Category: Corona Virus Vaccine

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Seattle plays big role in coronavirus vaccine that boosted immune response – KING5.com

July 16, 2020

Researchers and volunteers in the Puget Sound region are advancing toward testing a COVID-19 vaccine on thousands of people to see if it really does work.

SEATTLE A Seattle researcher whos studying a coronavirus vaccine undergoing clinical trials is pleased with early results that show the vaccine mounts an immune response.

The vaccine, which is being developed by the National Institute of Allergy and Infectious Diseases and drugmaker Moderna, was the first to be tested in the U.S. On Tuesday, researchers reported 45 volunteers developed neutralizing antibodies in their bloodstream similar to levels seen in patients who survived COVID-19.

Seeing this is just wonderful, said Dr. John Dunn, a researcher with the Kaiser Permanente Washington Health Research Institute in Seattle.

Dunn said so far theres no serious safety concerns with the vaccine, which is given in two shots, a month apart. One of the participants, Neal Browning of Bothell, said he did experience a little soreness at the injection site the morning after he received a dose but that only lasted a few minutes.

Much like you'd get when you had a typical flu shot, Browning said.

Researchers are still waiting to see how the vaccine affects people over the age of 55, which is a population more vulnerable to serious illness.

They also don't yet know how long the immunity from this experimental vaccine lasts. That's something they're still studying.

However, Dunn praised these early results as a big step.

The advancement of knowledge of medicine in general is usually made up of hundreds of little tiny steps and this, as little steps go, this is a big one in fact, Dunn said.

By the end of the month, the trial will expand to include 30,000 participants, who will help prove if the vaccine can indeed extinguish the coronavirus.

The Associated Press contributed.

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Seattle plays big role in coronavirus vaccine that boosted immune response - KING5.com

Global report: Bangladesh hospital owner accused of faking thousands of Covid-19 test results – The Guardian

July 16, 2020

A Bangladesh hospital owner has been arrested over allegations he issued thousands of fake negative coronavirus test results, as the Australian state of Victoria recorded the worst daily rise in cases for the nation since the pandemic began, and global coronavirus cases passed 13.5 million, according to Johns Hopkins University data.

Regent hospital owner Mohammad Shahed was arrested trying to fleeing to India in a burqa after a nine-day hunt, police said. He is one of more than a dozen people detained by authorities in recent days over allegations that clinics in Uttara and Mirpur issued fake certificates to patients saying they were virus-free without testing them.

Experts say false documents have worsened the already dire virus situation in the country of 168 million people by casting doubt on the veracity of certificates issued by clinics.

Bangladesh has reported just over 193,000 infections and 2,457 deaths so far but the real figures are likely much higher because little testing has been carried out.

Police spokesman Colonel Ashique Billah told AFP: He was arrested from the bank of a border river as he was trying to flee to India. He was wearing a burqa.

His hospitals carried out 10,500 coronavirus tests, out of which 4,200 were genuine and the rest, 6,300 test reports, were given without conducting tests.

Shahed is also accused of charging for the certificates and virus treatments despite agreeing that his hospitals in the capital, Dhaka, would provide free care.

Italy last week suspended flights to Rome from Bangladesh after several passengers arriving from Dhaka tested positive for Covid-19. Some of those who tested positive in Italy were allegedly carrying negative coronavirus certificates from Bangladesh, said Shakirul Islam of migrant rights group OKUP.

The government must ensure quality of Covid-19 tests in local laboratories for the sake of its overseas job market, said Islam.

Nearly $19bn was sent back to Bangladesh by an estimated 12 million migrant workers last year, according to the central bank.

In Australia, the state of Victoria, reported two more deaths and 317 cases on Thursday: the largest daily increase in cases for an Australian state since the start of the pandemic. Two men in their 80s died, bringing the total coronavirus deaths in the state to 29 and upping the national toll to 113. There are 109 people in hospital with 29 in intensive care, with total of 4750 cases since the pandemic began, state premier Daniel Andrews said.

The state government has paused some elective surgeries including hip and knee surgery at Melbourne health services to make sure extra beds are available.

In the United States, Dr Anthony Fauci, the senior public health expert on the White House coronavirus task force, said the US needed to focus from a federal level on getting the virus now surging in the south and west under control rather than these games people are playing.

Weve got to almost reset this and say, OK, lets stop this nonsense, he said in an interview with the Atlantic when he was asked to describe the truth about the federal response to the pandemic.

Faucis comments came as US cases increased by a world daily record of more than 67,400, taking the total to nearly 3.5 million confirmed infections.

In better news, Fauci predicted on Wednesday the country would meet its goal of a vaccine by years end, he told Reuters in an interview, saying, I feel good about the projected timetable.

His comments follow promising early-stage data for Moderna Incs coronavirus vaccine, released on Tuesday, that was developed by scientists at the National Institute of Allergy and Infectious Diseases, which Fauci directs.

The news about the vaccine being developed by Moderna affected markets, which rallied in response to the rising hopes for a Covid-19 vaccine on Wednesday, and the S&P 500 climbed back to where it was a few days after it set its record early this year.

Other key global developments include:

Canadas efforts to flatten the curve have put the country on the brink of zero deaths for the first time since March, but officials see worrying signs of a new spike as provinces lift restrictions.

