Antigen identification strategies and preclinical evaluation models for advancing tuberculosis vaccine development … – Nature.com

Trunz, B. B., Fine, P. & Dye, C. Effect of BCG vaccination on childhood tuberculous meningitis and miliary tuberculosis worldwide: a meta-analysis and assessment of cost-effectiveness. Lancet 367, 11731180 (2006).

Article PubMed Google Scholar

Fine, P. E. Variation in protection by BCG: implications of and for heterologous immunity. Lancet 346, 13391345 (1995).

Article CAS PubMed Google Scholar

Colditz, G. A. et al. The efficacy of bacillus Calmette-Guerin vaccination of newborns and infants in the prevention of tuberculosis: meta-analyses of the published literature. Pediatrics 96, 2935 (1995).

Article CAS PubMed Google Scholar

Rodrigues, L. C., Diwan, V. K. & Wheeler, J. G. Protective effect of BCG against tuberculous meningitis and miliary tuberculosis: a meta-analysis. Int J. Epidemiol. 22, 11541158 (1993).

Article CAS PubMed Google Scholar

Louise, R., Skjot, V., Agger, E. M. & Andersen, P. Antigen discovery and tuberculosis vaccine development in the post-genomic era. Scand. J. Infect. Dis. 33, 643647 (2001).

Article CAS PubMed Google Scholar

Tameris, M. D. et al. Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial. Lancet 381, 10211028 (2013).

Article CAS PubMed PubMed Central Google Scholar

Hamasur, B. et al. A mycobacterial lipoarabinomannan specific monoclonal antibody and its F(ab) fragment prolong survival of mice infected with Mycobacterium tuberculosis. Clin. Exp. Immunol. 138, 3038 (2004).

Article CAS PubMed PubMed Central Google Scholar

Teitelbaum, R. et al. A mAb recognizing a surface antigen of Mycobacterium tuberculosis enhances host survival. Proc. Natl Acad. Sci. USA 95, 1568815693 (1998).

Article CAS PubMed PubMed Central ADS Google Scholar

Watson, A. et al. Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis. Nat. Commun. 12, 602 (2021).

Article CAS PubMed PubMed Central ADS Google Scholar

Krishnananthasivam, S. et al. An anti-LpqH human monoclonal antibody from an asymptomatic individual mediates protection against Mycobacterium tuberculosis. NPJ Vaccines 8, 127 (2023).

Article CAS PubMed PubMed Central Google Scholar

Hansen, S. G. et al. Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine. Nat. Med 24, 130143 (2018).

Article CAS PubMed PubMed Central Google Scholar

Leung-Theung-Long, S. et al. A multi-antigenic MVA vaccine increases efficacy of combination chemotherapy against Mycobacterium tuberculosis. PLoS One 13, e0196815 (2018).

Article PubMed PubMed Central Google Scholar

Darrah, P. A. et al. Prevention of tuberculosis in macaques after intravenous BCG immunization. Nature 577, 95102 (2020).

Article CAS PubMed PubMed Central ADS Google Scholar

Baldwin, S. L. et al. Evaluation of new vaccines in the mouse and guinea pig model of tuberculosis. Infect. Immun. 66, 29512959 (1998).

Article CAS PubMed PubMed Central Google Scholar

Andersen, P., Askgaard, D., Ljungqvist, L., Bentzon, M. W. & Heron, I. T-cell proliferative response to antigens secreted by Mycobacterium tuberculosis. Infect. Immun. 59, 15581563 (1991).

Article CAS PubMed PubMed Central Google Scholar

Orme, I. M. Induction of nonspecific acquired resistance and delayed-type hypersensitivity, but not specific acquired resistance in mice inoculated with killed mycobacterial vaccines. Infect. Immun. 56, 33103312 (1988).

Article CAS PubMed PubMed Central Google Scholar

Orme, I. M., Andersen, P. & Boom, W. H. T cell response to Mycobacterium tuberculosis. J. Infect. Dis. 167, 14811497 (1993).

Article CAS PubMed Google Scholar

Boesen, H., Jensen, B. N., Wilcke, T. & Andersen, P. Human T-cell responses to secreted antigen fractions of Mycobacterium tuberculosis. Infect. Immun. 63, 14911497 (1995).

