Altamira Therapeutics Ltd
HAMILTON, BERMUDA, March 25, 2024 (GLOBE NEWSWIRE) --
Altamira Therapeutics Ltd. (Altamira or the Company) (Nasdaq:CYTO), a company providing nanoparticle-based technology for efficient RNA delivery to extrahepatic targets, today announced that it has entered into a collaboration agreement with Univercells Group (Univercells) to evaluate the use of the Companys proprietary SemaPhore platform for the delivery of mRNA vaccines. Univercells is a global life sciences company creating platforms for developing and manufacturing biologics, including mRNA vaccines and therapeutics, in a simple, scalable and cost-efficient way.
Under the terms of the agreement, Univercells will test in vitro and in vivo a proprietary mRNA vaccine delivered with Altamiras SemaPhore nanoparticle platform. Should the experiments prove successful, Univercells and Altamira intend to discuss and negotiate a commercial agreement for the development and manufacturing of nanoparticle-based mRNA vaccines using Univercells production platform.
We are thrilled to initiate this collaboration with Univercells to explore SemaPhore as a delivery vehicle for mRNA vaccines, commented Covadonga Paeda, PhD, Altamiras Chief Operating Officer. SemaPhore has shown to be an efficient delivery vehicle for therapeutic RNA in many different disease models. With this collaboration we will explore for the first time its potential utility in delivering mRNA vaccines. Current delivery vehicles used in the field of mRNA vaccines suffer from significant rates of mRNA loss during cell entrance; in addition, they may cause local or systemic side effects. SemaPhore reduces mRNA loss during cell entrance, which may allow for using lower doses. This feature, together with its favorable tolerability profile could make SemaPhore a compelling alternative to conventional delivery vehicles.
Story continues
Were delighted to be partnering with Altamira to explore better ways to deliver mRNA to patients, said Jos Castillo, PhD, Chief Technology Officer of Univercells. mRNA vaccines, and mRNA in general, have proven to be a game-changer in how we prevent, treat, and cure diseases in a range of fields from oncology to infectious diseases. To unlock its full potential, however, we need constant innovation to make mRNA products more effective, efficient, and affordable. One key step is to develop platforms that use lower doses of mRNA.
mRNA vaccines work through priming the bodys immune system to recognize and destroy a pathogen. The vaccines introduce a small piece of the target pathogens proteins into specialized cells in our bodies that can produce the full protein. These cells then manufacture the target protein in small amounts triggering the production of specific antibodies to destroy any entity that has the same protein, such as a virus. Although our bodies break down the vaccines mRNA very quickly, the antibodies linger so that we are protected should we contract the virus in the future.
About SemaPhore
SemaPhore is a versatile platform designed to enable safe and effective delivery of mRNA into target cells, using systemic or local administration. It is based on a proprietary 21 amino acid peptide that can engage any type of RNA in rapid self-assembly into a polyplex. The polyplex has a size, charge, and other physical features that allow it to escape hepatic clearance and thus to reach target tissues other than the liver. SemaPhore protects the RNA payload from degradation in the circulation and allows for rapid and effective cell entrance. Efficient delivery and positive treatment outcomes have been demonstrated in multiple murine models of disease so far.