Brazils president, Jair Bolsonaro, has again tested positive, he told reporters on Wednesday in Brasilia, suggesting he has yet to recover from an infection first diagnosed last week, Reuters reports.

Irelands prime minister, Micheal Martin, said on Wednesday night the government continues to advise against non-essential overseas travel, as he announced that a planned move to phase 4 reopening had been postponed to 10 August because the countrys reproduction rate the number of people infected by a virus carrier had increased to more than 1.

South Africa surpassed 300,000 confirmed coronavirus cases late on Wednesday. The countrys 311,049 cases make up close to half of Africas total.

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Global report: Bangladesh hospital owner accused of faking thousands of Covid-19 test results - The Guardian

York County has one new death linked to COVID-19, 16 total statewide – York Dispatch

July 16, 2020

VIDEO: Coronavirus: 6 tips for staying healthy York Dispatch

York County saw its 67th death linked to COVID-19 as of noon Thursday, while 34 new cases pushed the total to 1,942 since the outbreak began, the state Health Department reported.

Statewide, the case total hit 98,446, an increase of 781 overthe day prior. There were also 16 new deaths. The death toll now stands at 6,973.

There have been 885,195 patients in the state who have tested negative for COVID-19,27,632 of whom reside in York County.

More: Coronavirus pandemic: Here's what York County's data looks like

More: And now ... a coin shortage?

The age breakdown of those who have been tested in the state are as follows, according to the Health Department:

As of Thursday morning,there were more than 13.5million confirmed cases of the coronavirus worldwide, with 585,500 deaths linked to the virus,according to Johns Hopkins University.

About 3.5million cases hadbeen confirmed in the U.S. with cases spiking in some states, particularly across the Sun Belt and in the Westwith the death toll exceeding 137,000.

Logan Hullinger can be reached at lhullinger@yorkdispatch.com or via Twitter at @LoganHullYD.

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York County has one new death linked to COVID-19, 16 total statewide - York Dispatch

Coronavirus: What’s happening around the world on Thursday – CBC.ca

July 16, 2020

The latest:

Florida reportedthe largest one-day increase in deaths from the novel coronavirus since the pandemic began and its second-largest increase in cases ever on Thursday.

Florida announced 13,965 new cases on Thursday, bringing the total number of cases in the state and the centre of the latest outbreak to over 315,775, according to the state health department.

Florida's COVID-19-related deaths rose by 156 to a total of 4,782, surpassing its previous one-day record of 133 new deaths on July 12. Current hospitalizations of patients with COVID-19 was the highest ever reported at 8,626, up 321 in the past 24 hours, according to a state agency.

The United Statesis the worst-affected country in terms of infections, followed by Brazil and India. More than 137,000 people have died in the U.S. as a result of the virus, the highest of any country. As of 12:25 p.m. ETon Thursday, the global coronavirus case count stood at 13,589,273, with 584,990deaths and 7,607,033 cases considered recovered, according to data from Johns Hopkins University.

On Thursday,CVSsaidit would require customers to wear face coverings while shopping at its U.S. pharmacies, joining a host of retailers, including Walmart,in their push to curb the spread of the coronaviruspandemic.

Meanwhile, Republicans will significantly limit the number of attendees at the party's August convention nominating U.S. President Donald Trump for a second White House term in Jacksonville, Fla., amid the ongoing surge of cases.

The shift to a smaller gathering is the latest in a series of changes sought by organizers as they scramble to host a large-scale event next month amid the health crisis.

WATCH |Infection control epidemiologist responds to questions on the evolving risk of coronavirus:

"We had hoped to be able to plan a traditional convention celebration to which we are all accustomed. However, adjustments must be made to comply with state and local health guidelines," Republican National Committee chairRonna McDaniel said in a letter delivered to delegates on Thursday.

Elsewhere in the U.S., bars and restaurants in New York City that receive three "strikes" for failing to enforce physical distancing will be forced to close, Gov.Andrew Cuomo said on Thursday. Separately, an announcement on whether New York City would enter Phase 4 of reopening will be made at 4 p.m. ET on Friday, Cuomo said.

In Georgia, officialswere headed for a clash over masks to fight the spread of the coronavirusafter the Republican governor barred mayors from requiring residents to wear them. Gov.Brian Kemp issued an executive order late on Wednesday suspending local regulations requiring "face coverings, masks, face shields or any other personal protective equipment" in public.

The order said residents were "strongly encouraged" to wear face coverings in public. Kempsuggested any order mandating masks would be too restrictive. Savannah Mayor Van Johnson, who issued a mask mandate in his city on July 1, reacted swiftly.

"It is officially official. Governor Kemp does not give a damn about us. Every man and woman for himself/herself. Ignore the science and survive the best you can," Johnson, a Democrat, wrote on Twitter. "In Savannah, we will continue to keep the faith and follow the science. Masks will continue to be available!"

Atlanta Mayor Keisha Lance Bottoms, a Democrat, issued an order requiring masks in Georgia's largest city on July 8.

As of 12:25 p.m. ET on Thursday, Canada had 109,082confirmed and presumptive coronavirus cases. Provinces and territories listed 72,782of those as recovered or resolved. ACBC News tallyof deaths based on provincial reports, regional health information and CBC's reporting stood at 8,858.

WATCH |Labour lawyer cautions that enforcing mask policies is likely to cause some conflict:

A Russian hacking group has gone after COVID-19-related vaccine research in Canada, the U.K. and the U.S., according to Canada's cyber spies.

