Category: Corona Virus Vaccine

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Fossie says discoveries about the corona virus vaccine are expected in early December – DodoFinance

October 26, 2020

In early December, we will know if a vaccine is safe and effective by the end of December, said the U.S. National Director of Allergy and Infectious Diseases. The amount available in December will certainly not be enough to vaccinate everyone you have to wait several months by 2021.

Speaking to the BBCs Andrew Mar Show, Fucci said vaccinating a significant proportion of the population could not have a significant impact on the dynamics of the eruption until the second or third quarter of 2021.

What I anticipate is that as a continuation of a successful vaccination and some kind of public health activity, it is only natural that as we progress in the months of 2021, we will see a substantial approach to some form in the third and fourth quarters, Fossie told Marr.

Fassi stressed that he believed US President Donald Trump was right in saying that the United States was going around the corner during the epidemic, but said he believed it was a lie.

The data speak for themselves, Fassi said.

Unfortunately, what I see from a distance, Im sorry for what I see in the UK After being hit as badly as we did, you went to a much lower level, but now you start to increase as we are here, he said.

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Fossie says discoveries about the corona virus vaccine are expected in early December - DodoFinance

Members of Vice Pres. Pence Inner Circle Test Positive for COVID-19 – 9&10 News

October 26, 2020

As Vice President Mike Pence continues on the campaign trail, at least five people in his inner circle have tested positive for COVID-19 in recent days.

One of them being the vice presidents Chief of Staff Marc Short.

The White House says Vice President Pence and his wife tested negative for the virus on Sunday.

They also said Pence will continue campaigning every day leading up to the election.

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Members of Vice Pres. Pence Inner Circle Test Positive for COVID-19 - 9&10 News

We still dont know what COVID-19 immunity means or how long it lasts – San Antonio Current

October 24, 2020

Even as U.S. President Donald Trump claims his bout with COVID-19 has granted him immunity, reports of people getting the disease a second time are emerging. While reinfection still appears to be rare, it remains unclear to what extent immunity can truly protect a person.

Immunity is also in the news because a debate is simmering among scientists over herd immunity, the point at which enough people are immune to a pathogen to slow its spread(SN: 3/24/20). While herd immunity might put the end of the pandemic in sight, experts estimate that around 40 to 60 percent of a population would need to be infected to reach it.

One groupof researchers is pushing for governments to reach herd immunity without a vaccine, by allowing COVID-19 to spread among those at low risk while protecting vulnerable populations. This approach, however, puts the entire population at riskof significant illness and death, another group argues in a letter published October 14 in the Lancet.

Because SARS-CoV-2 is a new virus, scientists cant say how long a person will be protected after theyve recovered from an infection. If immunity wanes quickly, that sets the stage for recurrent outbreaks unless theres a vaccine, the authors say.

Heres what we know so far about our long-term defenses against the coronavirus:

Because SARS-CoV-2 is a new virus, scientists cant say how long a person will be protected after theyve recovered from an infection. If immunity wanes quickly, that sets the stage for recurrent outbreaks unless theres a vaccine, the authors say.

Heres what we know so far about our long-term defenses against the coronavirus:

How does the body build immunity

The immune system has two ways to provide lasting protection: T cells that remember the pathogen and trigger a rapid response, and B cells that produce antibodies proteins the body makes to fight off a specific pathogen.

Ideally, long after a person has recovered from an infection, these antibodies stick around in their blood. Then if the person is exposed to the same pathogen again in the future, those antibodies recognize the threat and work to prevent another infection from taking hold.

So-called memory T cells also stick around. Ideally, they live up to their name and recognize a previously encountered pathogen and either help coordinate the immune system or kill infected cells.

With one type of immunity, called sterilizing immunity, the virus never gets a chance to begin replicating and never infects a cell. Sterilizing immunity, however, is hard to achieve. More often, people achieve partial immunity, which provides a rapid response that may make the second bout of the disease less severe, or less easily transmitted to others.

Its unclear what type of immunity people who have recovered from COVID-19 have, and only time will tell. A vaccine could possibly trigger a stronger immune response than a natural infection, although its yet to be seen if that will be the case for the coronavirus vaccinesin trials (SN: 7/10/20).

For some illnesses, like measles, antibodies may last a lifetime. But for SARS-CoV-2, the jury is still out. Its unknown how long antibodies last in the blood, or importantly whether their presence is a sign of immunity. Just because a person has antibodies, it doesnt mean they are effective at fighting the virus.

Neutralizing antibodies are ones that halt the virus in its tracks, stopping it from infecting a host cell and replicating. Such antibodies typically recognize the virus spike protein, which helps it break into host cells. So far, those kinds of antibodies have been a focus of studies seeking to understand whether a person may be immune.

For the majority of people, it does appear that they are generating neutralizing antibodies, says Aubree Gordon, an epidemiologist at the University of Michigan in Ann Arbor. So thats promising.

Yet its still unknown what amount of neutralizing antibody is sufficient for protection. And even if they are protective, its unclear how long these immune proteins stick around. Studies of recovered COVID-19 patients have shown that antibodies for the coronavirus can wane after a SARS-CoV-2 infection, but overall, their levels remain relatively stableover a span of threeto sixmonths.

Because the coronavirus only began its sweep around the world at the beginning of the year, theres just been a limited time for people to study this, Gordon says.

Some data suggest the immune system might not have a great memory for coronavirus infections. One study found that during a COVID-19 infection, the organ that produces memory B cells long-lived cells that will rapidly produce antibodies if a person is re-exposed to a pathogen doesnt properly activatethe cell types capable of becoming memory B cells. Without that immunological memory, antibodies for SARS-CoV-2 may not last very long, researchers report August 19 in Cell.

Maybe that means that those memory responses are going to be on the short side, says Brianne Barker, an immunologist at Drew University in Madison, N.J.

Studies have shown that COVID-19 patients typically developan immune response involving T cells. Even recovered patients without a detectable antibody response have T cellsin their blood, researchers report October 15 in Emerging Infectious Diseases.

But the role of T cells in infection and immune memory remains unclear. Studies have shown that memory T cells can persist in patients who were infected with the coronavirus responsible for the 20032004 SARS outbreak for up to 11 yearsafter recovery. Since that virus no longer circulates, however, its impossible to say whether those T cells might be protective.

Some people may already have T cells that can recognize piecesof the new coronavirus (SN: 5/15/20). Those immune cells may be left over from previous exposures to coronavirusesthat cause the common cold, researchers report August 4 in Science. These cross-reactive T cellsmight help reduce the length or severity of COVID-19 illness. On the flip side, such T cellscould make the disease worse, perhaps by overstimulating the immune system and causing a condition called cytokine storm, which is behind some severe COVID-19 cases.

Researchers have now documented a small number of cases where people have been infected with the coronavirus twice. The first such case was reported in Hong Kong, with additional reports the United States, the Netherlandsand elsewhere (SN: 8/24/20).

