Pfizer-BioNTech
The Pfizer-BioNTech vaccine (brand name: Comirnaty) was granted full Food and Drug Administration (FDA) approval in August 2021 for people ages 16 and older. Before that, it was the first COVID vaccine to receive FDA Emergency Use Authorization (EUA) back in December 2020, after the company reported that its vaccine was highly effective at preventing symptomatic disease. This is a messenger RNA (mRNA) vaccine, which uses a relatively new technology. It must be stored in freezer-level temperatures, which can make it more difficult to distribute than some other vaccines.
Status: Pfizers vaccine has been updated over time to target new virus variants. First introduced in December 2020, the original COVID mRNA vaccines from both Pfizer and Moderna protected against the original SARS-CoV-2 virus. They were replaced in September 2022 by bivalent vaccines, which targeted both the original virus and Omicron variants BA.4 and BA.5. New updated vaccines in September 2023 replaced the bivalent shots with ones targeting the XBB lineage of the Omicron variant.
The original and bivalent vaccines are no longer in use, and it has yet to be decided whether updated shots will be administered annually, like the flu shot.
Who can get it: People 6 months and older. The CDC has specific recommendations for the following groups, noting that anyone who recently had COVID may need to consider delaying their vaccination by 3 months:
Possible side effects: Pain, redness, or swelling at the site where the shot was administered, and/or tiredness, headache, muscle pain, chills, fever, or nausea throughout the rest of the body. If these side effects occur, they should go away in a few days. A few side effects are serious, but rare. These include anaphylaxis, a severe reaction that is treatable with epinephrine (the drug in EPIPENs).
FDA warnings: The FDA added a warning label on the mRNA vaccines regarding serious (but rare) cases of inflammation of the heart muscle (myocarditis) and of the outer lining of the heart (pericarditis) in adolescents and young adults, more often occurring after the second dose of an mRNA vaccine. The inflammation, in most cases, gets better on its own without treatment.
How it works: It uses mRNA technology, which is a way of sending instructions to host cells in the body for making copies of a spike protein (like the spikes you see sticking out of the coronavirus in pictures). Our cells recognize that this protein doesnt belong, and the immune system reacts by activating immune cells and producing antibodies. This will prompt the body to recognize and attack the real SARS CoV-2 spike protein if you become exposed to the actual virus.
How well it works: The 2023-2024 updated vaccines were approved based on preclinical studies of their efficacy against the latest circulating strains. Some people may still become infected even though they have been vaccinated, but the goal of the vaccines now is to prevent severe disease, hospitalization and death. Research has suggested that people who are infected after vaccination also are less likely to report Long COVID (defined as signs, symptoms, and conditions that continue or develop after acute COVID infection), compared to those who were not vaccinated.
In its preclinical data, Pfizers updated COVID vaccine produced strong immune responses to XBB.1.5.
In its recommendations for the most recent vaccines, the CDC also cited a study showing the risk of cardiac complications, including myocarditis (an inflammation of the heart muscle), in males 12-17 years old was 1.85.6 times higher after a COVID infection compared to after COVID vaccination.
In December 2020, Pfizer-BioNTechs Phase 3 clinical data for its original vaccine showed 95% efficacy for preventing symptomatic COVID. Later data on real-world effectiveness for adults showed that the protection from the mRNA two-dose primary series waned over time, suggesting that updated vaccines would be needed to bring the immune system back to robust levels.
The FDA granted the Moderna vaccine (brand name: Spikevax) full approval for people 18 and older in January 2022, upgrading the vaccines EUA, which was granted in December 2020 (a week after Pfizer-BioNTech). Moderna uses the same mRNA technology as Pfizer-BioNTech and had a similarly high efficacy at preventing symptomatic disease when the companies applied for authorization; it also needs to be stored in freezer-level temperatures.