The Communications Security Establishment, responsible for Canada's foreign signals intelligence, said APT29 also known as Cozy Bear and the Dukes is behind the malicious activity. The group "almost certainly operates as part of Russian intelligence services," the CSE said in a statement released Thursday morningin co-ordination with its international counterparts, an allegation the Kremlin immediately denied.

Cozy Bear has been identified by Washington as one of two Russian government-linked hacking groups that broke into the Democratic National Committee computer network and stole emails ahead of the 2016 presidential election. The other group is usually called Fancy Bear.

Spain paid tribute Thursday to the nation's victims of the novelcoronavirus and workers who put their lives at risk during the worst of the pandemic with a solemn state ceremony in Madrid.

Relatives of around 100 people who died during the pandemic, andrepresentatives of medical personnel, police and other essential workers, joined King Felipe VI and Queen Letizia, government members and officials from the European Union and the World Health Organization at an esplanade in Madrid's Royal Palace.

The guests, masked and seated in a physicallydistanced fashion surrounding a central cauldron, included representatives from a dozen religious organizations and ambassadors. As a live performance of string music took over from the speeches, attendees left white roses by the cauldron.

Spain has officially recorded 28,413 deaths from the virus, although excess mortality figures suggest the actual figure is thousands higher. The country is grappling with dozens of fresh outbreaks after it emerged from a strict lockdown last month.

WATCH |White roses, black masks in Spanish tribute to COVID-19 victims:

In France, new Prime Minister Jean Castex said masks will be mandatory in closed public places as of next week, sooner than Aug. 1 as announced earlier by President Emmanuel Macron.

The change in date comes as the Mayenne area of the Loire region has seen several COVID-19 outbreaks, and authorities have recorded a marginal increase in infections in the Paris region.

Calling the situation in Mayenne "problematic," French Health Minister Olivier Veran said he asked the prefect of Mayenne personally to make masks compulsory in closed public places without waiting for the later date.

Australia's coronavirus hot spot the state of Victoria is reporting a record 317 newly confirmed cases in a day. The tally for Thursday surpassed the state's previous high of 288 on July 10.

The previous one-day Australian record was 212 cases set March 28 by New South Wales state duringthe first peak of the pandemic. New South Wales reported only 10 new cases Thursday. Two men in their 80s died in Victoria in the last 24 hours, bringing the country's death toll for the pandemic to 113.

Victoria's government is reducing the number of non-urgent surgeries allowed in hospitals to increase beds available for COVID-19 patients. State officials had planned to restore hospitals to normal medical services by the end of July before infections began to rise in recent weeks.

WATCH | Australian PM says situation in Victoria 'very concerning'

Confirmed coronavirus cases in Tokyo hit a new daily record with 286, raising alarm Japan may be reopening too quickly. Tokyo Gov. Yuriko Koike said one reason for the recent rise in cases is increased testing, which numbered more than 4,000 on Thursday.

She said 760 people are hospitalized, seven of them in serious condition, while more than 350 are quarantined at hotels and homes.Japan has had fewer than 23,000 confirmed coronavirus cases, and about 1,000 deaths.

Israel reached a new daily record of confirmed coronavirus cases, the country's Health Ministry said Thursday, as a new nationwide lockdown to curb the pandemic appeared imminent.

The Health Ministry on Thursday reported 1,898 new cases of the virus. The country has registered more than 44,500 total cases. At least 380 Israelis have died of COVID-19, the illness caused by the virus.

Adding to Prime Minister Benjamin Netanyahu's troubles, a new economic bailout plan announced by the embattled premier came under tough criticism from some of the government's top economic experts.

The growing coronavirus outbreak, coupled with a struggling economy, have marked a dramatic turnaround for Netanyahu. The Israeli leader received widespread praise for moving quickly to contain the coronavirus last spring.

But since lifting a series of restrictions in May, the country has experienced a surge in cases. With unemployment over 20 per cent, the pandemic's economic impact is generating domestic unrest and Netanyahu's approval rating is plummeting.

Hospitals in Iran face acute shortages of medical personnel and beds as the country tackles a powerful second wave of the COVID-19 pandemic, a senior official of Tehran's anti-coronavirus task force said on Thursday.

Iran, the Middle East country hardest hit by the pandemic, began relaxing its lockdown in mid-April. But a second wave of infections emerged in early June and has proven much more serious than the first one, said Reza Jalili-Khoshnood, who is himself infected, the semi-official ISNA news agency reported.

WATCH | Where are we in the pandemic?

Iran recorded 13,608 related deaths as of Thursday, including 198 in the previous 24 hours, according to Health Ministry spokespersonSima Sadat Lari, who wasspeaking on state TV.Sadat Lari told state television that the total number of diagnosed cases in the country had reached 267,061, up by 2,500 in the last 24 hours.

Jalili-Khoshnood was quoted as saying that at one hospital Tehran's Shohada, where he is hospitalized 172 medical staff have been infected themselves or are caring for infected family members. He said he there were also shortages of beds, including of intensive care beds.

His comments contrast with President Hassan Rouhani's regular assurances that Iran has sufficient supplies of medical personnel and facilities. While struggling to curb the spread of COVID-19, Iranian authorities are concerned that tougher measures against it could wreck an economy already reeling under U.S. sanctions.