Article CAS PubMed PubMed Central Google Scholar

Roberts, A. D. et al. Characteristics of protective immunity engendered by vaccination of mice with purified culture filtrate protein antigens of Mycobacterium tuberculosis. Immunology 85, 502508 (1995).

CAS PubMed PubMed Central Google Scholar

Young, D. B., Kaufmann, S. H., Hermans, P. W. & Thole, J. E. Mycobacterial protein antigens: a compilation. Mol. Microbiol 6, 133145 (1992).

Article CAS PubMed Google Scholar

Andersen, P. Effective vaccination of mice against Mycobacterium tuberculosis infection with a soluble mixture of secreted mycobacterial proteins. Infect. Immun. 62, 25362544 (1994).

Article CAS PubMed PubMed Central Google Scholar

Pal, P. G. & Horwitz, M. A. Immunization with extracellular proteins of Mycobacterium tuberculosis induces cell-mediated immune responses and substantial protective immunity in a guinea pig model of pulmonary tuberculosis. Infect. Immun. 60, 47814792 (1992).

Article CAS PubMed PubMed Central Google Scholar

Nagai, S., Wiker, H. G., Harboe, M. & Kinomoto, M. Isolation and partial characterization of major protein antigens in the culture fluid of Mycobacterium tuberculosis. Infect. Immun. 59, 372382 (1991).

Article CAS PubMed PubMed Central Google Scholar

Andersen, P. et al. Identification of immunodominant antigens during infection with Mycobacterium tuberculosis. Scand. J. Immunol. 36, 823831 (1992).

Article CAS PubMed Google Scholar

Horwitz, M. A., Lee, B. W., Dillon, B. J. & Harth, G. Protective immunity against tuberculosis induced by vaccination with major extracellular proteins of Mycobacterium tuberculosis. Proc. Natl Acad. Sci. USA 92, 15301534 (1995).

Article CAS PubMed PubMed Central ADS Google Scholar

Sinha, R. K., Verma, I. & Khuller, G. K. Immunobiological properties of a 30 kDa secretory protein of Mycobacterium tuberculosis H37Ra. Vaccine 15, 689699 (1997).

Article CAS PubMed Google Scholar

Andersen, P., Askgaard, D., Ljungqvist, L., Bennedsen, J. & Heron, I. Proteins released from Mycobacterium tuberculosis during growth. Infect. Immun. 59, 19051910 (1991).

Article CAS PubMed PubMed Central Google Scholar

Abou-Zeid, C. et al. Characterization of fibronectin-binding antigens released by Mycobacterium tuberculosis and Mycobacterium bovis BCG. Infect. Immun. 56, 30463051 (1988).

Article CAS PubMed PubMed Central Google Scholar

Barnes, P. F. et al. Immunoreactivity of a 10-kDa antigen of Mycobacterium tuberculosis. J. Immunol. 148, 18351840 (1992).

Article CAS PubMed Google Scholar

Haslov, K. et al. Guinea pig cellular immune responses to proteins secreted by Mycobacterium tuberculosis. Infect. Immun. 63, 804810 (1995).

Article CAS PubMed PubMed Central Google Scholar

Launois, P. et al. T-cell-epitope mapping of the major secreted mycobacterial antigen Ag85A in tuberculosis and leprosy. Infect. Immun. 62, 36793687 (1994).

Article CAS PubMed PubMed Central Google Scholar

Roche, P. W. et al. Differential T cell responses to mycobacteria-secreted proteins distinguish vaccination with bacille Calmette-Guerin from infection with Mycobacterium tuberculosis. J. Infect. Dis. 170, 13261330 (1994).

Article CAS PubMed Google Scholar

Daniel, T. M. & Ferguson, L. E. Purification and Characterization Of Two Proteins From Culture Filtrates of Mycobacterium tuberculosis H(37)Ra Strain. Infect. Immun. 1, 164168 (1970).

