What to Know About the Updated COVID Vaccine for Fall, Winter 202425 – Johns Hopkins Bloomberg School of Public Health

Amid an unexpectedly large surge of summer COVID infections in the U.S., and with the fall/winter virus season around the corner, updated COVID vaccines have arrived.

COVID vaccines are one of the best and safest ways to protect against severe illness and hospitalization. Updated COVID vaccines are chosen to target the variants currently circulating and are recommended for everyone 6 months of age and older.

In this Q&A, Andy Pekosz, PhD, a professor in Molecular Microbiology and Immunology, discusses who the updated vaccine is recommended for, when to get yours, whether its safe to get it alongside other seasonal vaccines.

The updated mRNA COVID vaccines from Moderna and Pfizer are based on the KP.2 strain, one of the FLiRT variants that have been spreading since early spring. These variants and their sub-variants have caused the majority of infections during this summers COVID wave.

Everyone 6 months and older should get vaccinated against COVID, according to the CDCs recommendations.

For children ages 6 months to 4 years: Vaccination is recommended, but the number of vaccinations is based on which vaccine they receive, their age, and whether theyve received a previous COVID vaccine. Parents and guardians should refer to CDC guidance and check with their pediatrician to see whats recommended for their child.

For people ages 5 years and up: One dose of the updated COVID vaccine is recommended, regardless of whether theyve been vaccinated previously. If someone has received a COVID vaccine recently, they should wait at least two months before getting the updated one for this season.

According to updated CDC guidelines, individuals who are immunocompromised may receive additional doses with their health care providers guidance.

This summers surge has been larger and lasted longer than many experts anticipated, making it a little trickier than years past to determine the best time to get vaccinated.

People who have not had COVID in the past few months have a couple options:

People at higher risk of severe illness should consider getting an updated COVID vaccine as soon as possible. Everyone who is eligible should get an updated COVID vaccine by mid-October in order to build immunity ahead of holiday travel and gatherings. Remember, it takes about two weeks to build up immunity following a vaccine, so schedule your vaccination accordingly.

Broadly speaking, the COVID vaccine provides strong protection against infection for up to three months and protection against severe disease out to six months. That said, there are a lot of variables that can affect duration and strength of protection, including any new variants that may emerge and how different they are from the vaccine formulation.

If youve had COVID this summer, youll have strong infection-based immunity and can wait a few months after your infection before getting the vaccine. According to the CDC, you can wait three months since your symptoms began or, for asymptomatic cases, since you first tested positive.

Theres some evidence to support waiting as long as six months after a COVID infection to receive an updated vaccine. Waiting longer than the CDCs guidance of three months is not recommended for high-risk groups, but its something people can discuss with their doctor.

Between the two mRNA vaccines from Moderna and Pfizer, there is no reason to get one over the other. They target the same KP.2 variant, are similarly effective, and elicit similar side effects.

The COVID vaccine is free under most health insurance plans and Medicare.

If you dont have insurance to cover the cost of the COVID vaccine, look for vaccination clinics run by your local or state health department. Children under 18 may also be eligible to get a free COVID vaccine through the CDCs Vaccines for Children Program.

You can find local pharmacies offering COVID vaccines at Vaccines.gov or by contacting your health care provider or local health department.

The common side effects are the same as with previous COVID vaccines. Symptoms like soreness at the injection site, achiness or joint pain, fatigue, slight fever, chills, or nausea are normal and not cause for concern. These side effects are a sign that your body is mounting an immune responseexactly what its supposed to do following a vaccine. Side effects generally subside within a day or two.

If youve never been vaccinated against COVID, now is a great time to start. People 5 years of age and older are considered up to date on COVID vaccination once they receive one dose of an updated mRNA COVID vaccine.

The vaccine is a close match to variants currently circulating and provides good protection against severe disease, hospitalization, and death. While KP.2 is not causing a significant number of infections, the most prevalent variants circulating right now are very closely related to them. The vaccine will never be a perfect match to the circulating variants because it takes 2-4 months to make the vaccine, and during that time the virus continues to change as it infects people.

Vaccine-induced immunity is better because its safer. When you get infected with COVID, symptoms from the infection wreak havoc on your body. Whether or not youve been infected or vaccinated previously, the updated COVID vaccine is going to strengthen your immune responses to high levels and do so in a safe way.

People who are vaccinated can still get COVID, but it is much more likely they will experience mild symptoms. Vaccinated people are much less likely to experience severe illness or get so sick that they need to be hospitalized. Data continue to show that those who are hospitalized with COVID are largely people who have not received a COVID vaccine within the past 12 months.

Particularly for people at higher risk of severe COVID, vaccination is an essential tool for reducing COVID complications, hospitalization, and death.

Yes! In fact, studies have shown that people who decide to spread out their vaccines into separate appointments often dont follow through with getting both. Weve also seen that the immune response generated by each vaccine does not change based on whether they are administered at the same time or separately.

Its important to remember that many of the same populations at high risk of experiencing severe illness from COVID are also at high risk of severe influenza. Especially for these vulnerable populations, its a good idea to time your vaccines together.

Some vaccine manufacturers have been working on developing a combined vaccine for COVID and flu, but were not there yet. We certainly wont see a combined vaccine this year. Its possible one will be ready in time for fall 2025, but we wont know for sure until more clinical trial results are available.

Aliza Rosen is a digital content strategist in the Office of External Affairs at the Johns Hopkins Bloomberg School of Public Health.

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What to Know About the Updated COVID Vaccine for Fall, Winter 202425 - Johns Hopkins Bloomberg School of Public Health