experience some inflammation or damage to the heart. What scientists did not know is whether the damage occurs because the virus infects the heart tissue itself, or because of systemic inflammation triggered by the bodys well-known immune response to the virus.

This was a critical question and finding the answer opens up a whole new understanding of the link between this serious lung injury and the kind of inflammation that can lead to cardiovascular complications, said Michelle Olive, Ph.D., associate director of the Basic and Early Translational Research Program at the National Heart, Lung, and Blood Institute (NHLBI), part of NIH. The research also suggests that suppressing the inflammation through treatments might help minimize these complications.

Watch the relatedVIDEO: How to Image COVID-19 and Radiological Presentations of the Virus Interview with Margarita Revzin, M.D.

To reach their findings, the researchers focused on immune cells known as cardiac macrophages, which normally perform a critical role in keeping the tissue healthy but can turn inflammatory in response to injury such as heart attack or heart failure. The researchers analyzed heart tissue specimens from 21 patients who died from SARS-CoV-2-associated ARDS and compared them with specimens from 33 patients who died from non-COVID-19 causes. They also infected mice with SARS-CoV-2 to follow what happened to the macrophages after infection.

In both humans and mice, they found the SARS-CoV-2 infection increased the total number of cardiac macrophages and also caused them to shift from their normal routine and become inflammatory.

When macrophages are no longer doing their normal jobs, which includes sustaining the metabolism of the heart and clearing out harmful bacteria or other foreign agents, they weaken the heart and the rest of the body, said Matthias Nahrendorf, M.D., Ph.D., professor of Radiology at Harvard Medical School and senior author on the study.

The researchers then designed a study in mice to test whether the response they observed happened because SARS-CoV-2 was infecting the heart directly, or because the SARS-CoV-2 infection in the lungs was severe enough to render the heart macrophages more inflammatory. This study mimicked the lung inflammation signals, but without the presence of the actual virus. The result: even in the absence of a virus, the mice showed immune responses strong enough to produce the same heart macrophage shift the researchers observed both in the patients who died of COVID-19 and the mice infected with SARS-CoV-2 infection.

What this study shows is that after a COVID infection, the immune system can inflict remote damage on other organs by triggering serious inflammation throughout the body and this is in addition to damage the virus itself has directly inflicted on the lung tissue, said Nahrendorf. These findings can also be applied more generally, as our results suggest that any severe infection can send shockwaves through the whole body.

The research team also found that blocking the immune response with a neutralizing antibody in the mice stopped the flow of inflammatory cardiac macrophages and preserved cardiac function. While they have yet to test this in humans, Nahrendorf said a treatment like this could be used as a preventive measure to help COVID-19 patients with pre-existing conditions, or people who are likely to have more severe outcomes from SARS-CoV-2 associated ARDS.

For more information:www.nih.gov

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Severe Lung Infection During COVID-19 Can Cause Damage to the Heart - Diagnostic and Interventional Cardiology

COVID-19 testing and vaccination in a deprived local authority: Blackpool – GOV.UK

March 21, 2024

Executive summary

This case study describes the experiences of those working in Blackpool Council and its public health team in supporting testing and vaccination among vulnerable groups, as well as some of the local responses implemented to overcome challenges. It also includes the perspectives of the programme director of a third-sector organisation and 3 Blackpool community champions. The case study has been compiled from a series of in-depth interviews. While there may be themes common to other local authorities, findings may not be generalisable: each local area has its own blend of challenges.

The following themes emerged from our in-depth interviews.

According to interviewees, the high rates of transience and temporary accommodation have constituted important barriers to the effective rollout of the testing and vaccination programmes. They have made it difficult to locate residents in temporary housing, efficiently run the local test and trace system, and create a sense of community cohesion.

Houses of multiple occupation (HMOs) have been described as particularly problematic due to the high number of unregistered HMOs and the severe level of deprivation commonly found among occupants.

Widespread apathy and disengagement among disadvantaged groups, and more particularly within those living in HMOs, was a prominent theme in the interviews. Members of the public health team and Community Champions reported that many Blackpool residents were withdrawn from society and completely disengaged from public health initiatives.

Interviewees reported that a lack of awareness or understanding as one of the barriers to increasing uptake of asymptomatic testing in the community. Some residents were reportedly unclear about the purpose of taking regular lateral flow tests (LFTs), and/or where to collect LFTs.

Blackpool public health team reported having worked closely with local employers to promote asymptomatic testing among employees. According to interview participants, they had found the workplace to be an effective setting to engage migrant workers and younger or disengaged groups. However, the local authority had faced some reluctance from large private organisations concerned about identifying positive cases and losing part of their workforce as a result.