Article CAS PubMed PubMed Central Google Scholar

Fukui, Y., Hirai, T., Uchida, T. & Yoneda, M. Extracellular proteins of tubercle bacilli. IV. Alpha and beta antigens as major extracellular protein products and as cellular components of a strain (H37Rv) of Mycobacterium tuberculosis. Biken J. 8, 189199 (1965).

CAS PubMed Google Scholar

Wiker, H. G. & Harboe, M. The antigen 85 complex: a major secretion product of Mycobacterium tuberculosis. Microbiol. Rev. 56, 648661 (1992).

Article CAS PubMed PubMed Central Google Scholar

Belisle, J. T. et al. Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis. Science 276, 14201422 (1997).

Article CAS PubMed Google Scholar

Andersen, P., Andersen, A. B., Sorensen, A. L. & Nagai, S. Recall of long-lived immunity to Mycobacterium tuberculosis infection in mice. J. Immunol. 154, 33593372 (1995).

Article CAS PubMed Google Scholar

Berthet, F. X., Rasmussen, P. B., Rosenkrands, I., Andersen, P. & Gicquel, B. A Mycobacterium tuberculosis operon encoding ESAT-6 and a novel low-molecular-mass culture filtrate protein (CFP-10). Microbiology 144, 31953203 (1998).

Article CAS PubMed Google Scholar

Fortune, S. M. et al. Mutually dependent secretion of proteins required for mycobacterial virulence. Proc. Natl Acad. Sci. USA 102, 1067610681 (2005).

Article CAS PubMed PubMed Central ADS Google Scholar

Parkash, O., Singh, B. P. & Pai, M. Regions of differences encoded antigens as targets for immunodiagnosis of tuberculosis in humans. Scand. J. Immunol. 70, 345357 (2009).

Article CAS PubMed Google Scholar

Bottai, D. et al. Increased protective efficacy of recombinant BCG strains expressing virulence-neutral proteins of the ESX-1 secretion system. Vaccine 33, 27102718 (2015).

Article CAS PubMed Google Scholar

Pym, A. S. et al. Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis. Nat. Med. 9, 533539 (2003).

Article CAS PubMed Google Scholar

Heijmenberg, I. et al. ESX-5-targeted export of ESAT-6 in BCG combines enhanced immunogenicity & efficacy against murine tuberculosis with low virulence and reduced persistence. Vaccine 39, 72657276 (2021).

Article CAS PubMed Google Scholar

Andersen, A. B., Yuan, Z. L., Haslov, K., Vergmann, B. & Bennedsen, J. Interspecies reactivity of five monoclonal antibodies to Mycobacterium tuberculosis as examined by immunoblotting and enzyme-linked immunosorbent assay. J. Clin. Microbiol. 23, 446451 (1986).

Article CAS PubMed PubMed Central Google Scholar

Jungblut, P. R. et al. Comparative proteome analysis of Mycobacterium tuberculosis and Mycobacterium bovis BCG strains: towards functional genomics of microbial pathogens. Mol. Microbiol. 33, 11031117 (1999).

Article CAS PubMed Google Scholar

Coler, R. N. et al. Molecular cloning and immunologic reactivity of a novel low molecular mass antigen of Mycobacterium tuberculosis. J. Immunol. 161, 23562364 (1998).

Article CAS PubMed Google Scholar

Coler, R. N. et al. Vaccination with the T cell antigen Mtb 8.4 protects against challenge with Mycobacterium tuberculosis. J. Immunol. 166, 62276235 (2001).

Article CAS PubMed Google Scholar

Covert, B. A., Spencer, J. S., Orme, I. M. & Belisle, J. T. The application of proteomics in defining the T cell antigens of Mycobacterium tuberculosis. Proteomics 1, 574586 (2001).

Article CAS PubMed Google Scholar

Ernst, J. D. The immunological life cycle of tuberculosis. Nat. Rev. Immunol. 12, 581591 (2012).

Article CAS PubMed Google Scholar

Wayne, L. G. The bacteriology of respected tuberculous pulmonary lesions. 2. Observations on bacilli which are stainable but which cannot be cultured. Am. Rev. Respir. Dis. 82, 370377 (1960).

CAS PubMed Google Scholar

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