India's virus cases have surged another 32,695, taking the national count closer to one million and forcing a new lockdown in the popular western beach state of Goa, two weeks after it reopened to tourists.

The new confirmed cases took the national total to 968,876. The Health Ministry on Wednesday also reported a record number of 606 deaths for a total of 24,915.

The Indian Medical Association said 99 doctors have died and another 1,302 are infected with the coronavirus. It called for shortening of working hours for health workers following safety concerns. It also said the fatality rate among doctors was 7.6 per cent, much higher than the national average of about 2.5 per cent.

About a dozen states, including Maharashtra, Tamil Nadu, West Bengal and Assam, have put high-risk areas under lockdowns, allowing only essential food supplies and health services.

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Coronavirus: What's happening around the world on Thursday - CBC.ca

COVID-19 Daily Update 7-13-2020 – 6 PM – West Virginia Department of Health and Human Resources

July 14, 2020

TheWest Virginia Department of Health and Human Resources (DHHR)reports as of 6:00 p.m., on July 13, 2020, there have been 211,006total confirmatorylaboratory results received for COVID-19, with 4,313 totalcases and 97 deaths.

DHHR has confirmed the death of an 85-yearold female from Ohio County. Pleasejoin with me as we grieve the loss of another West Virginian, said DHHRCabinet Secretary Bill J. Crouch.

In alignment with updated definitions fromthe Centers for Disease Control and Prevention, the dashboard includes probablecases which are individuals that have symptoms and either serologic (antibody)or epidemiologic (e.g., a link to a confirmed case) evidence of disease, but noconfirmatory test.

CASESPER COUNTY (Case confirmed by lab test/Probable case):Barbour(20/0), Berkeley (518/19), Boone (34/0), Braxton (5/0), Brooke (27/1), Cabell(192/7), Calhoun (4/0), Clay (12/0), Fayette (84/0), Gilmer (13/0), Grant(21/1), Greenbrier (71/0), Hampshire (42/0), Hancock (41/3), Hardy (46/1),Harrison (122/0), Jackson (148/0), Jefferson (253/5), Kanawha (421/12), Lewis (21/1),Lincoln (9/0), Logan (39/0), Marion (106/3), Marshall (65/1), Mason (25/0),McDowell (8/0), Mercer (63/0), Mineral (66/2), Mingo (29/2), Monongalia(554/14), Monroe (14/1), Morgan (19/1), Nicholas (19/1), Ohio (147/0),Pendleton (15/1), Pleasants (4/1), Pocahontas (37/1), Preston (81/21), Putnam(90/1), Raleigh (80/3), Randolph (188/2), Ritchie (2/0), Roane (12/0), Summers(2/0), Taylor (22/1), Tucker (6/0), Tyler (10/0), Upshur (31/2), Wayne (127/1),Webster (1/0), Wetzel (37/0), Wirt (6/0), Wood (179/9), Wyoming (7/0).

As case surveillance continues at thelocal health department level, it may reveal that those tested in a certaincounty may not be a resident of that county, or even the state as an individualin question may have crossed the state border to be tested.Such is the case of Cabell, Lewis, Logan, Marion, Mingo, Nicholas, Ohio, andPreston counties in this report.

Please visit thedashboard at http://www.coronavirus.wv.gov for more detailed information.

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COVID-19 Daily Update 7-13-2020 - 6 PM - West Virginia Department of Health and Human Resources

Modified vaccine against yellow fever also seems to work against COVID-19 – Innovation Origins

July 14, 2020

[Update] A yellow fever vaccine, which is already around 80 years old, also seems to work in a modified form against COVID-19. Virologists from the Rega Institute at the Belgian university KU Leuven have booked good results with this modified vaccine in tests on hamsters.

The Belgian researchers will begin the first clinical trials on humans at the end of this year.

The team led by Professor Johan Neyts and Dr. Kai Dallmeier started in January with the development of eight variants of a vaccine against the novel coronavirus. The trials identified one candidate vaccine that appears to work particularly well in hamsters. After the administration of this vaccine, the virus was no longer or barely detectable in the hamsters lungs.

We saw up to half a million times less of the virus infection in the hamsters that received the candidate vaccine than in the hamsters from the control groups. The animals were also spared any lung infections. By contrast, the lungs of the test animals in the control groups were clearly damaged, Neyts explains. Whats more, even a single dose of the candidate vaccine was enough to protect against the infection. This also occurred in several animals even within ten days of being vaccinated.

The candidate vaccine was produced based on the existing yellow fever vaccine and is thus able to trigger an immune response in both COVID-19 and yellow fever in the test animals. A piece of the genetic code of the SARS-CoV-2 virus was incorporated into the yellow fever vaccine. The team had already used this platform to make candidate vaccines against ebola, zika, and rabies.

The effectivity of the yellow fever vaccine has been proven more than once, Neyts goes on to explain. It has already been in use for about eighty years and almost 800 million people have been vaccinated with it during that period. One dose of the vaccine results in lifelong protection against yellow fever. Of the more than 160 vaccines under development to combat COVID-19, we are the only ones who are using yellow fever as a basis.

In order to select the most potent of the eight prototype vaccines, we not only tested which prototype generates the most antibodies in hamsters but also which one offers the most effective protection against infection. This increases our chances of finding a successful candidate, says Professor Neyts. Only by using an infection model will you be able to find out if one or more doses are needed and how quickly the vaccine will be effective enough after vaccination.