The close collaboration between the public health team and Voluntary Community and Faith Sector (VCFS) organisations was described as having been an essential feature of the response in Blackpool to the pandemic. All interviewees emphasised the key role played by the voluntary community and faith sector in delivering the national testing and vaccination schemes. They reported that the 211,690 grant received in January 2021, as part of the Community Champions Programme, had contributed to supporting vulnerable groups with a variety of needs related to testing and self-isolation.

Interviewees emphasised the importance of a localised approach to supporting testing and vaccination in Blackpool. A localised approach involves using local assets including VCFS, police, fire and rescue teams and other organisations in the community; offering pragmatic support to HMO tenants through the local network; and operating a local test and trace system that complements the national scheme.

According to interview data, the local authoritys efforts towards creating tailored communication was driven by 2 principles: simplifying messaging and emphasising the role of local government as a support provider. It was reported that this tailored approach led to many residents being more receptive towards information on coronavirus (COVID-19) testing.

Blackpool is a large town and seaside resort in Lancashire. It has a high level of deprivation, an older population and a high level of transience. These characteristics have created a singular set of challenges in managing the COVID-19 pandemic. In this study, we explore the experiences of the Blackpool public health team, a third-sector organisation and Community Champions to develop and promote COVID-19 testing and vaccination. We also describe some of the local initiatives implemented to address some of the reported challenges.

This report sets the research context including Blackpools socio-demographic profile, COVID-19 positivity and death rates, as well as test and vaccine uptake numbers. It describes the barriers to testing and vaccination reported by Blackpool public health team and the Programme Director of a large third-sector organisation. The report then outlines the local responses put in place to address these barriers. Finally, we conclude this paper with some future considerations.

This study draws on semi-structured interviews, which were conducted in May and June 2021, with 8 stakeholders who were:

Each interview was conducted remotely, was audio-recorded and lasted between 50 and 60 minutes. Thematic analysis was applied to all interviews in order to identify prominent themes and findings were submitted to interview participants to maintain quality and minimise interviewer bias. In addition to qualitative data, quantitative evidence from NHS Test and Trace data management systems was used to determine levels of testing in Blackpool and describe the local context.

This study was conducted in line with government social research guidance (1) and research participants provided informed consent before data collection. This report was reviewed and approved by the research participants.

The report was completed in July 2021.

The focus of the qualitative element of this report is community testing, and as such, it does not address testing or vaccination in institutional settings such as care homes and hospitals neither of staff nor residents or patients.

While much can be learned from a case study, the generalisability of findings from one locality is limited (2). This research draws on a small sample of participants who shared their personal experiences of developing and managing testing and vaccination services within their local authority.

This study focuses on barriers to testing and vaccination, as reported by interviewees. It also presents the experiences of Community Champions, who have been supporting vulnerable residents during the pandemic, but does not involve any direct reporting from disadvantaged groups in Blackpool. With these limitations in mind, the purpose of the case study is not to generalise the results to the wider population. Instead, it provides a description of some the challenges faced by local authorities, charity organisations and volunteers during the COVID-19 pandemic.

Finally, another limitation of this study is the lack of data on hidden groups such as occupants of unregistered HMOs or temporary migrant workers. As a result, these groups are not included in some calculations, such as positivity rates.

We would draw your attention to a postscript to this case study, provided in May 2023 by the Director of Public Health for Blackpool. This can be found in the Annex to this report.

Blackpool is a unitary authority in the county of Lancashire, in North West England. It has a population of 140,000 and an area of 35 square kilometres. Table 1 gives the age breakdown of Blackpools population. As in other coastal authorities, older people (those aged over 65 years) account for a greater proportion of Blackpools population than is observed at national level. People aged 17 years and under represent 21% of the population (3).

Source: Lancashire.gov.uk

Table 2 gives the ethnicity of Blackpools population. The majority of Blackpool residents are of White ethnicity, with minority ethnic groups estimated to make up just 3% of the population, compared with 15% for all of England and Wales (4).

Source: 2011 Census.

The total does not equal 100% due to rounding.

Population turnover in Blackpool is high. Transience the movement of people with a high degree of residential mobility, which frequently accompanies a chaotic lifestyle has been recognised in Blackpool for a long time (5). Population statistics (6) show that some areas in Blackpool have extremely high levels of population inflow and outflow. For example, Blackpool South Shore has a population inflow rate of 193 per 1,000 population. The 2011 census revealed that, using commonly accepted criteria, 11% of the population in Blackpool could be classified as transient. Further evidence from housing and benefits data suggests that within the first 6 months of settlement, 55% of Blackpools transient residents are likely to move again (4). The section on barriers that the high level of transience and the socio-economic circumstances of transient residents pose for test and trace services.

