May 22, 2024
During the Covid-19 pandemic, vaccines were the main line of defense. Startlingly effective shots quickly helped immunize a large portion of the population at least initially, and in high-income countries.
Antiviral treatments were not as impactful. Remdesivir requires transfusions, which made it difficult to access; Paxlovid is easier to obtain, but has more unpleasant side effects, and carries the risk of rebound. Molnupiravir is taken orally, but is less effective than the other options.
Yet the need for effective antivirals remains even with strong vaccines, to protect people who are unvaccinated, immunocompromised, or otherwise unable to build an antibody response to a vaccine.
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Next-generation antiviral effective against coronaviruses in mice - STAT - STAT
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