But its still unclear how common reinfections are. And with only a handful of cases so far, we cant really say that reinfections are telling us a whole lot at this point, Barker says, either about immunity or whether vaccines will provide long-term protection or will need to become part of our yearly routine, like flu shots.

Some reinfections are expected; some peoples immune memory may not be potent enough to prevent the infection entirely, though it may prevent them from getting sick.

Its hard to prove that someone has been reinfected, because researchers need to conclusively show that two different viruses caused each infection, Barker says. That requires genetic testing. Whats more, experts are not necessarily on the lookout for such cases, especially in people who are not displaying symptoms.

Without knowing how long immunity lasts after an infection, and how much that varies from person to person, its impossible to know whether ending the pandemic through herd immunity is even possible. What is clear, experts say, is that attempting to reach herd immunity without a vaccine will lead to more illness and death.

Promoting the concept of herd immunity as an answer to the COVID-19 pandemic is inappropriate, irresponsible and ill-informed, Thomas File Jr., president of the Infectious Diseases Society of America, and Judith Feinberg, chair of the HIV Medicine Association, said in a statement October 14.

And to date, herd immunity is still far off. Throughout the United States, we are nowherenear herd immunity, Gordon says. Taking the approach of herd immunity through natural infection will lead to hundreds of thousands of unnecessary deaths.

This story was originally published byScience News, a nonprofit independent news organization.

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We still dont know what COVID-19 immunity means or how long it lasts - San Antonio Current

Coronavirus vaccine: When will it be ready and will it be safe? – WFLA

October 24, 2020

by: Marni Hughes and Michael Geheren and Nexstar Media Wire

WASHINGTON (NewsNation Now) Its the topic on the minds of many Americans: When will we have a vaccine and will it be safe?

NewsNation sat down at the White House for anin-depth interview with three of the top officials on the front lines of Americas fight against the COVID-19 pandemic: Dr. Deborah Birx, the White House coronavirus response coordinator, Health and Human Services Secretary Alex Azar and Surgeon General Jerome Adams.

Hughes asked three members of the White House Coronavirus Task Force: Whats ahead?

WatchMarni Hughes full interview in the player above.

Hughes:The vaccine is critical Im not telling you anything you dont already know. The biggest question that I hear from people is: When will the vaccine be ready and will it be safe for me and my family to take?

Azar:So in terms of the vaccine timelines, we have two products that are almost fully enrolled in clinical trials,PfizerandModernasvaccines. We havesix vaccines total that we have invested in or contracted with, four in phase three final stage of clinical trials these two that are almost fully enrolled. We cant predict when well get data from them, because unlike just a therapeutic where you have someone whos sick and within a couple of days you can look at a clinical outcome to see if theyve gotten better and gotten out of the hospital, with the vaccine youre looking at preventing them getting the virus or lessening the disease progression in them if they do get the virus. And so that means you vaccinate thousands and thousands of people in each of these trials. Thirty-thousand people, half of them get the vaccine, half of them get a placebo and you have to then wait until a certain number of people get coronavirus and symptoms in that trial.

When we get that data that will be an independent process, therell be an independent, its called the data and safety monitoring board that will determine that pre-specified statistical endpoints have been met. That will then go to the drug companies and the FDA. The drug companies will determine whether the data meets their ethical standards to submit for FDA approval, will go to the FDA. FDA will consider that data against public guidance that theyve already laid out saying what the standards are to hold that to. They will use a public advisory committee process to get external input and the FDA career scientists will make the call as to whether the vaccine meets the FDAs legal and regulatory science and data standards for approval.

So, we dont know the timing of when well see the data, but Pfizer CEO of the worlds leading global biopharmaceutical companyhas publicly said that they think that we can see data from their trial as early as late October, so next week. And they have said that as once they get that data will take some time to clean up the data and be ready to submit and they would submit by late November. Stop and think about that. Thats 10 months from the entry of this virus to the United States. This is historic and unprecedented achievement thanks to President Trumps leadership and vision of Operation Warp Speed.

Hughes:No one will deny that 10 months is fast for a vaccine to come to market, but there is a saying you cant rush science. So can you address those concerns that are valid, that people do have, given what youve already stated about the process and the approval?

Dr. Birx:I think its really important for everyone to understand, the reason this is faster is because they moved everything consecutively. In many cases, you have large delays in between but pharmaceutical companies need to make money. And so they investigate whats the utility of that drug or vaccine will be. Will it be acceptable? How will it be used? And then they determine the market impact of that vaccine. That was all taken off the table, because the federal government said if this vaccine is safe and effective, were going to make the decision right now to manufacture it. And so no shortcuts were taken in the science and the safety. What it did do was cost a lot more, and I think that was an investment made by the federal government to say it is worth it with this kind of pandemic to make to those kind of investments.

Dr. Adams:There were horrific things done to people in this country, particularlypeople of color in the name of science, historically. We need to acknowledge that. We need to help everyone understand that there are protections now in place. TheOffice of Human Research Protectionswhich the Secretary (Azar) oversees. Independent data safety monitoring board which has unblinded the data before it even gets to the FDA and FDA process which is recognized around the globe is the safest in the world, in the safest of all time. And probably the most reassuring thing I can tell the Americans, is that as a Black man, the surgeon general of the United States, as a practicing physician, as someone with a masters in public health I will be getting a COVID vaccine when they tell me its been authorized or approved, and that I can get one, and my family will get it a COVID vaccine when they are told that they can get one because I trust the process. Were in the midst of a social justice movement right now. I think one of the greatest injustices in the world are the people who are pushing misinformation out there that is causing minorities in particular to disproportionately be harmed by vaccine-preventable diseases. Fifty percent of Americans get a flu shot in a given year. Only 40% of Hispanics and African Americans and Native Americans get their flu shot in a given year. That results in tens of thousands of people of color dying every year because of a lack of vaccine confidence, because we havent done enough to make it easier.

Watch the exclusive interview with White House Coronavirus Task Force members Secretary Alex Azar, Surgeon General Dr. Jerome Adams, and Dr. Deborah Birx on NewsNation on WGN America.

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Coronavirus vaccine: When will it be ready and will it be safe? - WFLA

COVID-19 vaccine expected to be two rounds of shots, Health Director says – KIIITV.com

October 24, 2020

Health leaders in the Coastal Bend say they have a plan to distribute a COVID-19 vaccine based on their experience dealing with the outbreak of H1-N1.

NUECES COUNTY, Texas The City-County Health District tells 3News that doses of the coronavirus vaccine could be shipped to the Coastal Bend as early as January 2021.

This is all subject to change and depends on the approval of a vaccine. It could still be a while before the general public will be able to receive one.

President Donald Trump called it Operation Warp Speed during Thursday night's debate in which he announced the military would be helping to distribute the COVID-19 vaccine.

