Largest Covid vaccine study to date finds link to health conditions – GB News

Vaccines that protect against severe illness, death and lingering long Covid symptoms from a Covid-19 infection are linked to small increases in neurological, blood, and heart-related conditions, according to the largest global vaccine safety study to date.

The study is likely to deepen the debate over the relative merits of getting vaccinated and whether the response was proportional.

Researchers stress that the risk of an adverse event from a Covid vaccine remains relatively low and that association does not prove causation.

However, among the 13.5 billion doses administered globally, a small proportion of people immunised developed complications, fuelling a debate over the trade-offs involved.

The rare events identified early in the pandemic included a higher risk of heart-related inflammation

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The rare events identified early in the pandemic included a higher risk of heart-related inflammation from mRNA shots made by Pfizer Inc, BioNTech SE, and Moderna Inc, and an increased risk of a type of blood clot in the brain after immunisation with viral-vector vaccines such as the one developed by the University of Oxford and made by AstraZeneca Plc.

The viral-vector jabs were also tied to an increased risk of Guillain-Barre syndrome, a neurological disorder in which the immune system mistakenly attacks the peripheral nervous system.

The new research, by the Global Vaccine Data Network, dove further into the data. The full results are published in the journal Vaccine.

Researchers looked for 13 medical conditions that the group considered adverse events of special interest among 99 million vaccinated individuals in eight countries, aiming to identify higher-than-expected cases after a Covid shot.

Myocarditis, or inflammation of the heart muscle, was consistently identified following a first, second and third dose of mRNA vaccines, the study found.

The highest increase in the observed-to-expected ratio was seen after a second jab with the Moderna shot. A first and fourth dose of the same vaccine was also tied to an increase in pericarditis, or inflammation of the thin sac covering the heart.

Researchers found a statistically significant increase in cases of Guillain-Barre syndrome within 42 days of an initial Oxford-developed ChAdOx1 or Vaxzevria shot that wasnt observed with mRNA vaccines.

Based on the background incidence of the condition, 66 cases were expected but 190 events were observed. ChAdOx1 was linked to a threefold increase in cerebral venous sinus thrombosis, a type of blood clot in the brain, identified in 69 events, compared with an expected 21.

The small risk led to the vaccines withdrawal or restriction in Denmark and multiple other countries. Myocarditis was also linked to a third dose of ChAdOx1 in some, but not all, populations studied. Possible safety signals for transverse myelitis spinal cord inflammation after viral-vector vaccines was identified in the study.

Widespread immunity through vaccination allowed the UK to lift lockdown measures

So was acute disseminated encephalomyelitis inflammation and swelling in the brain and spinal cord after both viral-vector and mRNA vaccines.

Seven cases of acute disseminated encephalomyelitis after vaccination with the Pfizer-BioNTech vaccine were observed, versus an expectation of two.

The adverse events of special interest were selected based on pre-established associations with immunisation, what was already known about immune-related conditions and preclinical research. The study didnt monitor for postural orthostatic tachycardia syndrome, or POTS, that some research has linked with Covid vaccines.

This the largest study to date looking at the risks associated with Covid vaccination. The size of the study sample is pause for thought but the number of people injured is relatively small when compared to the people immunised without incident.

It's also important to understand the bigger picture here. Covid was a moving target and so were the interventions taken to stop it.

Furthermore, widespread immunity offered through vaccination allowed the UK to lift lockdown measures, revive the economy and restore a sense of normality to back to people's lives.

And numerous studies suggest vaccination saved lives. The largest study of its kind ever carried out in the UK has found that 7,180 of the 40,393 hospitalisations and deaths from COVID-19 could have been avoided had the population been fully vaccinated.

Still, those left injured by vaccination are demanding answers and dissent should not be silenced - a point powerfully articulated by a man who recently confronted Rishi Sunak over Covid vaccine injuries on GB News.

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Largest Covid vaccine study to date finds link to health conditions - GB News