The candidate vaccine stimulates the body to produce antibodies against the corona viruss protrusions, thereby preventing the virus from attaching itself to healthy cells.

Given that an experimental vaccine from a research laboratory cannot be administered to people straightaway, a specialist company accredited for that purpose now needs to manufacture the candidate vaccine. This is done according to the strictest quality standards. The team is currently in talks with manufacturing partners.

If everything else continues to run smoothly, we expect to start the first clinical trials on humans by winter, says Kai Dallmeier, who runs the vaccine team. Normally it takes at least ten years to develop a vaccine. So, we worked at a very fast pace. And we are not alone: a lot of vaccines are being developed all over the world. Thats a good thing because at this stage its important to be able to bet on different horses.

The study A potent single-dose live-attenuated YF17D-vectored vaccine against SARS-CoV-2 by Lorena Sanchez Felipe et al. was published on the pre-print bioRxiv server pending peer review.

In an earlier release of this article, the suggestion was made that the vaccine being tested now is the eighty-year-old yellow fever vaccine. This is not accurate. It concerns a vaccine based on the old vaccine.

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Modified vaccine against yellow fever also seems to work against COVID-19 - Innovation Origins

COVID-19 patients can be overwhelmed with inflammation. Doctors are learning to calm that storm. – The Philadelphia Inquirer

July 14, 2020

When it was all boiled down, people with COVID seemed to cluster into three broad immunotypes, said E. John Wherry, director of Penns Institute for Immunology. Loosely speaking, some patients immune systems seemed to have overreacted to the virus, while others were slow to react. In a third group, the immune system did not seem to respond much at all.

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COVID-19 patients can be overwhelmed with inflammation. Doctors are learning to calm that storm. - The Philadelphia Inquirer

Coronavirus daily news updates, July 13: What to know today about COVID-19 in the Seattle area, Washington state and the world – Seattle Times

July 14, 2020

Editors note:This is a live account of COVID-19 updates from Monday, July 11, as the day unfolded. It is no longer being updated. Clickhereto see all the most recent news about the pandemic, andclick hereto find additional resources.

Throughout Monday, on this page, well be posting Seattle Times journalists updates on the outbreak and its effects on the Seattle area, the Pacific Northwest and the world.

Updates from Sunday can be found here, and all our coronavirus coverage can be found here.

The following graphic includes the most recent numbers from the Washington State Department of Health, released Monday evening.

Washington health officials released two unusual numbers related to the coronavirus pandemic on Monday evening, confirming 1,101 additional COVID-19 cases and 39 fewer deaths than the day before.

That amounts to a record-high one-day count of diagnoses, bringing the total in the state to 41,757. The previous one-day high was 1,087, reported July 6, the Monday after the holiday weekend. Tallies are often slightly higher on Mondays as the state catches up with data from diagnoses over the weekend.

It's also a rare and significant drop in the death tally, bringing the state's total deaths to 1,399. The state Department of Health (DOH) did not immediately respond to requests for an explanation of the anomaly.

The updated numbers mean about 3.5% of people diagnosed in Washington have died,according to DOH.

So far, 708,274 tests for the novel coronavirus have been conducted in the state, per DOH. Of those, 5.9% have come back positive since testing began slightly higher than the rate of positive tests in the past week, whichthe state reportsis at 5.5%.

About 44.6% of the state's deaths have occurred in King County, Washington's most populous, where DOH on Monday confirmed 12,077 diagnoses and 624 deaths (13 fewer deaths than the state reported for King County on Sunday).

Elise Takahama

WASHINGTON With U.S. virus cases spiking and the death toll mounting, the White House is working to undercut its most trusted coronavirus expert, playing down the danger as President Donald Trump pushes to get the economy moving before he faces voters in November.

The U.S. has become a cautionary tale across the globe, with once-falling cases now spiraling. However, Trump suggests the severity of the pandemic that has killed more than 135,000 Americans is being overstated by critics to damage his reelection chances.

Trump on Monday retweeted a post by Chuck Woolery, once the host of TVs Love Connection, claiming that Everyone is lying about COVID-19. Woolerys tweet attacked not just the media and Democrats but the Centers for Disease Control and Prevention and most doctors that we are told to trust. I think its all about the election and keeping the economy from coming back, which is about the election.

At the same time, the president and top White House aides are ramping up attacks against Dr. Anthony Fauci, the nations top infectious diseases expert. Fauci has been increasingly sidelined by the White House as he sounds alarms about the virus, a most unwelcome message at a time when Trump is focused on pushing an economic rebound.

Associated Press

As scientists race to test coronavirus vaccines in humans, a parallel scramble is underway to produce billions of medical-grade vials and syringes that will be needed to inoculate the worlds population.

The job of delivering vaccine to a majority of humans within two years is so vast that global production of pharmaceutical vials needs to be ramped up by 5 to 10% within two years, a job the industry says requires immediate preparation and increases in production but is not an insurmountable challenge.

Governments and drug companies around the world are placing huge orders worth hundreds of millions of dollars and pushing the makers of vials and syringes to add manufacturing capacity.

Compared with the rush of laboratory studies and clinical trials needed to produce vaccines that can safely and effectively block the virus, the work of producing vials is prosaic stuff but just as important.