"We have a vaccine that is coming," Trump said. "It's ready. It's going to be announced within weeks and its going to be delivered."

Nueces County stands at the ready. However, it's still something that might not happen until mid-2021. Also, you would need to get the vaccine twice.

Rodriguez said we have a local plan for the distribution. It's a plan based on their experience dealing with the outbreak of H1-N1 back in 2009.

"The main goal is to distribute vaccines to as much of the community as possible when we have as much vaccine at that point," Rodriguez said.

Rodriguez said the only difference is that instead of the vaccine being sent to the health department first, it will be sent directly to doctors and other health care providers.

That will essentially cut out the middle man, making for an expedited process. Rodriguez said initially, there will be a limited number of doses available.

So, who gets vaccinated first?

It will be broken down into phases. Phase One includes front line workers.

"Those hospital individuals; those people on the front lines, even public health, those people working the drive thru, because they are seeing people who potentially have COVID-19," Rodriguez said.

Emergency Medical Service crews would be included in that phase as well.

Among those in Phase Two are the more vulnerable populations, those 65 years of age or older. This includes those at nursing home facilities.

"The nice thing about nursing homes is that they can also sign up as a provider and they can receive their vaccine directly, vaccinate all of their employees and residents," Rodriguez said.

Then, people with comorbidities would be vaccinated.

"Once we get to the point when we are getting a lot of shipments and doses, we can open it up on a large scale and have as many people in the community who want to get vaccinated against COVID-19 get vaccinated," Rodriguez said.

"The difference with this one, with the last time around, the last one was one vaccine, and you were protected," Rodriguez said. "This one is two vaccines. We know we need to get as many people vaccinated because we need to start round two 21-28 days later."

This is not a vaccine for children. Currently, the vaccine would be for those 18 years and older.

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COVID-19 vaccine expected to be two rounds of shots, Health Director says - KIIITV.com

ISDH reports 2,765 newly reported COVID-19 cases in Indiana – Fox 59

October 24, 2020

Posted: Oct 24, 2020 / 11:54 AM EDT / Updated: Oct 24, 2020 / 11:54 AM EDT

INDIANAPOLIS The Indiana State Department of Health (ISDH) reported 2,765 new positive coronavirus cases Saturday, bringing the states total to 160,454.

Those new cases were reported to ISDH between May 15 through October 23.

ISDH also announced 24 additional confirmed deaths from coronavirus, bringing Indianas total to 3,882. The new deaths were reported to ISDH from October 20 through October 23.

ISDH dashboard data indicated a 7-day unique individual positivity rate of 13.1%, with a cumulative rate of 9.9% positive.

The latest ISDH dashboard data indicates a 7-day all-test positivity rate of 6.9%, with a cumulative rate of 5.8% positive.

According to the data, 38,746 new tests were administered statewide, with the total number of tests at 2,681,197.

ISDH says 30.9% of ICU beds and 78.1% of ventilators are available across the state.

Marion County reported a total of 25,691 cases and 791 coronavirus deaths to date, the most in the state.

The agency also is reporting 236 total probable deaths in Indiana. Probable deaths are those for which a physician listed COVID-19 as a contributing cause based on X-rays, scans and other clinical symptoms but for which no positive test is on record.

For complete statistics reported by ISDH, including total tests administered and demographic data, visitCoronavirus.In.Gov.

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ISDH reports 2,765 newly reported COVID-19 cases in Indiana - Fox 59

A Third Coronavirus Surge Has Taken Root in the U.S. – The New York Times

October 23, 2020

Heres what you need to know:

key data of the day

In Ohio, more people are hospitalized with the coronavirus than at any other time during the pandemic. North Dakota, which is leading the nation in coronavirus cases per capita, reported more than 1,000 cases on Tuesday, the states worst daily total yet. And as of Monday, 16 states had added more cases in the prior week than in any other seven-day stretch.

After weeks of spread and warnings in certain areas, a third surge of coronavirus infections has now firmly taken hold across much of the United States.

The latest wave which is raging most acutely in the Midwest and the West, but is also spreading in various areas around the country threatens to be the worst of the pandemic yet.

Its arrival comes as cooler weather is forcing people indoors, setting up a grueling winter that will test the discipline of many Americans who have grown weary of wearing masks and turning down invitations to see family and friends. Over the last week, the country has averaged about 59,000 new cases a day, the most since the beginning of August. The daily total could soon surpass 75,687, a record previously set on July 16.

The high case count which has so far not translated to soaring deaths in part reflects increased testing. With about one million people tested on many days, the country is getting a far more accurate picture of how widely the virus has spread than it did in the spring.

But the latest developments also reflect a serious new level of the outbreak. Hospitalizations, the most accurate picture of how many people are seriously sick from the virus, are on the rise nationwide, worrying many public health officials. A rise in deaths tends to lag behind a spike in cases. And deaths are creeping up in places: Officials in Wisconsin reported 36 on Tuesday, a single-day record.

Deaths among hospitalized patients have also dropped, to 7.6 percent from 25.6 percent in the spring, according to one study. That may be because doctors have better treatments at hand, and the patients are younger and in better health on average than those in the first wave.

Still, Dr. Michael Osterholm, an infectious diseases expert at the University of Minnesota, recently offered an ominous warning: With infections rising and compliance eroding, he said, the next six to 12 weeks are going to be the darkest of the entire pandemic.

The pandemic has caused nearly 300,000 deaths in the United States through early October, the Centers for Disease Control and Prevention said in a report released Tuesday. The tally includes not only deaths directly caused by the coronavirus but also nearly 100,000 fatalities that are indirectly related but would not have occurred if not for the virus.

The study is an attempt to measure excess deaths fatalities from all causes that statistically exceed those normally occurring in a certain time period.

Many experts believe this measure tracks the pandemics impact more accurately than the case fatality rate. The figure includes deaths from Covid-19 that were misclassified or missed and deaths from emergencies like heart attacks that went untreated because people were afraid to go to the hospital.

Hidden in the new numbers from the C.D.C. is a statistic that may not mean as much as it appears: While the pandemic has taken the greatest toll on older citizens, the biggest percentage increase in excess deaths has occurred among young adults ages 25 to 44, among whom there was a 26.5 percent increase as compared with an increase of 14.4 percent in those over 85, a group with a large proportion of the nations excess deaths.

But in nonpandemic times, the death rate among people in that age group is very low, so a disaster such as Covid-19 can easily bump up their death statistics without adding up to large numbers of excess deaths.

Excess deaths among Black people and Hispanics of all age groups also rose compared with previous years, the C.D.C. reports. Hispanics experienced a 54 percent increase, while Black people saw a 33 percent rise.

By comparison, the increase for white Americans was 12 percent, according to the C.D.C.

Another report, published in the Proceedings of the National Academy of Sciences, found that in April nearly half of the nations excess deaths were in New York and New Jersey. A third were in people over age 85.