About Altamira Therapeutics
Altamira Therapeutics (Nasdaq: CYTO) is developing and supplying peptide-based nanoparticle technologies for efficient RNA delivery to extrahepatic tissues (OligoPhore / SemaPhore platforms). The Company currently has two flagship siRNA programs using its proprietary delivery technology: AM-401 for KRAS driven cancer and AM-411 for rheumatoid arthritis, both in preclinical development beyond in vivo proof of concept. The versatile delivery platform is also suited for mRNA and other RNA modalities and made available to pharma or biotech companies through out-licensing. In addition, Altamira holds a 49% stake (with additional economic rights) in its commercial-stage legacy asset Bentrio, an OTC nasal spray for allergic rhinitis. Further, the Company is in the process of partnering / divesting its inner ear legacy assets. Founded in 2003, Altamira is headquartered in Hamilton, Bermuda, with its main operations in Basel, Switzerland. For more information, visit:https://altamiratherapeutics.com
About Univercells
Univercells is a global life sciences company with the mission of making biologics accessible. Using our combined expertise in scaling, production and bioprocessing, Univercells finds new and sustainable ways to widen access to life-changing drugs. Our affiliate companies deploy innovations in infrastructure, drug substance manufacturing, equipment manufacturing, equipment design, training, and on-the-ground health services to drive down costs, shrink manufacturing footprints and meet the needs of the entire health value chain. Headquartered in Jumet (Belgium), Univercells is supported by regional and national investors, as well as international investors active in vaccines and healthcare, such as the European Investment Bank and Global Health Investment Fund, among others. https://www.univercells.com/ Forward-Looking Statements
This press release may contain statements that constitute "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements are statements other than historical facts and may include statements that address future operating, financial or business performance or Altamiras strategies or expectations. In some cases, you can identify these statements by forward-looking words such as "may", "might", "will", "should", "expects", "plans", "anticipates", "believes", "estimates", "predicts", "projects", "potential", "outlook" or "continue", or the negative of these terms or other comparable terminology. Forward-looking statements are based on management's current expectations and beliefs and involve significant risks and uncertainties that could cause actual results, developments and business decisions to differ materially from those contemplated by these statements. These risks and uncertainties include, but are not limited to, the success of strategic transactions, including licensing or partnering, with respect to Altamiras legacy assets, Altamiras need for and ability to raise substantial additional funding to continue the development of its product candidates, the clinical utility of Altamiras product candidates, the timing or likelihood of regulatory filings and approvals, Altamiras intellectual property position and Altamiras financial position, including the impact of any future acquisitions, dispositions, partnerships, license transactions or changes to Altamiras capital structure, including future securities offerings. These risks and uncertainties also include, but are not limited to, those described under the caption "Risk Factors" in Altamiras Annual Report on Form 20-F for the year ended December 31, 2022, and in Altamiras other filings with the Securities Exchange Commission (SEC), which are available free of charge on the SECs website at: http://www.sec.gov. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those indicated. All forward-looking statements and all subsequent written and oral forward-looking statements attributable to Altamira or to persons acting on behalf of Altamira are expressly qualified in their entirety by reference to these risks and uncertainties. You should not place undue reliance on forward-looking statements. Forward-looking statements speak only as of the date they are made, and Altamira does not undertake any obligation to update them in light of new information, future developments or otherwise, except as may be required under applicable law.
Investor contact
Read more:
- Booster dose of the Pfizer-BioNTech/BNT162b2 COVID19 vaccine | IDR - Dove Medical Press [Last Updated On: August 9th, 2022] [Originally Added On: August 9th, 2022]