Status: Modernas COVID vaccine has been updated over time to target new virus variants. First introduced in December 2020, the original COVID mRNA vaccines aimed to protect against the original SARS-CoV-2 virus. They were replaced in September 2022 by bivalent vaccines designed to prevent both the original virus, and Omicron variants BA.4 and BA.5. New updated vaccines in September 2023 replaced the bivalent shots with ones targeting the XBB lineage of the Omicron variant.
The original and bivalent vaccines are no longer in use, and it has yet to be decided whether updated shots will be administered annually, like the flu shot.
Who can get it: People ages 6 months and older. The CDC has specific recommendations for the following groups, noting that anyone who recently had COVID may need to consider delaying their vaccination by 3 months:
Possible side effects: The side effects are similar to Pfizer-BioNTechs vaccine: Pain, redness, or swelling at the site where the shot was administeredand/or tiredness, headache, muscle pain, chills, fever, or nausea throughout the rest of the body. If any of these side effects occur, they should go away in a few days. A few side effects are serious, but rare. These include anaphylaxis, a severe reaction that is treatable with epinephrine (the drug in EPIPENs).
FDA warnings: The FDA placed a warning label on the Moderna vaccine regarding a likely association with reported cases of heart inflammation in young adults. This inflammation may occur in the heart muscle (myocarditis) or in the outer lining of the heart (pericarditis)it more often occurs after the second dose of an mRNA vaccine. The inflammation, in most cases, gets better on its own without treatment.
How it works: Similar to the Pfizer vaccine, this is an mRNA vaccine that sends host cells in the body instructions for making a spike protein that will train the immune system to recognize it. The immune system will then attack the spike protein the next time it sees one (attached to the actual SARS CoV-2 virus).
How well it works: The 2023-2024 updated vaccines were approved based on preclinical studies of their efficacy against the latest circulating strains. Some people may still become infected even though they have been vaccinated, but the goal of the vaccines now is to prevent severe disease, hospitalization, and death. Research has suggested that people who are infected after vaccination also are less likely to report Long COVID compared to those who were not vaccinated.
To support its 2023-2024 updated shot, Moderna shared clinical trial data that showed a strong immune response against some of the variants that are common now, including XBB.1.5, EG.5, and FL.1.5.1. Antibody responses after vaccination were about 17-times higher against XBB 1.5 and about 10-times higher against BA.2.86.
In its recommendations for the most recent vaccines, the CDC also cited a study showing the risk of cardiac complications, including myocarditis (an inflammation of the heart muscle), in males 12-17 years old was 1.85.6 times higher after a COVID infection compared to after COVID vaccination.
Modernas initial Phase 3 clinical data in December 2020 was similar to Pfizer-BioNTechsboth vaccines showed about 95% efficacy for prevention of COVID. Later data on real-world effectiveness for adults showed that the protection from the mRNA two-dose primary series wanes over time, but booster doses brought the immune system back to robust levels.
The Novavax vaccine (brand names: Nuvaxovid and Covovax) was the fourth COVID vaccine to be administered in the U.S (after Johnson & Johnson, which is no longer available). This vaccine, which is a protein adjuvant, had a 90% efficacy in its clinical trial, performing almost as well as the mRNA vaccines in their early trials. It is simpler to make than some of the other vaccines and can be stored in a refrigerator, making it easier to distribute.
Status: The FDA amended its earlier Novavax authorization to allow for a new adjuvanted 2023-2024 Novavax vaccine for ages 12 and older to target the XBB.1.5 strain in October 2023, a few weeks after the updated mRNA shots were approved. The Novavax vaccine is the only non-mRNA updated COVID vaccine available in the U.S.
The previous Novavax vaccine is no longer authorized in the U.S.
Who can get it: People 12 and older. There are specific recommendations for the following groups:
Possible side effects: Injection site tenderness, fatigue, headache, muscle pain. There were rare cases of myocarditis and pericarditis (six cases in 40,000 participants) in the clinical trial.