The Washington Post

President Donald Trump and Education Secretary Betsy DeVos have told public school districts they must open fully for the 2020-2021 school year during the coronavirus pandemic, and they threatened to withhold federal funding from school districts that dont comply.

The threats, however, are largely just that: threats without real teeth behind them.

While presidents can in some cases legally withhold funding appropriated by Congress, they cant do it without notifying Congress and in some cases getting approval. (Some have tried and been struck down by courts, and DeVos has been held in contempt of court as education secretary for refusing to stop collecting loans from former students of a chain of for-profit colleges that closed.)

Trump and DeVos who often talk about the importance of local control of education also have no authority to force schools to open at a particular time or in a specific way.

Those are state and local decisions, regardless of how much Trump and DeVos shout about it.

Read the full story here.

Valerie Strauss, The Washington Post

SACRAMENTO, Calif. California Gov. Gavin Newsom on Monday extended the closure of bars and indoor dining statewide and ordered gyms, churches and hair salons closed in most places as coronavirus cases keep rising in the nations most populated state.

On July 1, Newsom ordered 19 counties with a surging number of confirmed infections to close bars and indoor operations at restaurants, wineries, zoos and family entertainment centers like bowling alleys and miniature golf.

The Democratic governor extended that order statewide Monday. He also imposed additional restrictions on the 30 counties now with rising numbers, including the most populated of Los Angeles and San Diego, by ordering worship services to stop and gyms, hair salons, indoor malls and offices for noncritical industries to shut down.

The data suggests not everybody is practicing common sense, said Newsom, whose order takes effect immediately.

He didnt include schools, which are scheduled to resume in a few weeks in much of the state. But Monday, the states two largest school districts, San Diego and Los Angeles, announced their students would start the school year with online learning only. LA Unified is the second-largest public school district in the country.

Read the full story here.

The Associated Press

Mass transit systems around the world have taken unprecedented and expensive steps to curb the spread of the coronavirus, including New York shutting down its subways overnight and testing powerful ultraviolet lamps to disinfect seats, poles and floors.

The cleaning measures produced something commuters have not seen in a while, or possibly ever: thousands of freshly scrubbed cars that look, feel and even smell clean. But experts say those steps solve only part of the problem, and transit officials are studying more advanced methods that might someday automatically disinfect transit systems around the clock.

All that cleaning does cut the threat of catching the virus, experts say, but the benefits are limited.

The virus transmits predominantly through droplets in the air its everywhere and could be nowhere, said Robyn Gershon, a clinical professor of epidemiology at New York University.

Cleaning a train car at a maintenance yard overnight or even several times during the day, as New Yorks Metropolitan Transportation Authority does might not help the transit employee or passenger stuck in close quarters with a coughing person.

Wearing a face mask will protect us the most, having that control among ourselves, Gershon said. I think the rest of it is really more the illusion, and thats not a small thing because it plays with our psyches.

"But to what extent are we now overspending, or veering too far into security theater? asked Nick Sifuentes, executive director of the New York-based advocacy group Tri-State Transportation Campaign, which found that cleaning topped a list of actions people wanted before they would feel comfortable riding mass transit again.

Read the story here.

The Associated Press

Approximately 3 percent of front-line UW Medicine health care workers have COVID-19 antibodies, below the rate found in the general population, the UW MedicineVirology Labannounced Monday

These early results show that steps taken to protect health care workers are effective and that front-line workers at UW Medicine are at no greater risk than the the population at large, UW Medicine said in a statement.

UW Medicines goal in offering antibody testing to all employees has been to determine the prevalence of previous COVID-19 infection within the population of health care workers compared to the prevalence in the general public.

The initial phase of testing focused on staff at Harborview Medical Center, UW Medical Center, Airlift Northwest and UW Neighborhood Clinics with direct exposure to COVID-19 patients, including those working in the Emergency Department and dedicated COVID-19 intensive and acute care units.

A second phase of testing included health care workers from regular inpatient units. UW Medicine employees who fall outside of these two groups are also being offered the test in a third phase, UW Medicine said.

"Coronavirus transmission risk can be successfully mitigated if early and frequent testing and safety measures are implemented," the statement said. "This allows for the rapid isolation of known coronavirus cases, which creates a safer environment for hospital workers and patients while lowering risk to the general public they interact with outside of work."

Christine Clarridge

A Wisconsin congressman whose coughing fit at the state Republican Party convention drew widespread attention because masks were not required at the event was suffering from nothing more than a dry throat, his campaign said Monday.

U.S. Rep. Glenn Grothman, 65, began coughing Saturday when he started his speech at the convention before about 300 attendees at a Green Bay conference center. The event proceeded even as Wisconsin saw a spike in coronavirus cases, breaking a daily record for newly confirmed cases for a third straight day.

Its time to talk about Donald John Trump, said an unmasked Grothman, before coughing and loosening his tie. Grothman regained his composure and proceeded to give a defense of Trumps first term in office on a variety of issues.

One clip of him coughing that circulated on Twitter had been viewed more than 4.3 million times as of Monday morning. Democratic U.S. Rep. Mark Pocan, who represents the Madison area in Congress, commented on Grothmans coughing with, Wow.

Congressman Grothmans cough was due to a dry throat and a need for a drink of water, Grothmans campaign manager, Alec Hanna, said in an email Monday. It has not persisted and he is exhibiting no other symptoms associated with COVID-19. He previously took a COVID-19 test, with a negative result.