- Monkeypox vaccines have arrived in Victoria. Here's how the rollout will work - ABC News [Last Updated On: August 9th, 2022] [Originally Added On: August 9th, 2022]
- UHD, H-E-B Offering Students Bacterial Meningitis Vaccine On Campus With Deferred Payment Option - UHD News [Last Updated On: August 9th, 2022] [Originally Added On: August 9th, 2022]
- Vaccine effectiveness of two-dose BNT162b2 against symptomatic and severe COVID-19 among adolescents in Brazil and Scotland over time: a test-negative... [Last Updated On: August 9th, 2022] [Originally Added On: August 9th, 2022]
- Japan plans booster shots of Omicron vaccine in October | The Asahi Shimbun: Breaking News, Japan News and Analysis - [Last Updated On: August 9th, 2022] [Originally Added On: August 9th, 2022]
- EyeGene to conduct vaccine projects with government support - KBR [Last Updated On: August 9th, 2022] [Originally Added On: August 9th, 2022]
- Monkeypox Vaccine: Where to Get It - countynewscenter.com [Last Updated On: August 9th, 2022] [Originally Added On: August 9th, 2022]
- Vaccines for Covid-19 arent required in schools this fall - Vox.com [Last Updated On: August 9th, 2022] [Originally Added On: August 9th, 2022]
- 600 in Wisconsin receive monkeypox vaccination, says health department - Green Bay Press Gazette [Last Updated On: August 11th, 2022] [Originally Added On: August 11th, 2022]
- Effectiveness of third vaccine dose for coronavirus disease 2019 during the Omicron variant pandemic: a prospective observational study in Japan |... [Last Updated On: August 11th, 2022] [Originally Added On: August 11th, 2022]
- Why Monkeypox Vaccine Shortage May Threaten the Immunocompromised - The New York Times [Last Updated On: August 11th, 2022] [Originally Added On: August 11th, 2022]
- UK will run out of monkeypox vaccine in 10 to 20 days - The Guardian [Last Updated On: August 11th, 2022] [Originally Added On: August 11th, 2022]
- New method of nasal vaccine delivery could lead to better vaccines for HIV and COVID-19 - UMN News [Last Updated On: August 11th, 2022] [Originally Added On: August 11th, 2022]
- Phillys monkeypox vaccine shortages arent solved yet as feds make move to increase access to the shots - The Philadelphia Inquirer [Last Updated On: August 11th, 2022] [Originally Added On: August 11th, 2022]
- Vaccines are now approved for children aged six months to five years, but what about newborn babies? - ABC News [Last Updated On: August 11th, 2022] [Originally Added On: August 11th, 2022]
- Bottling the monkeypox vaccine could take until early 2023 - POLITICO [Last Updated On: August 11th, 2022] [Originally Added On: August 11th, 2022]
- The Brazilian Scientists Inventing An mRNA Vaccine And Sharing The Recipe : Short Wave - NPR [Last Updated On: August 11th, 2022] [Originally Added On: August 11th, 2022]
- 2,000 Monkeypox Vaccine Appointments Are Available in Chicago This Weekend. Here's How to Get One - NBC Chicago [Last Updated On: August 11th, 2022] [Originally Added On: August 11th, 2022]
- 'Vaccine fatigue' could hit autumn Covid boosters | News | The Sunday Times - The Times [Last Updated On: August 28th, 2022] [Originally Added On: August 28th, 2022]
- Q&A: The new COVID vaccine booster is coming. Should you get it? - The Lawton Constitution [Last Updated On: August 28th, 2022] [Originally Added On: August 28th, 2022]
- Former CRH surgeon who survived polio disheartened by vaccination lapses - The Republic [Last Updated On: August 28th, 2022] [Originally Added On: August 28th, 2022]
- 'Only the beginning': Hundreds protest Western University vaccine mandate - CBC.ca [Last Updated On: August 28th, 2022] [Originally Added On: August 28th, 2022]
- Vaccine hesitancy and trust in health experts: Shifting the focus - Medical News Today [Last Updated On: August 28th, 2022] [Originally Added On: August 28th, 2022]
- I Was There When: AI helped create a vaccine - MIT Technology Review [Last Updated On: August 28th, 2022] [Originally Added On: August 28th, 2022]
- The USDA is sprinkling fish-flavored vaccines from the sky to fight rabies - CNN [Last Updated On: August 28th, 2022] [Originally Added On: August 28th, 2022]
- COVID-19 Vaccines | FDA [Last Updated On: August 28th, 2022] [Originally Added On: August 28th, 2022]
- Novavax COVID-19 vaccine available for ages 12 and up; CDC Community Level back at Low - Communications and Outreach - New Hanover County [Last Updated On: August 28th, 2022] [Originally Added On: August 28th, 2022]
- Vaccine Definition & Meaning - Merriam-Webster [Last Updated On: August 28th, 2022] [Originally Added On: August 28th, 2022]
- National health agency apologises over Covid vaccine ads it was ordered to remove - RNZ [Last Updated On: September 3rd, 2022] [Originally Added On: September 3rd, 2022]