Transience in Blackpool is closely related with a high rate of temporary accommodation and HMOs. The market for poor quality private rented sector properties is fuelled by former hotel accommodation reaching the end of its life, when it is then converted with or without permission to privately rented small flats and bedsits. There are approximately 3,000 known HMOs in the authority (7).

As a major tourist destination, Blackpool has a lower than average rate of employee jobs in the manufacturing sector and a much greater reliance on service sector employment. It is well-represented in the employment sector of arts, entertainment, recreation and other services (3). As a result, Blackpool has a high proportion of seasonal workers employed in the tourism and hospitality industries. The number of Eastern Europeans, mostly Polish immigrants, working in the resort and surrounding area has grown in recent years (8).

The 2019 Indices of Multiple Deprivation revealed that Blackpool was ranked the most deprived area out of 317 districts and unitary authorities in England (9). Forty-two percent of its lower layer super output areas (LSOAs) were among the 10% most deprived in the country, and 8 of these were also in the top 10 (3). The unitary authority also has a high rate of child poverty with 35% of children in Blackpool living in poverty (nearly half in wards with the worst rates of deprivation), compared with 21% of all children in England.

Unemployment (those actively seeking employment but currently not in a job) is around 8% in Blackpool. This is higher than England (6%) and the North West (6%). The Blackpool working-age population claiming employment and support allowance or incapacity benefit is 13%, compared to 8% for the North West region, and 6% for England (10). Blackpool also has more residents with no qualifications (31%) than the national average (22%) (4)

The high level of poverty in Blackpool is reflected in the public health of this authority. According to the Office for Health Improvement and Disparities annual Local Authority Health Profiles (11), residents in Blackpool have a lower life expectancy than the national average. In the poorest parts, life expectancy is 12.3 years lower than the average for men and 10.1 years lower for women.

Behavioural risk factors for Blackpool (2018 Local Authority Health Profile) include high rates of alcohol-related harm hospital admissions. In Blackpool alone, the hospital admission rate for alcohol-related conditions is 1,015 per 100,000 per year, compared with 663 for England (3). In addition, estimated levels of excess weight in adults (aged 18 and over), smoking prevalence in adults (aged 18 and over) and physically active adults (aged 19 and over) are worse than the England average. In 2019, the suicide rate in Blackpool was well above the country average, with 14 per 100,000 compared to 10 per 100,000 for England (12).

As of 28 June 2021, Blackpool achieved good vaccination uptake, with 95,534 people having received one dose and 77,279 people having received 2 doses. Figure 1 below shows the percentage of people, by age group, who have received at least one dose of vaccination in Blackpool and in Lancashire and South Cumbria. The figure is a column chart, the X-axis representing 13 different age ranges and the Y-axis representing the percentage range from 0 to 100. The green columns represent data derived from people living in Lancashire and South Cumbria and the blue columns represent data derived from people living in Blackpool. Vaccine uptake in both areas is about 55% in the 18 to 24 age range and steadily increases to mid to high 90% in the 55 to 59 age range and remains high for all later age groups.

Source: NHS England

As table 3 illustrates, the proportion of people who had taken a polymerase chain reaction (PCR) test in Blackpool from April 2020 until 26 May 2021 was slightly lower than the test uptake for the North West region (42% versus 47% of the population).

Source: NHS Test and Trace Data Management System

Source: NHS Test and Trace Data Management System

Although the uptake in PCR testing in both regions was much reduced between 1 January to 26 May 2021 (Table 4), the number of tests administered per capita was higher in Blackpool (Table 5). This indicates a higher rate of multiple testing of some Blackpool residents.

Source: NHS Test and Trace Data Management System

Similar to PCR uptake, lateral flow test (LFT) rates show that, while the number of individuals tested is at the same level in Blackpool and North West (Table 6), the number of tests administered is higher in Blackpool (Table 7). This, again, indicates a higher rate of repeated testing in Blackpool.

Source: NHS Test and Trace Data Management System

Source: NHS Test and Trace Data Management System

Note: the provision for asymptomatic testing of staff at Blackpool Teaching Hospitals NHS Trust was via a technology called Loop Mediated Isothermal Amplification (LAMP) which would not have been included in either LFT or PCR testing numbers via NHS Test and Trace Data Management System. At the time of the study, the Universal Testing Offer was in place and NHS staff using LFTs may have been accessing testing via this route. The implications of this are that when comparing testing rates between geographies there may have been an impact on the calculation of testing rates (both proportion of individuals participating in testing and number of tests per person). Given the intensity of testing in care homes, and the relatively low number of care homes in the Blackpool local authority area, this may also explain why slightly lower rates of testing were observed via the NHS Test and Trace testing programme.

Blackpool has a substantial transient population, with approximately 8,000 people moving into and out of the area over the course of 2015 (13). These include people moving from other parts of the country to access low-cost housing, seasonal workers, especially from Eastern Europe, and an estimated 500 Gypsy families, according to Blackpool public health officials.