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The Associated Press

Amid pervasive backsliding on social distancing, Britain and France are weighing whether to require people to wear masks in public places.

Scientists say the two countries governments should have done so ever since they started easing lockdowns like many other European nations did instead of exposing their populations to the risk of infections from mass dance parties and summer vacationers who think theres no longer anything to worry about.

Whether to make masks mandatory isnt just a matter of debate in the United States, where infection rates are still climbing fast.

British Prime Minister Boris Johnson urged U.K. residents Monday to wear face coverings in shops and other tight indoor spaces but stopped short of making it compulsory.

Critics have accused Johnsons government of failing to provide clarity on mask-wearing in the days since he began backtracking on previous advice that suggested face covers were not necessary. After the prime minister then was photographed wearing one in a shop, government ministers appeared on TV urging personal choice in the mask issue.

Meanwhile, Frances government said Monday its considering requiring masks in all indoor public places amid signs of a small rise in confirmed virus cases and a big drop in public vigilance.

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The Associated Press

The United Nations says the ranks of the worlds hungry grew by 10 million last year, and warns that the coronavirus pandemic could push as many as 130 million more people into chronic hunger this year.

The grim assessment was contained in the latest edition of the State of Food Security and Nutrition in the World, an annual report released Monday by the five U.N. agencies that produced it.

Preliminary projections based on available global economic outlooks suggest the pandemic may add an additional 83 (million) to 132 million people to the ranks of the undernourished in 2020, the report said.

Compounding the situation is what the reports authors described as unprecedented Desert Locust outbreaks in Eastern Africa.

The U.N. agencies estimated that nearly 690 million people, or nearly 9% of the worlds population, went hungry last year, an increase of 10 million since 2018 and of nearly 60 million since 2014.

As a result of the pandemic, food supply disruptions, lost livelihoods and the inability of people working abroad to send remittances home to their families mean its even more difficult for the poorer and vulnerable populations to have access to healthy diets, the U.N. agencies concluded.

The report noted that after steadily declining for decades, chronic hunger slowly began to rise in 2014 and continues to do so.

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The Associated Press

The first states to endure the coronavirus this spring hoped the worst would be behind them.

Instead, the virus is coming back.

Many places that suffered most in the first wave of infections, including California, Louisiana, Michigan and Washington state, are seeing case counts climb again after months of declines. Its not just a matter of more testing. Hospitalizations and, in some places, deaths are rising, too.

The disease is raging Florida reported 15,300 cases Sunday, the biggest single-day increase of the U.S. pandemic and experts say the resurgence in the original battlegrounds has common causes. They include a population no longer willing to stay inside, Republicans who refuse face masks as a political statement, street protests over police violence and young people convinced the virus wont seriously hurt them.

And even though some of the states led by Democratic governors delayed restarting their economies until weeks after more eager peers like Georgia, they still jumped too soon, critics say.

I dont think theres any question about that anymore. Even in California, we opened up too fast, said John Swartzberg, a doctor who is a clinical professor emeritus at the University of California at Berkeley.

So far, the rebound hasnt reached the states hardest hit by the first wave: New York, New Jersey and Massachusetts. But New York Gov. Andrew Cuomo said Friday that its on its way.

Were going to go through an increase, and I can feel it coming, he told WAMC radio. The only question is how far up our rate goes. But you cant have it all across the country and then have it not come back.

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Bloomberg

Until now, California hospitals avoided the dreaded surge in coronavirus patients that threatened to overwhelm wards and stretch thin staff and supplies. But now, with coronavirus hospitalizations in the state at an all-time high, doctors and nurses at some hospitals say the nightmare has arrived.

Hospitals up and down the state report that their beds are filling up fast, staffers are tiring and medications used to treat coronavirus patients are running low. The surge has hit California unevenly, with some facilities reporting their numbers staying flat in recent weeks, while others have risen sharply.

Were getting to the point where were just overwhelmed emotionally, physically exhausted. We dont have enough workers for all these patients; were working extra shifts, said Mary Lynn Briggs, an intensive care unit nurse at Mercy Hospital in Bakersfield. Im expecting things to go from bad to worse over at least the next couple of weeks.

Sylvain Trepanier, chief clinical executive for Providence Southern California whose 13 hospitals in Orange, L.A. and San Bernardino counties had as of Friday experienced a 40% increase in COVID-19 patients over the last 10 days, said, Thank God we didnt see that wave [then] as big as we anticipated, but that allowed us to be ready.

The months since March allowed hospitals time to prepare for such a surge. Doctors learned more about how to treat COVID-19 patients, hospital administrators obtained more protective gear, and staffers know more about how the coronavirus is transmitted and how to protect themselves.

Recent projections suggest that the hospital system in California will be able to handle the demand, in part because busier hospitals can transfer patients to facilities with more space. But even still, the strain on some hospitals is unprecedented.

Statewide, the number of people hospitalized with COVID-19 has increased nearly 50% over the last two weeks and now sits at a record high. The earlier peak of 3,497 hospitalized patients in California on April 29 was surpassed June 20, and the number has continued to climb every day since then. On Saturday, 6,322 people were hospitalized with COVID-19 in California.

Health officials have linked the surge to an increase in transmission of the coronavirus thatbegan in late May,as some counties began reopening businesses, thousandsgathered in large protestsand some people, tired of staying home, met up with family and friends.