- Editorial: How Jewish space lasers and vaccine nanobots seized the brains of GOP voters - St. Louis Post-Dispatch [Last Updated On: September 3rd, 2022] [Originally Added On: September 3rd, 2022]
- Novel HER2-hICD Vaccine to be Investigated for Treatment of HER2-Low Breast Cancer - Targeted Oncology [Last Updated On: September 3rd, 2022] [Originally Added On: September 3rd, 2022]
- Brazilian Covid vaccine to be tested in humans in 2023 - The Brazilian Report [Last Updated On: September 3rd, 2022] [Originally Added On: September 3rd, 2022]
- A Review on the Use of the HPV Vaccine in the Prevention of Cervical Cancer - Cureus [Last Updated On: September 3rd, 2022] [Originally Added On: September 3rd, 2022]
- City Offering Second Doses of Monkeypox Vaccine to New Yorkers and Begin Accepting Walk-In Appointments - nyc.gov [Last Updated On: September 3rd, 2022] [Originally Added On: September 3rd, 2022]
- Monkeypox vax has disproportionately gone to white Philadelphians. This clinic sought to balance that. - The Philadelphia Inquirer [Last Updated On: September 3rd, 2022] [Originally Added On: September 3rd, 2022]
- Hopeful New Entry In The Race For A Universal Covid Vaccine - Forbes [Last Updated On: September 3rd, 2022] [Originally Added On: September 3rd, 2022]
- Study raises concerns about the effectiveness of the monkeypox vaccine - STAT [Last Updated On: September 3rd, 2022] [Originally Added On: September 3rd, 2022]
- newsroom.heart.org [Last Updated On: September 3rd, 2022] [Originally Added On: September 3rd, 2022]
- Did the affordable, no-patent COVID vaccine Corbevax live up to its promise? : Goats and Soda - NPR [Last Updated On: September 3rd, 2022] [Originally Added On: September 3rd, 2022]
- In CDC Survey of Over 13,000 Children, More Than Half Had 'Systemic Reaction' After COVID-19 Vaccine - The Epoch Times [Last Updated On: September 6th, 2022] [Originally Added On: September 6th, 2022]
- Department of Health working with community to administer monkeypox vaccines - Honolulu Star-Advertiser [Last Updated On: September 6th, 2022] [Originally Added On: September 6th, 2022]
- Fact check: Post-vaccine hospitalization odds not 3 times higher as ex-Japan PM claimed - The Mainichi - The Mainichi [Last Updated On: September 6th, 2022] [Originally Added On: September 6th, 2022]
- Impact of vaccinia virus-based vaccines on the 2022 monkeypox virus outbreak - News-Medical.Net [Last Updated On: September 6th, 2022] [Originally Added On: September 6th, 2022]
- Microsoft and Unicef drive Covid-19 vaccine roll-out with COVAX platform - Technology Record [Last Updated On: September 6th, 2022] [Originally Added On: September 6th, 2022]
- School Mask, Vaccine Mandates Are Mostly Gone. But What if the Virus Comes Back? - The 74 [Last Updated On: September 6th, 2022] [Originally Added On: September 6th, 2022]
- Immunogenicity and safety of an inactivated whole-virus COVID-19 vaccine (VLA2001) compared with the adenoviral vector vaccine ChAdOx1-S in adults in... [Last Updated On: September 6th, 2022] [Originally Added On: September 6th, 2022]
- Getting a Grip on Influenza: The Pursuit of a Universal Vaccine (Part 4) - Forbes [Last Updated On: September 7th, 2022] [Originally Added On: September 7th, 2022]
- Why So Few Young Kids Are Vaccinated against COVIDAnd How to Change That - Scientific American [Last Updated On: September 7th, 2022] [Originally Added On: September 7th, 2022]
- UK Travel Vaccine Market Report 2022: Increasing Travel and Tourism & Growing Incidences of Infectious Diseases Fuel Sector -... [Last Updated On: September 7th, 2022] [Originally Added On: September 7th, 2022]
- At long last, we might have an HIV vaccine - Big Think [Last Updated On: September 7th, 2022] [Originally Added On: September 7th, 2022]
- The associations between vaccination status, type, and time since vaccination with lineage identity during the emergence of new SARS-CoV-2 variants -... [Last Updated On: September 7th, 2022] [Originally Added On: September 7th, 2022]
- Needle-less COVID-19 vaccine developed at Washington University approved for use in India - KSDK.com [Last Updated On: September 10th, 2022] [Originally Added On: September 10th, 2022]
- Study: COVID-19 Vaccine Prevented Approximately 27 Million Infections in US Adults - Pharmacy Times [Last Updated On: September 10th, 2022] [Originally Added On: September 10th, 2022]
- Health System Warns Exemptions to COVID Vaccines May Expire With New Options - Medpage Today [Last Updated On: September 10th, 2022] [Originally Added On: September 10th, 2022]
