Lockdowns work against coronavirus. But they take a few weeks to show theyre working. – Vox.com

Now that many parts of the US have shut down temporarily to combat the coronavirus, our greatest enemy is our own impatience.

The measures taken in California last week and 15 other states since then hurt. They kill off businesses that were critical to the livelihoods of millions of people. They throw millions of Americans out of work and off their health insurance.

And for the next two weeks, it wont even be clear if theyre doing anything.

We have sacrificed so much already, but it feels like nothing is working. Thats because it takes weeks to see results. We must stay committed and trust that the social distancing we are enduring now will save thousands of lives, Dr. Caitlin Rivers at the Johns Hopkins Center for Health Security wrote Monday.

Heres why it will take so long for our sacrifices to have visible effects. The thing were trying to reduce new coronavirus infections is invisible at first. It takes between 2 and 14 days for a newly infected person to start showing symptoms. After symptoms begin to show, it can take more than a week for them to be eligible for testing (many people are not eligible at all). And then, thanks to backlogs in testing availability, it can take days for them to learn they tested positive.

As a result, every positive test today reflects infections that occurred, on average, a few weeks ago. And it will be a few weeks from now before we see new case numbers start to fall if our lockdown measures today are successful.

In other words, once you shut down your city to fight the virus, you should actually expect things to get worse before they get better. And because of that, theres a very real risk that that will discourage us and prompt us to give up. We shouldnt.

Lets say we lock down a city to prevent the further spread of the coronavirus, and the lockdown works very well, as the one in Wuhan seems to have. Where previously the average infected person spread the disease to 2-3 other people, after the lockdown in Wuhan it is estimated that each infected person only spread the disease to .32 people.

If we accomplished the same thing, the number of new infections would start declining right away. But heres the thing: The number of new positive tests? It would keep growing.

Heres why: Symptoms of the coronavirus typically take some time to start showing after infection. The average incubation period is 5-6 days but may range from 2-14 days, according to the Center for Disease Control and Prevention. So keep that in mind when thinking about people who are starting to develop symptoms now those were people who were exposed to coronavirus about a week ago, in some cases even longer.

Now, most people cannot get a test as soon as they start to show symptoms. In some parts of the country, in fact, its impossible to get a test until you are hospitalized, unless you are a health care worker, or are otherwise considered high risk.

The coronavirus has a long course of illness people are usually sick for a while before they get sick enough to need hospitalization. In one study from China, the average time from symptom onset to hospitalization was nine days, and in another study, difficulty breathing usually surfaced 5-13 days after symptoms started.

That means that, in the parts of the US where most patients arent tested for the coronavirus until they are hospitalized, a patient may be tested 14 days after they were infected five days for the average patient to show symptoms and nine days after that to end up in the hospital.

Finally, tests dont always get results right away. There are some testing sites that advertise same-day turnaround, but other labs are backlogged, and in many parts of the country results take longer. Rand Pauls positive test for coronavirus reportedly took six days to come back.

Add it all up, and it will take at least two weeks, likely longer, for a coronavirus infection to be reported in official statistics.

That means that it will look for weeks like the measures were taking now like self-quarantines, school closures, and social distancing are not working, even if they are. And if theyre not actually working? Same thing we wont know for at least a couple of weeks.

On January 23, China locked down the city of Wuhan amid a growing epidemic. On that date, the country had 830 cases. Much of the rest of Hubei province locked down later that week, and then restrictions were imposed on the whole country.

For the next few weeks, things got worse. By February 13, the country had 63,851 cases most of them in Wuhans Hubei province. But things were starting to turn around. That day, China reported 5,090 new cases more than on any previous day (except the day of a one-time change in the types of cases reported). On February 14, however, officials reported 2,641 new cases. On the 15th, 2,008. New case numbers kept declining from there; China now reports no new local transmission cases (though they could be either missing some or hiding some, experts dont think theyre hiding a full-blown epidemic.)

Take a look at that gap again: The peak of new cases came fully three weeks after the lockdown started. In Italy, its starting to look like the same dynamic is at work.

These big social distancing measures take time to work, Johns Hopkins Center for Health Security director Tom Inglesby tweeted Monday. The impact of big interventions in Wuhan China took about 3 wks to start to reverse things. And then everyday after the situation got better.

Should the US expect the same thing?

Not necessarily. Some things are definitely different. The US implemented social distancing measures more gradually than Wuhan, which escalated quickly from few restrictions to a full lockdown. No place in the US is employing measures as strict as Wuhans. China separated symptomatic people from their families, and locked people in their houses. Enforcement of stay-at-home orders has, so far, been lax in the US.

But if our measures suffice to reduce transmission so that each new patient infects less than one person, it wouldnt be surprising if the overall trajectory of the disease in a city like New York looks somewhat like Chinas, with cases peaking three weeks after the measures went into place. That would put us into early April.

In other parts of the country, where those measures havent yet been put into place, the peak is even farther off.

We know when this started. We can get a good estimate on when it will end, former FDA Commissioner Scott Gottlieb argued Tuesday, projecting a peak in New York in 2-3 weeks.

Its difficult to be patient and wait for that. The costs of social distancing measures upended routines, shuttered stores, and restaurants, lost jobs, vulnerable people put at risk are apparent already, while the benefits arent. Social distancing measures save lives, but the lives they save are a month away while the lives they throw into turmoil are visible right now.

Unsurprisingly, there is overwhelming pressure to identify results from these measures right now. And preliminary data that looks good is not hard to find. Articles have proliferated comparing states that implemented social distancing to states that didnt, or declaring that early data shows Californias stay-at-home order is working.

Its tempting to draw those conclusions. But its really too early to say any of those things with certainty. The numbers published today reflect measures taken in the last week of February before awareness of the virus in the US was widespread through the first week of March. They dont reflect the effects of the lockdowns or even the school closures. The states that are doing well cannot credit their success to measures theyve taken in the last few weeks, and the states that have imposed such measures shouldnt expect results yet.

Whats important to remember is that if the numbers suddenly get worse in a state that recently implemented stay-at-home measures, it wont prove that stay-at-home doesnt work. The confirmed cases we are seeing today are largely people infected a few weeks ago, and the data on how well our current measures are working wont be available for a while.

For a while it will feel like nothing is working but it takes time, Rivers wrote Monday.

When things are changing as rapidly as they are with this crisis and when families are struggling with lost jobs, wiped retirement accounts, sick loved ones, and closed schools the few weeks well need to wait before case numbers hopefully start declining feel like an eternity. But the best thing we can do is help our cities develop a plan for the next stage of virus response, support essential workers, stay home, and wait.

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Lockdowns work against coronavirus. But they take a few weeks to show theyre working. - Vox.com