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Los Angeles Times

The Texas Supreme Court on Monday upheld Houstons refusal to allow the state Republican convention to hold in-person events in the city due to the coronavirus pandemic.

The state GOP convention had been scheduled to begin Thursday at Houstons downtown convention center and was expected to draw thousands of participants.

Houston Mayor Sylvester Turner, a Democrat, said last week that he had directed city lawyers to terminate the contract because he believed the event could not be held safely. He denied that the convention was cancelled due to political differences and cited the potential risk to service workers and first responders if the virus spread through the convention.

The state party sued a day later, alleging the city illegally breached the contract and accusing Turner of shedding crocodile tears.

State District Judge Larry Weiman sided with Turner, citing Houston statistics that show major hospitals exceeding their base intensive-care capacity due to an influx of COVID-19 patients.

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Coronavirus daily news updates, July 13: What to know today about COVID-19 in the Seattle area, Washington state and the world - Seattle Times

Bill Gates warns against coronavirus vaccine going to highest bidder ‘We’ll have a deadlier pandemic’ – CNBC

July 14, 2020

Microsoft founder Bill Gates on Saturday said that Covid-19 medication and future vaccines should be distributed to people who need them the most and not to "the highest bidder."

"If we just let drugs and vaccines go to the highest bidder, instead of to the people and the places where they are most needed, we'll have a longer, more unjust deadlier pandemic," Gates, a billionaire philanthropist, said during a remote Covid-19 conference hosted by the International AIDS Society.

"We need leaders to make these hard decisions about distributing based on equity, not just on market-driven factors," he added.

As countries and companies race to bring a vaccine to the market, concerns have risen about wealthier nations receiving more drugs than developing countries.There have been calls for future coronavirus vaccines to be treated as public goods for everyone, without profit.

The World Health Organization said that 21 candidate vaccines are currently in clinical trials being tested on human volunteers, three of which are in the third phase of those trials.

U.S. biotech firmModerna,U.K. pharmaceutical companyAstraZenecaand China's Sinovac Biotech have made the most progress towards developing vaccine candidates for the coronavirus. However, Moderna, which is working with the U.S. National Institutes of Health, recently said that its late-stage trial for a vaccine will be delayed, possibly by a few weeks.

A potential vaccine being developed by the drug giantPfizerand the biotech firmBioNTechhas garnered immune responses in healthy patients, but also caused fever and other side effects.

Gates said a main takeaway from the battle against HIV/AIDS two decades ago is the significance of creating a fair global distribution system to make drugs available for everyone. He said the AIDS crisis serves as a model in making Covid-19 drugs more equally and widely available, pointing to the 2002 Global Fund to Fight AIDS, Tuberculosis, and Malaria as an example.

"Global cooperation, a resolve to invent the tools and get them out where they're needed most is critical," Gates said. "When we have those things, nations, institutions and advocates working together on this collective response, we do see remarkable impact."

Link:

Bill Gates warns against coronavirus vaccine going to highest bidder 'We'll have a deadlier pandemic' - CNBC

Virus immunity may disappear within months: study – CTV News

July 14, 2020

PARIS, FRANCE -- Patients who recover from coronavirus infections may lose their immunity to reinfection within months, according to research released on Monday that experts said could have a "significant" influence on how governments manage the pandemic.

In the first study of its kind, a team led by researchers from King's College London examined the levels of antibodies in more than 90 confirmed virus patients and how they changed over time.

Blood tests showed even individuals with only mild COVID-19 symptoms mounted some immune response to the virus.

Of the study group, 60 per cent showed a "potent" viral response in the first few weeks after infection.

However, after three months only 16.7 per cent had maintained high levels of COVID-19-neutralizing antibodies, and after 90 days several patients had no detectable antibodies in their bloodstream.

When the body encounters an external danger such as a virus, it mobilises cells to track down and kill the culprit.

As it does so, it produces proteins known as antibodies that are programmed to target the specific antigen the body is fighting, like a key cut for a particular lock.

As long as someone has enough antibodies, they will be able to snub out new infections, giving them immunity.

But Monday's research suggests immunity cannot be taken for granted and may not last more than a few months, as is true with other viruses such as influenza.

Experts said the findings may change how governments plan for the next phase of the pandemic, including how they fund and organise vaccine research and development.

"This is an important study that starts to define the longer-term dynamics of the antibody response to SARS-CoV-2," said Lawrence Young, professor of Molecular Oncology at the University of Warwick, using the full name of the virus strain.

"It further emphasises the need for us to better understand what a protective immune response looks like if we are to develop an effective vaccine," said Young, who was not involved in the research.

James Gill, an honorary Clinical Lecturer at Warwick Medical School, said the research reiterated the need for everyone to continue taking measures to mitigate the virus spreading, particularly at the start of Europe's holiday season.

"In the same way that these patients were surprised to have antibodies to COVID19, we should NOT be surprised if any protective benefit is mild, or at least transient," he said.

"If you played the lottery and won 10, you wouldn't immediately think that you had acquired increased natural luck, and used your life savings to buy further lottery tickets.

"Even those with a positive antibody test -- especially those who cannot account for where they may have been exposed -- should continue to use caution, social distancing and appropriate mask use."

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Virus immunity may disappear within months: study - CTV News

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