The high rate of transience results in high levels of movement between properties within Blackpool, especially in the private rented sector. The local authority has a large proportion of poor quality privately rented housing, often converted from former guest houses. These have led to intense concentrations of deprivation, and an environment that contributes to lack of opportunity and poor health. Participant B described the severity of the housing situation as follows:

We have the largest tourist economy in the country. Huge stock of ex-holiday homes, ex-bed and breakfasts, converted into very poor accommodations. Its really shocking. It was never built to house people all year round. We have this problem. Bigger here than anywhere else in the country.

Interviewees reported that the high level of low-quality temporary accommodation has been one of the main challenges of rolling out testing and vaccination programmes in Blackpool. They explained that a high level of transience not only makes it extremely difficult to create a sense of community cohesion, but also hinders their ability to locate residents in temporary housing and run the local test and trace system as efficiently as they could.

Interviewees reported that problems associated with inadequate and poor-quality HMOs were identified before the pandemic but that they have since been exacerbated.

Regarding HMOs, that was recognised way before COVID. Weve looked at the uptake in these areas, we know the uptake falls by age, we know its lower for males. Its not a feeling. We know theres a problem in HMOs.

(Participant B)

According to interviewees, one of the main challenges of reaching residents living in HMOs has been the high proportion of unlicensed HMOs and unregistered HMO residents. As 2 interviewees said:

We have a lot of people not registered and living in HMOs. We cant know what our rates are if we dont know the actual numbers. Landlords have been using terms such as students accommodations, but theyre not.

(Participant C)

Theres a lot of sofa surfing and things like that. Informal arrangements. About demographics, we actually dont know since many people arent registered with GP practices. Were suspecting its more than in other places.

(Participant B)

Interviewees description of a sizeable hidden population in Blackpool indicates that the number of positive cases in the authority may be higher than the official figures. Another reported obstacle of engaging HMO occupants was that many are vulnerable individuals living in precarious conditions.

Its not a student population in HMOs. Theyre older than that. People who have been around, theyve got drug problems, drifted around, ended up in Blackpool because its cheap accommodation here, just go to the pub and live on the social security.

(Participant C)

Members of the local public health team concurred that the greatest constraint to rolling out COVID-19 vaccination in HMOs has been the imposition of an age limit. They believed that promoting the vaccine among HMO tenants, while only a proportion of occupants may be in the relevant age bracket, would be ineffective.

The biggest barrier is the vaccine age limit. Were going to get in there once we get in there, we need to be able to offer it to everybody. The message go get the vaccine if youre the right age is too complicated for our population. Its either get the vaccine or dont get the vaccine.

(Participant C)

Theres no point going to an HMO where 6 people live and say Three of you, you can get it, and the rest of you cant have it.

(Participant B)

A prominent theme in interview data was reported apathy and disengagement around COVID-19 testing and vaccination commonly found within some disadvantaged groups, and more specifically among HMO occupants. Interviewees described some Blackpool residents as showing low levels of either health literacy or engagement. One of the interviewees described the phenomenon as follows:

Weve done segmentation work before. We know we have a really large population that are just not engaged with their own health and well-being in general. If they fell ill, they wouldnt do anything about it.

(Participant B)

Furthermore, members of the public health team highlighted that the town includes a large number of residents who are withdrawn from society and, as a result, disengaged from public health initiatives.

The fatalistic and disengaged are a large chunk of people who come to Blackpool and live in HMOs, arent really interested in the wider world. It doesnt matter what the message is, they arent interested.

(Participant C)

One of the barriers to asymptomatic testing described in the interviews is a lack of awareness, as well as some level of confusion, about regular symptomatic testing. Some residents are reportedly unclear about the purpose of taking regular LFTs and/or where to collect LFTs.

The comms to get tested twice a week hasnt really reached anyone anywhere. Theres a large part of the community that seems unaware that they can get tests from the chemist, et ceteraThere seems to be a void in the comms.

(Participant B)

Members of the public health team said that they had detailed data on polymerase chain reaction (PCR) uptake, but were not well sighted on asymptomatic home testing.

For some things we have a huge amount of details. Because we do our own contact tracing. Weve got good information on the symptomatic PCR testing going on. In terms of positive and negative tests. The bit were unsure is the LFT routine, we dont have as much detail there.

(Participant B)

Interviewees described 2 reasons for lack of traceability of LFTs being a barrier to promoting regular asymptomatic testing. First, the local authority is unable to identify the final recipients of collected LFTs unless self-tests are associated with a given official structure such as a school, a workplace or medical setting.