But excess deaths are only part of the story, noted the authors of that paper, led by Amy Finkelstein, a professor of economics at M.I.T. While deaths last spring were concentrated in New York and New Jersey, the economic ravages from the pandemic extended nationwide, even in states with almost no deaths.

Job losses in New York and New Jersey were just a small fraction 7 percent of job losses throughout the country. And while deaths were concentrated in older people, half of those who lost their jobs nationwide were ages 25 to 44.

Concentrating on case counts or death counts, they conclude, provides only a partial picture of the pandemics devastation.

Health crises concentrated in one part of the country and one age group may have substantial economic spillovers that are felt throughout the rest of the country and on other age groups, the authors wrote.

In what might be the final months of the Trump administration, Dr. Stephen M. Hahn, the head of the Food and Drug Administration, seems to be trying to save the agency from the fate of the Centers for Disease Control and Prevention, whose scientists have been stripped of much of their authority and independence in responding to the pandemic.

To many F.D.A. scientists, Dr. Hahn has been a disappointment. Under his leadership, the F.D.A. authorized hydroxychloroquine for hospitalized Covid-19 patients despite a lack of evidence, only to reverse the decision once the drug was tied to severe side effects.

In late August, Dr. Hahn made a significant error at a news conference with the president announcing the approval of plasma treatments for Covid-19, greatly exaggerating its benefits. He later publicly corrected the record.

That debacle seems to have been a turning point for Dr. Hahn and agency scientists.

On Sept. 10, F.D.A. directors wrote a joint statement, warning that political interference could destroy the agencys credibility. Dr. Hahn tweeted his support of the statement, and later that day noted that new vaccine guidelines were coming.

Experts in the Office of Vaccines Research and Review drafted new guidelines, to make its standards unmistakable to drugmakers and reassure jittery Americans that the agency would not cut corners when assessing a vaccines safety and effectiveness.

Within days of submitting the guidelines to the White House, F.D.A. scientists, fearing they would never be made public, decided to include them in the briefing materials for an outside group of vaccine experts scheduled to meet on Oct. 22. They slipped a version into the appendix of the committees briefing materials, with a new title.

Executives from Johnson & Johnson and Merck, each with vaccine candidates, called for the guidelines release. Dr. Albert Bourla, Pfizers top executive, wrote on Twitter that he had faith in the F.D.A.s ability to set standards.

The same morning, the materials were quietly posted online. The White House was given about an hours notice, according to a senior administration official. Later that day, the White House abruptly cleared the guidelines, which were then posted to the F.D.A. website.

Despite an uptick of coronavirus cases in New Jersey, Connecticut and Pennsylvania, New York officials said on Tuesday that travelers from those three neighboring states would not be required to quarantine, though each state meets the qualifications for the restriction.

The announcement came with no small amount of confusion: A senior adviser to the governor confirmed that Pennsylvania would be added to the quarantine list, and Mr. Cuomo later indicated in a news conference that New Jersey and Connecticut would not be required to quarantine, but he did not initially mention Pennsylvania.

But the governor later clarified in a statement that enforcement from Pennsylvania would also be too difficult to maintain, considering the vast number of people who cross the states northern border into New York and its eastern border into New Jersey.

That rationale was also articulated by Mr. Cuomo in reference to Connecticut and New Jersey, two neighbors to New York that have worked together for months to try to coordinate a response to the coronavirus crisis.

There is no practical way to quarantine New York from New Jersey and Connecticut, Mr. Cuomo, a third-term Democrat, said in a morning news conference. There are just too many interchanges, there are too many interconnections, there are too many people that live in one place and work in the other.

Adding to the confusion, Beth Garvey, special counsel to Mr. Cuomo, said during the morning news conference that New Jersey and Connecticut were both being added to the list on Tuesday, despite Mr. Cuomo earlier suggesting they would not be. In a brief aside after Ms. Garveys remarks, the governor said Pennsylvania, we have the same basic issue.

None of the states were on a quarantine list released on Tuesday afternoon by the governors office.

Still, Mr. Cuomo said that all nonessential travel among New York and the three states should be avoided and promised he would issue more guidance on that point on Wednesday.

New York did add two states to its list on Tuesday: Maryland and Arizona. All told, 40 states and territories are now on the travel advisory list, which Mr. Cuomo referred to as really a bizarre outcome considering that New York once faced one of the worst outbreaks in the country.

On Monday, more than 64,200 new cases and at least 517 new deaths were reported in the United States. Over the past week, there have been an average of 59,269 cases per day, an increase of 34 percent from the average two weeks earlier, and fears are growing in New York about a potential second wave. Two weeks ago, Mr. Cuomo closed nonessential businesses in parts of Queens and Brooklyn where positivity rates had spiked.

Since late June, New York, New Jersey and Connecticut have worked in concert to create a list of states from which travelers to the region are subject to a two-week quarantine.

Essential workers have been exempt from the quarantine since it began in June. Other workers who cross state lines have technically been subject to the advisory, but officials have also said that the quarantine is only required by those who spend at least 24 hours in a state on the list which would exclude most commuters.

The quarantine was intended to apply to any person arriving from an area with a positivity rate higher than 10 per 100,000 residents over a 7-day rolling average or an area with a 10 percent or higher positivity rate over a 7-day rolling average.

New Jersey has a population of about 8.88 million people, and so anything over an average of about 888 new cases puts the state above that threshold. According to a New York Times database, New Jersey has seen an average of 1,016 cases per day in the past week, an increase of 54 percent from the average two weeks earlier.

For Connecticut, the threshold is around 356, and its daily average in the past week was at 378 cases per day.

Though New York has seen a significant increase in cases in parts of New York City and its suburbs, its overall positivity rate has remained lower than its neighbors. On Tuesday, Mr. Cuomo said the daily rate was 1.32 percent statewide, and 2.91 percent in the so-called red zones, areas where he recently imposed severe restrictions as virus hot spots sprang up across the state. Hospitalizations in the state increased by eight, to 942.

In New York City, Mayor Bill de Blasio said Tuesday that the citywide seven-day average positivity rate was at 1.58 percent.

An earlier version of this item incorrectly described when more than 64,200 new cases and at least 517 new deaths were reported in the U.S. It was Monday, not Tuesday.

President Trump and other politicians have repeatedly warned that lockdowns and similar measures could cause at least as much distress as they prevent, in particular by increasing the risk of overdoses and suicides because of economic hardship. But the evidence for that claim is sparse; on Monday, a study posted on Medrxiv, a prepublication site, found that in Massachusetts, the suicide rate during the states lengthy stay-at-home advisory last spring remained steady, neither increasing nor decreasing.

The analysis is being submitted to a journal; it has not yet undergone peer review.

This narrative that longer stay-at-home policies drive suicides doesnt bear out, said Dr. Jeremy Faust, an emergency medicine physician at Brigham and Womens Hospital in Boston and the lead author of the study. At least in a state that had a very long stay-at-home advisory, which, for all intents and purposes, was a shutdown. It was a ghost town here.