How well it works: Novavax has reported that its updated COVID vaccine can generate an immune response against emerging strains of the coronavirus. Earlier studies of its original vaccine showed it to be 90% effective overall against lab-confirmed, symptomatic infection and 100% effective against moderate and severe disease in Phase 3 trial results published in The New England Journal of Medicine in December 2021.
Read more from the original source:
Comparing the COVID-19 Vaccines: How Are They Different? - Yale Medicine
- Booster dose of the Pfizer-BioNTech/BNT162b2 COVID19 vaccine | IDR - Dove Medical Press [Last Updated On: August 9th, 2022] [Originally Added On: August 9th, 2022]
- Monkeypox vaccines have arrived in Victoria. Here's how the rollout will work - ABC News [Last Updated On: August 9th, 2022] [Originally Added On: August 9th, 2022]
- UHD, H-E-B Offering Students Bacterial Meningitis Vaccine On Campus With Deferred Payment Option - UHD News [Last Updated On: August 9th, 2022] [Originally Added On: August 9th, 2022]
- Vaccine effectiveness of two-dose BNT162b2 against symptomatic and severe COVID-19 among adolescents in Brazil and Scotland over time: a test-negative... [Last Updated On: August 9th, 2022] [Originally Added On: August 9th, 2022]
- Japan plans booster shots of Omicron vaccine in October | The Asahi Shimbun: Breaking News, Japan News and Analysis - [Last Updated On: August 9th, 2022] [Originally Added On: August 9th, 2022]
- EyeGene to conduct vaccine projects with government support - KBR [Last Updated On: August 9th, 2022] [Originally Added On: August 9th, 2022]
- Monkeypox Vaccine: Where to Get It - countynewscenter.com [Last Updated On: August 9th, 2022] [Originally Added On: August 9th, 2022]
- Vaccines for Covid-19 arent required in schools this fall - Vox.com [Last Updated On: August 9th, 2022] [Originally Added On: August 9th, 2022]
- 600 in Wisconsin receive monkeypox vaccination, says health department - Green Bay Press Gazette [Last Updated On: August 11th, 2022] [Originally Added On: August 11th, 2022]
- Effectiveness of third vaccine dose for coronavirus disease 2019 during the Omicron variant pandemic: a prospective observational study in Japan |... [Last Updated On: August 11th, 2022] [Originally Added On: August 11th, 2022]
- Why Monkeypox Vaccine Shortage May Threaten the Immunocompromised - The New York Times [Last Updated On: August 11th, 2022] [Originally Added On: August 11th, 2022]
- UK will run out of monkeypox vaccine in 10 to 20 days - The Guardian [Last Updated On: August 11th, 2022] [Originally Added On: August 11th, 2022]
- New method of nasal vaccine delivery could lead to better vaccines for HIV and COVID-19 - UMN News [Last Updated On: August 11th, 2022] [Originally Added On: August 11th, 2022]
- Phillys monkeypox vaccine shortages arent solved yet as feds make move to increase access to the shots - The Philadelphia Inquirer [Last Updated On: August 11th, 2022] [Originally Added On: August 11th, 2022]
- Vaccines are now approved for children aged six months to five years, but what about newborn babies? - ABC News [Last Updated On: August 11th, 2022] [Originally Added On: August 11th, 2022]
- Bottling the monkeypox vaccine could take until early 2023 - POLITICO [Last Updated On: August 11th, 2022] [Originally Added On: August 11th, 2022]
- The Brazilian Scientists Inventing An mRNA Vaccine And Sharing The Recipe : Short Wave - NPR [Last Updated On: August 11th, 2022] [Originally Added On: August 11th, 2022]
- 2,000 Monkeypox Vaccine Appointments Are Available in Chicago This Weekend. Here's How to Get One - NBC Chicago [Last Updated On: August 11th, 2022] [Originally Added On: August 11th, 2022]