Whether it goes to all the right places and engaging all the right peopleWe dont have that level of detail. Especially with the testing at home. When its attached to a certain setting: school, NHS centre, et cetera, we do have this data. Otherwise, we dont know

(Participant A)

Secondly, although the Blackpool public health team was able keep track of the number of LFTs collected from the various available outlets, they reported a gap in the data where residents do not register their results online.

We know how many packs theyre taking from us but other than that we dont know the results.

(Participant C)

Interviewees expected that many Blackpool residents would not register negative LFT results due to the perceived complexity of the online registration process, which they described as too difficult and very long-winded. On the other hand, they believed that positive LFTs do get reported and are followed by a confirmatory PCR test.

Interviewees described large private organisations reluctance to support testing in the workplace as a missed opportunity (Participant A). While local employers had reportedly embraced the local authoritys campaign for regular testing of asymptomatic employees, national companies in Blackpool had not engaged. According to interviewees, large companies disengagement was due to trade unions opposition to workplace testing schemes, as well as employers concerns about identifying positive asymptomatic cases and losing part of their workforce as a result.

In the workplace, we have an issue with the largest national employers. We cant get it in supermarkets, we couldnt get it in [organisation name redacted] where we have 3,500 people in Blackpool. Because of the trade unions and this not being part of their policy.

(Participant C)

In response to COVID-19, Blackpool public health team reported having established close collaboration with the voluntary community and faith sector (VCFS) which were already providing services to the community pre-pandemic. One aspect of the cooperation between the local authority and VCFS consisted of fortnightly briefings during which the council, Blackpool public health and third-sector organisations discussed the latest official guidance, local priorities and barriers or concerns experienced by the community. Interviewees spoke positively about the collaboration:

The councils approach was key. They very quickly created the infrastructure to bring together the third sector. Council pulled together the infrastructure of the third sector and did it on a geographical basis, so it is accessible equally. The relationship between third sector and local authority is much better than before the pandemic. Having access to the [director of public health] on a regular basis has made a great difference.

(Participant E)

There has traditionally been a third sector-local authority split. Because local authorities used to provide funding. In working together, weve proven that we could achieve so much more.

(Participant D)

In January 2021, Blackpool Council received a 211,690 grant from central Government through the Community Champions Programme. This funding has contributed to supporting the work of volunteers who have offered vulnerable groups assistance with a variety of needs related to testing and self-isolation. Interviewees reported that Community Champions funding was split among 9 organisations in key areas and has made a significant difference (Participant E). Community Champions funds were used to provide VCFS organisations with physical resources, including food parcels, to support vulnerable residents.

Community Champions activities have also been supported by the creation of the Corona Kindness Hub whose goal has been to provide a single point of contact for residents in need of assistance during the pandemic. The hub is staffed with over 100 approved volunteers who have intimate knowledge of their community and how to engage it. In order to minimise negative socio-economic impacts of self-isolation, the Corona Kindness Hub has helped disadvantaged Blackpool residents by providing a wide breadth of support, including help to obtain food, health care and medication; with welfare, mental health and loneliness; help for someone they care for; with utilities and bills, and around debt or benefits (including claiming Statutory Sick Pay).

According to interview data, another important role of VCFS and Community Champions has been to disseminate public health messages and tackle any misinformation from the early stage of the pandemic.

Misinformation isnt really an issue because it was addressed by third sector organisations very early on. Digital comms have been useful to address that.

(Participant E)

Members of the public health team described VCFS as an invaluable asset to support vulnerable groups with testing, self-isolation and vaccination. They also explained that close collaboration with VCFS is aligned with the local authoritys effort to adopt a localised approach drawing on community resources.

A prominent theme that emerged from interviews was the importance of a localised or geographical (Participant E) approach to supporting testing and vaccination in Blackpool.

We have close neighbourhoods in Blackpool. It is not diverse in terms of its population. People identify with the estate or the area they live in. We look at the geographical split and trusted organisations within those geographies.

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COVID-19 testing and vaccination in a deprived local authority: Blackpool - GOV.UK

Four years after shelter-in-place, COVID-19 misinformation persists – Austin American-Statesman

March 19, 2024

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COVID vaccines found to cut risk of heart failure, blood clots following virus infection: Study – ABC News

March 19, 2024

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Brazil: Bolsonaro indicted over alleged falsification of vaccination data – The Associated Press

March 19, 2024

SAO PAULO (AP) Former Brazilian President Jair Bolsonaro was formally accused Tuesday of falsifying his COVID-19 vaccination status, marking the first indictment for the embattled far-right leader, with more allegations potentially in store.

The federal police indictment released by the Supreme Court alleged that Bolsonaro and 16 others inserted false information into a public health database to make it appear as though the then-president, his 12-year-old daughter and several others in his circle had received the COVID-19 vaccine.