Dr. Faust led a team of researchers from Harvard and Yale who compared suicide rates from March to May, when the state was largely shut down, with the rates during the same months in 2019, which were in line with previous years. The team adjusted for background trends (U.S. rates have been increasing steadily for many groups since at least 2008) and for the numbers of deaths still under investigation as possible suicides. The rate this spring was unchanged from previous years just under one suicide a month per 100,000 people.

Our data are reassuring that an increase in suicide deaths in Massachusetts during the stay-at-home advisory did not occur, the authors concluded. Moving forward, effective prevention efforts will require comprehensive attention to the full spectrum of mental health services.

At the Andbe Home, a private nursing home in northern Kansas, a single resident tested positive for the coronavirus on Oct. 7. Two weeks later, all 62 residents have become infected, along with at least 12 staff members, and 10 of the residents have died.

That is how hard, and how fast, the virus can hammer the vulnerable in the rural Great Plains and Mountain West, where the pandemic is now raging. States in the region that were little affected in the spring and summer and tended to see the virus as a distant threat now have some of the highest per capita infection rates in the country.

It is with great sadness and concern that I announce that we have a full Covid outbreak in our home, despite the precautions we have been taking since March, Megan Mapes, the administrator of the Andbe Home, wrote Friday on Facebook.

The home has barred all visitors, and residents are isolated in their rooms, Ms. Mapes wrote.

Covid-19 is known to be particularly lethal to adults in their 60s and older who have underlying health conditions, which has put nursing home populations at a higher risk of being infected and dying. In 15 states, the number of residents and workers at nursing homes who have died accounts for at least half of all deaths from Covid-19.

Coming in a small community, such an outbreak inevitably hits home for many people. My grandmother was one of the 10 deaths, Jamie McCreery posted on Facebook. Im shattered and angry, but not at this facility or the workers, who have known the residents and their families for many years.

With a population of just 5,400, Norton County, where the Andbe Home is located, is the hardest-hit county in Kansas right now, relative to its size. The county is grappling with two serious outbreaks in the nursing home and in the Norton Correctional Facility, a state prison where 18 prisoners and three officers have tested positive. Of the 340 cases the county has reported in all, more than 300 have come this month.

The virus spreads readily in congregate living facilities like prisons, group homes and college dorms, and nursing homes have suffered some of the worst outbreaks, because older people with health issues are among the most vulnerable to the disease.

More than 540,000 coronavirus infections and more than 84,000 deaths have been reported among residents and employees of nursing homes and other long-term care facilities for older adults in the United States, according to a New York Times database.

Deaths in the facilities represent about 38 percent of total coronavirus deaths in the country, a slight decline from late June, when nursing homes made up about 43 percent of U.S. deaths. However, the decline may be temporary, experts warn, amid a new surge of cases.

The American Health Care Association and National Center for Assisted Living, which represents more than 14,000 nursing homes and assisted living communities across the country, released a report on Tuesday warning that U.S. nursing homes could be facing another spike.

Danielle Ivory, Mitch Smith and Timothy Williams contributed reporting.

Lucy Tompkins and Jordan Allen

Argentina has become the fifth country in the world to surpass one million confirmed Covid-19 cases.

With a population of around 45 million, Argentina is by far the smallest country on the list, which also includes the United States, India, Brazil and Russia, according to worldwide tracking by The New York Times.

Almost 100,000 of Argentinas cases have been detected in the last seven days, reflecting how infections are soaring in the country, and experts worry that the true total could be far higher. Argentinas reported test positivity rate has hovered around 50 percent for weeks and has reached as high as 75 percent, but the reliability of that data has been questioned recently, with reports that many negative test results were not recorded.

Argentina reported 12,982 new cases and 451 deaths on Monday. In total, 26,716 people have died of the coronavirus in the country, a fatality rate of 2.7 percent, according to the Health Ministry.

Argentina received praise early in the pandemic for imposing a strict quarantine in mid-March. It closed its borders and managed to keep the coronavirus largely under control while other South American countries, including neighboring Brazil, suffered gigantic outbreaks.

Though certain restrictions have since been relaxed, much of Argentina remains under some type of lockdown order.

Once concentrated in the Buenos Aires metropolitan area, the virus has since spread to much of the country, including remote areas with scarce medical resources, even though domestic flights and long-distance buses and trains have largely been grounded.

Argentinas early success in controlling the virus, which was accompanied by a sharp increase in approval ratings for President Alberto Fernndez, led to what some critics call an undue focus on the lockdown as the main strategy to combat the crisis.

What they failed to do in parallel was containment and mitigation of the pandemic, said Adolfo Rubinstein, an epidemiologist who was health minister under the previous president, Mauricio Macri, who was defeated by Mr. Fernndez last year. They needed to go out and detect community cases early, and mitigate the expansion of the pandemic.

U.S. ROUNDUP

With the number of coronavirus infections reaching record levels in New Mexico, Gov. Michelle Lujan Grisham announced new restrictions on Tuesday in the hopes of tamping down the viruss spread.

The governor indicated that the new policies were driven in part by the states health systems being overwhelmed with inpatient coronavirus cases, which has led to 81 percent of all adult hospital beds and 71 percent of intensive care unit beds being filled.

Those policies go into effect Friday, and apply to restaurants and bars, retail stores and other businesses that typically involve close contact between patrons and employees. Any that report four or more positive coronavirus cases over a two-week period will have to close their doors for 14 days. All retail establishments across New Mexico, including grocery stores, will have to close at 10 p.m. each night, and the state will also close state museums and historical sites to visitors.

This last week has been scary, Ms. Lujan Grisham said. Its been unsettling and upsetting to see everybodys hard work and sacrifice undone in only a few short weeks. That is the awful, relentless nature of this virus.

Over the past week, there have been an average of 563 cases per day, an increase of 139 percent from the average two weeks earlier, according to a New York Times database.

New Mexicos positivity rate is 6.5 percent and climbing fast, an indicator of the viruss rapid spread.

According to state contact tracers, restaurants and bars remain a top source of possible exposure to the coronavirus. Those that offer indoor dining will now have to be certified by the state to do so, including consenting to health checks for employees, as well as keeping a record of patrons to assist with contact tracing if needed. Certification will be required after Oct. 30, and indoor dining capacity will be limited to 25 percent of an establishments usual maximum.

In other U.S. news:

In Washington State, colleges and universities will now have to provide quarantine facilities for students if they are exposed to Covid-19 On Tuesday, Gov. Jay Inslee issued more restrictions for higher education campuses as the University of Washington struggles to contain an outbreak among its fraternities and sororities. There have been outbreaks in Whitman County, home of Washington State University, as well.

Officials in North Dakota reported 1,029 new cases on Tuesday, a single-day record and the first time the state has reported more than 1,000 cases in a single day.