- 'Vaccine fatigue' could hit autumn Covid boosters | News | The Sunday Times - The Times [Last Updated On: August 28th, 2022] [Originally Added On: August 28th, 2022]
- Q&A: The new COVID vaccine booster is coming. Should you get it? - The Lawton Constitution [Last Updated On: August 28th, 2022] [Originally Added On: August 28th, 2022]
- Former CRH surgeon who survived polio disheartened by vaccination lapses - The Republic [Last Updated On: August 28th, 2022] [Originally Added On: August 28th, 2022]
- 'Only the beginning': Hundreds protest Western University vaccine mandate - CBC.ca [Last Updated On: August 28th, 2022] [Originally Added On: August 28th, 2022]
- Vaccine hesitancy and trust in health experts: Shifting the focus - Medical News Today [Last Updated On: August 28th, 2022] [Originally Added On: August 28th, 2022]
- I Was There When: AI helped create a vaccine - MIT Technology Review [Last Updated On: August 28th, 2022] [Originally Added On: August 28th, 2022]
- The USDA is sprinkling fish-flavored vaccines from the sky to fight rabies - CNN [Last Updated On: August 28th, 2022] [Originally Added On: August 28th, 2022]
- COVID-19 Vaccines | FDA [Last Updated On: August 28th, 2022] [Originally Added On: August 28th, 2022]
- Novavax COVID-19 vaccine available for ages 12 and up; CDC Community Level back at Low - Communications and Outreach - New Hanover County [Last Updated On: August 28th, 2022] [Originally Added On: August 28th, 2022]
- Vaccine Definition & Meaning - Merriam-Webster [Last Updated On: August 28th, 2022] [Originally Added On: August 28th, 2022]
- National health agency apologises over Covid vaccine ads it was ordered to remove - RNZ [Last Updated On: September 3rd, 2022] [Originally Added On: September 3rd, 2022]
- Editorial: How Jewish space lasers and vaccine nanobots seized the brains of GOP voters - St. Louis Post-Dispatch [Last Updated On: September 3rd, 2022] [Originally Added On: September 3rd, 2022]
- Novel HER2-hICD Vaccine to be Investigated for Treatment of HER2-Low Breast Cancer - Targeted Oncology [Last Updated On: September 3rd, 2022] [Originally Added On: September 3rd, 2022]
- Brazilian Covid vaccine to be tested in humans in 2023 - The Brazilian Report [Last Updated On: September 3rd, 2022] [Originally Added On: September 3rd, 2022]
- A Review on the Use of the HPV Vaccine in the Prevention of Cervical Cancer - Cureus [Last Updated On: September 3rd, 2022] [Originally Added On: September 3rd, 2022]
- City Offering Second Doses of Monkeypox Vaccine to New Yorkers and Begin Accepting Walk-In Appointments - nyc.gov [Last Updated On: September 3rd, 2022] [Originally Added On: September 3rd, 2022]
- Monkeypox vax has disproportionately gone to white Philadelphians. This clinic sought to balance that. - The Philadelphia Inquirer [Last Updated On: September 3rd, 2022] [Originally Added On: September 3rd, 2022]
- Hopeful New Entry In The Race For A Universal Covid Vaccine - Forbes [Last Updated On: September 3rd, 2022] [Originally Added On: September 3rd, 2022]
- Study raises concerns about the effectiveness of the monkeypox vaccine - STAT [Last Updated On: September 3rd, 2022] [Originally Added On: September 3rd, 2022]
- newsroom.heart.org [Last Updated On: September 3rd, 2022] [Originally Added On: September 3rd, 2022]
- Did the affordable, no-patent COVID vaccine Corbevax live up to its promise? : Goats and Soda - NPR [Last Updated On: September 3rd, 2022] [Originally Added On: September 3rd, 2022]
- In CDC Survey of Over 13,000 Children, More Than Half Had 'Systemic Reaction' After COVID-19 Vaccine - The Epoch Times [Last Updated On: September 6th, 2022] [Originally Added On: September 6th, 2022]