Police detective Fbio Alvarez Shor, who signed the indictment, said in his report that Bolsonaro and his aides changed their vaccination records in order to issue their respective (vaccination) certificates and use them to cheat current health restrictions.

The investigation found several false insertions between November 2021 and December 2022, and also many actions of using fraudulent documents, Shor added.

The detective said in the indictment that Bolsonaros aide-de-camp, Mauro Cid, told investigators the former president asked him to insert the false data into the system for both himself and his daughter. Cid also said he delivered the vaccination certificates to Bolsonaro personally.

During the pandemic, Bolsonaro was one of the few world leaders who railed against the vaccine. He openly flouted health restrictions and encouraged other Brazilians to follow his example. His administration ignored several offers from pharmaceutical company Pfizer to sell Brazil tens of millions of shots in 2020, and he openly criticized a move by Sao Paulo states governor to buy vaccines from Chinese company Sinovac when no other doses were available.

Brazils prosecutor-generals office will have the final say on whether to use the indictment to file charges against Bolsonaro at the Supreme Court. The case stems from one of several investigations targeting Bolsonaro, who governed from 2019 to 2022.

Bolsonaros lawyer, Fbio Wajngarten, called his clients indictment absurd and said he did not have access to it.

When he was president, he was completely exempted from showing any kind of certificate on his trips. This is political persecution and an attempt to void the enormous political capital that has only grown, Wajngarten said.

The former president denied any wrongdoing during questioning in May 2023.

Gleisi Hoffmann, chairwoman of the Workers Party, whose candidate defeated Bolsonaro, celebrated his indictment on social media. She said she hopes the former president stands trial in many other cases, including for his alleged attempt to sneak $3 million in diamond jewelry into the country and the sale of two luxury watches he received as gifts from Saudi Arabia while in office.

He has lied until this day about his nefarious administration, but now he will have to face the truth in the courts. The federal polices indictment sent to prosecutors is just the first of several, Hoffmann said. What is up now, Big Coward? Are you going to face this or run away to Miami?

Brazils Supreme Court has already seized Bolsonaros passport.

Police accuse Bolsonaro and his aides of tampering with the health ministrys database shortly before he traveled to the U.S. in December 2022, two months after he lost his reelection bid to Luiz Incio Lula da Silva.

Bolsonaro needed a certificate of vaccination to enter the U.S., where he remained for the final days of his term and the first months of Lulas term. The former president has repeatedly said he has never taken a COVID-19 vaccine.

If convicted for falsifying health data, the 68-year-old politician could spend up to 12 years behind bars or as little as two years, according to legal analyst Zilan Costa. The maximum jail time for a charge of criminal association is four years, he said.

What Bolsonaro will argue in this case is whether he did insert the data or enable others to do it, or not. And that is plain and simple: Either you have the evidence or you dont. It is a very serious crime with a very harsh sentence for those convicted, Costa told The Associated Press.

Shor also said he is awaiting information from the U.S. Justice Department to clarify whether those under investigation did make use of the false vaccination certificates upon their arrival and stay in American territory.

If so, further charges could be leveled against Bolsonaro, Shor wrote without specifying in which country.

The indictment sheds new light on a Senate committee inquiry that ended in October 2021 with a recommendation for nine criminal charges against Bolsonaro alleging that he mismanaged the pandemic. Then prosecutor-general Augusto Aras, who was widely seen as a Bolsonaro ally, declined to move the case forward.

Brazilian media reported that Aras successor, Paulo Gonet, was scheduled to meet lawmakers later Tuesday to discuss the possibility of filing charges.

Bolsonaro retains staunch allegiance among his political base, as shown by an outpouring of support last month, when an estimated 185,000 people clogged Sao Paulos main boulevard to decry what they and the former president characterize as political persecution.

The indictment will not turn off his backers and will only confirm his detractors suspicions, said Carlos Melo, a political science professor at Insper University in Sao Paulo.

It is definitely worse for him in courts, Melo said. He could be entering a trend of convictions, and then arrest.

Brazils top electoral court has already ruled Bolsonaro ineligible to run for office until 2030, on the grounds that he abused his power during the 2022 campaign and cast unfounded doubts on the countrys electronic voting system.

Another investigation relates to his alleged involvement in the Jan. 8, 2023, uprising in the capital of Brasilia, soon after Lula took power. The uprising resembled the U.S. Capitol riot in Washington two years prior. Bolsonaro has denied wrongdoing in both cases.

Shor wrote that the indictment will be folded into the investigation of Jan. 8, which is being overseen by Supreme Court Justice Alexandre de Moraes. That justice authorized the unsealing of the indictment.