A private school in California was ordered to pay $15,000 for ignoring a judges order to stop in-person teaching, in what The Associated Press reported could be the first ruling of its kind in California against a school for violating virus-related health orders. The judgment ended a nearly three-month legal battle between the health authorities and Immanuel Schools, a private Christian school in Californias Central Valley.

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Across the world, the countries that are waging the most successful fights against coronavirus are adopting regional and local measures to protect their populations. And thats why last week, we launched the three local Covid alert levels for England with interventions based on the prevalence of the virus in local areas. Since then weve been undertaking discussions with local leaders in those parts of the country, which are currently bearing the brunt of the second wave of this epidemic. I dont want anybody to think that your actions, our actions, are in vain or the efforts in vain because our collective action across the country has brought the R number well below its natural rate of about 3. As a result, the virus is not spreading as quickly as it did in February and March. Informed by the data that weve just seen, I can announce that Greater Manchester will move to the Very High Alert level. That means that pubs and bars must close unless theyre serving substantial meals. Households cant mix indoors or in most outdoor settings. In some public outdoor spaces, groups must be limited to the Rule of Six. And we strongly advise against travel into and out of the area.

Prime Minister Boris Johnson of Britain announced on Tuesday that Greater Manchester, the countrys second-largest urban area, would be put under the highest level of virus restrictions, shutting many pubs and bars and forbidding indoor socializing by people from different households.

The announcement came despite opposition from the areas mayor, Andy Burnham, who had pushed for greater financial aid for affected residents, and amid a spike in cases around Europe that has reinvigorated the debate over how to balance economic and health concerns.

I know these restrictions are tough on businesses and on individuals, Mr. Johnson said. Not to act would put Manchesters N.H.S. and the lives of many of Manchesters residents at risk.

Mr. Johnson pointed to the areas growing outbreak it has reported more cases over the last seven days than any other place in England, according to a New York Times database. He added that he hoped that local officials would work with the central government to carry out the restrictions, which take effect Friday.

The government will provide some 22 million pounds in aid, which Mr. Burnham argued was woefully insufficient. Talks over relief funds collapsed shortly before the announcement was made, though Mr. Johnson indicated they could be restarted.

At no point today were we offered enough to protect the poorest people in our communities through the punishing reality of the winter to come, Mr. Burnham said.

In London on Tuesday, Heathrow Airport, the countrys largest, began offering rapid tests for 80 ($104) to Hong Kong-bound passengers to meet its entry requirements, in an effort to encourage travel. The service will initially be offered for four weeks, and passengers must book it ahead of time. The tests will be done by private-sector nurses, with results expected within an hour.

Ireland on Monday became the first European country to reimpose a national lockdown, in a dramatic U-turn for the government, which two weeks ago fell short of imposing the highest level of restrictions despite advice from public health experts. The six-week period will begin on Wednesday.

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A Third Coronavirus Surge Has Taken Root in the U.S. - The New York Times

‘There will be many, many problems’: What to expect after a coronavirus vaccine is approved – The Daily Briefing

October 23, 2020

Federal health officials, public health experts, and drugmakers have said they believe FDA could issue an emergency use authorization (EUA) for a coronavirus vaccine candidate by the end of this year, meaning America could have just a few months to develop a plan to distribute the vaccine nationwide.

A vaccine approval is coming. Get ready to ask these 8 questions.

Currently, state, local, and federal officials are working on such plans, aiming to vaccinate as many Americans as possible against the novel coronavirus, which has infected nearly eight million people in the United States and has been linked to more than 215,000 deaths. But doing so won't be nearly as easy as it might seemmeaning that, even once the United States has a vaccine against the coronavirus, it could still be a while before life in America returns to "normal," experts say. Here's why.

According to the Center for American Progress (CAP), administering two doses of an authorized vaccinewhich is the dosing currently being tested in many late-stage coronavirus vaccine trialswould require the manufacturing and distribution of a total of 660 million doses to vaccinate the entire U.S. population, or at least 462 million doses to vaccinate enough Americans to achieve herd immunity. But manufacturing that many doses of a vaccine may prove difficult, particularly in light of unique challenges posed by the coronavirus pandemic.

For instance, the pandemic has caused disruptions in America's health care supply chain, which has become largely reliant on ingredients, materials, and products made in other countries. Labor and supply shortages throughout the world have resulted in the United States facing shortages of critical medical supplies, from ventilators and personal protective equipment (PPE) to ingredients needed to manufacture some prescription drugs and supplies that could be critical to the storage and distribution of coronavirus vaccines.

According to the Wall Street Journal, pharmaceutical companies are working to build supply chains of both raw materials and factory capacity to manufacture billions of doses of coronavirus vaccinesa task that's no easy feat. According to CAP, one industry executive explained that the undertaking is especially difficult because the pandemic has caused a lack of visibility on all sides of the supply chain.

And even if drugmakers can get the ingredients needed to make the vaccines, they may have a hard time finding the materials they need to store the doses. That's because medical glass has been in short supply since the start of the pandemic, which could prove to be an obstacle for vaccine manufacturers who will need millions of vials for vaccine storage, the Journal reports.

As a result, even though pharmaceutical companies are working to ramp up production as quickly as they can, it's possible that there could be a gap of months between when the first doses of an authorized coronavirus vaccine are released and the point at which a company has manufactured enough doses to vaccinate the entire country, experts say. Neel Jones Shah, global head of air carrier relationships at Flexport, told CAP, "To a T, [manufacturers are] extremely nervous about being able to bring these to market as quickly as people might expect."

Even if companies can manufacture the needed number of doses of a coronavirus vaccine, the effort to distribute a vaccine would require the "largest" vaccination campaign "ever undertaken" in America, needing unprecedented planning and coordination, according to the Washington Post.

The first obstacle the United States could encounter when distributing a new coronavirus vaccine is having the capacity and equipment needed to properly store and ship the vaccine doses, which also could be affected by the country's supply shortages, experts say. And the country could face a particular challenge when it comes to storing and shipping Pfizer's and BioNTech's coronavirus vaccine candidate, which could require a refrigeration temperature of minus 70 degrees Celsius, STAT News reports.

"[V]accine supply chains are exponentially more complex than the PPE supply chain," Shah told CAP. "You can't ruin PPE by leaving it on the tarmac for a couple of days," but "[y]ou will destroy vaccines."

And Joachim KuhnCEO of Va-Q-Tec, a manufacturer that is increasing its production of shipping containers by 50% this yeartold STAT News, "We're seeing increased demand for containers that can store product at low temperatures and longer transport duration."

Supply chain shortages also could affect health care providers' ability to administer the vaccines, the Journal reports, as syringes and needles are in high demand.

Further, officials also must craft and implement a plan detailing who would receive and administer coronavirus vaccinesand determine which Americans, if any, would get priority for receiving a vaccine first.

