A leading COVID-19 vaccine scientist answers our questions – World Economic Forum

Work to fast-track the development of a coronavirus vaccine received a boost last week as the UK government announced 42.5 million in funding for the countrys two leading efforts at Oxford University and Imperial College London. Last Thursday, Oxford Universitys programme, led by Professor Sarah Gilbert, became Europes first to enter human trials while the Imperial College team aim to begin clinical trials in June. This takes the total number of coronavirus vaccine clinical trials started in 2020 to 11.

Heading up the Imperial team is Professor Robin Shattock. In 2019, he spoke at the World Economic Forums Annual Meeting in Davos about the new techniques he was developing to facilitate the rapid development, testing and crucially local production of vaccines. Together, these techniques help to ensure that outbreak responses can be made quickly, with no region or country left behind. We spoke to him to learn how his teams efforts were progressing and to get his thoughts on the global response so far.

In 2019, you warned audiences in Davos of the threat posed by a pandemic, calling for action to ensure the world could respond quickly if one should occur. How did it feel to watch COVID-19 spread and how do you think the global effort to find a vaccine is doing so far?

It's been an interesting time to live through. When we presented in Davos, we were saying that these things will happen, but we were not thinking it was going to happen so soon, or that it would be a coronavirus. Everybody was predicting it would probably be an avian influenza outbreak.

In terms of the global response, its good news that there are many different vaccines being developed, with I think over 90 at the last count. There is a degree of coordination but all these groups are working independently on their own approaches or technology. Thats not necessarily a bad thing given theres so much risk in developing a vaccine, that means the risk is spread out, and I think its pretty clear that some groups will come through with an effective vaccine.

Your team has been working on developing a vaccine for COVID-19 since early February. Could you describe for our readers how a typical vaccine is made and how your approach using RNA differs?

The traditional vaccine approaches usually rely on physically growing the virus. This can be done either by growing the virus in huge volumes, 10s or 100s of thousands of litres, and then inactivating it, or by culturing viruses over time to gradually weaken them until they are safe. Both methods take a long time before they are ready for clinical use and require a lot of virus for an effective dose.

Our approach is to focus on just the genetic code of the spike protein on the surface of the virus and use that as our vaccine. When the vaccine is injected into the body, muscle cells naturally "amplify" it by producing copies of the spike protein which the immune system detects as a threat. This trains the bodys immune system to defend against SARS-CoV-2 through being able to recognise the spike protein if it encounters it again.

What are the advantages to working with RNA?

Using RNA allows us to be fast because the genetic sequence can be made synthetically in the lab, and because it can self-amplify, we need only a very low dose of the vaccine for it to be effective we can make the equivalent of a million doses in one litre of reaction material. This allows us to scale up very quickly and it is feasible to be making 10s of millions of doses per week from our lab. Adding more vaccine platforms working in parallel will only increase production capacity further.

Is distributed production ready to help and what other measures can be taken to ensure vaccines reach all those in need?

Right now, the distributed production mechanism is not there. Manufacturing facilities around the world are not set up with the same technology, so identical methods cannot be used. There is also a need for harmonization of regulatory approval to ensure that when a vaccine is cleared for use in one location, other manufacturing sites around the world can move swiftly to scale production.

I do not expect that such a network will get up and running in time to contribute significantly to the COVID-19 response. When effective vaccines are identified they will probably still be produced through a more traditional approach of working with very large manufacturers. However, developing such distributed production capabilities should be a key part of strengthening global resilience after this crisis has passed.

An example of what more can be done is that of the Serum Institute in India and some others that are offering to make vaccines royalty-free to ensure they are available to as many as possible without the obstacle of high cost.

A distributed approach to vaccine production would help distribute it faster and more widely.

Image: R. Shattock, Imperial College London

Some researchers are reporting lower than expected levels of viral antibodies in people who have recovered from COVID-19, possibly implying that any immunity gained will be temporary. Will a vaccine be able to stimulate a stronger response, giving longer lasting immunity?

Yes, a vaccine must do better than natural immunity and there is strong evidence that it will. COVID-19 is a respiratory infection and those with a mild infection will not be exposed to much virus because it will only be on their respiratory surfaces. The natural immune response to such an infection will be much lower than that generated from a potent vaccine injection. If the vaccine does not generate a strong response, then it should not be rolled out to the general population.

For a vaccine to be highly effective, it should prevent infection in over 80% of vaccinated people and give them immunity for a minimum of a year (which would allow for annual boosting) but ideally longer.

In normal times, vaccine development takes many years but today we are seeing accelerated timelines coupled with pressure from governments, the media and the public. As a researcher, how are you dealing with this?

Its difficult to get the right balance. Its important for people to understand that were moving faster than anybodys moved before because were aiming to have a fully tested vaccine within 12-18 months when normally it would be five to eight years, or longer. That said, when the need is as urgent as it is today, even 1218 months seems slow.

There is a need to temper expectations slightly though, as while we will have vaccines tested soon, we wont have vaccines globally available for a much longer time period.

Vaccine hesitancy has reduced the efficacy of public vaccination programs in some areas, leading to outbreaks of measles and other preventable diseases. Are you at all concerned that such behaviour could limit the potential of a coronavirus vaccine?

Right now, I think people want a vaccine. I dont think there will be much hesitancy about having a vaccine while COVID-19 is at the forefront of our minds. The issue with vaccines is theyre so successful in preventing the disease that it goes away and the reason theyre necessary becomes less apparent.

A new strain of Coronavirus, COVID 19, is spreading around the world, causing deaths and major disruption to the global economy.

Responding to this crisis requires global cooperation among governments, international organizations and the business community, which is at the centre of the World Economic Forums mission as the International Organization for Public-Private Cooperation.

The Forum has created the COVID Action Platform, a global platform to convene the business community for collective action, protect peoples livelihoods and facilitate business continuity, and mobilize support for the COVID-19 response. The platform is created with the support of the World Health Organization and is open to all businesses and industry groups, as well as other stakeholders, aiming to integrate and inform joint action.

As an organization, the Forum has a track record of supporting efforts to contain epidemics. In 2017, at our Annual Meeting, the Coalition for Epidemic Preparedness Innovations (CEPI) was launched bringing together experts from government, business, health, academia and civil society to accelerate the development of vaccines. CEPI is currently supporting the race to develop a vaccine against this strand of the coronavirus.

If in two, three or more years time, weve had a successful vaccine and were not seeing new COVID-19 infections, people may increasingly choose not to be vaccinated. That could be due to hesitancy or simply it not being top of their priority list since the virus no longer appears to be a threat. This could lead to outbreaks popping up and effective public engagement strategies will be needed to minimize the risk of this occurring.

What message would you like to leave our readers with?

We are already seeing the massive impact of this pandemic on the economies of the world. We must learn from this and make the necessary investments to limit the impact of future pandemics now. The investment needed is tiny compared with the economic and human toll of another pandemic. It just makes total financial sense and anything else doesnt. The world needs an insurance policy against pandemics.

This interview has been edited for brevity and clarity.

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Written by

Sam Leakey, Programme Specialist, Science and Society, World Economic Forum

The views expressed in this article are those of the author alone and not the World Economic Forum.

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A leading COVID-19 vaccine scientist answers our questions - World Economic Forum