Adjuvanted Flu Shot Protects Seniors Better – Precision Vaccinations

(Precision Vaccinations News)

A recent study found that the Fluad MF59-adjuvanted influenzavaccine (aTIV) was more effective than the high-dose flu vaccine (HD-TIV) at preventing severe respiratory complications in older adults with risk factors.

Published inOpen Forum Infectious Diseases on August 16, 2024, the study included 1,115,725 aTIV and 2,561,718 HD-TIV recipients. For the primary outcome, the analysis found comparable effectiveness between aTIV and HD-TIV (rVE [95% CI]: 5.2% [-5.915.1]) among those with 0 risk factors, whereas aTIV was more effective than HD-TIV among patients with 1, 12, or 3 risk factors (12.5% (10.015.0), 18.4% (13.722.9), and 10.4% (7.413.3), respectively).

The same trends were observed for the secondary outcomes.

Previous studies have found the two vaccines to be similar in effectiveness in older adults.

The Fluad vaccinehas an extensiveclinical legacy and has been licensed in 30 countries since its first approvalin 1997. Fluad is available at most pharmacies in the U.S. for the 2024-2025 flu season.

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Adjuvanted Flu Shot Protects Seniors Better - Precision Vaccinations