Last month, the National Academies of Sciences, Engineering, and Medicine (NASEM) released a draft plan for distributing a coronavirus vaccine that prioritizes Americans based on their risk of infection, with health care workers among the first to receive the vaccine. NASEM created the plan at the request of CDC and NIH, and the proposal aims to serve as a guide for more detailed plans on how the United States should prioritize coronavirus vaccinations once a vaccine candidate is approved. For example, NASEM's proposal is intended to serve as a model for the Advisory Committee on Immunization Practices, which is an expert panel responsible for developing vaccination guidance for CDC and local, state, and tribal health authorities.

CDC also called on and has been working with states to craft plans to distribute possible coronavirus vaccines, but federal and state governments haven't yet released official details on those plans. According to the National Governors Association (NGA), CDC in July developed a preliminary coronavirus vaccine distribution plan that expanded on public health infrastructure that was originally developed to distribute a H1N1 vaccine.

Under the plan, manufacturers would deliver coronavirus vaccines to a central distributor that would then send weekly supplies of the vaccine to individual states and territories, the Post reports. The states and territories then would approve requests for vaccine doses from providers and clinics and distribute the doses to their facilities, where providers would administer the inoculation. In addition, NGA said additional supplies of the vaccine would be made available to "select private partners," such as CVS Health and Walgreens, to further "expand access."

But senior Trump administration officials have implied that the federal government could take on a bigger role in distributing the vaccine, saying the effort would be a "joint venture" between CDC and the Department of Defense (DOD), the Post reports. One of the officials said DOD would be responsible for "getting the vaccines to the right place, at the right time, in the right conditions" and supplying needles and syringes, according to the Post.

However the United States ends up distributing a coronavirus vaccine, the effort will be a major undertaking and will require a system to "track the supply, manage the allocation equitably around the country, deal with concerns with the vaccine that arise, track adverse events, and communicate clearly and transparently," Tom Inglesby, director of the Johns Hopkins Center for Health Security, said.

And Bill Foege, a former CDC director and current co-chair of the NASEM panel that released the draft distribution plan, said Americans should expect snafus. "There will be many, many problems with distribution," he told STAT News.

Another factor that could complicate plans to get Americans vaccinated is that the country's initial vaccines against the novel coronavirus may not be totally effectiveand Americans will have to choose between getting one of these initial vaccines or waiting until they know which vaccine is the most effective.

As the New York Times reports, the first round of coronavirus vaccines that become available in the United States "may provide only moderate protection, low enough to make it prudent to keep wearing a mask." And "[b]y next spring or summer, there may be several of these so-so vaccines, without a clear sense of how to choose from among them," according to the Times.

That's because current late-stage trials on coronavirus vaccine candidates are testing the candidates against placebos, instead of against each other. If the experimental vaccines were being tested against each other, researchers would have information which vaccine candidates are more effective than others. But those trials aren't happening at this time, because some U.S. officials thought it would take too long to get such trials off the ground, the Times reports. As such, it will be difficult to know which among the first batch of authorized coronavirus vaccines is most effective, according to the Times.

Further, because the first round of vaccines that become available in the United States may be effective to at least some degree, they could make it difficult for drugmakers working on potentially "superior" vaccines to conduct and complete clinical trials, the Times reports. That's because, instead of participating in a coronavirus vaccine trial or completing a vaccine trial in which they are already enrolled, Americans could choose instead to get an authorized coronavirus vaccine to acquire at least some protection against the virus.

In addition, manufacturers of later coronavirus vaccine candidates may have to prove that their candidates are more effective than the initial batch of authorized vaccines. That could make it tough to gain FDA's approval, as "[t]he difference between two vaccines will be smaller than between a vaccine and a placebo. As a result, these trials may have to be bigger and run longer," and "[t]he steep cost may be more than many of the small start-ups working on innovative vaccines can afford," the Times reports.

"That basically prevents the development of better vaccines," Naor Bar-Zeev, a vaccine expert at the Johns Hopkins University School of Medicine, told the Times.

Overall, Gregory Poland, director of the Vaccine Research Group at the Mayo Clinic, told the Times that officials and scientists will need to be honest and open with Americans about how coronavirus vaccine candidates and what their effectiveness could mean in the future. "As long as you frame something in advance, people do better with it," he said (Spiro/Emanuel, Center for American Progress, 7/28; Twohey, New York Times, 7/16; Sun, Washington Post, 8/3; Sun, Cowan, Reuters, 7/31; Washington Post, 8/14; Fox, CNN, 8/19; Sun, Washington Post, 7/29; Silverman, "Pharmalot," STAT+, 7/30; Chen, Wall Street Journal, 7/30; Murray/Griffin, Bloomberg, 7/25; Loftus, Wall Street Journal, 8/5; Lupkin, NPR, 8/6; Rosenthal, Kaiser Health News, 7/8; Branswell/Silverman, STAT News, 10/9; Zimmer, New York Times, 10/12).

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'There will be many, many problems': What to expect after a coronavirus vaccine is approved - The Daily Briefing

US is a week away from ‘rapid acceleration’ of COVID-19 cases – Live Science

October 23, 2020

The U.S. is bracing for a third wave of COVID-19 infections as it moves into the frigid winter months. The country is only about a week away from a "rapid acceleration" in COVID-19 cases, Dr. Scott Gottlieb, former commissioner of the Food and Drug Administration said on CNBC on Monday (Oct. 19).

Coronavirus cases have increased in the U.S. by 36% in the past two weeks, with an average of 60,160 new cases per day over the past week, according to a New York Times analysis. Coronavirus case counts are going up in 45 states and hospitalizations are increasing in 42, Gottlieb said. "We're facing a tough circumstance right now," he said. "It's going to be a difficult fall and winter."

New waves of the virus have also taken hold elsewhere. In Europe, COVID-19 cases have been rising exponentially, and governments have once again resorted to lockdowns some of these lockdowns are as strict as the ones put in place in the spring. Ireland will enact a six-week long nationwide shutdown starting tomorrow, according to NPR. Wales will enact a "firebreak" lockdown that will require everyone to remain at home for two weeks starting on Friday, according to CNN.

Related: Coronavirus live updates

The U.S. is about two or three weeks behind Europe in terms of an increase in cases, Gottlieb said. "So we're about a week away from starting to enter a period where we're going to see a rapid acceleration of cases and I think November and December are going to be tough months." Especially as the holidays approach, and people want to gather indoors to see their families, "we can't let our guard down," he added.

Public health experts have been saying since nearly the start of the pandemic that COVID-19 cases may worsen in the fall and winter months. One reason experts are worried is that as the weather cools, people will gather in close quarters inside, allowing the virus easily spread from person to person, according to NBC12. And the dryer air that's common in the winter months might allow the virus to remain viable in the air for longer, Live Science previously reported. Of course, winter months also threaten to provide a double-whammy with the onset of the flu season, according to another Live Science report.

