KP.3 COVID variant is dominant in the US: What are the symptoms? – NBC DFW
							June 16, 2024
							    In recent weeks, a new COVID-19 variant called KP.3 has gained    dominance in the United States. KP.3 is part of a family of    mutated strains nicknamed "FLiRT," which are driving an    increasing proportion of cases across the country. As KP.3    spreads, some are concerned about potential summer wave.  
    The FLiRT strains  which include KP.3, KP.2, and KP.1.1  now    account for more than half of all COVID-19 infections    nationwide, according to the latest data fromthe U.S. Centers for    Disease Control and Prevention.  
    These new variants, which scientists dubbed"FLiRT"after the locations of    their spike protein mutations, have been circulating in the    U.S. since the early spring. In April, KP.2 quickly    overtookJN.1,theomicron    subvariantthat drove asurge in COVID cases    this past winter.  
    In a matter of weeks, the KP.3 variant overtook KP.2 to become    the most prevalent strain in the U.S., per the CDC.  
    During a two-week period ending on June 8, KP.3 made up an    estimated 25% of cases in the U.S., up from about 9% in early    May. After KP.3, the next most common variant is KP.2, another    FLiRT variant that gained dominance in May and now accounts for    about 22% of cases. It's followed by LB.1, a JN.1 subvariant,    and another FLiRT variant, KP.1.1.  
    Together, the FLiRT variants make up an estimated 55% of cases    in the U.S.  
    Although hospitalizations are down and COVID-19 numbers are    relatively low, there has been a small uptick in test    positivity and emergency room visits, per the latest CDC data.    These trends, along with previous summer waves, have stoked    fears about a surge of infections this summer.  
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    Scientists are warning that the FLiRT variants may be better at    evading the immune system due to their spike protein mutations,    and that waning immunity and poor uptake of the latest COVID-19    vaccine have created a more susceptible population.  
    Will there be another COVID-19 wave? What are the symptoms of    the FLiRT variants? Are vaccines still effective? We spoke to    experts to learn more.  
    KP.3 is one of the FLiRT variants  along with KP.2 and KP.1.1     which are spinoffs of JN.1.11.1, a direct descendant of JN.1.    They were initially detected in wastewater samples from across    the country.  
    KP.3 and the other new variants have additional mutations that    set them apart from JN.1 and appear to give them an advantage    over previous variants, Dr. Albert Ko, infectious disease    physician and professor of public health, epidemiology and    medicine at Yale School of Public Health, tells TODAY.com.  
    The nickname "FLiRT" is based on the technical names for their    mutations, according to theInfectious Disease    Society of America.  
    Just like other COVID-19 strains that have gained dominance in    the U.S. over the last year  JN.1,HV.1,    EG.5 aka Eris,    andXBB.1.16 or    Arcturus the FLiRT variants part of    theomicron    family.  
    The emergence of KP.3 and other FLiRT variants is the "same old    story," Andrew Pekosz, Ph.D., virologist at Johns Hopkins    University, tells TODAY.com. The SARS-CoV-2 virus mutates and    gives rise to a new, highly contagious variant, which becomes    the dominant strain. "The timeline that it happens in, three to    six months, is much faster than we see with other viruses like    influenza," says Pekosz.  
    Its still early days, but the initial impression is that this    variant is rather transmissible, Dr. William Schaffner,    professor of infectious diseases at Vanderbilt University    Medical Center, tells TODAY.com.  
    The proportion of cases caused by KP.3 is increasing, while the    proportion caused by other variants is decreasing, which    suggests the FLiRT variants have features that give it an    advantage, the experts note.  
    Over 97% of people in the U.S. have natural or vaccine-induced    antibodies against the the SARS-CoV-2 virus, per the CDC, but    this immune protection fades over time.  
    Low vaccination rates and waning immunity create a vulnerable    population, which may allow the FLiRT variants to take hold.    Only time and more data will tell, the experts note.  
    Laboratory studies suggest that the FLiRT variants are mutated    enough such that current vaccines and immunity from prior    infection will only provide partial protection, says Schaffner.    "We'll have to see how true that is, but it appears, over time    to be becoming a more prominent variant," he adds.  
    Its still really early ... but I dont think we need to sound    the alarm bells as of yet, says Ko.  
    It's too soon to tell whether KP.3 and the FLiRT variants will    cause a summer wave or surge, the experts note. However, it is    clear that COVID-19 is still circulating and won't be taking    any time off.  