- Department of Health working with community to administer monkeypox vaccines - Honolulu Star-Advertiser [Last Updated On: September 6th, 2022] [Originally Added On: September 6th, 2022]
- Fact check: Post-vaccine hospitalization odds not 3 times higher as ex-Japan PM claimed - The Mainichi - The Mainichi [Last Updated On: September 6th, 2022] [Originally Added On: September 6th, 2022]
- Impact of vaccinia virus-based vaccines on the 2022 monkeypox virus outbreak - News-Medical.Net [Last Updated On: September 6th, 2022] [Originally Added On: September 6th, 2022]
- Microsoft and Unicef drive Covid-19 vaccine roll-out with COVAX platform - Technology Record [Last Updated On: September 6th, 2022] [Originally Added On: September 6th, 2022]
- School Mask, Vaccine Mandates Are Mostly Gone. But What if the Virus Comes Back? - The 74 [Last Updated On: September 6th, 2022] [Originally Added On: September 6th, 2022]
- Immunogenicity and safety of an inactivated whole-virus COVID-19 vaccine (VLA2001) compared with the adenoviral vector vaccine ChAdOx1-S in adults in... [Last Updated On: September 6th, 2022] [Originally Added On: September 6th, 2022]
- Getting a Grip on Influenza: The Pursuit of a Universal Vaccine (Part 4) - Forbes [Last Updated On: September 7th, 2022] [Originally Added On: September 7th, 2022]
- Why So Few Young Kids Are Vaccinated against COVIDAnd How to Change That - Scientific American [Last Updated On: September 7th, 2022] [Originally Added On: September 7th, 2022]
- UK Travel Vaccine Market Report 2022: Increasing Travel and Tourism & Growing Incidences of Infectious Diseases Fuel Sector -... [Last Updated On: September 7th, 2022] [Originally Added On: September 7th, 2022]
- At long last, we might have an HIV vaccine - Big Think [Last Updated On: September 7th, 2022] [Originally Added On: September 7th, 2022]
- The associations between vaccination status, type, and time since vaccination with lineage identity during the emergence of new SARS-CoV-2 variants -... [Last Updated On: September 7th, 2022] [Originally Added On: September 7th, 2022]
- Needle-less COVID-19 vaccine developed at Washington University approved for use in India - KSDK.com [Last Updated On: September 10th, 2022] [Originally Added On: September 10th, 2022]
- Study: COVID-19 Vaccine Prevented Approximately 27 Million Infections in US Adults - Pharmacy Times [Last Updated On: September 10th, 2022] [Originally Added On: September 10th, 2022]
- Health System Warns Exemptions to COVID Vaccines May Expire With New Options - Medpage Today [Last Updated On: September 10th, 2022] [Originally Added On: September 10th, 2022]
- Does Moderna's vaccine IP lawsuit herald the end of the pandemic? - Medical Marketing and Media [Last Updated On: September 10th, 2022] [Originally Added On: September 10th, 2022]
- The Unintended Consequences of COVID-19 Vaccine Policy The Wire Science - The Wire Science [Last Updated On: September 10th, 2022] [Originally Added On: September 10th, 2022]
- Astrocytes, the Covid vaccine and the 2021 classification - Brain Tumour Research [Last Updated On: September 18th, 2022] [Originally Added On: September 18th, 2022]
- Nearly 50 Members of Congress Call on Pentagon to End Military Vaccine Mandate - The Epoch Times [Last Updated On: September 18th, 2022] [Originally Added On: September 18th, 2022]
- New Omicron-fighting Covid vaccine supplied with flimsy needles across Scotland to get replacement syringes - STV News [Last Updated On: September 18th, 2022] [Originally Added On: September 18th, 2022]
- Is There A Minimum Age for the Shingles Vaccine? - Healthline [Last Updated On: September 18th, 2022] [Originally Added On: September 18th, 2022]