- Does Moderna's vaccine IP lawsuit herald the end of the pandemic? - Medical Marketing and Media [Last Updated On: September 10th, 2022] [Originally Added On: September 10th, 2022]
- The Unintended Consequences of COVID-19 Vaccine Policy The Wire Science - The Wire Science [Last Updated On: September 10th, 2022] [Originally Added On: September 10th, 2022]
- Astrocytes, the Covid vaccine and the 2021 classification - Brain Tumour Research [Last Updated On: September 18th, 2022] [Originally Added On: September 18th, 2022]
- Nearly 50 Members of Congress Call on Pentagon to End Military Vaccine Mandate - The Epoch Times [Last Updated On: September 18th, 2022] [Originally Added On: September 18th, 2022]
- New Omicron-fighting Covid vaccine supplied with flimsy needles across Scotland to get replacement syringes - STV News [Last Updated On: September 18th, 2022] [Originally Added On: September 18th, 2022]
- Is There A Minimum Age for the Shingles Vaccine? - Healthline [Last Updated On: September 18th, 2022] [Originally Added On: September 18th, 2022]
- Detection of circulating vaccine derived polio virus 2 (cVDPV2) in environmental samples the United Kingdom of Great Britain and Northern Ireland and... [Last Updated On: September 18th, 2022] [Originally Added On: September 18th, 2022]
- 850 more unvaxxed NYC teachers, aides fired for not complying with mandate - New York Post [Last Updated On: September 18th, 2022] [Originally Added On: September 18th, 2022]
- 'India's vaccine growth story' book review: Far from being a dry collection of facts and figures - The New Indian Express [Last Updated On: September 18th, 2022] [Originally Added On: September 18th, 2022]
- Health care workers appeal dismissal of lawsuit over Maine's vaccine mandate - Kennebec Journal and Morning Sentinel [Last Updated On: September 18th, 2022] [Originally Added On: September 18th, 2022]
- Department of Health Expands Eligibility for the Monkeypox Vaccine - Anne Arundel County Department of Health [Last Updated On: September 25th, 2022] [Originally Added On: September 25th, 2022]
- Could This Be Pfizer's Next Billion-Dollar Vaccine? - The Motley Fool [Last Updated On: September 25th, 2022] [Originally Added On: September 25th, 2022]
- Many Vaccinated Youth Who Suffered Heart Inflammation Had Abnormal MRI Results Months Later: CDC Study - The Epoch Times [Last Updated On: September 25th, 2022] [Originally Added On: September 25th, 2022]
- Second vaccine doses to be offered to those at highest risk from monkeypox - GOV.UK [Last Updated On: September 25th, 2022] [Originally Added On: September 25th, 2022]
- Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies - Nature.com [Last Updated On: September 25th, 2022] [Originally Added On: September 25th, 2022]
- Coronavirus Roundup: A CDC Team Is Honored for Its Vaccine Distribution Work - GovExec.com [Last Updated On: September 25th, 2022] [Originally Added On: September 25th, 2022]
- Everything to know about the Monkeypox vaccine | Health - Red and Black [Last Updated On: September 25th, 2022] [Originally Added On: September 25th, 2022]
- The U.S. ordered 171 million updated COVID booster shots but only 4.4 million went into arms as Biden says the pandemic is over - Fortune [Last Updated On: September 25th, 2022] [Originally Added On: September 25th, 2022]
- Why mosquitoes were the vaccinators in a new malaria vaccine trial : Goats and Soda - NPR [Last Updated On: September 25th, 2022] [Originally Added On: September 25th, 2022]
- Lyme disease is on the rise. Why is there still no vaccine? - AAMC [Last Updated On: September 25th, 2022] [Originally Added On: September 25th, 2022]
- Government of Canada announces funding for advancements in mRNA vaccine technology at the University of British Columbia - Canada NewsWire [Last Updated On: October 3rd, 2022] [Originally Added On: October 3rd, 2022]
- 130 people have received incorrect doses of COVID-19 vaccines: MOH - CNA [Last Updated On: October 3rd, 2022] [Originally Added On: October 3rd, 2022]
- Health unit hosts pop-up vaccine clinics throughout the week - BradfordToday [Last Updated On: October 3rd, 2022] [Originally Added On: October 3rd, 2022]
- Doctor who gave anti-vaccine speech in front of effigies of officials being hanged faces discipline hearing - CBC.ca [Last Updated On: October 3rd, 2022] [Originally Added On: October 3rd, 2022]
- What's really happening with global vaccine access? - Gavi, the Vaccine Alliance [Last Updated On: October 3rd, 2022] [Originally Added On: October 3rd, 2022]
- Study confirms link between COVID-19 vaccination and temporary increase in menstrual cycle length - National Institutes of Health (.gov) [Last Updated On: October 3rd, 2022] [Originally Added On: October 3rd, 2022]