The U.S. has now reported more than 8.2 million cases of COVID-19 and more than 221,400 deaths, according to the Johns Hopkins dashboard. With the prospect of a potential coronavirus vaccine looming on the horizon, "we can look to happier days," Gottlieb said. "But these are going to be some tough months ahead of us."

Originally published on Live Science.

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US is a week away from 'rapid acceleration' of COVID-19 cases - Live Science

CDC warns of ‘distressing trend’ of rising COVID-19 cases across US – KING5.com

October 23, 2020

The CDC says it sees an uptick of COVID-19 cases across the US, especially in the Midwest. The rise in cases and hospitalizations is alarming to medical experts.

BOISE, Idaho Hospitals across the United States are starting to buckle from a resurgence of COVID-19 cases, with several states setting records for the number of people hospitalized and leaders scrambling to find extra beds and staff. New highs in cases have been reported in states big and small from Idaho to Ohio in recent days.

The rise in cases and hospitalizations was alarming to medical experts.

Around the world, disease trackers have seen a pattern: First, the number of cases rises, then hospitalizations and finally there are increases in deaths. Seeing hospitals struggling is alarming because it may already be too late to stop a crippling surge.

By the time we see hospitalizations rise, it means were really struggling, said Saskia Popescu, an epidemiologist at George Mason University.

Dr. Jay Butler, deputy director for infectious diseases for the Centers for Disease Control and Prevention, said Wednesday the United States is seeing a distressing trend with COVID-19 cases growing in nearly three-quarters of the country.

Were seeing cases increase in really all parts of the country in the Midwest, particularly likely in part because people are moving indoors with the arrival of cooler temperatures, Butler told reporters at a briefing at CDC headquarters in Atlanta.

Another factor is that smaller, more intimate gatherings of family, friends and neighbors may be driving infections as well, especially as these gatherings move indoors and adherence to face coverings and social distancing may not be optimal.

Surges in coronavirus cases have led hospitals in Rocky Mountain states to raise concerns as their intensive care bed space dwindles. Utah, Montana and Wyoming have all reported record highs this week for the number of people hospitalized with COVID-19. Seven of 10 intensive care beds were filled in Utah hospitals and about six in 10 in Montana.

In Nevada, where the economy relies heavily on the tourism industry, officials have stressed the need to maintain steady trends to bring back concerts and conventions that employ thousands on the Las Vegas Strip.

When Gov. Steve Sisolak, a Democrat, lifted the 50-person cap on gatherings on Oct. 1, he said he hoped to ensure safety while preventing a rollercoaster of up and down cases that leads to uncertainty for meeting and convention and event planners.

Now, amid an autumn surge in new cases, Nevada is among seven states with more than 8% of hospital capacity taken up by COVID-19 patients. Due to competing demands, particularly from flu season, 71% of the states hospital beds are occupied, the Nevada Hospital Association reported.

State officials worry that hospital beds will fill up if trends continue. Nevada reported 535 confirmed and suspected COVID-19 hospitalizations on Wednesday, up 19% from Oct. 1.

One day is fine and youre not at the capacity. A week later, you can be bumping up against your capacity for beds and for ICU units. Hospitals can then be teetering on the edge of having to turn patients away. We have to avoid that, Sisolak said.

More than 40 million people around the globe have contracted the virus and more than 1.1 million people have died. In the United States, there have been more than 8 million confirmed cases and more than 220,000 deaths. The seven-day rolling average for daily new cases has reached nearly 60,000 the highest since July.

The spikes come as President Donald Trump has sounded an optimistic tone that the virus is rounding the corner and that a vaccine is imminent. But public health experts maintain the virus will continue to persist and that a vaccine is several months away.

In some cases, spikes are happening as schools reopen and as Americans grow weary of wearing masks and practicing social distancing.

At this point in the pandemic, everybodys tired. Everybodys craving human interaction, Popescu, the epidemiologist, said.

Winter is a busy season for hospitals as influenza and other respiratory illnesses ramp up with more people congregating indoors. I worry a COVID wave that causes a heavy surge on hospitals that are already very busy will further add stress to a system that is exhausted, Popescu said.

Selin Berts mother-in-law is among those who had to be hospitalized in recent weeks. The Mesquite, Nevada, woman had symptoms at home for a few days but her health deteriorated so much that she had to be rushed to the hospital after a family member found her on the bathroom floor.

She ended up in the ICU in Las Vegas and has since been released, but remains severely fatigued.

Bert suspects her mother-in-law was infected during a visit from her grandchildren, who traveled from Montana. But the topic of how she got infected is a delicate one in the family given how serious her illness was.

We dont want to even ask because now its become a very touchy subject. Because if someone says to you, Hey, you potentially killed your mom, or could have killed your mom, it doesnt really bode well for the family reunion."

Coronavirus cases are rising so fast in North Dakota that its taking officials up to three days to notify people after they test positive, and as a result the state has fallen way behind on tracing their close contacts who might have been exposed.

Republican Gov. Doug Burgum and the North Dakota Department of Health said theyre shifting 50 National Guard members from contact tracing to simply notifying people who test positive. And public health officials will no longer notify close contacts of people who tested positive; instead people will be instructed to self-notify their close contacts and direct them to the departments website.

Nebraska began imposing new coronavirus restrictions Wednesday, after the number of people hospitalized remained at a record level of 380 for two straight days and the state reported 11 new deaths from the virus.

Cliff Robertson, CEO of CHI Health, said his hospital group is working to bring in nurses from other parts of the country to handle the additional cases.

Over the past seven days, Nebraska has reported an average of 854 new cases per day, up significantly from two weeks ago when the state was reporting an average 525 cases per day, according to data from Johns Hopkins University.

The trend led Republican Gov. Pete Ricketts to announce new restrictions that took effect Wednesday. Hospitals now must keep 10% of their beds free for COVID-19 patients, and customers at restaurants and bars must remain seated at tables with no more than eight people.

Meanwhile, deaths were on the rise in some states. Minnesota reported 35 confirmed new COVID-19 deaths on Wednesday, tying a single-day record set on May 28. And the Iowa Department of Public Health reported 31 new deaths, the most confirmed in a 24-hour period since the beginning of the pandemic.

Despite having some of the strictest rules in the country, New Mexico Gov. Michelle Lujan Grisham, a Democrat, has been struggling in recent weeks with a surge in cases and increases in transmission and positivity rates. The governor said she believes the increases are the result of people letting their guard down.

Shes imposing more restrictions on businesses in hopes of curbing the surge, saying her goal is to limit pressure on hospitals.

We dont have much time, she said. If we dont attack and snuff out the virus right now by working collectively with businesses and each other, then the virus will win and it leaves us very little opportunity to save lives and to keep our health systems from being overrun.

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CDC warns of 'distressing trend' of rising COVID-19 cases across US - KING5.com

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