    "We're seeing these infections year-round, at modulating    levels. ... Were probably not at the stage yet where well see    COVID go away completely at any time of the year, says Pekosz.  
    Test positivity, which is an early indicator of case levels,    was 5.4% as of June 8, up 0.8% from the previous week but a    sharp decline from a peak of about 12% in    mid-January,per the CDC. (The    CDC no longer tracks the total number of cases in the U.S.)  
    "We're not seeing a lot of hospitalizations, and we're    certainly much lower than we were in the winter, so I'd say    right now we're at a low point, which is reassuring," says Ko.  
    Wastewater    datapublished by the CDC show that the viral activity    level for COVID-19 is currently low  it was considered high    or very high for most of January and February.  
    "It seems like transmission is pretty low right now, and that    makes sense because usually the big peaks are in the winter,    when people are inside and in more contact," says Ko.  
    COVID-19 has caused    summer wavesin the past, the experts note, which are    often smaller than the winter surges. I dont think that well    see any kind of massive surge in cases, says Pekosz.  
    The seasonality of COVID-19 is something scientists are still    trying to understand. But one thing is obvious: This virus is    now integrating itself into our population and our way of    life, says Schaffner.  
    Adds Ko: Im not expecting a large surge in the summer, but    again, we have to be cautious and we have to follow the data.    ... We always have to be humble because SARS-CoV-2 has taught    us a lot of new things.  
    It is still too early to tell whether the symptoms of KP.3,    KP.2 and other FLiRT variants are different from previous    strains.  
    The FLiRT variants are probably not going to create very    distinctive symptoms. It looks at the moment to follow the    other subvariants, says Schaffner.  
    The symptoms of the FLiRT variants are similar to those caused    by JN.1, which include:  
    According to the CDC, the type and severity of symptoms a    person experiences usually depend more on a persons underlying    health and immunity rather than the variant that caused the    infection.  
    Similar to JN.1 and other omicron subvariants, the FLiRT    variants seem to be causing milder infections, says Schaffer.  
    Early laboratory studies indicate that the vaccines will    continue to provide protection the FLiRT variants  "a little    less protection, but not zero by any means," says Schaffner.  
    As the virus mutates, it is becoming progressively different    from the omicron strain targeted in thelatest updated    boosterreleased in the fall of 2023. "We would expect    that to happen, and we anticipate the plan is to have an    updated vaccine in the fall available to everyone," says    Schaffner.  
    Advisers to theU.S. Food and Drug    Administrationmet on Tuesday, June 5, to decide which    strains to include in the updated COVID-19 vaccines for    20242025. The committee unanimously voted to recommend a    monovalent vaccine targeting the JN.1 variant for this fall,    the agency said in a press release.  
    Even if vaccines do not prevent infection, they can still offer    some protection by preventing severe disease, hospitalization,    and COVID-19 complications,TODAY.com previously    reported.  
    Its still clear that the more severe cases that come into the    emergency room predominate in people who either are not up to    date on their vaccines or havent gotten a vaccine in a really    long period of time, says Pekosz.  
    Vaccination is especially important for the elderly, says    Pekosz, which is why the CDC recently recommended adults ages    65 and older get an additional dose of the2023-2024 updated    COVID-19 vaccine.  
    Unfortunately, vaccination uptake is still poor, the experts    note. "The vaccines are still showing signatures of    effectiveness, but they're not being utilized anywhere close to    the level that they should be," says Pekosz.  
    As of April 2024, only about 22% of adults and 14% of children    have reported receiving the updated COVID-19 vaccine released    in September 2023,according to the    CDC.  
    All current PCR and at-home tests are recognizing KP.3 and    other FLiRT variants, the experts note. (Though if you    havesymptoms of COVID and    test negative, it's a good idea to stay home to avoid    potentially exposing other people, TODAY.com previously    reported.  
    If you are using an at-home antigen test, always remember to    check the expiration date and whether its been extended    bythe FDA.  
    Antivirals (such as Paxlovid) are also working well. ...    Theres not any major signals of antiviral resistance in the    population, which is a positive sign, says Pekosz.  
    While it's too early to tell how the FLiRT variants will pan    out this summer, people can always take steps to protect    themselves and others against COVID-19.  
    The CDC recommends the following prevention strategies:  
    This story first appeared on TODAY.com. More    from Today:  
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KP.3 COVID variant is dominant in the US: What are the symptoms? - NBC DFW