Bloodbrain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated … – Nature.com

Wu, Z. & McGoogan, J. M. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA 323, 12391242 (2020).

Article CAS PubMed Google Scholar

Zhu, N. et al. A novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med. 382, 727733 (2020).

Article CAS PubMed PubMed Central Google Scholar

Helms, J. et al. Neurologic features in severe SARS-CoV-2 infection. N. Engl. J. Med. 382, 22682270 (2020).

Article PubMed Google Scholar

Taquet, M., Geddes, J. R., Husain, M., Luciano, S. & Harrison, P. J. 6-month neurological and psychiatric outcomes in 236379 survivors of COVID-19: a retrospective cohort study using electronic health records. Lancet Psychiatry 8, 416427 (2021).

Article PubMed PubMed Central Google Scholar

Bohmwald, K., Glvez, N. M. S., Ros, M. & Kalergis, A. M. Neurologic alterations due to respiratory virus infections. Front. Cell. Neurosci. 12, 386 (2018).

Article CAS PubMed PubMed Central Google Scholar

Amraei, R. et al. Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells. Proc. Natl Acad. Sci. USA 119, e2113874119 (2022).

Article CAS PubMed PubMed Central Google Scholar

Cantuti-Castelvetri, L. et al. Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Science 370, 856860 (2020).

Article ADS CAS PubMed PubMed Central Google Scholar

Hoffmann, M. et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell 181, 271280 (2020).

Article CAS PubMed PubMed Central Google Scholar

Ni, W. et al. Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19. Crit. Care 24, 422 (2020).

Article PubMed PubMed Central Google Scholar

Vanlandewijck, M. et al. A molecular atlas of cell types and zonation in the brain vasculature. Nature 554, 475480 (2018).

Article ADS CAS PubMed Google Scholar

Iadecola, C., Anrather, J. & Kamel, H. Effects of COVID-19 on the nervous system. Cell 183, 1627 (2020).

Article CAS PubMed PubMed Central Google Scholar

Lersy, F. et al. Cerebrospinal fluid features in patients with coronavirus disease 2019 and neurological manifestations: correlation with brain magnetic resonance imaging findings in 58 patients. J. Infect. Dis. 223, 600609 (2021).

Article CAS PubMed Google Scholar

Schweitzer, F. et al. Cerebrospinal fluid analysis post-COVID-19 is not suggestive of persistent central nervous system infection. Ann. Neurol. 91, 150157 (2022).

Article CAS PubMed Google Scholar

Thakur, K. T. et al. COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital. Brain 144, 26962708 (2021).

Article PubMed PubMed Central Google Scholar

Yang, A. C. et al. Dysregulation of brain and choroid plexus cell types in severe COVID-19. Nature 595, 565571 (2021).

Article ADS CAS PubMed PubMed Central Google Scholar

Stein, S. R. et al. SARS-CoV-2 infection and persistence in the human body and brain at autopsy. Nature 612, 758763 (2022).

Article ADS CAS PubMed PubMed Central Google Scholar

Monje, M. & Iwasaki, A. The neurobiology of long COVID. Neuron 110, 34843496 (2022).

Article CAS PubMed PubMed Central Google Scholar

Natale, N. R., Lukens, J. R. & Petri, W. A. Jr The nervous system during COVID-19: caught in the crossfire. Immunol. Rev. 311, 90111 (2022).

Article CAS PubMed PubMed Central Google Scholar

Abbott, N. J., Patabendige, A. A., Dolman, D. E. M., Yusof, S. R. & Begley, D. J. Structure and function of the bloodbrain barrier. Neurobiol. Dis. 37, 1325 (2010).

Article CAS PubMed Google Scholar

Greene, C., Hanley, N. & Campbell, M. Claudin-5: gatekeeper of neurological function. Fluids Barriers CNS 16, 3 (2019).

Article PubMed PubMed Central Google Scholar

Lee, M.-H. et al. Microvascular injury in the brains of patients with Covid-19. N. Engl. J. Med. 384, 481483 (2021).

Article PubMed Google Scholar

Lee, M. H. et al. Neurovascular injury with complement activation and inflammation in COVID-19. Brain 145, 25552568 (2022).

Article PubMed Google Scholar

DeOre, B. J., Tran, K. A., Andrews, A. M., Ramirez, S. H. & Galie, P. A. SARS-CoV-2 spike protein disrupts bloodbrain barrier integrity via RhoA activation. J. Neuroimmune Pharmacol. 16, 722728 (2021).

Article PubMed PubMed Central Google Scholar

Krasemann, S. et al. The bloodbrain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2. Stem Cell Reports 17, 307320 (2022).

Article CAS PubMed PubMed Central Google Scholar

Pellegrini, L. et al. SARS-CoV-2 infects the brain choroid plexus and disrupts the bloodCSF barrier in human brain organoids. Cell Stem Cell 27, 951961.e5 (2020).

Savarraj, J. et al. Brain injury, endothelial injury and inflammatory markers are elevated and express sex-specific alterations after COVID-19. J. Neuroinflammation 18, 277 (2021).

Article CAS PubMed PubMed Central Google Scholar

Schwabenland, M. et al. Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions. Immunity 54, 15941610 (2021).