- Detection of circulating vaccine derived polio virus 2 (cVDPV2) in environmental samples the United Kingdom of Great Britain and Northern Ireland and... [Last Updated On: September 18th, 2022] [Originally Added On: September 18th, 2022]
- 850 more unvaxxed NYC teachers, aides fired for not complying with mandate - New York Post [Last Updated On: September 18th, 2022] [Originally Added On: September 18th, 2022]
- 'India's vaccine growth story' book review: Far from being a dry collection of facts and figures - The New Indian Express [Last Updated On: September 18th, 2022] [Originally Added On: September 18th, 2022]
- Health care workers appeal dismissal of lawsuit over Maine's vaccine mandate - Kennebec Journal and Morning Sentinel [Last Updated On: September 18th, 2022] [Originally Added On: September 18th, 2022]
- Department of Health Expands Eligibility for the Monkeypox Vaccine - Anne Arundel County Department of Health [Last Updated On: September 25th, 2022] [Originally Added On: September 25th, 2022]
- Could This Be Pfizer's Next Billion-Dollar Vaccine? - The Motley Fool [Last Updated On: September 25th, 2022] [Originally Added On: September 25th, 2022]
- Many Vaccinated Youth Who Suffered Heart Inflammation Had Abnormal MRI Results Months Later: CDC Study - The Epoch Times [Last Updated On: September 25th, 2022] [Originally Added On: September 25th, 2022]
- Second vaccine doses to be offered to those at highest risk from monkeypox - GOV.UK [Last Updated On: September 25th, 2022] [Originally Added On: September 25th, 2022]
- Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies - Nature.com [Last Updated On: September 25th, 2022] [Originally Added On: September 25th, 2022]
- Coronavirus Roundup: A CDC Team Is Honored for Its Vaccine Distribution Work - GovExec.com [Last Updated On: September 25th, 2022] [Originally Added On: September 25th, 2022]
- Everything to know about the Monkeypox vaccine | Health - Red and Black [Last Updated On: September 25th, 2022] [Originally Added On: September 25th, 2022]
- The U.S. ordered 171 million updated COVID booster shots but only 4.4 million went into arms as Biden says the pandemic is over - Fortune [Last Updated On: September 25th, 2022] [Originally Added On: September 25th, 2022]
- Why mosquitoes were the vaccinators in a new malaria vaccine trial : Goats and Soda - NPR [Last Updated On: September 25th, 2022] [Originally Added On: September 25th, 2022]
- Lyme disease is on the rise. Why is there still no vaccine? - AAMC [Last Updated On: September 25th, 2022] [Originally Added On: September 25th, 2022]
- Government of Canada announces funding for advancements in mRNA vaccine technology at the University of British Columbia - Canada NewsWire [Last Updated On: October 3rd, 2022] [Originally Added On: October 3rd, 2022]
- 130 people have received incorrect doses of COVID-19 vaccines: MOH - CNA [Last Updated On: October 3rd, 2022] [Originally Added On: October 3rd, 2022]
- Health unit hosts pop-up vaccine clinics throughout the week - BradfordToday [Last Updated On: October 3rd, 2022] [Originally Added On: October 3rd, 2022]
- Doctor who gave anti-vaccine speech in front of effigies of officials being hanged faces discipline hearing - CBC.ca [Last Updated On: October 3rd, 2022] [Originally Added On: October 3rd, 2022]
- What's really happening with global vaccine access? - Gavi, the Vaccine Alliance [Last Updated On: October 3rd, 2022] [Originally Added On: October 3rd, 2022]
- Study confirms link between COVID-19 vaccination and temporary increase in menstrual cycle length - National Institutes of Health (.gov) [Last Updated On: October 3rd, 2022] [Originally Added On: October 3rd, 2022]