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Brazil: Bolsonaro indicted over alleged falsification of vaccination data - The Associated Press

Brazil police indict Bolsonaro over alleged falsification of vaccination data – The Guardian

March 19, 2024

Covid-19 investigations

Former president allegedly inserted false information into public health database to make it appear he received Covid vaccine

Staff and agencies in So Paulo

Tue 19 Mar 2024 10.57 EDT

Brazils federal police have accused Jair Bolsonaro of criminal association and falsifying his own Covid-19 vaccination data, marking the first indictment for the embattled far-right leader with others potentially in store.

The supreme court on Tuesday released the polices indictment which alleges Bolsonaro and 16 others inserted false information into the public health database to make it appear as though the former president, his 12-year-old daughter and several others in his circle had received the Covid-19 vaccine.

During the pandemic, Bolsonaro was one of the few world leaders railing against the vaccine, openly flouting health restrictions and encouraging society to follow his example. His administration ignored several emails from the pharmaceutical company Pfizer offering to sell Brazil tens of millions of shots in 2020 and openly criticized a move by So Paulo states then governor, Joo Doria, to buy vaccines from the Chinese company Sinovac when no jabs were otherwise available.

Brazils prosecutor-generals office will have the final say on whether to use the police indictment to file charges against Bolsonaro at the supreme court. It stems from one of several investigations targeting Bolsonaro, who governed between 2019 and 2022.

The former president reiterated that he had not taken the Covid-19 vaccine and said he was calm. Its a selective investigation. Im calm, I dont owe anything, Bolsonaro told Reuters. The world knows that I didnt take the vaccine.

Police accuse Bolsonaro and his aides of tampering with the health ministrys database shortly before he traveled to the US in December 2022, two months after he lost his re-election bid to Luiz Incio Lula da Silva.

Bolsonaro needed a certificate of vaccination to enter the US, where he remained for the final days of his term and the first months of Lulas term.

If convicted for falsifying health data, the 68-year-old politician could spend up to 12 years behind bars, and as little as two years, according to legal analyst Zilan Costa. The maximum jail time for a charge of criminal association is four years, he said.

Bolsonaro retains staunch allegiance among his base, as shown by an outpouring of support last month, with an estimated 185,000 people clogging So Paulos main boulevard to decry what they and the former president characterize as political persecution.

Brazils top electoral court has already ruled Bolsonaro ineligible until 2030, on the grounds that he abused his power during the 2022 campaign and cast unfounded doubts on the countrys electronic voting system.

Other investigations include one seeking to determine whether Bolsonaro tried to sneak two sets of expensive diamond jewelry into Brazil and prevent them from being incorporated into the presidencys public collection. Another relates to his alleged involvement in the 8 January 2023 uprising in the capital, Braslia, soon after Lula took power, that resembled the Capitol riot in Washington two years earlier. He has denied wrongdoing in both cases.

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Brazil police indict Bolsonaro over alleged falsification of vaccination data - The Guardian

Exploring the Link Between COVID-19 Research and Psoriatic Disease – Dermatology Times

March 19, 2024

Four years after the start of the COVID-19 pandemic, researchers are continuing to make strides in their understanding of the relationship between the virus and dermatologic conditions, including psoriasis.

This week,Dermatology Timesis highlighting recent COVID-19 research affecting skin, hair, and nails. Recently-published studies have explored the relationship between COVID-19 infection and psoriatic disease severity, case reports of psoriasis onset and exacerbation following vaccination, and more. We review these studies below.

In one study, researchers investigated psoriasis flare-ups following COVID-19 vaccinations, examining 71 patients with a history of plaque psoriasis who experienced flare-ups post-vaccination.1 They also explored cases of new-onset psoriasis and modifications in psoriasis subtypes. The research delved into various factors including patient characteristics, vaccination details, and exposome traits such as sex, age, comorbidities, and UV exposure. Clinical manifestations aligned with traditional symptoms of psoriasis, with pustular psoriasis being the most frequently reported subtype modification. The study found no significant association between biological treatment and flare occurrence, and timing of flare-ups varied widely. Additionally, there was an analysis of psoriasis flare-ups following non-COVID-19 vaccinations, albeit with fewer cases identified.

In one systematic review, registered on PROSPERO, researchers investigated cases of psoriasis exacerbation or induced psoriasis post-COVID-19 vaccination.2 The review included research articles and correspondence reporting such cases, excluding active psoriasis cases. Through searches in PubMed, Google Scholar, and EBSCOHost until June 2022, 33 relevant articles were identified and analyzed. The included studies detail demographics, vaccine types, onset of psoriasis symptoms, comorbidities, and treatments. Most cases involved individuals with a history of psoriasis, with Pfizer being the most commonly associated vaccine. The onset of symptoms varied from 1 to 90 days post-vaccination, and treatments ranged from topical steroids to monoclonal antibodies, with notable clinical improvement observed in many cases.