Article CAS PubMed PubMed Central Google Scholar

Wenzel, J. et al. The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells. Nat. Neurosci. 24, 15221533 (2021).

Article CAS PubMed PubMed Central Google Scholar

Montalvan, V., Lee, J., Bueso, T., De Toledo, J. & Rivas, K. Neurological manifestations of COVID-19 and other coronavirus infections: a systematic review. Clin. Neurol. Neurosurg. 194, 105921 (2020).

Article CAS PubMed PubMed Central Google Scholar

Ng Kee Kwong, K. C., Mehta, P. R., Shukla, G. & Mehta, A. R. COVID-19, SARS and MERS: a neurological perspective. J. Clin. Neurosci. 77, 1316 (2020).

ODoherty, L. et al. Study protocol for the St Jamess Hospital, Tallaght University Hospital, Trinity College Dublin Allied Researchers (STTAR) Bioresource for COVID-19. HRB Open Res. 5, 20 (2022).

Article PubMed PubMed Central Google Scholar

Ryan, F. J. et al. Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection. BMC Med. 20, 26 (2022).

Article CAS PubMed PubMed Central Google Scholar

Finlay, J. B. et al. Persistent postCOVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium. Sci. Transl. Med. 14, eadd0484 (2022).

Zhou, G., Lane, G., Cooper, S. L., Kahnt, T. & Zelano, C. Characterizing functional pathways of the human olfactory system. eLife 8, e47177 (2019).

Article CAS PubMed PubMed Central Google Scholar

Saive, A.-L., Royet, J.-P. & Plailly, J. A review on the neural bases of episodic odor memory: from laboratory-based to autobiographical approaches. Front. Behav. Neurosci. 8, 240 (2014).

Article PubMed PubMed Central Google Scholar

Phetsouphanh, C. et al. Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection. Nat. Immunol. 23, 210216 (2022).

Article CAS PubMed Google Scholar

Zheng, H.-Y. et al. Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19. Signal Transduct. Target. Ther. 5, 294 (2020).

Article ADS CAS PubMed PubMed Central Google Scholar

Taquet, M. et al. Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization. Nat. Med. 29, 24982508 (2023).

Article CAS PubMed PubMed Central Google Scholar

Douaud, G. et al. SARS-CoV-2 is associated with changes in brain structure in UK Biobank. Nature 604, 697707 (2022).

Article ADS CAS PubMed PubMed Central Google Scholar

Donegani, M. I. et al. Brain metabolic correlates of persistent olfactory dysfunction after SARS-Cov2 infection. Biomedicines 9, 287 (2021).

Article CAS PubMed PubMed Central Google Scholar

Fitsiori, A., Pugin, D., Thieffry, C., Lalive, P. & Vargas, M. I. COVID-19 is associated with an unusual pattern of brain microbleeds in critically ill patients. J. Neuroimaging 30, 593597 (2020).

Article PubMed PubMed Central Google Scholar

Guedj, E. et al. 18F-FDG brain PET hypometabolism in patients with long COVID. Eur. J. Nucl. Med. Mol. Imaging 48, 28232833 (2021).

Article CAS PubMed PubMed Central Google Scholar

Qin, Y. et al. Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations. J. Clin. Invest. 131, e147329 (2021).

Article PubMed PubMed Central Google Scholar

Tian, T. et al. Long-term follow-up of dynamic brain changes in patients recovered from COVID-19 without neurological manifestations. JCI Insight 7, e155827 (2022).

Article PubMed PubMed Central Google Scholar

Aleksovska, K. et al. Systematic review and meta-analysis of circulating S100B blood levels in schizophrenia. PLoS ONE 9, e106342 (2014).

Article ADS PubMed PubMed Central Google Scholar

Thelin, E. P., Nelson, D. W. & Bellander, B.-M. A review of the clinical utility of serum S100B protein levels in the assessment of traumatic brain injury. Acta Neurochir. 159, 209225 (2017).

Article PubMed Google Scholar

Greene, C. et al. Microvascular stabilization via bloodbrain barrier regulation prevents seizure activity. Nat. Commun. 13, 2003 (2022).

Article ADS CAS PubMed PubMed Central Google Scholar

Montagne, A. et al. Bloodbrain barrier breakdown in the aging human hippocampus. Neuron 85, 296302 (2015).

Article CAS PubMed PubMed Central Google Scholar

Senatorov, V. V. et al. Bloodbrain barrier dysfunction in aging induces hyperactivation of TGF signaling and chronic yet reversible neural dysfunction. Sci. Transl. Med. 11, eaaw8283 (2019).

Article CAS PubMed Google Scholar

Kamintsky, L. et al. Bloodbrain barrier imaging as a potential biomarker for bipolar disorder progression. Neuroimage Clin. 26, 102049 (2020).

Article PubMed Google Scholar

Kamintsky, L. et al. Bloodbrain barrier leakage in systemic lupus erythematosus is associated with gray matter loss and cognitive impairment. Ann. Rheum. Dis. 79, 15801587 (2020).

Article CAS PubMed Google Scholar

Abdelhak, A. et al. Blood GFAP as an emerging biomarker in brain and spinal cord disorders. Nat. Rev. Neurol. 18, 158172 (2022).

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Bloodbrain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated ... - Nature.com

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