Opinion: COVID, 4 Years on – Medscape

The following first appeared in the Substack of Eric Topol, MD, called Ground Truths.

As we recently hit March 11, 2020 the 4-year anniversary of when WHO finally declared COVID a global pandemic, and today, March 13th, when the US declared it a national emergency, we're still learning every day about SARS-CoV-2's impact, its evolution, protection from vaccination, and more. Here's a quick summary of what I think is worth reviewing:

The global excess mortality hasreached about 30 million lost livesattributable to COVID, and theGlobal Burden of Disease published a major paperthis week in The Lanceton the toll it has taken for reducing life expectancy in 204 countries summarized as "The COVID-19 pandemic caused the most severe drops in life expectancy seen in 50+ years."The study did not address disability among survivors, with multiple concurrent studies reinforcing the prevalence of long COVID in tens of millions of people.

Here in the United States, it is striking to review the updated data on partisan gap death rates, as reflected by counties who voted Republican in the 2020 election. According to Ashley Wu, graphics editor at the New York Times, the curves are continuing to diverge, both weekly and cumulatively. There was no divergence when vaccines were first administered but since that time the death rates continue to worsen in counties with 70%+ Republican voters compared with <30%.

Multiple state level data, such as Washington's, indicate the protection from death with a booster, almost halving the rate in people age 65 and older.

The JN.1 variant took over globally and a number of subvariants (JN.1.11.1, JN.1.18,JN.1.13, JN.1.18) are showing up with added spike mutations such as R346T and F456L, but without signs of wastewater levels on the rise or other concerning metrics.

But BA.2.87.1, is the major "Omicron-like" event out there that has been the subject of five recent papers/preprints (here,here,here,hereandhere). That, in itself, should tell you it's a variant of interest. It's chock full of new mutations compared with the variants that came long previously, and many of these are deletions.

In itself, it is not a threat as there's no sign it is more immunoevasive or transmissible. In fact, the consensus is that it's less evasive of our immune response, the current booster works to achieve good levels of neutralizing antibodies, and some of the monoclonal antibodies that were previously found to be resistant to earlier variants may be effective again.That's great news. But as Yunlong Cao and his team appropriately warned us,"BA.2.87.1 may not become widespread until it acquires multiple [receptor binding domain] RBD mutations to achieve sufficient immune evasion comparable to that of JN.1."

It's much too early to know whether (and when) this will take place, but after 4 years if there's anything to predict, it is that the virus will find its way (through selection) to infect more hosts and repeat human hosts.

A big study was reportedyesterday that addressed the question of protection from COVID shots against blood clotsdeep vein thrombosis and pulmonary embolism, heart attacks, strokes, and heart failure. The data are from three countriesUK, Spain and Estonia, from electronic health records of over 20 million people. All these outcomes were reduced by prior COVID vaccination compared with no vaccination, especially in the first 30 days after an infection, but many showed durable protection out to 1 year follow-up (stroke, TIA, heart failure, DVT, PE).

This is different from the 40-50% protection of vaccinations vs long COVID symptoms. It's specifically addressing major cardiovascular outcome protection from being vaccinated. Major welcome news!

I remain very disappointed and surprised by the recent change (1 March) of CDC policy towards isolation, without regard to using rapid antigen tests.Their own data shows that at least 1 in 3 people will still be infectious at 5 days after symptom onset!That's by culturable virus, the gold standard, which tracks very closely with the rapid tests. To reduce infecting others, especially high risk vulnerable individuals, no less adding to the toll of long COVID, rapid tests should be used before people circulate.

Thanks for reading Ground Truths and please share the post to your network of friends and colleagues if you found it useful.

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Opinion: COVID, 4 Years on - Medscape