Another study explored the rare but potentially life-threatening variant of psoriasis known as generalized pustular psoriasis (GPP) and its interaction with COVID-19 infection, a topic scarcely documented previously.3 The report presented 2 cases of individuals with GPP who experienced fatal outcomes following SARS-CoV-2 infection. The first case involved a 20-year-old male with a history of psoriasis vulgaris who experienced a sudden exacerbation of GPP leading to acute respiratory distress syndrome (ARDS) due to COVID-19 infection. Despite medical intervention, including methotrexate and acitretin treatment, the patient succumbed to the illness. The second case was a 52-year-old female with a history of GPP under treatment with acitretin and cyclosporine, who also developed ARDS following COVID-19 infection and passed away despite medical management. Both cases underscore the potential severity of COVID-19 infection in individuals with GPP and emphasize the importance of awareness among dermatologists regarding the heightened risk of mortality in such patients.

A study conducted at the Second Affiliated Hospital of Zhejiang University aimed to assess the impact of COVID-19 infection on patients with plaque psoriasis, particularly those treated with or without biologic agents.5 Involving 209 patients over 18 years old with confirmed SARS-CoV-2 infection, the research categorized participants into non-biologics, ADA, IXE, and SEC treatment groups. Analysis of demographic data, treatment history, and PASI scores before and after COVID-19 infection revealed a significant increase in median PASI scores across all groups post-infection, indicating exacerbated psoriasis severity. Notably, patients treated with IXE demonstrated a lower likelihood of psoriasis exacerbation following COVID-19 infection compared to those on other biological agents. Additionally, serum analysis showed that biological agents, including ADA, SEC, and IXE, suppressed serum OAS2 and OAS3 levels while elevating OAS1 levels, potentially contributing to the protective effect against psoriasis exacerbation.

A population-based multicenter study investigated the incidence of COVID-19, medical interventions, and COVID-19-associated mortality among patients with psoriasis from December 2022 to February 2023 across 6 hospitals in China.6 Patients receiving psoriasis treatment were included, with those undergoing immunosuppressive therapy for reasons other than psoriasis excluded. Data on COVID-19 diagnoses, interventions, and mortality were collected, along with patient characteristics and treatment details. Statistical analysis revealed significant associations between treatment types, COVID-19 incidence, and outcomes. Specifically, IL-23 inhibitor treatment showed a decreased risk of COVID-19 compared to other treatments, with patients experiencing fewer symptoms and lower COVID-19 mortality. Outdoor work was associated with reduced COVID-19 risk, while vaccination status did not significantly correlate with infection rates. Additionally, patients with other allergic diseases exhibited lower COVID-19 risk.

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Exploring the Link Between COVID-19 Research and Psoriatic Disease - Dermatology Times

Analysis finds positive risk-benefit for Novavax COVID vaccine – University of Minnesota Twin Cities

March 19, 2024

A new analysis of data in Influenza and Other Respiratory Viruses finds that the incidence of COVID-19 hospitalization is more than double among patients with any psychiatric disorder compared to adults with no psychiatric disorder.

The longitudinal study is based on electronic health records collected from four health systems and research centers in Indiana, Oregon, Texas, and Utah that partner with the Centers for Disease Control and Prevention (CDC). The study follow-up period lasted from December 2021 to August 2022, after both widespread vaccination campaigns and the Omicron variant became features of the pandemic in the United States.

Among the 2,436,999 adults included in the study, the median age was 47. Women composed 58.3% of the sample, 66.1% were White, 12.9% were Black, 12.0% were Hispanic, and 3.6% were Asian. Among participants, 41.6% were unvaccinated, 35.7% had received two doses, and 22.7% had received three doses.

A total of 538,034 adults had any psychiatric disorder, including 13.6% with anxiety disorders, 12.9% with mood disorders, 3.1% with trauma or stressor-related disorders, 1.9% with attention-deficit hyperactivity disorders, and 1.0% with psychotic disorders.

Adults with psychiatric disorders were hospitalized at a rate of 394 per 100,000 person-years, compared with a rate of 156 per 100,000 person-years for those without psychiatric disorder.

Psychiatric disorder was a significant predictor of COVID-19-associated hospitalization (adjusted hazard ratio, 1.27; 95% confidence interval, 1.18 to 1.37). Mood disorders, anxiety, and psychotic disorders were most associated with hospitalization.

Adjusted hazard ratios for hospitalization among vaccinated and unvaccinated adults with or without psychiatric disorders was the same.

The relative protection associated with mRNA vaccination was similar irrespective of psychiatric disorder status.

"The relative protection associated with mRNA vaccination was similar irrespective of psychiatric disorder status, underscoring the benefit of COVID-19 vaccination in this population," the authors concluded.

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Analysis finds positive risk-benefit for Novavax COVID vaccine - University of Minnesota Twin Cities

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